Archive for the ‘Toxoplasmosis’ Category

A Bug for Alzheimer’s?

https://aeon.co/essays/how-microbial-infections-might-cause-alzheimers-disease

Please read the article above, written by Melinda Wenner Moyer, edited by Pam Weintraub.

A brief summary:

Robert Moir, a neurologist at Massachusetts General Hospital in Boston, believes that beta-amyloid, a key player in Alzheimer’s, might be a good guy who is actually protecting the brain from pathogens.

This idea is coming from numerous corners of the world and has been labeled ‘pathogen hypothesis.’ Others pointing this out are pathologist Alan MacDonald, neuropathologist Judith Miklossy, and microbiologist Tom Grier.

Moir has published mouse studies showing that their brains create amyloid plaques within hours of contracting infections and they actually kill pathogens.

This observation flies in the face of accepted dogma about beta-amyloid and it is rarely discussed in AD groups.

A meta-analysis of 25 published studies has shown that infected folks are 10 times more likely to develop AD, leading international researchers to co-sign an editorial begging others to consider pathogens in relation to AD.

But, the cabal isn’t having it. Moir’s 2016 paper was rejected six times without even a review before finally getting the nod.  https://madisonarealymesupportgroup.com/2017/01/13/lyme-science-owned-by-good-ol-boys/

The author reminds the reader that infections in the brain are nothing new and a short list of them includes: Syphillis, Herpes simplex encephalitis, tick borne disease, HIV, Toxoplasma gondii, Chlamydia pneumoniae, HSV-1, and Zika.

https://madisonarealymesupportgroup.com/2016/04/10/bugs-causing-alzheimers/

https://madisonarealymesupportgroup.com/2016/06/03/borrelia-hiding-in-worms-causing-chronic-brain-diseases/

https://madisonarealymesupportgroup.com/2016/08/09/dr-paul-duray-research-fellowship-foundation-some-great-research-being-done-on-lyme-disease/

http://www.huffingtonpost.com/david-michael-conner/man-diagnosed-with-als-di_b_8891262.html

The journalist also points out that pathogen causation is not proven and that Alzheimer’s patients might be prone to infection but that some studies suggest the infections came first. She also says that the majority of folks suggesting the ‘pathogen hypothesis’ do not feel the infections work alone but rather can cause a domino effect that over time can accumulate causing AD.

And lastly, if beta-amyloid causes AD then removing these plaques should get rid of symptoms, but when 145 beta-amyloid-reducing drugs were tested, not one slowed progression of the disease.

Once again, proving a science cabal exists, Moir recounts how at a Korean conference, attendees were asked to raised hands if they thought infections played a part in AD and a majority of hands went up.

“Ten years ago, it would have been four guys in a corner, all huddled together, not talking to anyone else, Moir says.

https://madisonarealymesupportgroup.com/2017/01/02/fake-science/

Isn’t that sad?

Dr. Zubcevik Challenges TBI Standard of Care

http://www.mvtimes.com/2016/07/13/visiting-physician-sheds-new-light-lyme-disease/

Dr. Nevena Zubcevik, attending physician at Harvard Medical School and co-director of Dean Center for Tick Borne Illness at Spaulding Rehabilitation Hospital, http://spauldingrehab.org/research-and-clinical-trials/lyme-disease/, recently spoke at a weekly meeting of clinicians, which was open to the public at Martha’s Vineyard Hospital.

In standing room only, Zubcevic admonished that singer/actor Kris Kristofferson’s recent cure of dementia, once diagnosed and properly treated for Lyme Disease, should be a lesson for medical professionals.  https://madisonarealymesupportgroup.com/2016/06/09/alzheimers-byproduct-of-infection/.  She also stated that children present differently than adults, with headache being the most common symptom but to get them tested if they are acting out, experiencing mood issues, irritability, and fatigue.  (They need to be tested; however, with sensitive testing that Lyme Literate Doctors – LLMD’s use.  One lab that offers these tests is Igenex Labs in CA.  The best way to get good information is to contact a Lyme Support Group in your state.  They have all the information regarding LLMD’s, testing, costs, and educational materials.)

She explained of a haunting case of a young male institutionalized for schizophrenia. After proper testing for Lyme Disease, he started daily antibiotics and within six months he was normal.

For more information on how borrelia, the causative agent of Lyme Disease, and various coinfections can and often do affect the brain see: https://madisonarealymesupportgroup.com/2015/10/18/psychiatric-lymemsids/ .  Also, see Amy Hilfiger’s story: https://madisonarealymesupportgroup.com/2016/07/01/ally-hilfiger-on-fox-5-ny/, as well as how Toxoplasmosis can affect the brain: https://madisonarealymesupportgroup.com/2016/05/21/toxoplasmosis/.

