Archive for the ‘Inflammation’ Category

What Lyme & Autism Have in Common Will Surprise You

https://dariningelsnd.com/lyme-and-autism/

July 6, 2020

By Dr. Darin Ingels N.D.

When speaking with children who are chronically ill, it can be difficult to understand what is causing their symptoms.

Children, naturally, might not know how to accurately describe their pains or illness. When there are multiple symptoms, it can be even more challenging as they grow and change so quickly.

For children with autism or other language disorder, they may be limited or unable to communicate why they feel the way they feel. Autism Spectrum Disorder (ASD) and Lyme disease are examples of what seem to be entirely different diseases, but they share an overlap of symptoms.

While autism is usually seen as a developmental disorder and Lyme disease and infectious disease, the two have more in common than you might think. There are interesting connections between the two, especially when diagnosed in children.

Sad boy with symptoms of lyme disease

Symptoms shared by both Autism and Lyme:

  • Neurological symptoms that include difficulty with communication and confusion, disorientation, muscle twitching, sensitivity to light, brain fog, and delayed development.
  • Psychological problems that impact behaviors, obsessive-compulsive disorder, an increased sense of doom, anxiety and outbursts.
  • Physical health issues such as muscle weakness, arthritis, and rashes.
  • Gut health issues including food allergies, bloating, constipation or diarrhea, and abdominal pain.

These symptoms are common features of autism and Lyme disease.

Coincidentally, many of these symptoms are also displayed in auto-immune disorders.

Tests for Lyme can be misleading, as they have a poor accuracy. A specialist is always needed in order to get a better sense of other treatment options because both autism and Lyme can have long-term issues.

However, there are treatments that benefit Lyme and autism alike. Focusing on gut health has been an important part of treatment for both conditions. This is because we are seeing the benefits of specific diets in patients with autism and/or Lyme.

Nutritional support strengthens the integrity of the intestinal membranes, balances the billions of bacteria in our gut and improves digestion and elimination.

All of this help support the immune function of the gut, which ultimately affects brain function.

An effective nutritional protocol would support the immune system, reduce symptoms, calm the nervous system and strengthen the body’s ability to fight infections.

Autoimmune conditions such as autism and Lyme disease benefit greatly from proper diet and lifestyle modifications.

Wheat

Removing casein, dairy, sugar, processed foods and gluten from the diet will allow the body to heal and aid in the detoxification process, naturally.

Reducing environmental factors like external and emotional stressors are extremely important for both Lyme and ASD.

Stress responses increase the load on the immune & nervous system, which can lead to exhaustion and further relapse into symptoms.

Identifying these triggers help you to work around them and eventually train your nervous system to create new patterns and get rid of the old ones. Autoimmune conditions have very unique impacts on the immune system, especially Lyme and autism.

Consider speaking to a specialist about your symptoms, especially if they mimic other autoimmune conditions. And never be afraid to get a second or even third opinion, as it may be necessary in order to get to the root of problem.

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For more:  https://madisonarealymesupportgroup.com/2019/12/22/identification-evaluation-and-management-of-children-with-autism-spectrum-disorder/

https://madisonarealymesupportgroup.com/2018/09/28/toxic-metal-pollution-linked-with-development-of-autism-spectrum-disorder/

https://madisonarealymesupportgroup.com/2018/09/05/pans-autism-the-immune-system-an-interview-with-expert-neurologist-dr-richard-frye/

https://madisonarealymesupportgroup.com/2017/10/26/clinical-trial-shows-most-kids-with-autism-are-not-born-with-it/

Benefits of Berberine Against Chronic Disease

https://www.foundmyfitness.com/topics/berberine?

