Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :4203–4219, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants.
Using molecular modeling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.
Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.
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Important points:
Antibodies developed from the current COVID injections cause the body to overreact to mutations like Delta, proving ADE.
Mutations/variations are a normal, mundane aspect of viral evolution, but experts are stating that mass vaccination campaigns are causing them as they push the virus to mutate to survive.
Logic would indicate these vaccination campaigns should be stopped for this very reason, along with the fact these jabs have caused more reports of adverse reactions and death than any other jabs in the history of VAERS, and VAERS typically only captures 1% of reports, so it’s actually far, far worse in reality.
Dr. Lee Merrit explains that ALL animals in previous mRNA biologic studies DIED from ADE (antibody dependent enhancement). Key word: ALL
Naturalimmunity should be accepted and embraced, as historically it is the only thing that confers lasting immunity.
France’s long-time vaccine policy chief: Covid policy is “completely stupid” and “unethical”
UK Column was recently able to interview top French vaccine expert Professor Christian Perronne on the subject of Covid-19 “vaccines”.
Professor Perronne is Head of the Medical Department at Raymond Poincaré Hospital in Garches, the teaching hospital for the University of Versailles-St Quentin near Paris. He was the University’s Head of Department for Infectious and Tropical Diseases from 1994 onwards, but was fired from that position a few months ago. He is a Fellow of France’s biomedical research centre of world standing, the Institut Pasteur, from which he graduated in bacteriology and virology and where he served as Deputy Director of the National Reference Centre for Tuberculosis and Mycobacteria until 1998.
He has chaired many top-level health committees, including the French Specialist Committee for Communicable Diseases, and the High Council on Public Health (French acronym: HCSP), which advises the government on public health policy and vaccination policy. He is not anti-vaccine and indeed wrote France’s vaccination policy for many years, as well as presiding over the National Consultation Group on Vaccination, also known as the Technical Committee on Vaccination (CTV).
Professor Perronne was also the Vice-President of the European Advisory Group to the World Health Organisation. At national level in France, he has chaired the Infectious and Tropical Diseases Teaching College (CMIT), the Infectious Diseases Federation (FFI, which he co-founded), the High Council for Public Hygiene (CSHP), and the National Medical and Healthcare products Safety Agency (ANSM, previously AFSSAPS), which evaluates the health risks of medicines and is France’s sole regulator of biomedical research. Until 2013, he sat on the Scientific Council of the French Microbiology and Infectious Diseases Research Institute (IMMI/INSERM).
Despite Professor Perronne’s extensive knowledge and experience of communicable diseases, vaccines and vaccine policy at national and governmental level in France, he was quickly censored for speaking out on the subject of Covid-19 vaccines, their claimed efficacy and their identifiable risks. In short, he was professionally sidelined, his reputation was attacked and his professional opinions were censored.
We are therefore delighted to be able to offer this very brave and highly knowledgeable man the opportunity to express his professional opinions and concerns to our audience both in the UK and worldwide, by means of this crucial video interview.
Professor Perronne was joined by Dr Anne-Marie Yim, who kindly facilitated this interview. Anne-Marie is herself highly qualified to speak on vaccines and their effects in the body, having worked as a protein and immune response research expert within the wider pharmaceutical and vaccine industry.
Please share widely
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**Comment**
Dr. Perronne is also a Lyme literate doctor who has spoken out widely in support of treating Lyme patients appropriately a well as the fact these infections are serious but overlooked and denied by many ‘authorities’ and doctors.
