Archive for the ‘Adrenals’ Category

Bb, Genetic, & Environment in Pathogenesis of Autoimmune Thyroid Diseases

Infections, genetic and environmental factors in pathogenesis of autoimmune thyroid diseases.

Shukla SK, et al. Microb Pathog. 2018.


In Autoimmune disease a combination of infection, genetic and environmental factors causes an autoimmune response to the thyroid gland (characterized by lymphocytic infiltrations), thyroid stimulating hormone receptor (TSHR) and different thyroid antigens. Graves’ and Hashimoto disease are autoimmune disorders with genetic predisposition. CD40 that stimulates the proliferation and differentiation of lymphocytes is an essential immunomodulatory component for follicular cells in the thyroid and the cell that present the antigen. CD40, PTPN22 and thyroid-specific genes are immunomodulating genes for the TSH receptor and thyroglobulin. CD40 used to be associated with Graves’s disease as positional candidate on the basis of Graves’ disease linkage study connecting with 20q11 genome chromosomal region.

The PTPN22 gene gives rise to a substantial risk of specific autoimmune phenotypes and frequent disease mechanisms. Infections have been implicated in the pathogenesis of AITD including Coxsackie virus, Yersinia enterocolitica, Borrelia burgdorferi, Helicobacter pylori and retroviruses (HTLV-1, HFV, HIV and SV40). Infectious hepatitis C agents are the strongest proof supporting an affiliation with AITD.

The essential environmental triggers of AITD are iodine, drugs, infection, smoking and perhaps stress. Autoimmune disease provide important facts on genetic mechanisms that influence the prognosis and treatment of the disease and by recent molecular techniques through gene expression study by quantitative Real Time-PCR and microarray, we can identify novel genes which are responsible for Graves’ and Hashimoto disease.


Insurance Claims Show Rural-Urban Divide With Lyme Disease   by Lisa Schnirring  July 27, 2017

Lyme disease insurance claims show disease rise, rural-urban divide


Lyme disease levels in the United States have been rising since 2007, and patterns show differences in rural and urban settings, according to new findings released today from a nonprofit health insurance group, which based its analysis on more than 23 billion privately billed insurance claims.

The study from FAIR Health, which studies healthcare costs and health insurance information, found that insurance claims involving Lyme disease diagnosis rose 185% in rural areas from 2007 to 2016, with a smaller 40% increase in urban areas. The group’s findings appear on its Web site.

Lyme disease, caused by Borrelia burgdorferi bacteria, is spread through the bite of blacklegged ticks. Symptoms include fever, headache, fatigue, and a characteristic skin rash. When untreated, the disease can lead to joint, cardiac, and neurological complications.

The US Centers for Disease Control and Prevention (CDC) says about 30,000 Lyme disease infections are reported from states each year, a number it says probably reflects only a fraction of the disease burden.

Timing, ages also vary between rural and urban Lyme claims

In its full report, researchers said it’s not clear how many Lyme disease diagnoses from urban areas are the result of exposure to ticks in city yards and parks or from visits to rural settings.

The peak for Lyme disease claims is June and July, which the group said isn’t surprising. However, it noted that claims during winter and early spring months are more common from urban areas, though the location of the medical visit may vary from the patient’s exposure location.

The age at which patients were diagnosed with Lyme disease varied between the rural-urban divide as well, with rural areas reporting higher numbers of claims for middle-aged and older people and urban areas reporting a larger share of younger people.

Regarding geographic distribution, the insurance claims analysis suggests that Lyme disease is spreading beyond the two traditionally hardest hit areas: the northeast and the upper Midwest. From the review of 2016 claims, North Carolina is now among the five states the highest percentage of claims, and FAIR Health said the disease has apparently found a foothold in the south.

Disease complication findings

To probe the relationship between Lyme disease and other health problems, researchers conducted a retrospective longitudinal study that looked at insurance claims between 2013 and 2017.

The most common diagnoses that came in the wake of a Lyme disease diagnosis were joint pain, fatigue, soft-tissue disorders, and hypothyroidism. When they compared the diagnoses by age to people not affected by Lyme disease, the same conditions still stood out as more common in those sickened by Lyme disease.

“Our data suggest that at least some autoimmune diagnoses correlate with Lyme disease,” they wrote, alluding to previous research studies that have suggested a possible autoimmune reaction link to disease complications.

For more:

PCOS & Lyme: My Story

***For those of you who have read anything I’ve ever written, you understand that by Lyme, I actually mean MSIDS or multi systemic infectious disease syndrome – as research has shown most of us are infected with far more than just borrelia, the causative agent of Lyme Disease. and

Borrelia alone is a formidable, complex, pleomorphic bacteria(ish) that shape shifts to avoid medications and forms biofilm to evade our immune systems.  There are 300 strains and counting of borrelia worldwide, and 100 strains and counting in the U.S.  Current CDC Two-tiered testing tests for ONE strain.  So when I write about Lyme Disease, I mean the whole ball of wax.  Research, BTW is abysmal on all of this and dominated by what I call The Cabal.,  and,

OK, now that we’ve cleared that up….

My story


Around the same time our dog Bucky (Go Wisconsin Badgers!) tested positive for Lyme and we finally got to the bottom of my husband’s bizarre issues (he too had it), I suffered from severe pelvic pain. The pain appeared to originate in my ovaries but radiated everywhere leaving me hunched over like an old woman, holding my gut.  I was scheduled to undergo the knife for a small epigastric hernia but at the last minute the surgeon recommended an MRI which revealed two deflating cysts. No surgery needed, I continued to suffer in silence with pain that honestly felt like someone put a shot gun up my vagina and pulled the trigger.