Benefits of berberine against chronic disease

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By Rhonda Patrick

Background

Berberine is an alkaloid compound present in the roots, stems, rhizomes, and bark of a variety of plants, including Californian poppy, goldenseal, cork tree, Chinese goldthread, Oregon grape, and several plants in the Berberis genus. It is also widely available as a dietary supplement. Berberine has a long history of use in the ancient and traditional medicine systems of India, China, and Persia. Animal and limited human studies demonstrate that berberine may exert pharmacological effects against certain chronic health conditions such as cardiovascular disease, gastrointestinal disorders, neurodegenerative disease, depression, and metabolic dysfunction. Preliminary research in animals also suggests that berberine may exert anti-aging properties and might be beneficial in combating aging-related diseases. However, the bulk of research involving berberine has been conducted in animals, with a paucity of trials in humans. (See link for article)

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**Comment**

Berberine has been a God-send for us.  It has been shown to:

  1. lower lipids
  2. have antioxidant properties
  3. have anti-inflammatory properties
  4. reduce blood glucose levels
  5. protect the liver (in cell-culture studies)
  6. help neurodegenerative disorders
  7. have anti-depressant effects (in mice)
  8. have anti aging effects (in cells, insects, and rodents)
  9. thwarts negative effects of some pharmaceutical drugs
  10. have action against Bartonella:  https://madisonarealymesupportgroup.com/2019/05/05/good-news-for-bartonella-patients-identification-of-fda-approved-drugs-with-higher-activity-than-current-front-line-drugs/

For more:  https://madisonarealymesupportgroup.com/2019/04/05/study-shows-berberine-induces-cell-death-in-leukemia/

Interestingly, Japanese Barberry, a source of Berberine, is a hot-spot for ticks.  https://madisonarealymesupportgroup.com/2015/09/30/barberry-friend-or-foe/

https://madisonarealymesupportgroup.com/2018/06/25/juvenile-tick-attachment-on-mice-significantly-greater-in-japanese-barberry-shrubs/

https://madisonarealymesupportgroup.com/2018/01/20/manage-barberry-lower-ticks/

Yale Researchers Find Explanation for Stress’ Damage in Brown Fat

https://news.yale.edu/2020/06/30/fat-check-researchers-find-explanation-stress-damage-brown-fat

Fat check: Yale researchers find explanation for stress’ damage in brown fat

A man overcome by stress due to work
(© stock.adobe.com)

In their search for what triggers the damaging side-effects caused by acute psychological stress, Yale researchers found an answer by doing a fat check.

In the face of psychological stress, an immune system response that can significantly worsen inflammatory responses originates in brown fat cells, the Yale team reports June 30 in the journal Cell.

Since the hormones associated with stress, cortisol and adrenaline, generally decrease inflammation, it has long puzzled researchers how stress can worsen health problems such as diabetes and autoimmune disease as well as depression and anxiety.

In the clinic, we have all seen super-stressful events that make inflammatory disease worse, and that never made sense to us,” said Dr. Andrew Wang, assistant professor of internal medicine and immunobiology, and corresponding author of the study.

Cortisol and adrenaline, hormones released in the classic “flight or fight” stress response, generally suppress the immune system, not activate it. These hormones also initiate a massive metabolic mobilization that provides fuel to the body as it addresses threats.

The scientists found that it was an immune system cell — the cytokine interleukin-6 (IL-6) — that triggers inflammation in times of stress. IL-6 has also been shown to play a role in autoimmune diseases, cancer, obesity, diabetes, depression and anxiety.

Wang and colleagues began to study the role of IL-6 in stress after a simple observation: When the researchers drew blood from mice, a very stressful procedure, the blood showed elevated levels of the cytokine.

In a series of experiments in mice, designed by Hua Qing and Reina Desrouleaux in Wang’s lab, the researchers found that IL-6, which is usually secreted in response to infections, was induced by stress alone and worsened inflammatory responses in the stressed animals.

And to their surprise, they found that in times of stress IL-6 was secreted in brown fat cells, which are most known for their roles in regulating metabolism and body temperature. When signals from the brain to brown fat cells are blocked, stressful events no longer worsened inflammatory responses.

This was a completely unexpected finding,” said Qing, a postdoctoral associate at Yale School of Medicine.

The researchers reasoned that IL-6 must play another role in the “fight or flight” response besides triggering inflammation. They learned it also helps prepare the body to increase production of glucose in anticipation of threats. The brown fat cell response causes IL-6 levels to peak well after the metabolic production of glucose and the release of cortisol and adrenaline. This may explain why stress can trigger inflammation even while immune-suppressing hormones are being released, the researchers said.

