Archive for the ‘research’ Category

Interview With Talia Jackson & GLA CEO Scott Santarella – Lyme Disease

https://globallymealliance.org/news/interview-talia-jackson-and-gla-ceo-scott-santarella-on-fox-5/  NEWS VIDEO HERE

Interview:  Talia Jackson & GLA CEO Scott Santarella On Fox 5

fox-5-talia-jackson

Actress Talia Jackson shares her personal story of being diagnosed with and living with Lyme disease on Good Day NY, FOX 5. She is joined by GLA CEO Scott Santarella. Talia currently stars in the Netflix show “Family Reunion” and was in New York to attend GLA’s 5th Annual New York Gala on October 10, 2019.

For more of Talia’s story, read her interview with Parade Magazine.

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**Comment**

Great interview, but please know some people’s only symptoms are psychological:  https://madisonarealymesupportgroup.com/2015/10/18/psychiatric-lymemsids/

Also, Lyme is the famous actor we all know by name. There are many wanna-be’s standing off stage such as: Bartonella, Babesia, Mycoplasma, Rocky Mountain Spotted Fever, etc. To date there are approximately 20 bacteria and viruses transmitted by ticks: https://madisonarealymesupportgroup.com/2017/05/01/co-infection-of-ticks-the-rule-rather-than-the-exception/

https://madisonarealymesupportgroup.com/2019/09/18/more-than-lyme-tick-study-finds-multiple-agents-of-tick-borne-diseases/

And while some want to blame “climate change,” current research has proven that to be a red herring:  https://madisonarealymesupportgroup.com/2018/11/07/ticks-on-the-move-due-to-migrating-birds-and-photoperiod-not-climate-change/

Independent Canadian Tick researcher, John Scott, states:

“The climate change range expansion model is what the authorities have been using to rationalize how they have done nothing for more than thirty years. It’s a huge cover-up scheme that goes back to the 1980’s. The grandiose scheme was a nefarious plot to let doctors off the hook from having to deal with this debilitating disease. I caught onto it very quickly. Most people have been victims of it ever since.  This climate change ‘theory’ is all part of a well-planned scheme. Even the ticks are smarter than the people who’ve concocted this thing.  Climate change has nothing to do with tick movement. Blacklegged ticks are ecoadaptive, and tolerate wide temperature fluctuations…..It’s all a red herring to divert your attention.”

Recently, Scott wrote a scathing correction on erroneous research done by Ontario public officials on the fake climate change tick connection: https://madisonarealymesupportgroup.com/2019/06/17/ontario-public-health-officials-called-out-on-shoddy-biased-research-utilizing-an-erroneous-climate-change-model-to-program-a-futuristic-tick-problem/

Please understand the DOD, DARPA, & EPA are funding this very “climate change” research.

https://madisonarealymesupportgroup.com/2019/06/25/lyme-disease-cases-are-exploding-and-its-only-going-to-get-worse/  This is an interesting finding considering the following excerpt from an article written by By Alex Bhattacharji:

Although conspiracy theorists have suggested — falsely — that Lyme disease was created in a U.S. military lab, it is true that in the years following World War II, the U.S. employed top German scientists who explored the tick’s potential in biological warfare for Nazi Germany. The researchers were investigating the tick’s ability to spread pathogens across wide areas with the potential to incapacitate entire populations.

Seventy-five years later, the tick timebomb is detonating on its own. Thanks to climate change, globalization, and other factors, ticks are not only proliferating but also becoming more malignant, more aggressive, and more likely to carry infection. A public health crisis is hiding in plain sight.

Bhattacharji got the “tick timebomb” portion correct but not the climate change non-issue regarding ticks.

I will state once again, ticks will be the last species on earth besides the IRS.