It appears that Dr. Perronne, a vaccine proponent, is clashing yet again with ‘the powers that be’ – this time over COVID injections, and due to this was recently fired as Head of the Medical Department at Raymond Poincaré Hospital in Garches.
these injections contain the sequence of a gene—the first time this has ever been done
genetic material is being injected into your body, which is why it should not be labelled a “vaccine”, because that’s deceiving
when you inject messenger RNA to produce a huge amount of a spike protein, a fragment of the SARS-CoV-2 virus, you can’t control the process
in human cells, RNA might go back to DNA
never before has the state or politicians recommended systematic vaccinations for billions of people for a disease whose rate of mortality now is 0.05%
in states where ivermectin, zinc, Doxycycline and Vitamin D, were used, the epidemic remained at a very low rate and was soon over
in the states where they banned these antibiotic and antiviral treatments, but promoted the “vaccine” and Remdesivir (toxic and not efficacious), the epidemic came back, with new cases of mortality
“vaccinated” people should be put in quarantine and isolated as they are dangerous to others. Israel and the UK are perfect examples as severe cases there are among the “vaccinated”
variants are not very dangerous and are less and less virulentwhich is always the case in infectious diseases
the epidemic is OVER in manycountries worldwide, yet governments are forcing these injections upon their citizens
Vietnam is a perfect example as they only had a few dozen deaths in over more than a year until the leaders made injections nearly mandatory, which caused the epidemic to came back with subsequent fatalities
these examples prove these injections are not vaccines but actually may facilitatedisease and death
the WHO’s statement that herd immunity will be achieved when 80% of the population is “vaccinated” is not based on science and should be considered null and void
immunologist Dolores Cahill states once you’ve been infected and have recovered you have antibodies FOR LIFE
Dr. Bhakdi based on new scientific evidence states:
your immune system is your best defense against SARS-CoV-2
if you have been infected, even if you experienced no symptoms at all, you are immune to all variants
we have already reached herd immunity
there is no scientific reason to vaccinate against SARS-CoV-2
there is no benefit and the rollout must be stopped
we still have no reliable serological tests and most of the tests are “bulls**t”. They can not correctly identify the numbers of antibodies
the scientific community due to conflicts of interest don’t want to develop these tests because it would show Britain, France, Germany, and Spain are now immunized. There is herd immunity.
this is a big problem for pharmacological companies trying to impose “vaccination” policies
since the first lockdown in March, doctors are reporting the same things
a political protocol was put in place to detect and treat the disease that amounts to total malpractice
many doctors received orders to close their practices and were required to work in military centers 48-72 hours where they could not treat patients appropriately
seriously ill patients were put in an induced coma to be intubated with oxygen
they were forbidden to take heparin, an anti-inflammatory or aspirin, an anticoagulant
their lungs failed, systemic inflammation, water in the lung, and inability to breathe led to bacterial infections – often sepsis, and they would die – there was only a 50% chance of recovery
if you administer 2 mg hydroxychloroquine in the ICU in an induced coma, you can have heart attack problems resulting in death. That’s what they have been trying to show with the RECOVERY Trial, which Dr. Didlier Raoult has stated it was “the Marx Brothers doing science.” The person in charge of the trial (Professor Landray from Oxford University) used the “usual” dosage for amoebic dysentery, but HCQ is not even the usual treatment for this. He does not understand anything about infectious diseases or anti-infection drugs but led an international trial anyway.
‘Authorities’ stated, “See, hydroxychloroquine doesn’t work!Of course, because you should treat it at an early stage! The same is true of ibuprofen. In the Recovery Trial, they used 4-5 times the maximum authorized dose. They also modified the evaluation criteria, and doctors could not gain access to the original database. (See FLACCC protocols for every stage of COVID, which are saving lives.)
Dr Ochs found that people who have been ‘vaccinated” have a very high level of D-dimers [proteins in blood tests indicating a clotting process], and a lot of physicians have been reporting blood clots forming with AstraZeneca (and other shots)
with COVID, there is thrombocytopoenia (low platelets) induced by interactions of E-selectin with Leukocytes which is why Dr. Ochs prescribes vitamin C and ibuprofen to the “vaccinated” who have high D-dimers. If the disease progresses, clots form in the brain and if too much heparin or aspirin is given to dissolve the clots the patient can have hemorrhaging due to low platelets, so it’s a complex issue. The same medicine can save or kill depending upon when and how it’s used.
