Archive for the ‘research’ Category

Cipro Derivatives Show Promise Against Babesia In Vitro

https://pubmed.ncbi.nlm.nih.gov/32677000/

. 2020 Jul 16.

doi: 10.1007/s00436-020-06796-z. Online ahead of print.

Inhibitory effects of novel ciprofloxacin derivatives on the growth of four Babesia species and Theileria equi

Affiliations expand

Abstract

The problems of parasite resistance, as well as the toxic residues to most of the commercially available antipiroplasmic drugs severely weaken their effective, curative, and environmental safe employment. Therefore, it is clear that the development of treatment options for piroplasmosis is vital for improving disease treatment and control. Ciprofloxacin is a broad-spectrum antibiotic that targets mainly the DNA replication machinery by inhibiting DNA gyrase and topoisomerase enzymes. As a result, ciprofloxacin is used for treating several bacterial and parasitic infections.

In this study, the efficacy of 15 novel ciprofloxacin derivatives (NCD) that had been developed against drug-resistant Mycobacterium tuberculosis was evaluated against piroplasm parasite multiplication in vitro. The half-maximal inhibitory concentration (IC50) values of the most effective five compounds of NCD (No. 3, 5, 10, 14, 15) on Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi were 32.9, 13.7, 14.9, and 30.9; 14.9, 25.8, 13.6, and 27.5; 34.9, 33.9, 21.1, and 22.3; 26.7, 28.3, 34.5, and 29.1; and 4.7, 26.6, 33.9, and 29.1 μM, respectively. Possible detrimental effects of tested NCD on host cells were assessed using mouse embryonic fibroblast (NIH/3T3) and Madin-Darby bovine kidney (MDBK) cell lines. Tested NCD did not suppress NIH/3T3 and MDBK cell viability, even at the highest concentration used (500 μM).

Combination treatments of the identified most effective compounds of NCD/diminazene aceturate (DA), /atovaquone (AQ), and /clofazimine (CF) showed mainly synergistic and additive effects. The IC50 values of NCD showed that they are promising future candidates against piroplasmosis. Further in vivo trials are required to evaluate the therapeutic potential of NCD.

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For more:  https://madisonarealymesupportgroup.com/category/babesia-treatment/

Bartonella Causing Encephalitis

https://pubmed.ncbi.nlm.nih.gov/32675979/

. 2020 Apr 24;33(3):440-441.

doi: 10.1080/08998280.2020.1756141. eCollection 2020 Jul.

Cat scratch disease causing encephalitis

Free PMC article

Abstract

Cat scratch disease is often a benign infection caused by Bartonella henselae, which is transmitted from scratches or bites from kittens. Presentations can vary from localized lymphadenopathy to neurologic manifestations. We present a case of a 22-year-old man with a 3-week history of an enlarged inguinal lymph node who presented with status epilepticus.

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**Comment**

Unfortunately, many still consider Bartonella “benign” when for many it is extremely severe and tenacious.  I would consider it as bad if not worse than Lyme in many respects.  Many also do not have lymph node involvement. Some patient’s only manifestation is psychological.

For more:  https://madisonarealymesupportgroup.com/category/bartonella-treatment/  There is a checklist within this link of symptoms.

https://madisonarealymesupportgroup.com/2019/05/05/good-news-for-bartonella-patients-identification-of-fda-approved-drugs-with-higher-activity-than-current-front-line-drugs/  My husband and I use Berberine for Bartonella maintenance successfully.

https://madisonarealymesupportgroup.com/2019/04/24/human-bartonellosis-an-underappreciated-public-health-problem/

https://madisonarealymesupportgroup.com/2020/07/16/5-questions-to-discuss-with-your-physician-when-bartonellosis-is-suspected/

https://madisonarealymesupportgroup.com/2019/02/27/advanced-imaging-found-bartonella-around-pic-line/

 

Study Shows Lyme, Helicobacter Pylori, and Cytomegalovirus Are Risk Factors for All-Cause Mortality in the Elderly

https://pubmed.ncbi.nlm.nih.gov/32648237/

. 2020 Jul 9.

doi: 10.1007/s11357-020-00216-x. Online ahead of print.

Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study

Abstract

Immunostimulation by chronic infection has been linked to an increased risk for different non-communicable diseases, which in turn are leading causes of death in high- and middle-income countries. Thus, we investigated if a positive serostatus for pathogens responsible for common chronic infections is individually or synergistically related to reduced overall survival in community dwelling elderly. We used data of 365 individuals from the German MEMO (Memory and Morbidity in Augsburg Elderly) cohort study with a median age of 73 years at baseline and a median follow-up of 14 years. We examined the effect of a positive serostatus at baseline for the following selected pathogens associated with chronic infections on all-cause mortality with multivariable parametric survival models:

  • Helicobacter pylori
  • Borrelia burgdorferi sensu lato
  • Toxoplasma gondii
  • cytomegalovirus
  • Epstein-Barr virus
  • herpes simplex virus 1/2, and human herpesvirus 6

We found a reduced survival time in individuals with a positive serostatus for the following pathogens after adjusting for potential confounders:

  • Helicobacter pylori (accelerated failure time (AFT) – 15.92, 95% CI – 29.96; – 1.88)
  • cytomegalovirus (AFT – 22.81, 95% CI – 36.41; – 9.22)
  • Borrelia burgdorferi sensu lato (AFT – 25.25, 95% CI – 43.40; – 7.10)
The number of infectious agents an individual was seropositive for had a linear effect on all-cause mortality (AFT per additional infection – 12.42 95% CI – 18.55; – 6.30).

Our results suggest an effect of seropositivity for Helicobacter pylori, cytomegalovirus, and Borrelia burgdorferi sensu lato on all-cause mortality in older community dwelling individuals. Further research with larger cohorts and additional biomarkers is required, to assess mediators and molecular pathways of this effect.

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**Comment**

Recently I posted this article and that Cytomegalovirus, EBV, and Herpes Virus 6 has been found in those with ME/CFS:  https://madisonarealymesupportgroup.com/2020/07/23/cytomegalovirus-ebv-and-human-herpesvirus-6-infections-in-patients-with-me-cfs/

Some have been misdiagnosed with EBV but had Lyme:  https://madisonarealymesupportgroup.com/2017/04/11/diagnosed-with-ebv-had-lyme/

Dr. Waisbren, an IDSA founder and Wisconsin Doctor found that his Lyme patients often had high EBV titers:  https://madisonarealymesupportgroup.com/2017/07/09/idsa-founder-used-potent-iv-antibiotics-for-chronic-lyme/

Another important finding: The more pathogens a patient tested positive for, the higher the mortality, demonstrating that coinfected patients are sicker.

 

 

 

 

Possible Role for Ascorbic Acid in COVID-19

A Possible Role for Ascorbic Acid in COVID-19

pdf here: A_Possible_Role_for_Ascorbic_Acid_in_COVID-19

Excerpt:

IV ascorbic acid has a long track record of safety. It has been used historically in the management of viral infections and more recently for sepsis. Ongoing clinical trials in the United States, Canada, China, Italy, and other countries will hopefully support its widespread use for patients with COVID-19 infection in the larger medical community. (See pdf link for entire paper)

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For more:  https://madisonarealymesupportgroup.com/2020/06/15/the-functional-medicine-approach-to-covid-19-virus-specific-nutraceutical-botanical-agents/

https://madisonarealymesupportgroup.com/2020/05/08/natural-supplements-vs-coronaviruses/

https://madisonarealymesupportgroup.com/2020/03/20/herbal-treatment-for-covid-19-addendum-buhner/

https://madisonarealymesupportgroup.com/2020/07/13/nutritional-supplements-for-covid-19-prophylaxis-and-symptom-de-escalation/

https://madisonarealymesupportgroup.com/2020/04/11/85-covid-patients-zero-hospitalizations-no-deaths/

https://madisonarealymesupportgroup.com/2020/06/02/successful-covid-19-critical-care-stonewalled-by-cdc/?

https://madisonarealymesupportgroup.com/2020/06/26/math-protocol-shows-profound-impact-on-survival-from-covid-19/

https://madisonarealymesupportgroup.com/2020/05/22/new-study-hcq-zinc-greatly-reduces-covid-19-health-risk/

In short, COVID is a virus, which means the stronger your body is the more powerfully it can fight to keep you healthy.  Lyme/MSIDS patients have to learn this simple truth in their journey.  If there’s a silver lining in the COVID debacle, it’s that the general population has an opportunity to become educated on health – IF and only IF they do not accept the COVID narrative that is being spun by ‘authorities,’  which essentially is – cower in fear, wear a mask, and wait for our lucrative vaccine.