 

 

 

NIH Strategic Plan For Tickborne Disease Research

NIH STRATEGIC PLAN FOR TICKBORNE DISEASE RESEARCH

October 9, 2019

https://www.niaid.nih.gov/sites/default/files/NIH-Strategic-Plan-Tickborne-Disease-Research-2019.pdf

Please see link for:

  • Executive Summary   
  • Introduction
  • NIH Strategic Plan for Tickborne Disease 
  • Strategic Priority 1: Improve Fundamental Knowledge of TBDs
  • Strategic Priority 2: Advance Research to Improve Detection & Diagnosis of TBDs
  • Strategic Priority 3: Accelerate Research to Improve Prevention of TBDs
  • Strategic Priority 4: Support Research to Advance Treatment of TBDs
  • Strategic Priority 5: Develop tools & resources to Advance TBD research
  • Conclusion
  • Appendices 

Some respondents expressed a desire for greater transparency in the research planning and implementation processes, whereas others suggested changes to the peer review process to include wider representation from the TBD community, such as advocacy group representatives, community physicians, or members of the general public.

To which we all said, AMEN!

More Than Lyme: Tick Study Finds Multiple Agents of Tick-borne Diseases

NEWS RELEASE 

More than Lyme: Tick study finds multiple agents of tick-borne diseases

COLUMBIA UNIVERSITY’S MAILMAN SCHOOL OF PUBLIC HEALTH

IMAGE
IMAGE: THREE PRIMARY HUMAN-BITING TICK SPECIES PRESENT ON LONG ISLAND WERE EXAMINED IN THIS STUDY. LEFT — BLACKLEGGED TICK ALSO KNOWN AS THE DEER TICK, MIDDLE — THE AMERICAN DOG TICK,… view more 

CREDIT: SANTIAGO SANCHEZ-VICENTE, STONY BROOK UNIVERSITY

In a study published in mBio, a journal of the American Society for Microbiology, Jorge Benach and Rafal Tokarz, and their co-authors at Stony Brook University and Columbia University, reported on the prevalence of multiple agents capable of causing human disease that are present in three species of ticks in Long Island.

Tick-borne diseases have become a worldwide threat to public health. In the United States, cases more than doubled, from 22,000 in 2004 to more than 48,000 in 2016, according to the U.S. Centers for Disease Control. Tick-borne diseases range from subclinical to fatal infections with disproportionate incidence in children or the elderly. Moreover, some infections can also be transmitted by blood transfusions and cause severe disease in patients with underlying disorders. While public attention has focused on Lyme disease, in recent years, scientists have uncovered evidence that ticks can carry several different pathogens capable of several different tick-borne diseases, sometimes in a single tick.

In the new study, researchers collected ticks from multiple locations throughout Suffolk county in the central and eastern part of Long Island, where seven diseases caused by microbes transmitted by ticks are present. In total, they examined 1,633 individual ticks for 12 separate microbes. They found that more than half of the Ixodes (deer ticks) were infected with the Lyme disease agent, followed by infections with the agents of Babesiosis and Anaplasmosis. Importantly, nearly one-quarter of these ticks are infected with more than one agent, resulting in the possibility of simultaneous transmission from a single tick bite.

Notably, the lone star tick, a species originating from the southern U.S., has expanded its range, possibly fueled by climate change. This study documents that the invasive lone star tick is abundant in Long Island, and that it is a very aggressive tick that can transmit a bacterium that causes a disease known as Ehrlichiosis. The lone star tick has also been implicated in cases of a novel form of meat allergy, and the immature stages can cause an uncomfortable dermatitis.

Polymicrobial infections represent an important aspect of tick-borne diseases that can complicate diagnosis and augment disease severity,” says corresponding author Jorge Benach, PhD, Distinguished Professor at the Department of Microbiology and Immunology at the Renaissance School of Medicine at Stony Brook University. “Some of the polymicrobial infections can be treated with the same antibiotics, but others require different therapies, thus enlarging the number of drugs to treat these infections.”

“In evaluating tick-borne infection, more than one organism needs to be considered,” says senior author Rafal Tokarz, PhD, assistant professor of epidemiology in the Center for Infection and Immunity at the Columbia Mailman School of Public Health, and a graduate of the Department of Microbiology and Immunology at Stony Brook University. “This study emphasizes the need to focus on all tick-borne diseases, not just Lyme.”