regarding Ivermectin, when you have over 80%, sometimes 90% success,you don’t need a placebo. Even the WHO states that you don’t need a placebo in a crisis situation with non-toxic drugs that work. There are randomized studies and Ivermectin has been proven to work.
the only reason the FDA and other regulatory agencies state these drugs don’t work is due their conflicts of interest and the fact it would nullify their lucrative “vaccines”
its a bit ironic that “vaccine” manufacturers have all gotten rid of their placebo groups yet authorities deny effective treatments that did not have placebo groups
regarding the fraudulent studypublished in The Lancet, they said that hydroxychloroquine was “dangerous” or “not effective”, which led to the Minister saying, “Stop hydroxychloroquine!”
yet some slides from the intermediate analysis of these two studies leaked out on the Internet showed the only group that had an efficiency of less death was the group using either hydroxychloroquine in the DisCoVeRy study, or hydroxychloroquine plus azithromycin in the iCovid study. While not yet statistically significant, the curves showed it was spectacular in reducing death, but the damage was done and the minister never changed his policy and banned HCQ.
these so-called “experts” who are on the TV every day, and have huge conflicts of interest with pharmaceutical companies and are unscientific charlatans, along with the media – should be fired
The Indian Bar Association is suing the Chief Scientist of the [WHO in India] for the policies which have resulted in more than three million deaths
Perronne states he has never seen such severe side-effects from a “vaccine” as has been caused by the COVID shots but that most are not being reported
this is the first time in history we are told that “it’s a good ‘vaccine’ but you can still get the disease.” This is not normal. An efficient vaccine would be protective. No masks. Live normally
mandating these injections is a scandal and which is resulting in globalprotests and will probably result in a civil war
a Spanish team has been reportinggraphene oxide entering the brain, and is causing Guillain-Barré syndrome, and that is eating up the myelin, the coating on the nerves
polyethylene glycol. This goes into your brain. It can cross the blood-brain barrier. Normally, it shouldn’t, but it can go and pass into your brain. And there is also this graphene oxide. Basically, everything about this injection is poisonous: not just messenger RNA and spikeprotein, which cause inflammation and can be integrated into your DNA, but also the graphene oxide.
Perronne has written a recent book titled: “Crypto-infections: Denial, Censorship and Suppression―the Truth About What Lies Behind Chronic Disease”
The accepted message is that humankind has largely conquered infectious disease with a mixture of antibiotics and vaccines, yet it is becoming increasingly clear that chronic hidden or latent infections (crypto-infections) lie behind many of today’s big killers, including heart disease, dementia, and cancer. As an exemplar of how the organisms responsible can hide in plain sight, causing devastation while the medical world is in denial, Borrelia burgdorferi—the bacterium responsible for Lyme disease—has led Dr Perronne to clash with his fellow specialists in infectious disease (ID) and challenge the status quo. From his experience as one of France’s, and the world’s, leading ID specialists, he examines the threats that both Lyme in particular and crypto-infections in general pose and how we can rise to the challenge.
The ticks that carry the bacteria responsible for Lyme disease are tiny, their bites are painless, and they don’t always trigger a telltale bull’s-eye-shaped rash. Photograph by Edwin Remsburg / Getty
In May, an article with the unprepossessing title “Detecting Borrelia Spirochetes: A Case Study with Validation Among Autopsy Specimens” was published in the medical journal Frontiers in Neurology. The deceased person in question was a sixty-nine-year-old woman who suffered from severe cognitive impairment. Fifteen years before her death she had been treated for Lyme disease, the most prevalent tick-borne illness in the United States, and was thought to have fully recovered. Yet, when her brain and spinal-cord tissue were examined, researchers found intact Borrelia spirochetes, the bacteria responsible for Lyme. If the woman’s cognitive decline did result from Lyme disease—which the paper suggested was a strong possibility—then it was further evidence that the illness could persist and wreak havoc long after a tick bite, and long after treatment.