These ‘authorities’ are the same ones behind the Lyme/MSIDS debacle, following the same narrative: malign everyone else’s tests and treatments and bully doctors into only using things ‘authorities’ approve of.  

I recently posted a paper by none other than Dr. Fauci himself who insists that “Big Science” is the only way to go – sending a clear message to doctors.

Chris Newton explains it here:  https://www.linkedin.com/pulse/god-precious-randomized-control-trials-rcts-chris-newton/?

My husband and I and thousands of Lyme/MSIDS patients would be dead if it weren’t for doctors willing to treat us without those precious randomized controlled trials.  Right now there are thousands of Lyme/MSIDS patients being treated with Disulfiram/Antabuse based mainly upon 3 case studies and clinical experience.  Many of which are finally getting their health back after decades of suffering.

 

 

Researchers Investigating Possible Link Between Vitamin D Deficiency and COVID-19

https://www.azcentral.com/story/news/local/arizona-science/2020/07/22/coronavirus-research-study-link-between-vitamin-d-deficiency-covid-19/

Researchers investigating possible link between vitamin D deficiency and COVID-19

Amanda Morris

Arizona Republic
Southwest College of Naturopathic Medicine lab technician Beverly McCall takes a sample of blood from a COVID-19 clinical study participant.

For months, many of us have stayed home on the advice of health experts, quarantining indoors to help slow the spread of the coronavirus. Now some researchers are investigating the possibility that spending a little more time in the sun could actually help prevent COVID-19.

That’s because sunshine is a key ingredient for our bodies to make vitamin D. 

After seeing a correlation between severe COVID-19 patients and vitamin D deficiency, the researchers hypothesized that the vitamin, absorbed through sunlight by the skin, could play a role in helping the body’s immune system fight the novel coronavirus. (See link for article)

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**Comment**

I posted on this back in April and considered it common sense, but I’m discovering common sense isn’t so common.  https://madisonarealymesupportgroup.com/2020/04/09/you-are-safer-outside-than-inside-disease-expert-criticizes-restrictions/

The article discusses a study of nearly 500 patients and found those with vitamin D deficiencies were nearly twice as likely to test positive for COVID.  I’m not impressed with these findings because the tests are abysmal and not to be trusted..  Plus, testing positive means nothing as you may never even develop symptoms.

What’s important is the  correlation between COVID severity and vitamin D deficiency.

This review https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15777 found:

“When mortality per million is plotted against latitude, it can be seen that all countries that lie below 35 degrees North have relatively low mortality. Thirty‐five degrees North also happens to be the latitude above which people do not receive sufficient sunlight to retain adequate vitamin D levels during winter. This suggests a possible role for vitamin D in determining outcomes from COVID‐19

What is helpful in the article is that it reminds the reader that we make less vitamin D as we age and those with darker skin tones (higher melanin content) block UV rays which are required to make vitamin D.  This may explain COVID severity in the black population and why it’s imperative to know your vitamin D levels and to either get sun or supplement.  For those of us in the North, we can’t achieve the amount of sunlight necessary for most of the year and supplementation is required for us to have appropriate vitamin D levels.  Make sure you test before you supplement.

The article goes on to mention a study that showed the following percentages are at risk of low vitamin D

  • 21% of whites
  • 42% of hispanics
  • 73% of blacks

Interestingly, they state the higher rate of vitamin D deficiency in overweight people is due to the fact D is dissolved in fat and isn’t getting into the blood stream.  Another reason to keep your ideal weight.

I will add that not only is sunlight invaluable and the only way to increase vitamin D levels naturally, fresh air (oxygen) unimpeded by masks is also healthy..

Similarly to the attack on HCQ, ‘authorities’ are also coming down on vitamin D:  https://madisonarealymesupportgroup.com/2020/07/02/experts-criticize-government-review-of-vitamin-d-for-covid-19/

Here’s another example of misinformation:  https://articles.mercola.com/sites/articles/archive/2020/06/08/cnn-coronavirus-vitamin-d  Within this link Dr. Mercola highly advises you get your vitamin D levels optimal before fall and the seasonal flu.

That’s not to say there aren’t things to know.  Since Vitamin D is a fat soluble vitamin, it’s important to check your levels at least yearly.  For a great read on D and everything you need to know:  https://madisonarealymesupportgroup.com/2018/03/12/the-importance-of-vitamin-d-k-and-magnesium-for-lyme-msids-patients/