In January one of my knees swelled up to twice its size, became red and hot to the touch, and I developed a fever. My old retired doctor told me I had “Washer Woman’s Knees”  from scrubbing the floor (You can’t make this stuff up), so I continued to suffer in silence. Six months later I saw flashing lights, had racing, erratic heart beats, insomnia, memory loss, migrating joint pain, colitis, severe occipital headaches, and a stiff and painful neck and spine, and frankly, stuff I’ve blocked out. I could no longer deny I had Lyme/MSIDS. The infamous quote by Dr. Jemsek, “You either have 20 diseases or you have Lyme Disease,” certainly held true for me.  I actually diagnosed both of us by watching the documentary Under Our Skin, the best primer on Lyme Disease on the market.

I had done my reading by this point with my husband in Lyme/MSIDS treatment, and I got to a LLMD (Lyme literate doctor trained by ILADS), and tested positive on the IgeneX Extended Western Blot for Lyme.  Please see this wonderful presentation by IgeneX at our Lyme Support Group to learn why their testing is far more sensitive than the current CDC two-tiered testing that most GP’s use:

My LLMD told me to save my money on co-infection testing as he felt the testing was that poor and that his treatment would automatically treat co-infections. Of course, the rest is history, with over 4 years, and counting, of an intense, painful and expensive pulsed antibiotic regimen with IV blood ozone and UV light, herbs, IV vitamin C and other minerals, magnet therapy, chiropractic help, supplementation with numerous things including hormones (anabolic), LDN, and other modalities – to the tune of $10-$15 K out of pocket each year for over 4 years and counting.  

But, I often wonder – would the story have turned out differently had I been aware of the very real probability that Lyme/MSIDS can be spread sexually?

Looking back, many symptoms were there that I intentionally blocked out as I was more concerned with my husband who appeared far worse than me at the time.  I also didn’t know what I know now.  I find this tendency of one partner ignoring symptoms due to the seemingly more severe symptoms of the other partner to be a common thread in couples infected with Lyme/MSIDS.

I first became aware of the possibility of Lyme/MSIDS being sexually transmitted years ago when I started looking up PCOS (polycystic ovary syndrome) and Lyme. I discovered a hidden world of women who had severe pelvic pain, PCOS, and a Lyme diagnosis.

I wasn’t alone!

Here’s just a few sites: (Soul Cysters – gotta love the name!);f=1;t=043160;p=0   According to the U.S. Department of Health and Human Services, PCOS is a common health problem in the ovaries caused by imbalanced reproductive hormones. Essentially the egg may not develop or be released normally. It can cause irregular menstrual periods and lead to cysts and infertility.   Some other symptoms include hair where men usually have hair, acne, thinning of hair, weight gain, darkening of skin, skin tags, depression and anxiety, decreased sex drive, and an increase in stress levels. Experts feel genetics, and high levels of androgens and insulin play a role. And while there is no single test to diagnose it, doctors typically perform physical exams including a pelvic exam with an ultrasound as well as blood tests looking at male hormone levels, thyroid, cholesterol, and test for diabetes. Once other conditions are ruled out patients may be diagnosed with PCOS if they have at least two of the following:

*Irregular periods, including periods that come too often, not often enough, or not at all
*Signs of high androgen levels – extra hair growth on face and body, acne, thinning hair
*Higher than normal blood levels of androgens
*Multiple cysts on one or both ovaries

I want to point out that many of these symptoms overlap with Lyme/MSIDS. Numerous coinfections cause skin tags, many patients gain weight, lose head hair, have bizarre menstrual issues, experience anxiety and depression as well as can’t tolerate stress, and could care less about having sex.

There’s a hidden world of women with a LD diagnosis who also have pelvic pain and PCOS-like symptoms.  An article put out by my favorite compounding pharmacy discusses numerous issues with hormones and LD including adrenal depletion, low DHEA levels contributing to low testosterone levels, thyroid issues, and cortisol issues. Nearly every Lyme/MSIDS patient I know is severely low in magnesium which is needed in over 300 biochemical reactions in the body.

While many LD male patients have told me their testosterone levels are through the basement floor, I haven’t heard from women about their hormone levels. Could LD/MSIDS cause inflammation in the pelvic area caused by tick borne infection?

Once you go down the rabbit hole of gynecological symptoms of Lyme/MSIDS, the question of sexual transmission begs to be asked.

According to the CDC, Lyme is not sexually transmitted, despite being a spirochete that can burrow through any tissue and organ and despite being a cousin to Syphilis (T. pallidum). They also claim that the sole perp is the dastardly black legged tick.  I believe both of these tenants to be myths and time will reveal a much broader picture and complex picture.   Yet, Medical Daily reports a 2014 study in the Journal of Investigative Medicine that found Lyme (B. burgdorferi) in vaginal secretions of all women with Lyme and in half of the men with Lyme. One of the heterosexual couples with Lyme had the identical strain in their genital secretions.  Here is the updated article and the fact that 1 referee approved and 2 did not approve of the rigor of the study.

Lead author Marianne Middleveen stated, “Our findings will change the way Lyme disease is viewed by doctors and patients.”

That was in 2014, and……nothing’s changed.   Bizzarely, I found in this 2011 article a statement in quotations supposedly by the CDC which states, “Conversely, we find no study supporting that sexual intra-human Borrelia burgdorferi transmission does not occur. Inferential data strongly suggest the possibility of human sexual transfer.”
“This data come from sound veterinary studies, the finding of Borrelia burgdorferi in human semen and breast milk, and by similarity to Treponema pallidum where sexual transfer is abundantly documented. Our clinical experience strongly suggests that predictable, possibly inevitable Borrelia burgdorferi transfer between sexually active couples occurs.