The standard therapy for Lyme disease is a course of antibiotics, typically doxycycline. Ideally, the medication should be taken within a few days of infection, but it’s tricky. The ticks that carry the bacteria are about the size of a poppy seed, their bites are painless, and not everyone gets a telltale bull’s-eye-shaped rash at the site of the bite. Many people don’t know they’ve been infected until they become symptomatic with joint pain, fever, body aches, chills, heart palpitations, myocarditis, and brain fog, at which point the antibiotics may be ineffective. Of the estimated half a million people who get Lyme disease each year in the United States, around ten to twenty per cent might fall into this category. But, as the dead woman’s brain showed, sometimes, even when the antibiotic is administered at the right time, it’s insufficient. A more effective strategy would be to impede transmission before the bacteria have a chance to enter the bloodstream. And that, too, has been tricky—but may be about to change.
There used to be a Lyme vaccine—and then, in a rare occurrence in modern medicine, it disappeared.
(See link for article)
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**Comment**
A few points for consideration:
While GSK abandoned LYMErix, citing poor sales, the Lyme community knows the real story – it caused patients to develop Lyme-like symptoms and other severe adverse events – the very thing they were hoping to avoid.
LYMErix was given “permissive” recommendation by the CDC (the injection was only advised for those ‘at risk’, not the whole population). This designation allowed those suffering with adverse reactions to sue the manufacturer, which they did.
The author states the “unlikely villain” in this story are suffering patients. Wow.
The “scientists” the author talked with (likely the ones creating the vaccine) told her that “people came to believeit caused arthritis). The belief issue is a common refrain in Lyme-land. Can you blame patients for being highly skeptical when they aren’t believed?
The article insists that data show that “the arthritis incidence in the patients receiving Lyme vaccine occurred at the same rate as the background in unvaccinated individuals. . . .and that the FDA found no link between the vaccine and harm. If there’s one thing we should have learned this year, it’s that data can be manipulated to say whatever you want it to say. Flawed study design is rampant, but is used to control the narrative.
University researchers depend upon government money doled out by none other than the dishonorable and corrupt Dr. Fauci, head of NIAD for 7 presidencies, who makes more money than the President of the United States. John Aucott, realizing his funding comes from a bully who will pull his funding or discredit him if he speaks freely must straddle the fence and state that people have reactions after every vaccine and that occasionally there is a rare side-effect that can never be discerned between someone destined to have it or caused by the vaccine. PC at its best. Call me crazy, but I tend to believe thousands of patients who suddenly developed Lyme-like symptoms after a vaccine, that were fine previously.
Dr. Mark Klempner calls LYMErix’s removal a “tragedy.” His new lucrative jab called Lyme PrEP is now in Phase 1 trials. Please know the backstory on Klempner. He claims this new shot isn’t a “vaccine;” however, according to this, OspA is still in it. Here’s what Dr. Stricker has to say about OspA:Another Lyme OspA Vaccine Whitewash
The meta-analysis by Zhao and colleagues comes to the conclusion that “the OspA vaccine against Lyme disease is safe and its immunogenicity and efficacy have been verified.” The authors arrive at this sunny conclusion by excluding 99.6% of published articles that demonstrate potential problems with the OspA vaccine. Furthermore, the authors ignore peer-reviewed studies, FDA regulatory meetings and legal proceedings that point to major problems with OspA vaccine safety (1-3). This whitewash bodes ill for future Lyme vaccine candidates because it fosters disregard for vaccine safety among Lyme vaccine manufacturers and mistrust among potential Lyme vaccinees.
SamTelford, another member of The Cabal, laments it didn’t help that at the same time a rotavirus vaccine for children was demonstrated to actually do harm, adding to the growing anti-vaccine sentiment. Do these people have a hearts in their bodies at all?
French pharmaceutical company Valnevajoined up with Pfizer(a company which has been fined over 3.5 billion for safety violations, false medical claims, corruption, bribery and has demanded countries put up sovereign assets, bank reserves, military bases and embassy buildings as collateral for expected lawsuits from COVID shots) to develop a vaccine (currently in a 3rd phase II trial) that is reminiscent of LYMErix.