###

The first author is Santiago Sanchez, a post-doctoral fellow in the Department of Microbiology and Immunology at Stony Brook University. Teresa Tagliafierro from Columbia and James Coleman from Stony Brook are co-authors of the study.

This study was funded by a grant from the National Institutes of Health to Benach. Support was also provided by the Island Outreach Foundation in Blue Point, NY, to the Stony Brook Renaissance School of Medicine. Support from the Steven & Alexandra Cohen Foundation (CU18-2692) was provided to Tokarz.

 

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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**Comment**

Again, climate change has nothing to do with tick proliferation and disease spread: https://madisonarealymesupportgroup.com/2018/08/13/study-shows-lyme-not-propelled-by-climate-change/

https://madisonarealymesupportgroup.com/2018/11/07/ticks-on-the-move-due-to-migrating-birds-and-photoperiod-not-climate-change/

https://madisonarealymesupportgroup.com/2019/06/17/ontario-public-health-officials-called-out-on-shoddy-biased-research-utilizing-an-erroneous-climate-change-model-to-program-a-futuristic-tick-problem/

https://madisonarealymesupportgroup.com/2018/11/17/uw-madison-phd-in-ecological-climatology-climate-change-computer-models-fudged-except-russian-model/  Dr. Patrick Michaels, director of the Center for the Study of Science at the Cato Institute, provides insight into the debate over climate change and the political games played to create policy.

Political games surrounding Lyme/MSIDS have gone on long enough. Do research on important issues that will help patients.

 

 

 

A New Complication of Lyme Disease; Spinal Muscular Atrophy (SMA)

article_ejbps_volume_6_august_issue_8_1564794140

ejbps, 2019, Volume 6, Issue 8, 464-468.

http://www.ejbps.com

Year: 2019

A NEW COMPLICATION OF LYME DISEASE; SPINAL MUSCULAR ATROPHY (SMA)

Barbaros ÇETİN*

Dokuz Eylül University, Faculty of Science, Department of Biology, Izmir, Turkey.

*Corresponding Author: Barbaros ÇETİN

ABSTRACT

Lyme borreliosis is well known multisystem disease and can produce a wide array of neurological abnormalities in humans. It can effect both the central and peripheral nervous system. Spinal muscular atrophy (SMA) a leading genetic cause of infant death, is a neurodegenerative disease characterised by the selective loss of particular groups of motor neurones in the anterior horn of the spinal cord with concomitant muscle weakness. Spinal muscular atrophy (SMA) is also a neuromuscular disease caused by abnormally low cellular levels of the ubiquitous protein SMN. Recent study finds connection between ALS and SMA. Respiratory failure due to bilateral diaphragm palsy as an early manifestation of ALS. Diaphragmatic paralysis and respiratory failure as a complication of Lyme disease. Lyme –associated diaphragm weakness from phrenic nerve palsy is rare. One of the rarest manifestations of phrenic nerve disorder is neuroborreliosis. I report two cases.

  1. When she was 2 months baby, she had diagnosed with SMA. After three years, her LTT-Borrelia test result is positive. CD57+/CD3-(NK cells) % 0.48, (20 mm 3 ), very low. C3 Compleman test result is low. Her mother’s (38 years old), LTT-Borrelia test result also positive. It is documented that transplacental transmission of the spirochete from mother to fetus is possible.
  2. 13 years old son. He had diagnosed Emery-Dreifuss muscular dystrophy (EDMD),when he was 6 years old. He had, LTT-Borrelia positive test result, after 5 years. His father lyme test result was positive, when he was 57 years old.

Eventually, these results reveal the need for consideration of Lyme borreliyosis in patients diagnosed with SMA for the first time.

People who are diagnosed with SMA, DMD, ALS and similar neurodegenerative diseases have a great benefit in performing Lyme tests.

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**Comment**

I highly doubt that SMA is a “new” complication of Lyme disease – but rather is newly published information. Again, with all the under reporting going on, we haven’t a clue about prevalence in patients.