The article didn’t have a bibliography so I do not know where they found the CDC quotes.

Here’s what the current CDC website states:
“There is no credible scientific evidence that Lyme disease is spread through sexual contact. Published studies in animals do not support sexual transmission (Moody 1991; Woodrum 1999), and the biology of the Lyme disease spirochete is not compatible this route of exposure (Porcella 2001). The ticks that transmit Lyme disease are very small and easily overlooked. Consequently, it is possible for sexual partners living in the same household to both become infected through tick bites, even if one or both partners doesn’t remember being bitten.”

Regarding breast milk the CDC states, “There are no reports of Lyme disease being spread to infants through breast milk. If you are diagnosed with Lyme disease and are also breastfeeding, make sure that your doctor knows this so that he or she can prescribe an antibiotic that’s safe for use when breastfeeding.”

But the plot thickens with many credible doctors and researchers disagreeing.

Dr. Jones, a highly respected LLMD believes in both congenital transfer and via breast milk.  In this pdf there is a table of symptoms in children suspected of contracting Bb congenitally at or slightly after birth.

Here’s another Bibliography on Gestational Lyme & via lactation  From the CDC:  Untreated, Lyme disease can be dangerous to your unborn child.  Lyme disease that goes untreated can also cause you to have brain, nerve, spinal cord and heart problems.”  They also say there are NO reports of LD transmission from breast milk, which LLMD’s have found to be false.  Bb DNA found in urine and breast milk of Lyme patients.  Here we see borrelia found in colostrumblood, synovial fluid, and urine in cows and horses.  Gregory Bach, DO, International Scientific Conference on Lyme Disease, April 2001

“Lyme spirochetes/DNA have been recovered from stored animal semen. Recovery of spirochete DNA from nursing mother’s breast milk and umbilical cord blood by PCR (confirmed by culture/microscopy), have been found in samples provided to my office.

Surprisingly, initial laboratory testing of semen samples provided by male Lyme patients (positive by western blot/PCR in blood) and the male sexual partner of a Lyme infected female patient were positive approximately 40% of the time. PCR recovery of Lyme DNA nucleotide sequences with microscopic confirmation of semen samples yielded positive results in 14/32 Lyme patients (13 male semen samples and 1 vaginal pap).  ALL positive semen/vaginal samples in patients with known sexual partners resulted in positive Lyme titers/PCR in their sexual partners. 3/4 positive semen patients had no or unknown sexual partners to be tested.”  Another link with helpful information mostly regarding infection in children but also has links on pregnancy and transmission.

Then there’s that aforementioned study finding spirochetes in vaginal secretions and semen that was presented at the annual Western Regional Meeting of the American Federation for Medical Research (Reference: The Journal of Investigative Medicine 2014;62:280-281)  This informative 2014 article gives case studies of numerous medical practitioners showing interesting findings:  “I’ve seen women who were infected long before they were pregnant and I’ve checked their children – the first-born is in good shape, but the third-born is badly infected,” Kriz said. I’ve seen it in several families.”

And, a woman with symptoms all her life who was finally diagnosed with Lyme possibly contracted in utero stated, “All of the sudden, all my little quirks – the things that made me, me – those were the disease,” she said. “It wasn’t typical Lyme symptoms, it was little things, like severe anxiety, irrational fears, a poor memory.  I was bad with directions. I had a foggy brain. I thought everyone deals with these things.”  And, “Certainly, having a foggy brain in middle school and high school does not do a lot for your self-confidence,” she said. “It’s hard to feel confident in yourself when you can’t rely on your brain to do what you want it to do. It’s hard to make the commitment to decide what kind of career you want, or anything else.”  This link shows everything from Alan McDonald’s finding of borrelia in a chronically infected male’s testicle in an autopsy to survival of borrelia in blood products to an ancient 1986 study by none other than the NIH of uninfected mice becoming infected with Bb within 42 days after being put in a similar cage with infected mice.  The link also states it is well established that Bb is found in urine and that Willy Burgdorfer, the discoverer of Bb, got Lyme from infected rabbit urine when it got into his eye.  

And somebody went to a boatload of work collecting animal transmission studies on Bb:  I found this collection of studies years ago and am happier than a lark it’s still available.  Please read the variety of ways Bb is spread in animal studies.

Let’s suffice it to say the polarization continues unabated in the world of Lyme/MSIDS.

But, you are duly warned.






LD Therapies – Dr. Rawl

  Approx. 1 Hour

Published on Dec 8, 2016

Last weekend, Dr. Rawls gave a presentation titled Exploring Lyme Disease Therapies in the 21st Century to the North Carolina Lyme Foundation.  What you’ll learn from this video lecture:

– 6 components necessary for recovery
– 3 holistic approaches to overcoming Lyme
– The importance of immune function on the body
– My approach to boosting the immune system and regaining lost health

For more information, please visit

Endocrine Talk

If you have always wanted to understand the Endocrine System (glands that produce hormones) and how it is affected by the environment, now’s your chance.  A free event is open to the public and seating first come, first served.  Q & A follows the talk.

Where:  AmericInn Lodge & Suites, 550 State Highway 13, Wisconsin Dells, WI  53965, phone:  608-254-1700

When:  Wed, Nov 30 at 6:30 p.m.

Health Talks On-Line

The Chronic Lyme Disease Summit is online and FREE from April 4-11, 2016!  You must register by going to this link.