Blocking IL-6 production not only protected stressed mice from inflammation, it also made them less agitated when placed in a stressful environment.

Wang and his team also suspect IL-6 may play a role in mental health disorders such as depression and anxiety. Wang observes that many of symptoms of depression, such as loss of appetite and sex drive, mimic those caused by infectious diseases such as the flu — so-called “sickness behaviors” — that can be triggered by IL-6.

Existing drugs designed to treat autoimmune diseases such as rheumatoid arthritis block the activity of IL-6. Preliminary findings suggest these drugs may help alleviate symptoms of depression, the authors note. There is also preliminary evidence that IL-6 may also play a role in diabetes and obesity as well.

 “There is an ever-growing literature on the role of IL-6 outside of immunity. Our work is exciting because it contributes to shortening that gap of knowledge,” said Desrouleaux, a graduate student in biology and biomedical science.

Everything You Want to Know About Zinc

https://www.foundmyfitness.com/topics/zinc?

By Dr. Rhonda Patrick

Background

Zinc is an essential nutrient that participates in numerous biological processes and modulates the activity of more than 300 enzymes and 2,000 transcription factors.[1] First identified for its influence on growth and development, zinc is now understood to play critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.  (See link for article)

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**Comment**

Great read on the importance of zinc.  The article goes on to discuss zinc’s role in the immune system which includes T cell regulation as well as its ability to destroy pathogens as well as inhibit RNA viruses.

Important excerpt:

One study in particular identified zinc as an inhibitor of RNA-dependent RNA polymerase – an enzyme that drives the replication of RNA from an RNA template – in the virus SARS-CoV-1. Zinc is a positively charged ion and cannot enter cells without a transporter. As described above, zinc requires an ionophore, a molecule that can transport ions across a lipid membrane. The zinc-ionophore (pyrithione) in combination with supplemental zinc inhibited RNA polymerase activity and blocked viral replication of SARS-CoV-1.[84]

Hydroxychlorquine is an ionophore, which is why the combination of zinc and HCQ is so effective for COVID-19:  https://madisonarealymesupportgroup.com/2020/03/25/what-exactly-is-hydroxychloroquine-the-drug-that-is-being-tested-as-the-first-potential-coronavirus-treatment/

Please see Dr. Eric Berg‘s FB video explaining HCQ vs Remdesivir:  https://www.facebook.com/135796882846/posts/10158628517062847/?sfnsn=mo&d=n&vh=e

Zinc also helps control infections by preventing excess inflammation.

 

 

Top 5 Herbs to Fight Free Radicals and Boost Your Immunity

https://vitalplan.com/blog/top-5-herbs-to-fight-free-radicals-and-boost-your-immunity?

Top 5 Herbs to Fight Free Radicals and Boost Your Immunity

By Dr. Bill Rawls Posted 04-24-2020

A strong immune system has always been essential for good health, and it’s even more vital in these uncertain times. Not only do we need solid internal defenses to fight viruses and other illnesses, they also help keep us healthy while we manage the increasing amounts of psychological stress we’re all dealing with — from a bleak news cycle, worry about our loved ones or ourselves, disrupted routines, close quarters, and a number of other things out of our control.

While there are many ways to bolster your immune system, one approach is through controlling or balancing free radicals. You probably have a general sense of what free radicals are — as well as their “opposite,” antioxidants. At least, perhaps, you understand that free radicals are usually “bad” and antioxidants are “good.”

But the story is much more nuanced, and it’s worth understanding the details in order to take a strategic approach to improving immunity.

Free Radicals: The Good, The Bad, The Ugly

Here, five must-know facts about free radicals:

1. Your Body Needs Free Radicals to Live.

The human body uses oxygen to make a specialized type of free radical called reactive oxygen species. These act as a sort of catalyst, plucking electrons off carbohydrate and fat molecules to destabilize them, which allows your body to more easily convert those nutrients into usable fuel for energy. Without them, you’d die.

2. Free Radicals Indiscriminately Break Down Molecules.

The problem is that mitochondria — the power plants of cells — and every other part of the body are made of similarly high-energy organic molecules like fats and carbohydrates. And so they’re equally susceptible to being destabilized by free radicals.