She also debunked myths.

*Studies show you can get Anaplasmosis in 15 minutes from tick attachment, 10 minutes for Powassan virus, and that it is UNKNOWN how long it takes for the various strains of borrelia (LD). https://www.youtube.com/watch?v=296pVc5Zbxw&index=2&list=UUTXTo-yWGZkRwrQ9X6X7E0A

*Doxycycline CAN be given to children, infants, and pregnant women.
http://www.ncbi.nlm.nih.gov/pubmed/26680308  (no correlation between the use of doxycycline and teratogenic effects during pregnancy or dental staining in children was found)

*A two-day course of Doxy has little to no prophylactic value, and that the proper course is 100-200mg twice a day for 20 days, regardless of engorgement time.

*The current testing misses 69 out of 100 patients who have LD, and doesn’t pick up borrelia miyamotoi at all, not to mention other strains. Miyamotoi is prevalent in Massachusetts.

*The “classic” bullseye rash only happens 20% of the time and when it does present can look like a spider bite or bruise.

*Patients often have coinfections which tests do not pick up. These coinfections make patient cases extremely difficult and complex.

She also stated that borrelia can go into tissue, travel in the bloodstream and is twice the speed of a white blood cell which means it can swim against the flow of blood and evade the white cell by quickly burrowing into tissue, thereby avoiding the immune system.

She stated that having LD is a body-wide toxic war – leaving the patient feeling miserable, and that while she is fairly new to this field, she sees no controversy – that animal studies clearly show persistence after treatment and that human tests do too.

She mentions the work of Dr. Ying Zhang of Johns Hopkins Lyme Center and that his work has indicated that current treatments may not clear persisters. Due to this research she feels a combination of several antibiotics, particularly new combinations, are promising.

Zubcevik found that a patient with chronic LD, when given a PET scan, showed blue and purple, indicating atrophy, whereas after six months of IV antibiotics, presented with yellow and green, indicating metabolically active regions.

Zubcevik has patients who have been ignored, beaten down, and who have lost the will to live. They show signs of post-traumatic stress and have destroyed marriages often leaving them alone. They break down crying with she tells them she believes them.

Babesia Cure?

http://news.yale.edu/2016/06/06/combination-therapy-cures-tick-borne-illness-mice

Yale researchers have found that combining atovaquone and ELQ-334, at low doses, cleared Babesia in mice and prevented recurrence up to 122 days.

ELQ stands for Endochin like quinolone and is a preclinical candidate that targets the liver and blood stages of malarial organisms.

http://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-339  It’s been known since 1948 that Endochin has anti-malarial properties; however, it has proven to be ineffective in vivo against human malaria.  Recent advances have suggested revisiting previously abandoned lead molecules to be possible viable anti-malarial drug candidates.

http://www.ncbi.nlm.nih.gov/pubmed/23019377  ELQ-271 and ELQ-316 are effective against acute and latent toxoplasmosis.

When I asked my pharmacist about the ELQ’s, he said he couldn’t find anything about the manufacturing process, and that as far as side effects, there won’t be a much information available until ELQ-334 proceeds further in the approval process. Sometimes side effects don’t show up until well after drugs have been on the market.  He also stated that there were only 800 cases of neuropathy from 1998-2013 reported to the FDA for quinolines.  

While I could be wrong, Endochin like quinolone could possibly mean it is made with fluoride.

http://articles.mercola.com/sites/articles/archive/2009/07/18/antibiotics-to-avoid–the-plague-due-to-fdas-oversight-failure.aspx  Quinolones are made with fluoride, which enables them to penetrate into tissue, including your brain.  This ability is what makes them valuable against tick borne infections.

Omniflox, Raxar, Trovan, Zagam, and Tequin have all been banned due to their side effects; however, Cipro, Levaquin, Avelox, and Floxin continue to be prescribed.

In Dr. Cohen’s 2001 study, the following side effects were documented:

*Nervous system symptoms occurred in 91 percent of patients (pain, tingling and numbness, dizziness, malaise, weakness, headaches, anxiety and panic, loss of memory, psychosis)
*Musculoskeletal symptoms in 73 percent of patients (tendon ruptures, tendonitis, weakness, joint swelling)
*Sensory symptoms in 42 percent of patients (tinnitus, altered visual, olfactory, and auditory function)
*Cardiovascular symptoms in 36 percent of patients (tachycardia, shortness of breath, chest pain, palpitations)
*Skin reactions in 29 percent of patients (rashes, hair loss, sweating, intolerance to heat or cold)
*Gastrointestinal symptoms in 18 percent of patients (nausea, vomiting, diarrhea, abdominal pain)
A comprehensive list of reactions can be found at Dr. Cohen’s site Medication Sense.