Sally Schutz, MD: Mitochondrial Dysfunction

Kenneth Stoller, MD, FACHM:  Brain Conditions Have Infection with Them

Niki Gratrix, BA, Dip, ION, mBANT, CNHC:  The Role of Stress and Emotional Trauma with Lyme Disease

Trudy Scott, CN:  Tryptophan and GABA to Ease the Anxiety and Panic Attacks

Dean Martens, CH:  Energy Medicine

Fran Sussman:  A Unique Approach to Addressing Lyme Disease

Shiroko Sokitch, MD:  A Chinese Medicine Approach to Lyme Disease

Trina Hammack, FDN-P, CBT, CHC:  Energy Medicine and Its Role in Overcoming Lyme and Cancer

Trevor Cates, ND:  The Magic Mirror of the Skin

Laura Ricci, PT, DPT, WHNC:  Pelvic Floor Pain and Its Relation to Lyme Disease

Michael Acanfora, DC:  Lyme Disease and Trigeminal Neuralgia Connection

Scott Forsgren:  Recovering from the Many Layers of Lyme

Jason West, DC, NMD, FIAMA, DBDCN:  IV Vitamin C Treatment for Lyme Disease

Kevin Conners, DPSc, FICT, FAARFM:  3 Phases of Lyme and Rife Technology

Robby Besner, BS:  The Applied Science of Infrared Technology

Bradley Bush, ND:  A Lab Test That Actually Works for Detecting Lyme Disease

Connie Bennett:  Sugar and Lyme Disease

Raj Patel, MD:  Mold and Lyme Disease

B.J. Hardick, DC:  Nutrition Plan Steps Critical in a Bio-Detox

Jack Tips, PhD, CHom, CCN:  The Gut Microbiome and Lyme Disease

Shayne Morris, PhD, MBA, CNS:  Biofilm, Bugs and Phage (Bacteriophage)

Kate Hope, MS, CGP:  Using the GAPS™ Diet as Nutritional Therapy for Lyme Disease

Nikolas HedBerg, DC, DABCI, DACBN, BCNP:  A Ketogenic Diet’s Role with Lyme Disease

Jimmy Moore:  A Practical Approach to Nutritional Ketosis

Dietitian Cassie, RD, LD:  Food and Nutrition as They Relate to Lyme Disease

Peter Osborne, DC, DACBN, PScD:  Grainflammation (Grains = Inflammation)

Lee Cowden, MD:  A Comprehensive Look at Lyme Disease

Richard Horowitz, MD:  MSIDS Model and Its Role in Driving Inflammation

Connie Strasheim:  Lyme Disease and Cancer

Jay Davidson, DC, PScD:  Heavy Metal Detoxification and Lyme Disease

David Minkoff, MD:  Comprehensive Lyme Treatment Strategies  Calendar of other free talks





Lyme Disease Treatment

Due to space constraints this article will ONLY cover the treatment of borrelia, the causative agent of Lyme Disease. To see treatments for the various co-infections, type Bartonella, Babesia, Mycoplasma, Parasites, Toxoplasmosis, or Powassan Virus into the search bar for those articles. I hope to add to this list in the future.

Lyme Disease or borreliosis is caused by a Gram-negative bacterium belonging to the class of Spirochaetes, which have flagella allowing it to migrate through fluids and burrow through tissues, making it highly invasive. Borrelia burgdorferi is known for its outer surface proteins OspA and OspC which have a role in transmission into the host cell, whose metabolism is limited requiring Bb to rely on its host for energy precursors. Bb is slow growing, with a doubling time of 12-18 hours, unlike Strep or Staph which doubles every 20-30 minutes, which factors into the difficulty of diagnosis. This also necessitates longer treatment time for Bb as most antibiotics kill bacteria only when they divide. There are at least 37 known species, 12 of which are Lyme Disease related to date, and an unknown number of genomic strains; however, these numbers are constantly changing due to greater strain diversity than previously thought. Further complicating things, the strains differ in clinical symptoms and/or presentation as well as geographic distribution; however, again, to put Bb strain diversity into a geographical box is a huge mistake as the bird, reptile, fox, rodents, and humans are never confined to one location and migrate freely. Further complicating things, borrelia exists in three different forms. These are the spirochete, L-form (lives in cells), and microscopic cyst form or non cell wall. The form can change shape whenever it feels threatened and can lie dormant until conditions are beneficial.  Despite the denials’ insistence, here are 230 studies showing persistence.


Lyme Disease (LD) is the most common vector borne disease in the U.S with the CDC estimating that there are at least 300,000 new cases of LD diagnosed yearly, with actual infection rates much higher.
“We know that routine surveillance only gives us part of the picture, and that the true number of illnesses is much greater,” said Paul Mead, M.D., M.P.H, chief of epidemiology and surveillance for CDC’s Lyme disease program. “This new preliminary estimate confirms that Lyme disease is a tremendous public health problem in the United States, and clearly highlights the urgent need for prevention.”

Testing, by the way, is abysmal for ALL Tick borne infections including Lyme:  Current testing doesn’t measure actual pathogens but antibody response to infection.  They also are blood tests which are problematic due to borrelia’s preference for tissues to evade the immune system.  The CDC’s current two-tiered testing (ELISA followed by the Western Blot) is highly insensitive. The fact that over 300,000 new cases a year are recorded bely the fact that these arbitrary and stringent tests miss over half of all cases.  It’s a no-brainer that actual infection rates are much higher.