In other words, the free radicals the body produces to help it more easily generate energy can destabilize whatever other molecules are in the vicinity. That means they also end up breaking down mitochondria and affecting DNA — it’s the price of generating energy.

3. The Immune System Employs Free Radicals for Its “Cleanup Crew.”

Free radicals are deployed by your immune system to break down old cells and other cellular “debris.” That makes it easier for your body to clear them from your system.

Similarly, the immune system uses free radicals to help attack, destabilize, and dispose of harmful microbes in your system. In short, we have to put up with a certain amount of free radical damage in order to both produce energy and keep our bodies from becoming a sludge pile of cellular waste and harmful microbes.

That residual damage is essentially what ages us over time or contributes to illness. It’s why older adults are often more vulnerable when they get sick: More of their mitochondria and DNA have burned out from free radical damage, and more cells have died.

As for the cells that remain, they don’t produce as much energy, and DNA doesn’t reproduce as healthy of cells — including cells of our immune system. So, in older folks, immune systems don’t hum along at quite the same pace as they do in younger people.

4. Antioxidants Help Maintain Balance.

Antioxidants that the body produces and that you get from plants like fruit, vegetables, and herbs help control free radicals by neutralizing their activity; they donate an electron so that the free radical can’t pluck it off a cell. They essentially help police the free radicals so that there’s enough activity to do their job of breaking down fuel and debris while minimizing the damage to healthy tissue, mitochondria, and DNA.

5. Damaging Free Radicals Are All Around Us.

Along with the free radicals your body naturally produces, there are a number of other sources and types we’re exposed to. For example, the refined fats in many processed foods are very brittle and break apart easily, and those pieces then turn into damaging free radicals.

city view hidden my smog

Other aspects of processed foods, as well as pollutants and toxins in the air and pesticides in food, likewise act as free radicals in our system. Psychological stress can also set off a chain of events that trigger excess free radicals and damage.

The Free Radical-Inflammation Cycle

When cells are under stress from free radicals, they must work harder and produce more energy to try to keep up. But the harder cells have to work and the more energy they produce, the more free radicals they produce. That then also leads to more waste byproducts.

What’s more, because it’s the job of the immune system to clear up that waste — which it uses free radicals to do — more free radicals flood your system, creating a vicious cycle. All together, it puts an enormous amount of strain and pressure on your body’s systems, and particularly your immune system.

What starts happening: The immune system can’t keep up with the buildup of cellular debris and other waste. And, it’s so preoccupied, it can’t manage the waste and byproducts generated by your body’s microbes, either. All of that waste builds up around cells, creating what we think of as harmful inflammation — it’s as if your body’s sewer system gets clogged and starts backing up.

Conversely, under more normal circumstances, the healthy action of free radicals leads to some inflammation. When it’s kept in check, it’s a controlled burn. Think of how forest rangers might set small fires under safe conditions to help maintain the health of a forest and reduce the risk of larger fires down the road. The same is true in your body: A normal inflammatory response is not only good, it’s necessary for life.

fire growing in dark image

But just as with forest fires, problems occur when the flames rage uncontrolled. When free radicals overwhelm your antioxidant defenses and waste builds up, it triggers chronic or uncontrolled inflammation.

And that can ravage your system over time, contributing to a whole host of problems. For example, it can increase your risk of heart disease, stroke, chronic illness, and more, as well as accelerating the breakdown of cells — including immune cells.

Maintaining Balance is Key.

The goal, then, is to limit external sources of free radicals and maintain a careful balance of internal sources of free radicals. You can’t stop those produced from cells as they generate energy, and you need those produced by the immune system to clean up our body’s waste byproducts.

But you can reduce the influx of free radicals from external sources, and you can take other actions to protect your cells from becoming stressed and keep your microbiome in balance, which curbs runaway inflammation. Here’s how:

Freshen Up Your Diet

Minimize your intake of processed and high-carb foods, which increase free radical activity and inflammation. Instead, load up on more fresh, antioxidant-rich fruits, vegetables, and other plant foods.