This article also highlights congenital transmission of Lyme disease – something the CDC doesn’t even recognize to date: https://madisonarealymesupportgroup.com/2018/06/19/33-years-of-documentation-of-maternal-child-transmission-of-lyme-disease-and-congenital-lyme-borreliosis-a-review/

Which brings up the potential of sexual transmission as well: https://madisonarealymesupportgroup.com/2017/02/24/pcos-lyme-my-story/

It continues to battle me why authorities will not do the appropriate studies on much needed practical issues such as sensitive testing, appropriate treatment, and whether or not Lyme/MSIDS can be transmitted by numerous means: https://madisonarealymesupportgroup.com/2019/04/02/transmission-of-lyme-disease-lida-mattman-phd/

https://madisonarealymesupportgroup.com/2019/05/24/microbiology-professor-im-convinced-lyme-disease-is-transmittable-from-person-to-person/

Latest Paper Reviewing The Proposed IDSA Guidelines on Lyme Disease and Psychiatric Illnesses

https://www.mdpi.com/2227-9032/7/3/105  Go here for full paper)

Open AccessReview

Proposed Lyme Disease Guidelines and Psychiatric Illnesses

1
Department of Psychiatry, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
2
Independent Researcher, Dorset BH23 5BN, UK
3
General Counsel Red Paladin, Piscataway, NJ 08854, USA
*
Author to whom correspondence should be addressed.
Healthcare 2019, 7(3), 105; https://doi.org/10.3390/healthcare7030105 (registering DOI)
Received: 6 August 2019 / Revised: 3 September 2019 / Accepted: 4 September 2019 / Published: 9 September 2019
(This article belongs to the Special Issue Lyme Disease and Related Tickborne Infections)
The Infectious Disease Society of America, American Academy of Neurology, and American Academy of Rheumatology jointly proposed Lyme disease guidelines. Four areas most relevant to psychiatry were reviewed—the disclaimer, laboratory testing, and adult and pediatric psychiatric sections. The disclaimer and the manner in which these guidelines are implemented are insufficient to remove the authors and sponsoring organizations from liability for harm caused by these guidelines. The guidelines and supporting citations place improper credibility upon surveillance case definition rather than clinical diagnosis criteria. The guidelines fail to address the clear causal association between Lyme disease and psychiatric illnesses, suicide, violence, developmental disabilities and substance abuse despite significant supporting evidence.
If these guidelines are published without very major revisions, and if the sponsoring medical societies attempt to enforce these guidelines as a standard of care, it will directly contribute to increasing a national and global epidemic of psychiatric illnesses, suicide, violence, substance abuse and developmental disabilities and the associated economic and non-economic societal burdens.
The guideline flaws could be improved with a more appropriate disclaimer, an evidence-based rather than an evidence-biased approach, more accurate diagnostic criteria, and recognition of the direct and serious causal association between Lyme disease and psychiatric illnesses.View Full-Text
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**Comment**
In plain English this means the latest Lyme Guidelines once again place too much emphasis on criteria used for surveillance (positive blood serology, EM rash, etc) and not enough on symptoms used for clinical diagnosis: https://madisonarealymesupportgroup.com/2017/09/05/empirical-validation-of-the-horowitz-questionnaire-for-suspected-lyme-disease/
On top of this, the paper states the guidelines fail to address a clear causal association between Lyme disease and psychiatric illness.
If they are implemented as stands, we are in a world of trouble.

Please share with those in your sphere of influence. Suffering for 40 years is long enough.