This makes LD more prevalent than AIDS, breast cancer, West Nile Virus, H1N1, and Ebola. .  There are over 300 strains of Bb worldwide and 100 strains in the U.S. to date.  Please note that the current two-tiered testing only uses ONE strain.  To get a positive would be akin to winning the Lotto.
It has since been determined that Lyme disease (named for the town in which it was first identified) can be caused by any number of different species in the genus Borrelia, such as: B. andersonii, B. japonica, B. valaisiana, B. lusitanie, B. turdae. B. tunakii, B. bissettii, and B. lonestari, and the most recent discovery of B. mayonii.


Borrelia inhabits the lumen of a tick’s digestive tract. The disease is transmitted to humans from a tick bite when the bacteria migrates up to the ticks salivary glands, and through the opening created by the tick. Ticks increase salivation during gorging, prompting the migration of the saliva from the digestive tract. Because migration from the gut takes a few days, transmission of the disease usually does not happen until after the first 24 hours of attachment.  Please keep in mind; however, if spirochetes are in the tick’s salivary glands, theoretically, transmission could happen immediately despite the common CDC rhetoric that a tick must be attached for 36 to 48 hours or more.  Excellent, excellent article by Dr. Holtorf on why Lyme is hard to diagnose and treat, his integrative approach to managing chronic Lyme, plus his detailed listing of known facts about Lyme activity, diagnosis and treatment – a “culmination of the literature.”

Great video on transmission time by Lyme Action Network:

For information on ticks, go to:

04_rash316x316Clinical diagnosis must consider any skin rash, regardless of its resemblance to the bull’s-eye.  Many people never recall a rash or tick bite. “Researchers note that multiple textbooks and websites prominently feature the bull’s-eye image as a visual representation of Lyme disease.” They write, “This emphasis on target-like lesions may have inadvertently contributed to an underappreciation for atypical skin lesions caused by Lyme disease.”Some Visible Signs of Lyme Disease Are Easily Missed or Mistaken, Science Daily, Apr 22, 2013–+Lyme+Disease%29

An excellent primer on LD by Lyme Action Network (Approx. 5 min)

The CDC also states there is NO EVIDENCE that Bb is sexually or congenitally transmitted or spread through transfusion if a person has been treated with antibiotics,, despite the fact Bb is a cousin to Syphilis, is in the spirochete family, and has been found in semen and vaginal secretions.,, and the DNA of Bb has been found in breast milk.

They also emphatically state pets cannot spread the disease to their owners and that you can not become infected by air, food, water, or bites of other insects. Please glance at the following animal studies on Bb before you believe everything you are told:  and (spirochetes found in mosquitos and black flies) (Approx 50 min) Excellent video explaining the horrible testing, possible biowarfare agents including Lyme Disease (Bb), lab workers becoming infected at work, Plum Island’s work with ticks, the anti-trust investigation with testimony at 18:50 by Dr. Phillip in case after case for persistent (chronic) Lyme, at 35:30 clips of pathologist Alan MacDonald who’s getting 100% positive Bb in autopsies of Alzheimer patients, testimony of a woman who miscarried due to Bb, and much more).


Why the CDC continues to make such bold claims is foreign to me when there is so much at stake and much that is unknown or unproven. Prudence would err on the side of caution. Just a year ago a doctor showed up in an airport donning a hazmat suit and sign that read, “The CDC is lying!”
Due to this brave man’s actions, the CDC changed their position on transmission of Ebola.

The box of myths the CDC, NIH, and ISDA has conveniently thrown all of the factors of this complex illness(es) into are already beginning to claw their way out with a new species of Bb and Bartonella being “discovered” just this past week. I predict much more yet to come.

Before beginning any treatment, please read the article on the Herxheimer Die-off reaction: as well as the article, Tips for Newbies.


A successful treatment should treat all three forms of borrelia. There is disparity between LLMD’s as to the timing of this but many state you should treat all three forms at the same time. However, at the first treatment take care to avoid an intense die-­off reaction by starting one prescription antibiotic only. Too much inflammation is unhelpful.

LLMD, Ken Singleton states there are five classes of antibiotics commonly used for Lyme Disease (borrelia).

Tetracyclines are commonly used due to their ability to penetrate cell walls.
doxycycline (100-300mg twice a day with food, but not with dairy or minerals)
minocycline (100mg) twice a day

Both of these must produce high blood levels and may require monitoring. If they are not tolerated due to side effects, doxy may be administered intravenously and the dosage for that is 300-400mg once a day.
*NOT TO BE USED IN PREGNANT AND BREASTFEEDING WOMEN OR CHILDREN 8 AND UNDER (current information debunks this – talk to your doctor)
*Notify your LLMD if you experience a severely unrelenting headache upon taking a dose

Macrolides and Ketolides, similar to Tetracyclines penetrate cell walls and tissues.
Telithromycin (800mg/day) – need to check electrocardiogram and liver function regularly
Clarithromycin (1,000mg/day)
Azithromycin (250-600mg/day) IV dose: (500mg/day)

*Blood tests are needed to monitor liver function and white blood cell count.
*Macrolides can interfere with other drugs. Make sure to talk to your doctor and pharmacist about other medications you are taking prior to beginning macrolide treatment.

Cephalosporins ideally should be combined with antibiotic classes that target the L-form of borrelia and, ideally, the cystic form also.
Ceftin (500mg 2X/day – some require higher dosages)
Omnicef (600mg daily)
Rocephin (IV) 1-2gms every eight hours and Claforan (IV)- 2gms daily – high blood levels need to be reached and levels should be measured regularly.
*Regular blood testing should be done to detect any adverse reactions. Ceftriaxone can cause gallstones, which can be prevented by using ursodiol.
*People allergic to penicillins are also allergic to cephalosporins.