Iridescent food. Creative composition made of fruits and vegetables in rainbow colors on white background, flat lay

Brightly colored fruits and veggies, especially, like berries and leafy greens, as well as certain spices and herbs are loaded with antioxidants shown to fight free radical stress and inflammation. One review in the American Journal of Clinical Nutrition specifically found that higher intakes of fruits and veggies both reduce harmful inflammation and enhance immune cells.

Avoid Toxins.

Try to spend as little time as possible in highly polluted areas, which are known to trigger inflammation and cell death. In addition, use gentle, naturally sourced cleaning products, and eat organic foods whenever possible to minimize toxin intake.

Stay Active.

Moderate exercise helps reduce inflammation, as well as helps control inflammation-stoking stress. One study, for example, found that even just 20 minutes of activity could reduce inflammation and strengthen your immune system.

Mind Your Microbes.

An impressive 70% of your immune system is housed in your gut. The more you can feed your good gut bacteria foods that are fresh, fiber-rich, and plant-based, the better. The microbes will be less stressed, and better able to help send and receive messages, enabling your immune system to more effectively respond to threats and control unnecessary inflammation.

Taking herbs known to balance the good microbes in your gut and support your immune system is also a great strategy. Three of my favorite herbs for balancing the microbiome are andrographis, cat’s claw, and berberine.

The Power of Herbs

In addition to consuming antioxidant-rich produce, nuts, and other plant foods, herbs offer an excellent line of defense against free radicals and extra support for your immune system. Here’s why.

Over the centuries, all plants developed antioxidant defenses to protect themselves from various environmental stressors. And that’s especially true of herbs, many of which are still cultivated in the wild, where they’ve been able to retain naturally high levels of antioxidants and other beneficial compounds. Or, they’ve been specifically cultivated for potency, not for taste.

Herbs with alternative medicine herbal supplements and pills

So, which herbs are best for fighting free radicals? All of them do, to some extent, but there are two smart strategies you can use when picking herbs to optimize your benefits.

First, combine synergistic herbs that come from different environments. If the environment in which an herb evolved and the stress factors it deals with informs its defenses system, it makes sense to consume herbs that come from both high and low altitudes, warm and cool climates, for example. That will give you the broadest action and support possible.

Second, consider herbs’ other properties beyond being effective antioxidants. For example, look for herbs that also help balance hormones or your microbes, or that shore up communication between parts of the immune system. That way, you not only address the damage done by free radicals, but you get the additional supportive benefits as well.

5 Antioxidant, Immune-Supporting Herbs

While many different herbs could be on this list, these five provide potent and broad benefits, not only in terms of their antioxidant power, but in their overall ability to support your immune system, health, and longevity.

1. Rhodiola

Rhodiola rosea blossom by springtime at solar day.Beautiful green background

An adaptogen that grows primarily in harsh, Northern climates including Siberia, rhodiola helps the body manage and become more resistant to stress — both physical and emotional. It also supports and protects immune function and cells, helps balance hormones, and may enhance energy and stamina. One review, for example, noted that the herbal extract has been found to have both anti-inflammatory and immune-stimulating properties.

2. Reishi Mushroom

reishi mushrooms growing on wood

Although a fungi, reishi is often referred to as an herb because of its range of benefits. As a fungi, though, it naturally confronts excess stress from microbes, which gives it specialized powers to help rev up our own immune system against pathogenic microbes. That helps keep our microbiome — and, by extension, our immune system — balanced and healthy.

Research also suggests reishi may help increase the activity of immune cells and boost production of cytokines, cells in the immune system that act as messengers or effectors of other cells. Other studies have found reishi extract bolsters the activity of two of our body’s natural antioxidant enzymes — superoxide dismutase and catalase — which help fight damaging reactive oxygen species.

3. Turmeric

Turmeric powder in white cup.

This spice, which gives curry its bright yellow color, is loaded with antioxidants called polyphenols. While these antioxidants are effective at controlling free radicals, researchshows what traditional medicine practitioners have known for centuries: That turmeric is also a potent anti-inflammatory. That means, while it controls inflammation through its effect on free radicals, it’s also helping to regulate the messaging systems of the immune system and your body’s inflammatory response.