According to Dr. Mercola, quinolones are too often prescribed for minor problems such as sinus, bladder, and prostate infections. He feels these super-antibiotics should be used as a last line of defense.

 

Be armed with facts to make an informed decision about these antibiotics with your LLMD (Lyme literate doctor).  One of the most experienced LLMD’s in Wisconsin states that he has used quinolones for over 20 years without tendon rupture.  It’s important to notify your doctor immediately if you notice symptoms such as tendon pain or anything else that doesn’t seem right.

 

 

 

 

 

 

 

 

 

 

 

Toxoplasmosis

Toxoplasma-gondii-660x380

Toxoplasma gondii,

by AJ Cann http://phenomena.nationalgeographic.com/2013/04/26/mind-bending-parasite-permanently-quells-cat-fear-in-mice/

http://www.cdc.gov/parasites/toxoplasmosis/epi.html Toxoplasmosis is caused by a common protozoan parasite, Toxoplasma gondii, and is the leading cause of death attributed to food borne illness in the U.S. More than 60 million carry it but are asymptomatic. It is also on the of the CDC’s “Neglected Parasitic Infections,” and has been targeted for public health action.

Transmission:  food (undercooked contaminated meat, or knives, utensils, cutting boards, or other foods that had contact with contaminated meat), congenitally (mother to infant), and in blood transfusions, and organ transplants. Sexual transmission is theorized.  However, cats, the only known hosts, play an important role, by eating infected rodents, birds, or other small animals and shedding oocysts in their feces up to 3 weeks after infection. An infected cat contaminates the litter box and/or the soil or water if it goes outside. Transmission to humans occurs after accidental ingestion. In the human host, the parasites form tissue cysts in skeletal muscle, myocardium, brain, and eyes, and may remain for the life of the host, and can reactivate when the immune system is compromised.

http://www.ncbi.nlm.nih.gov/pubmed/16457490  There is evidence of coinfection of Toxoplasmosis with Lyme Disease. This particular patient was initially diagnosed with MS and had symptoms of clumsiness and weakness of the right extremities, and years later was also diagnosed with LD (borrelia). Toxoplasmosis is significant in people who are immuno-suppressed, and Lyme Disease will trigger a previous asymptomatic case.

http://chronic-lyme-disease-solutions.com/Toxoplasmosis.html  http://www.mayoclinic.org/diseases-conditions/toxoplasmosis/basics/symptoms/con-20025859

Symptoms: body aches, swollen lymph nodes, fatigue, headache, confusion, seizures, coordination problems, fever, lung problems, blurred vision, encephalitis, mental illnesses such as schizophrenia, depression, and bipolar disorder. It has been linked with anti-social, aggressive, and jealous behavior in men, and promiscuity in women. Children born with it may develop hearing loss, mental disability, blindness, and even death.

http://www.theatlantic.com/magazine/archive/2012/03/how-your-cat-is-making-you-crazy/308873/  Stanford’s Robert Sapolsky and British groups say that Toxoplasmosis in lab rats changes the wiring in their brains which can take away their fear response, drawing them to their number one predator — cats. Years ago Czech scientist, Jarosav Flegr, noticed reckless traits in his own behavior which included crossing the street in the middle of dense traffic and openly scorning the Communists who ruled his native Czechoslovakia. He accidentally discovered he had the parasite when he was asked to donate blood to test a diagnostic kit for Toxo. He discovered that the French have infection rates as high as 55%, due to their desire for steak prepared saignant, which literally means, “bleeding,” while Americans have a 10-20% infection rate. Neurobiologist Ajai Vyas found Toxo cysts in rat testicles and semen and that the protozoan then moves into the female womb, typically infecting 60% of pups, then heads to her brain to affect her behaviors eventually getting back to the cat. This leads to the possibility of sexual transmission in humans. The research also found that 75% of the females preferred the infected males. Psychiatrist E. Fuller Torry points out that schizophrenia rose in prevalence in the latter half of the 18th century just when people in London and Paris started keeping cats as pets. He believes that 75% of schizophrenia is associated with infections, with Toxo a significant portion.