The author of the article doubts that the vocal anti-vaccine sentiment around the various covid “vaccines” will affect these new Lyme-disease pharmaceuticals (which still have OspA in them), as they claim some are not traditional vaccines. She also feels that the high Lyme disease numbers due to ticks expanding their range will also make people take the jab.
Now Aucott is “cloning a bunch of proteins in tick saliva” to replicate tick resistance, but he’s also an adviser to Tarsus Pharmaceuticals, a biopharmaceutical company which is authorized by the F.D.A. to develop an oral preventative in humans using lotilaner, the active ingredient in Credelio, a veterinary medication prescribed for dogs and cats to prevent fleas and ticks which istargeted to the parasite’s nervous system but supposedly doesn’t have any effect on mammals.
Since it’s going to be a couple years before any of these lucrative drugs come to market The Cabal recommends taking normal precautions when going outdoors, and to not be afraid.
Ivermectin is a promising Covid treatment and prophylaxis, but the agency is denigrating it
By David R. Henderson and Charles L. Hooper
The Food and Drug Administration claims to follow the science. So why is it attacking ivermectin, a medication it certified in 1996?
Earlier this year the agency put out a special warning that “you should not use ivermectin to treat or prevent COVID-19.” The FDA’s statement included words and phrases such as “serious harm,” “hospitalized,” “dangerous,” “very dangerous,” “seizures,”“coma and even death” and “highly toxic.” Any reader would think the FDA was warning against poison pills. In fact, the drug is FDA-approved as a safe and effective antiparasitic.
Ivermectin was developed and marketed by Merck & Co. while one of us (Mr. Hooper) worked there years ago. William C. Campbell and Satoshi Omura won the 2015 Nobel Prize for Physiology or Medicine for discovering and developing avermectin, which Mr. Campbell and associates modified to create ivermectin.
Ivermectin is on the World Health Organization’s List of Essential Medicines. Merck has donated four billion doses to prevent river blindness and other diseases in Africa and other places where parasites are common. A group of 10 doctors who call themselves the Front Line Covid-19 Critical Care Alliance have said ivermectin is “one of the safest, low-cost, and widely available drugs in the history of medicine.”
The spin-doctors recently put out this hit-piece against Ivermectin, a safe, cheap, effective treatment for COVID. The author manipulates the fact there are some desperate self-treating people who are experiencing poisoning due to taking the animal form of ivermectin because mainstream medicine has shunned it. The hit-piece and the CDC uses this unfortunate event to recommend that “instead of prescribing ivermectin, physicians should urge patients to get ‘vaccinated’ against COVID,” use masks, social distance, and wash hands.” Federal agencies have launched an offensive against ivermectin prescribing this week, with the FDA issued a consumer warningabout ivermectin. The agency made a splash with a humorous tweet about the warning, stating, “You are not a horse. You are not a cow. Seriously, y’all. Stop it.”
If you are a Lyme/MSIDS patient, you quickly learn that those entrusted with public health are charlatans who are far more interested in power and money than in guiding the public to better health. Patients suffering from tick-borne illness are kicked to the curb and told to “go home and be well,” while smug conflict-riddled authorities have patents on virtually every aspect of the disease. Similarly to COVID, they rig testing for a pre-determined outcome that suits their vested interests. These ‘authorities’ have been virtually wrong about every single issue.
In the case of Ivermectin, a drug previously considered an “essential medicine” that is safe and effective, it is now dangerous, toxic, and harmful for COVID. Why the about-face?
The international group of doctors called “Frontline COVID-19 Critical Care Alliance” or FLACCC searched for cheap drugs that could be repurposed for COVID and found Ivermectin fit the bill perfectly. They have created protocols for every stage of the illness which have saved countless lives, yet are still being highly maligned and censored, with regular hit-pieces against them by corrupt medical journals. Now courts are having to orderhospitals to give these treatments to save lives. You will not hear about these success stories from the media.