Over-the-counter anti-inflammatories like ibuprofen, for example, do this by blocking an enzyme called COX-2, which “turns on” inflammation. But these drugs don’t do anything to stop the source of the inflammation, and they also block COX-1, a beneficial enzyme that helps protect our stomach.

Turmeric, on the other hand, decreases the formation of COX-2 in the long term, while its antioxidants help address the cause of inflammation. It also doesn’t impact COX-1. So, in the long run, turmeric helps better regulate and normalize the body’s inflammatory response.

4. Shilajit

black shilajit powder pile in front of mountain view

Another example of an “herb-adjacent” compound — meaning not technically a herb but often discussed with other herbs or referred to as one — shilajit is actually a herbomineral substance. Found in the Himalayan, Ural, and Caucasus Mountains, it seeps out from between rocks as a gummy substance (before it’s processed and purified into a useable form), the result of plant materials being compressed into the earth and decomposing.

Because of that, shilajit is concentrated with antioxidants from a variety of different plant sources. Much of its antioxidant properties comes from fulvic acid, which is produced from organisms in the soil.

In addition to its antioxidant powers, the acid may help regulate immune function and improve gastrointestinal function, according to research. It’s also known to help improve resistance to stress and guard against inflammatory conditions.

5. Gotu Kola

green Got Kola leaves

Unlike many of the other herbs and substances mentioned here, gotu kola grows primarily in tropical and subtropical locations, including the South Pacific, Southeast Asia, and India. The herb itself is a member of the carrot family, although it’s closely related to and resembles parsley. In India, it’s even eaten as a leafy green, and it’s known for its content of antioxidant nutrients, including vitamin C and carotenoids.

However gotu kola contains other powerful antioxidant phytochemicals, too, including triterpenes. It’s also a natural mood stabilizer that may help balance and manage the stress response by revitalizing the central nervous system and promoting production of GABA, a neurotransmitter linked to calm and relaxation, suggests a paper the journal Evidence-Based Complementary and Alternative Medicine. For those and other reasons, it’s traditionally been used as a general longevity and brain tonic.

While there are a lot about these times we can’t control, one thing you can do is take care of your immune system. Support it, so that it can better support you and keep you healthy now and for the long-term.

References
1. Srivastava, Kaushal K. and Kumar, Ratan. “Stress, Oxidative Injury and Disease.” Indian J Clin Biochem. 2015 Jan; 30(1): 3–10.
2. Pahwa, Roma et al. “Chronic Inflammation.” StatPearls. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK493173/
3. Serafini, Mauro and Peluso, Ilaria. “Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans.” . 2016 Dec; 22(44): 6701–6715.
4. Harvard Women’s Health Watch. “Foods that Fight Inflammation.” 2018, November 7. Retrieved from: https://www.health.harvard.edu/staying-healthy/foods-that-fight-inflammation
5. Hosseini, B. et al. “Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis.” Am J Clin Nutr. 2018 Jul 1;108(1):136-155.
6. Lodovici, Maura and Bigagli, Elisabetta. “Oxidative Stress and Air Pollution Exposure.” J Toxicol. 2011; 2011: 487074.
7. Dimitrov, S. et al. “Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β2-adrenergic activation.” Brain Behav Immun. 2017 Mar;61:60-68.
8. Li, Yonghong et al. “Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention.” Curr Pharmacol Rep. 2017 Dec; 3(6): 384–395.
9. Guggenheim, Alena G. et al. “Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology.” Integr Med (Encinitas). 2014 Feb; 13(1): 32–44.
10. Cor, Darija et al. “Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review.” Molecules. 2018 Mar; 23(3): 649.
11. Hewlings, Susan J. and Kalman, Douglas S. “Curcumin: A Review of Its’ Effects on Human Health.” Foods. 2017 Oct; 6(10): 92.
12. Menon, VP and Sudheer, AR. “Antioxidant and anti-inflammatory properties of curcumin.” Adv Exp Med Biol. 2007;595:105-25.
13. Winkler, John and Ghosh, Sanjoy. “Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes.” J Diabetes Res. 2018; 2018: 5391014.
14. Erdogan Orhan, Ilkay. “Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.” Evid Based Complement Alternat Med. 2012; 2012: 946259.