Bad Roommates: Study Tracks Mice To Nests, Finds Ticks Aplenty

Bad Roommates: Study Tracks Mice To Nests, Finds Ticks Aplenty

By Melissa Mayer

Scientists know a great deal about how blacklegged ticks (Ixodes scapularis) feed on hosts, such as whitefooted mice (Peromyscus leucopus) and woodland deer mice (Peromyscus maniculatus), but what happens after the ticks drink their fill is more mysterious. Lab studies suggest these ticks may detach from mouse hosts inside their nests. However, no field studies have confirmed the presence of blacklegged ticks in naturally occurring mouse nests—until now. Entire article here: https://entomologytoday.org/2019/08/22/bad-roommates-study-tracks-mice-nests-finds-ticks-aplenty/

 

The Macabre World of Mind-Controlling Parasites

https://neurosciencenews.com/brain-parasites-14791/

The macabre world of mind-controlling parasites

Summary: Understanding how parasites ‘hack’ the brains of their hosts may provide new insights into decision making and behavior.

Source: Frontiers

Imagine a parasite that makes an animal change its habits, guard the parasite’s offspring or even commit suicide. While mind-control may sound like something out of a science fiction movie, the phenomenon is very real — and has spawned a new field, neuro-parasitology. As outlined in an article published in Frontiers in Psychology, understanding how parasites “hack” their host’s nervous system to achieve a particular goal could provide new insights into how animals control their own behavior and make decisions.

“Parasites have evolved, through years of co-evolution with their host, a significant ‘understanding’ of their hosts’ neuro-chemical systems,” explains one of the article’s authors, Professor Frederic Libersat from Ben-Gurion University of the Negev in Israel. “Exploring these highly specific mechanisms could reveal more about neural control of animal behavior.”

The article describes some of the sophisticated, cunning and gruesome ways that various parasites outwit and exploit their insect hosts.

One method is to affect how an insect navigates. The spores of one parasitic fungus, for example, invade an ant’s body, where the fungus grows and consumes the ant’s organs while leaving the vital organs intact. The fungus then releases chemicals that cause the ant to climb a tree and grip a leaf with its mouthparts. After emerging from the ant’s body, the fungus releases spore-filled capsules that explode during their fall, spreading the infectious spores over the ground below. By forcing the ant to climb a tree, the fungus increases the dispersal of the falling spores and the chance of infecting another ant.

Similarly, a parasitic hairworm causes infected crickets to seek out water — where they drown. The cricket’s suicide enables the worms to enter an aquatic environment for reproduction.

In another type of interaction, called “bodyguard manipulation,” the parasite forces the infected insect to guard its young. One such parasite is a wasp, which injects its eggs into a caterpillar by stinging it. Inside the live caterpillar, the eggs hatch into larvae, which feed on the caterpillar’s blood. Eventually, as many as 80 larvae emerge from the caterpillar’s body before forming cocoons to complete their growth into adult wasps.

However, wasp larvae are vulnerable to predators in their cocoons. To scare potential predators away, one or two larvae remain in the caterpillar and control its behavior through an unknown mechanism, so that it acts aggressively towards predators — thereby protecting the cocoons.

These examples shed light on the very old and highly specific relationship between parasites and hosts. But how exactly do these parasites affect their host’s behavior?

This shows an ant with a parasite attached to it

Neuro-parasitology is still a young field, and in most cases, researchers do not yet fully understand the mechanisms involved. However, many such parasites produce their effects by releasing compounds that act on the neural circuitry of the host. Identifying and using these compounds in the lab could help scientists to work out how neural circuits control behavior.

“Because neurotoxins are the outcome of one animal’s evolutionary strategy to incapacitate another, they are usually highly effective and specific,” says Libersat.

“Chemical engineers can generate hundreds of potential neurotoxins in the lab, but these are random and often useless, whereas any natural neurotoxin has already passed the ultimate screening test, over millions of years of co-evolution.”

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source:
Frontiers
Media Contacts:
Conn Hastings – Frontiers
Image Source:
The image is adapted from the Frontiers news release.