Interestingly, when I posted Dr. Kory, a member of the group, speaking at the Senate hearing on the effectiveness of Ivermectin on COVID and his frustration with all of the information being censored, I had to go back and put in a pdf of the transcript as Youtube censored the Senate hearing!
This censoringmadness has hit a new low, as doctors are now being threatened by The Federation of State Medical Boards (FSMB) that doctors and health professionals could be at risk of losing their medical licenses if they spread COVID-19 vaccine misinformation on social media, online and in the media. Excerpt:
“They also have an ethical and professional responsibility to practice medicine in the best interests of their patients and must share information that is factual, scientifically grounded and consensus-driven for the betterment of public health.”
Hopefully it isn’t hard to ascertain that “consensus-driven” are the key words here.
Lyme/MSIDS has a long, dark history where nearly nothing about it is accepted and agreed upon. There is no consensus when it comes to tick-borne illness and the topic is still – 40 years after discovery – hotly debated leaving many doctors too afraid to treat it. Those that do are in the cross-hairs of public health authorities and are bullied, threatened, monitored, fined, and have their licenses restricted or revoked.
Remember when the consensus for COVID was to put everyone under medically-induced comas with ventilators and it killed some 85 percent of patients who received the “treatment”? I personally know of a man who was only offered that specific treatment at a local hospital. Thankfully, he declined and lived to tell the tale. Was he offered HCQ or Ivermectin or even IV vitamin C? Nope, because those treatments aren’t “consensus-driven,” or peddled by our corrupt public health authorities who stand to gain a lot of money by continuing to push the fear narrative.
These ‘authorities’ have done all in their power to inflate case numbers with a faulty, worthless test which is designed to be positive, and inflate the deathcount to perpetuate fear so everyone believes their only recourse is to take their lucrative, fast-tracked, experimental mRNA injection that isn’t approved, hasn’t gone through extensive safety testing, isn’t even a vaccine, that is causing microscopic blood clotting, and is allowing a toxic spike protein which has been labeled a “bioweapon” to go systemically into the body where it is accumulating in tissues and organs,crossing the blood, brain barrier – and is associated with Parkinson’s and Prion diseases.
An entire group of doctors have written a paper on how these experimental injections are “needless, ineffective, and dangerous,” on the healthy and sick alike.
Hardly sounds like“consensus” to me.
Yet, observe which side gets air-play with the bought-out media, which has already attacked doctors daring to speak against the “consensual” accepted narrative.
Hint: it won’t be for doctors who only stand to lose their jobs.
Remember when The Guardian stated Sweden’s approach was “a catastrophe” and CBS Newssaid Sweden had become “an example of how not to handle COVID-19?”
Well, they can apologize now.
Sweden’s singular open, relaxed approach, which continues to this day, has data showing the 7-day average for COVID deaths was zilch and has been for a week. The evidence is crystal clear for anyone who cares. Sweden did it right. The rest of the world got it wrong.
Overall mortality there is lower than most of Europe and its economy suffered far less.
Meanwhile, angry protests are breaking out elsewhere as tyrants continue their choke-hold. Source
“Bill de Blasio announced that, beginning August 16th, anyone who wants to enjoy indoor entertainment, such as bars, restaurants or movie theaters, and anyone entering an indoor gym, must show proof of vaccination. He’s calling it the ‘Key to New York City.’ After numerous other attempts to entice people into vaccination, from $100 gift cards giveaways, free Krispy Kreme and tickets to various attractions, the city has now turned to what you used to be considered a conspiracy theory—vaccine passports.”
Now, society has reached a new low thanks to corrupt public health ‘authorities’ and a bought out media, that has given the public a steady diet of fear and propaganda. Many now believe the “unvaxxed” should be jailed, shot, or forced into starvation, despite the fact naturalimmunity is always better than anything a vaccine could produce, and that there are many reasons to forego vaccination.
All this for shots that don’t prevent infection, transmission, or death, and have caused untold suffering.