Penicillins also should be combined with other antibiotic classes that target the L-form (such as macrolides & Ketolides) and cystic form (Metronidizole).
amoxicillin (1,000-2,000mg every eight hours) sometimes combined with probenecid (500mg) or Augmentin helps to keep blood levels high.
IV penicillin (1,200,000 units 2-3X/week). The LA form of Bicilin is more effective but painful than the CR form

Metronidazole kills borrelia in the cystic form. Use in combination with one or more of the above classes to kill all three forms.
Metronidazole (250-500mg 2-3X/day)
*Do NOT use Tetracyclines with metro because they inhibit metro’s effectiveness)
*Do NOT use if on blood-thinning medications
*Do NOT use if pregnant
*Do Not use alcohol while on this medication

Dr. Marty Ross’s borrelia treatment:
According to Ross, a successful borrelia treatment needs to boost the immune system, kill the infections, protect and repair the negative effects upon the body, and speed recovery.
He recommends staying on each of the natural medicines until you have marked improvement, then you can stop all naturals but probiotics, curcumin, ashwagandha, and a good multi-vitamin.

L-Theanine 100mg 1-6 pills a night an hour before bedtime. Do not exceed 1200mg a day, and/or
Herbal Combinations 1-4 pills one hour before bed (valerian, hops, yam, wild lettuce, l-theanine, and others)
Prescription: Zolpidem (Ambien) 10mg 1 pill 30 min before bed (use if you have trouble getting to sleep as it is short acting), and/or Clonazepam (Klonopin) 1 mg .5-2 pills 30 min to 1 hour before bed. (use if you have trouble staying asleep). If you have both getting to sleep and staying asleep issues, try Ambien first.

CYTOKINE CONTROL: (At the beginning of treatment and when you change antibiotics, an excessive amount of cytokines are made making you feel worse.)
Curcumin 500mg 1 pill 3X/day
Good multi vitamin

ADAPTOGEN: (based on animal studies, adaptogens improve energy, immune function, and adrenal/thyroid function)
Ashwagandha 400mg 1-2 pills am and 1-2 pills between 1-2pm. Taking late will disturb sleep.

HORMONES:  A person could have normal range testing for each of the hormones but still have clinically low hormones. Because of the unreliability of testing, treatment for low hormones should occur if there are clinical symptoms of low hormones as long as treatment does not increase hormone levels above the upper end of normal. Hormones provide many functions in the body. Proper levels improve energy and help the immune system to work more effectively.


Symptoms: fatigue, recurrent infections, poor recovery from infections, low blood sugar with shakiness and irritability relieved by eating, low blood pressure and dizziness on standing, afternoon crashing, and sugar cravings.

Naturals – Ashwagandha (same dosage and timing as listed above in Adaptogen)
Prescription – Cortef 5mg 1-2 pills am and 1-2 pills from 1-2pm. Taking late will disturb sleep.

Symptoms: Low thyroid: fatigue, achiness, low body temperatures averaging below 98.0 F, cold intolerance, weight gain, constipation, and changes in menstrual periods.
Naturals – good multivitamin to provide essential micronutrients for the thyroid
Prescription – Desiccated Thyroid 1/2 grain or Armour Thyroid 1/2 grain. 1 pill in the morning 30 min before anything else but water (empty stomach). Increase every 3-4 weeks by 1/2 grain if low thyroid symptoms persist.

According to Ross, “Low hormones occur often in chronic Lyme disease. Inflammatory cytokines made by white blood cells to fight Lyme decrease the effective functioning of an area of the brain called the hypothalamus and pituitary. This part of the brain produces chemicals that induce sleep and that regulate hormonal systems. Normally this part of the brain releases messengers such as thyroid stimulating hormone (TSH), adrenocorticotropin hormone (ACTH), and follicle stimulating hormone (FSH) to stimulate the thyroid, adrenal glands, and sex hormone organs respectively. Because of the dysfunction caused by the cytokines, these regulatory messengers are released based on an incorrect interpretation by the brain of the hormone environment. Thus measurements of these messengers is an unreliable way to determine the hormone status. Another way to check hormone status is to measure the actual hormone levels like T4/T3 (thyroid), or cortisol/dhea (adrenals), or estrogen/progesterone/testosterone (sex hormones). These tests give a broad range of normal, however.”

It has been my personal experience that most general practitioners do not think for themselves when it comes to hormones. Similarly to how they hide behind the CDC guidelines, they hide behind test results and refuse to diagnose and treat patients clinically.

For excellent information on thyroid disorders please watch:
Dr. Brownstein: (He starts by giving an intro of how he ditched what he’d been taught in med school and at 7:30 starts with the thyroid talk. He states thyroid disorders are epidemic – 60% of the population has an undiagnosed thyroid problem and they are not being diagnosed or treated properly by mainstream medicine. At 10:56 he hits vitamin D deficiency, and dispels myths about skin cancer and sunscreen. At 18:00 he gives hypothyroidism symptoms. Lab tests do not reveal everything and many go undiagnosed. Approx 1.5 hours (Sorry, nothing is simple)

Multivitamin: Use a vitamin that has numerous amino acids, antioxidants, minerals, and various vitamin Bs including b12 and folate. He prefers vitamin powders from Thorne and Integrative Therapeutics.

Probiotics – use a product shown to repopulate the intestines in scientific studies. Take at least 10 billion live cultures 1 hour away from antibiotics. During an active yeast infection consider increasing to 20 billion cultures one time a day or divided in to two doses.