Once a human becomes infected the parasite needs to get back into the cat, the only place where it sexually reproduces. Due to the impoverished Soviet economy, Flegr gave personality tests and computer-based tests to assess reaction times to infected and non infected Czech students. His findings were so strange he tested then civilian and military populations. He found: infected men wore rumpled old clothes, had fewer friends, and were more hesitant, while infected women wore expensive, designer brands, had more friends, and were extremely trusting – doing what they were told. Both had slower reaction times, less attentiveness, an abnormal fear response, and were two and a half more times more likely to be in traffic accidents. Two Turkish studies have replicated the traffic accident finding. He also also found that 12 of 44 schizophrenia patients had reduced gray matter, with the decrease occurring almost exclusively in those who tested positive for Toxoplasmosis.

http://www.medicalnewstoday.com/articles/295012.php?trendmd-shared=0  Medical News Today reported on a study claiming the parasite is responsible for around a fifth of schizophrenia cases. Now, new research by Johns Hopkins provides further evidence of this association after reviewing two previous studies which identified a link between cat ownership in childhood and development of schizophrenia and other mental disorders later in life and then  comparing them with the results of a 1982 National Alliance for the Mentally Ill (NAMI) questionnaire.  The questionnaire revealed that around 50% of individuals who had a cat as a family pet during childhood were diagnosed with schizophrenia or other mental illnesses later in life, compared with 42% who did not have a cat during childhood. 

T. gondii may be the culprit. 

Researchers at the Academic Medical Centre in Amsterdam, the Netherlands conducted a meta-analysis of more than 50 studies that established a link between T. gondii and increased risk of schizophrenia.

http://www.medicalnewstoday.com/articles/247346.php   Women carrying IgG antibodies to Toxo when giving birth have a higher risk of self-harm or suicide later on, especially if antibody levels are high.

Diagnosis:  http://www.mayoclinic.org/diseases-conditions/toxoplasmosis/basics/tests-diagnosis/con-20025859 Serology to check for antibodies to the parasite, although tissue cysts may be observed through stained biopsy. The CDC recommends all positive results be confirmed by a specialty lab for Toxoplasmosis. In some cases if testing is done too soon, there will be a false negative, and it would be wise to consider retesting later to give the body a chance to produce antibodies. A positive means you are actively infected or that you are asymptomatic. Congenital cases are found using molecular methods such as PCR or with an ultrasound scan that reveals hydrocephalus (fluid in the brain). A negative ultrasound does NOT rule out infection.

Please see your health practitioner for Treatment

Treatment: Healthy people keep the organism in check and do not require treatment; however, if you are also fighting MSIDS, you should consider this organism in your treatment picture.
http://www.mayoclinic.org/diseasesconditions/toxoplasmosis/basics/treatment/con-20025859
Pyrimethamine (Daraprim), a malarial drug is the typical drug of choice, which may prevent your ability to absorb the B vitamin, folate, necessitating supplementation. In conjunction, Sulfadiazine is used, with Clindamycin (Cleocin) as an alternative. Those with HIV/AIDS may need to take these medications for life or until the CD4 remains high for 3-6 months. Spiramycin, an experimental drug in the U.S., is used in Europe to reduce a baby’s risk of neurological problems and may be obtained from the FDA.

Similarly to borrelia, the causative agent of Lyme Disease, once the parasite is in brain cells; however, antibiotics cannot kill off the thick-walled cysts.

Prevention: http://www.mayoclinic.org/diseases-conditions/toxoplasmosis/basics/prevention/con-20025859

*Wear gloves when you garden or handle soil and wash your hands thoroughly with soap and water afterward.
*Don’t eat raw or undercooked meat.
*Wash kitchen utensils thoroughly. After preparing raw meat, wash cutting boards, knives and other utensils in hot, soapy water to prevent cross contamination of other foods. Wash your hands after handling raw meat.
*Wash all fruits and vegetables. Scrub fresh fruits and vegetables, especially if you plan to eat them raw. Remove peels when possible, but only after washing.
*Don’t drink unpasteurized milk. Unpasteurized milk and other dairy products may contain toxoplasma parasites.
*Cover children’s sandboxes. If you have a sandbox, cover it when your children aren’t playing in it to keep cats from using it as a litter box.

If you’re pregnant or otherwise at risk of toxoplasmosis or its complications, take these steps to protect yourself:
*Help your cat stay healthy. Keep your cat indoors and feed it dry or canned cat food, not raw meat. Cats can become infected after eating infected prey or undercooked meat that contains the parasite.
*Avoid stray cats or kittens. Although all stray animals need good homes, it’s best to let someone else adopt them. Most cats don’t show signs of T. gondii infection, and although they can be tested for toxoplasmosis, it may take up to a month to get the results.
*Have someone else clean your cat’s litter box. If that’s not possible, wear gloves and a face mask to change the litter. Then wash your hands well. Change the litter daily so that excreted cysts don’t have time to become infectious.