Original Research: Open access
“Mind Control: How Parasites Manipulate Cognitive Functions in Their Insect Hosts”.Frederic Libersat, Maayan Kaiser and Stav Emanuel.
Frontiers in Psychology. doi:10.3389/fpsyg.2018.00572

Abstract

Mind Control: How Parasites Manipulate Cognitive Functions in Their Insect Hosts

Neuro-parasitology is an emerging branch of science that deals with parasites that can control the nervous system of the host. It offers the possibility of discovering how one species (the parasite) modifies a particular neural network, and thus particular behaviors, of another species (the host). Such parasite–host interactions, developed over millions of years of evolution, provide unique tools by which one can determine how neuromodulation up-or-down regulates specific behaviors. In some of the most fascinating manipulations, the parasite taps into the host brain neuronal circuities to manipulate hosts cognitive functions. To name just a few examples, some worms induce crickets and other terrestrial insects to commit suicide in water, enabling the exit of the parasite into an aquatic environment favorable to its reproduction. In another example of behavioral manipulation, ants that consumed the secretions of a caterpillar containing dopamine are less likely to move away from the caterpillar and more likely to be aggressive. This benefits the caterpillar for without its ant bodyguards, it is more likely to be predated upon or attacked by parasitic insects that would lay eggs inside its body. Another example is the parasitic wasp, which induces a guarding behavior in its ladybug host in collaboration with a viral mutualist. To exert long-term behavioral manipulation of the host, parasite must secrete compounds that act through secondary messengers and/or directly on genes often modifying gene expression to produce long-lasting effects.

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**Comment**

Parasites are a whole new fantastical frontier. I’ll never forget this information on how parasites affect human behavior by Dr. Klinghardt, which I found here:  http://www.betterhealthguy.com/a-deep-look-beyond-lyme

  • Parasite patients often express the psyche of the parasites – sticky, clingy, impossible to tolerate – but a wonderful human being is behind all of that.

  • We are all a composite of many personalities. Chronic infections outnumber our own cells by 10:1. We are 90% “other” and 10% “us”. Our consciousness is a composite of 90% microbes and 10% us.

  • Our thinking, feeling, creativity, and expression are 90% from the microbes within us. Patients often think, crave, and behave as if they are the parasite.

  • Our thinking is shaded by the microbes thinking through us. The food choices, behavioral choices, and who we like is the thinking of the microbes within us expressing themselves.

  • Patients will reject all treatments that affect the issue that requires treating.

  • Patients will not guide themselves to health when the microbes have taken over.

For a great read on parasite treatments: https://madisonarealymesupportgroup.com/2017/10/03/removing-parasites-to-fix-lyme-chronic-illnesses-dr-jay-davidson/

as well as this one:  http://drallisonhofmann.com/wp-content/uploads/2015/11/TownsendLetter-Parasitosis.pdf

There’s a link between T. Gondii (Toxoplasmosis) and risky behavior as well as schizophrenia  https://madisonarealymesupportgroup.com/2018/08/01/risky-business-linking-t-gondii-entrepreneurship-behaviors/

https://madisonarealymesupportgroup.com/2016/05/21/toxoplasmosis/

It can be transmitted by ticks (Castor Bean) as well as by undercooked deer meat: https://madisonarealymesupportgroup.com/2019/04/06/toxoplasmosis-outbreak-due-to-undercooked-deer-meat-from-illinois/

PLEASE CONSIDER PARASITES AND DISCUSS WITH YOUR MEDICAL PRACTITIONER.

Providence certainly has a sense of humor. On one hand, similarly to how the Japanese Barberry provides a uniquely favorable environment for tick questing, which is undesirable to humans, https://madisonarealymesupportgroup.com/2018/06/25/juvenile-tick-attachment-on-mice-significantly-greater-in-japanese-barberry-shrubs/ we derive Barberry, the yellow root of the plant to treat inflammation in Lyme disease.  Recently, Barberry was listed as a FDA approved drug with higher activity than current front line drugs for Bartonella:  https://madisonarealymesupportgroup.com/2019/05/05/good-news-for-bartonella-patients-identification-of-fda-approved-drugs-with-higher-activity-than-current-front-line-drugs/

And, as mentioned in this article: the fungus Cordyceps hijacks the ant to propitiate itself but here again, many Lyme patients use Cordyceps to fight microbes, lower inflammation, and increase energy and oxygen:  https://rawlsmd.com/herbs/cordyceps