Natural medicine: Herbal Combinations. 2 pills 2 times a day. (Common herbs found individually or mixed together include: pau d’arco, caprilic acid, rosemary oil, thyme oil, garlic, and grapefruit seed extract.) Will take 3-4 months to get yeast overgrowth under control.
Prescription medicine: Nystatin 500,000IU 2 pills 2 times a day.
*You may add Fluconazole (Diflucan) 200mg 1 time daily for 30 days combined with nystatin for prevent drug resistance for a yeast overgrowth problem.

(Take either the naturals or the prescriptions, but not both together at the beginning; however, you may do so later on)

First Month
Naturals (work 85-90% of the time)
Otoba Bark Extract and Cat’s Claw 5 drops 2X/day of each and increase every 2 days by 1 drop per dose till taking 30 drops 2X/day. Take on an empty stomach. Do not take 30 min before through 2 hours after having food, medicines, or supplements. If you Herx, do not advance dosage until it decreases.
Doxycycline 100mg 2 pills 2X/day or 4 pills 1X/day. Take with food to prevent nausea. Do not take with calcium supplements or dairy or milk substitutes like rice milk. OR
Clarithromycin (Biaxin) 500mg 1 pill 2X/day
*Both of these antibiotics treat the L-form and the spirochete form.
B. After First Month
Remain on same as they kill all 3 forms of Lyme.
Work with LLMD to add additional antibiotics to treat all 3 forms of Lyme. You need to add an antibiotic to kill the cyst form of Lyme.

For an interesting article on what researcher Eva Sapi discovered about the effectiveness of various antibiotics: (Tindamax or Tinidazole was found to be the most effective drug overall killing 90% of cysts and spirochetes. It also works against biofilms.)

Eat organic
Avoid gluten, alcohol and tobacco, and synthetic scents
Lower stress
Multivitamin to support liver detox
Drink good water (1/2 of your ideal body weight in lbs. as ounces)
2-3 servings of beans, legumes, or whole grains/day. Fiber helps you detox.
Exercise – at a tolerable level
*Special Considerations for 6 months & beyond:
Detox treatments for MTHFR methylation defect, lyme and mold biotoxins, and heavy metals
Biofilm treatments
Chronic viral infection treatments
Autoimmune illness treatment such as Low Dose Naltrexone (LDN)
Yeast treatments
(Ups and downs in treatment is normal; however, if there is a significant decline after you are doing better, consider yeast (increased sugar cravings, intestinal gassiness or bloating, recent vaginal yeast infection, oral yeast, and/or vaginal or rectal itching), or a co-infection such as Bartonella, Babesia, or Mycoplasma. Please do Dr. Schaller’s checklists for these coinfections and discuss these possibilities with your health care professional)

Dr. Horowitz’s Lyme Treatment: (Derived from Why Can’t I Get Better?  Solving the Mystery of Lyme and Chronic Disease)
Combine antibiotics to address the 3 forms. Use enzymes to address biofilms, and continue until patient is symptom-free for 2 months.

Cell Wall form:
amoxicillin (500-875mg 2-3X/day) with probenecid 500mg 1X/day with meals. He states to check the peak (12-15 is optimal) and trough levels which may necessitate increasing the dose. Avoid probenecid if there is a sulfa sensitivity or use with caution if has kidney stones.
Augmentin (875-1,000mg 1-2X/day) alone or with amoxicillin.
IM Bicillin 1.2 million units 2-4X/week. Use Emla or lidocaine cream 1 hour prior to injection & massage area 2-3 minutes after and repeat several times per day.
Ceftin (500mg 1-2X/day)
Omnicef (300mg 1-2X/day)
Cedax (400mg 1-2X/day)
Suprax (400mg 1-2X/day)

*For those with significant CNS disease, or who have failed oral medications:
IV Rocephin (2g daily 5-7days/week, up to 2g every 12 pulsed 4-5 days/week). Use Actigall (300mg) 1X/day to prevent sludge and gallstones. Check CBC and CMP with liver functions every two weeks and use liver support (NAC, ALA, Hepa #2, milk thistle) as necessary.
IV Claforan (2g every 8-12 hours) may used instead of Rocephin if there are gallbladder problems. Check blood work as with Rocephin.
IV vancomycin (1-1.25gm/every 12 hours)
IV Primazin (500mg every 6 hours)
IV Cleocin (600mg every 8 hours or 900mg every 12 hours)

Cystic Forms: (also known as L forms, S-forms, spheroplasts, and non cell wall forms)
Grapefruit seed extract (use when can’t take plaquenil or when have yeast issues)
Flagyl – pulse either several days in a row per week or two weeks on, two weeks off
Tindamax – pulse same as Flagyl
*Avoid alcohol when taking Flagyl and Tindamax
*Horowitz uses high doses of B6 and B12 and nystatin to decrease side effects

Intracellular Forms:  Macrolides
Zithromax (250mg 1X/week with meals.
Biaxin or Biaxin XL (250mg 1X/day)

Tetracyclines: (Do not mix with dairy, antacids, or vitamins and minerals, avoid direct sunlight, and do not lie down within an hour of ingestion to avoid reflux esophagitis)
Doxycycline (100mg 2X/day with meals)
Minocycline (50-100mg 2X/day)
Tetracycline 250mg or 500mg 1-2 g per day total, 2X/day

Quinolones: (Do not use if pregnant, do not mix with antacids, or vitamins with minerals)
Cipro (500mg 2X/day)
Levaquine (500mg 1X/day)
Avelox (400mg daily)
Factive (320 daily)
*Check QT interval on Quinolones as well as drug interactions
*Advise patients of tendon issues and do not exercise vigorously. Discontinue if tendon pain starts. Take ALA, curcurmin, and magnesium to decrease side-effects.
*Consider pulsing these in 5 day cycles to reduce tendon damage.

Rifampin: (150mg to 300mg 2X/day) Do not use if pregnant. Use with another intracellular to avoid resistance.  An excellent PDF with treatment suggestions from Dr. Garth Nicolson.  Please remember that you can jump immediately to late disseminated Lyme without noticing any of the previous stages and while the literature often categorizes these stages with time frames, it is often the case that reality is far different.  He also goes into co-infection treatment as well.


I can’t overemphasize the need to consider the coinfections that typically come with Lyme (borrelia).  This fact is not being considered by mainstream medicine, to the detriment of patients.  All the doxy in the world thrown like napalm is not going to cure this.  For instance, if a person has parasitic involvement, they will need anti-parasitic medications.  Some patients have nematode (worm) involvement which requires anthelmintics such as Ivermectin and Albenza.  Research has shown that spirochetes have hidden in worms to go undetected.  Until the worms are killed, the spirochetes can’t be touched by antibiotics.  Borrelia is considered a stealth organism – quite adept at hiding within the human body.

Alternative Treatments

The Cowden Protocol: and  (PDF’s and videos to watch)
This herbal program utilizes 14 different Nutramedix products including 6 Microbial Defense herbals that are taken rotationally over at least 6 months. Richard Horowitz, MD in New York State has found the Cowden Support Program to be effective in markedly improving the condition of 70-80% of the advanced Lyme Borreliosis patients with co-infections over 4 to 6 months’ time, even if the patients had previously failed to improve on multiple courses of antibiotics.

Master Herbalist Stephen Buhner’s Herbal Protocol: (Please check this website for updates on treatments)

Japanese knotweed – Source Naturals Resveratrol with 500mg Polygonum cuspidatum per tablet) 1-4 tablets 3-4X/day for 8-12 months or for tincture dosage:
150lb – 1 tsp 3X/day
100lb – 2/3 tsp 3X/day
60lb – 1/3 tsp 3X/day
30lb – 1/5 tsp 3X/day
Cat’s claw (Uncaria tomentosa) Raintree brand, 1-4 tablets 3-4X/day for 2-3 months, then 2-3 capsules 3X/day or for tincture dosage: same as knotweed above.
Eleuthero (Eleutherococcus senticosus) HerbPharm tincture, 1/2 to 1 tsp upon rising and at lunch for all weights.
Astragalus (Astragalus membranaceus) 1,000mg daily (not to be used in chronic Lyme) or for tincture dosage: same as knotweed except for:
60lb – 1/2 tsp 3X/day
30lb – 1/3 tsp 3X/day
Ashwagandha (withania) 1,000g at night before bed for sleep issues and brain fog.
If you have questions, you may post them to Stephen at: I highly recommend all of Stephen’s books.

Zhang protocol:

Byron White Protocol:

Recently, work is being done on essential oils.  While this is potentially great news for patients, please remember this was all done in vitro (in a test tube), similarly to the work on Stevia. Also, we have no idea what dosage would be effective or safe for human consumption.
As to the work on Stevia, again, it’s all in vitro and needs to be proven in humans.

Ozone Ten-pass:  Infusing ozone into the blood is being used with some success.  It will kill all pathogens – including viruses in the blood.

As to duration of treatment – this varies highly; however, according to the most experienced Lyme literate doctor in the state of Wisconsin, treatment cases in the 70’s resolved within a month to a year, while current cases are taking three and more years.  Many LLMD’s (Lyme literate doctors) recommend a maintenance program for life.


I know this is overwhelming.  Take a deep breath and put one foot in front of the other.  One day at a time.  Trust me, before long you will be a quasi expert in all things TBI (tick borne infections).

You do need to get to an LLMD (Lyme literate doctor).  Regular practitioners at this point do not believe in the severity and complexity of MSIDS (multi systemic infectious disease syndrome or Lyme with friends).  They will not treat you properly with various and extended antibiotics and/or naturals.  Research shows that most are infected with more than borrelia, the causative agent of LD, and have various coinfections such as Bartonella and Babesia complicating our cases.  According to Horowitz, research shows that a person with both Babesia and borrelia are three times sicker than if they just had LD.  This is important to acknowledge and frankly, most GP’s are clueless on all of this.  These stealth pathogens are experts at fooling your immune system and they work symbiotically together and actually morph inside your body by changing their outer surface proteins to be different than when they entered.

If you find a doctor willing to be properly trained, please give them this link:

Realize you have a lot to learn.  Learn it.  Then, be your own advocate.  This is not going to be a sprint, and it’s far from fun.  It’s going to be a marathon, so strap yourself in for a wild ride.  If you are able, get to a Lyme Support Group to learn and be around others on the same journey.  We learn from each other.  If you aren’t able to get to a physical support group, I highly recommend getting on an on-line support group.  You can ask questions and read others’ experiences.  On the right hand side of the website, scroll down until you see “On-line Support Groups.”  Click and join.  Also, if you want to receive an email each time I post educational materials or meeting times for the Madison Lyme Support Group, pop me an email, I’ll send you an invite, and you will get an email directly to you when I post.  This is convenient because I always send reminders for meeting times!  You can also type in words in the search bar for articles to help you learn.  For instance, from here, I’d recommend “Tips for Newbies,” as this complex is far different than anything you’ve experienced.  Also, if you are struggling with cognitive and/or psychological issues, please type “Psychological Aspects of Lyme,” into the search bar.

No, you aren’t crazy, you have a brain infection which makes you feel crazy.  Treatment will resolve these issues.