Archive for the ‘Bartonella’ Category

The Role of Host Response in Chronic Illnesses

The Role of Host Response in Chronic Illnesses

Cutaneous Manifestations of Bartonellosis

2019 Sep – Oct;94(5):594-602. doi: 10.1016/j.abd.2019.09.024. Epub 2019 Oct 2.

Cutaneous manifestations of bartonellosis.


Bartonellosis are diseases caused by any kind of Bartonella species. The infection manifests as asymptomatic bacteremia to potentially fatal disorders. Many species are pathogenic to humans, but three are responsible for most clinical symptoms: Bartonella bacilliformis, Bartonella quintana, and Bartonella henselae.

Peruvian wart, caused by B. bacilliformis, may be indistinguishable from bacillary angiomatosis caused by the other two species.

Other cutaneous manifestations include maculo-papular rash in trench fever, papules or nodules in cat scratch disease, and vasculitis (often associated with endocarditis).

In addition

  • febrile morbilliform rash
  • purpura
  • urticaria
  • erythema nodosum
  • erythema multiforme
  • erythema marginatus
  • granuloma annularis
  • leukocytoclastic vasculitis
  • granulomatous reactions
  • angioproliferative reactions may occur.

Considering the broad spectrum of infection and the potential complications associated with Bartonella spp., the infection should be considered by physicians more frequently among the differential diagnoses of idiopathic conditions. Health professionals and researchers often neglected this diseases.


For more:

Dr. Ericson has incredible imaging showing Bartonella surviving around tissues where a PIC line pumped antibiotics directly into the body:

Bartonella is perhaps more tenacious than Lyme disease but hardly is mentioned in mainstream medicine.  If it’s mentioned at all, we are told it’s a rare disease that usually takes care of itself with time. Nothing could be further from the truth.

Antinuclear Antibodies in Infectious Diseases

2019 Nov 12:1-9. doi: 10.1080/23744235.2019.1690676. [Epub ahead of print]

Antinuclear antibodies in infectious diseases.


Introduction: Antinuclear antibody (ANA) tests are widely used for the diagnosis of autoimmune diseases, but ANAs are also commonly found in patients with various infections. This retrospective study aimed to investigate the relationship between infections and ANA status.

Methods: Patients that visited the Department of Infectious Diseases at Inha University Hospital between January 2007 and July 2018 were investigated. We analysed their ANA test results and reviewed rheumatic and infectious diagnoses of patients with positive ANA findings.

Results: Of the 9,320 patients during the study period, 1,111 underwent ANA testing and 110 tested positive. Seven of the 110 patients were previously diagnosed with ANA-positive disease, and 21 were diagnosed with autoimmune disease during the present study. Of the remaining 82 patients, 43 were confirmed with infectious disease. The most common pathogen was Mycobacterium tuberculosis (n = 10), followed by Treponema pallidum (n = 5), Orientia tsutsugamushi (n = 5), Escherichia coli (n = 5), Bartonella henselae(n = 3), and human immunodeficiency virus (n = 3). Of the 39 patients without a confirmed pathogen, 7 were seropositive for O. tsutsugamushi, B. henselae, or Rickettsia spp. Patients were observed at an average of 24 weeks in our hospital. One patient developed systemic lupus erythematosus after being diagnosed with Epstein-Barr virus-induced infectious mononucleosis, and another patient developed adult-onset Still’s disease after being diagnosed with scrub typhus.

Conclusion: This study showed that various relationships exist between infections and rheumatic diseases. In particular, several patients with a positive ANA test result were found to have intracellular infections such as mycobacterial infections, syphilis, or scrub typhus.






New Bartonella Species Found in Tick From Senegal

. 2019 Nov; 32: 100596.
Published online 2019 Aug 27. doi: 10.1016/j.nmni.2019.100596
PMCID: PMC6839013
PMID: 31719993

Bartonella massiliensis sp. nov., a new bacterial species isolated from an Ornithodoros sonrai tick from Senegal


Bartonella is the monotypic genus of the family Bartonellaceae among Alphaproteobacteria . Bartonella species are fastidious Gram-negative, slightly curved rod bacteria characterized by a small cell size (0.5–0.6 × 1.0 μm) . They are facultative intracellular bacteria with a unique intraerythrocyte lifestyle. Currently the Bartonella genus includes 35 validly published species and three subspecies , . Bartonella species usually colonize the intestine of the arthropod vector or the bloodstream of the mammalian host , . In addition, our understanding of the involvement of these microorganisms in human diseases continues to grow, as does the range of clinical manifestations , . At least 13 Bartonella species are responsible for human diseases, including B. bacilliformis, B. quintana and B. henselae, which cause Carrión disease, trench fever and cat-scratch disease respectively. Bartonella species are also associated with chronic bacteraemia and/or endocarditis, bacillary angiomatosis, peliosis hepatis, prolonged fever of unknown origin, retinitis, uveitis and myocarditis in humans . Other mammalian species that may host Bartonella species include dogs, coyotes, foxes, cattle, deer, elk, bats and many rodent species , , .

Here we present the description of Bartonella massiliensis strain OS09T (= CSURB624T = DSM 23169), a new species of the genus Bartonella isolated from a soft tick, Ornithodoros sonrai, including its complete annotated genome.


For more:


Development & Spontaneous Resolution of a Full-thickness Macular Hole in Bartonella Neuroretinitis

2019 Jul 9;15:100515. doi: 10.1016/j.ajoc.2019.100515. eCollection 2019 Sep.

The development and spontaneous resolution of a full-thickness macular hole in bartonella henselae neuroretinitis in a 12-year-old boy.



To describe an unusual case of Bartonella henselae neuroretinitis complicated by macular hole (MH) development.


A full-thickness macular hole developed in a 12-year-old boy in association with serology-confirmed Bartonella henselae neuroretinitis. Following a period of observation, the MH closed without intervention.


MH may occur as a complication of neuroretinitis secondary to Cat-Scratch Disease.



This great article by Galaxy Labs reveals that Bartonella loves the eyes:



Do You Know Your Sandflies?

Today I posted an article of a U.S. patient who had an enlarged spleen, skin lesions, and anemia. Blood testing did not reveal bartonellosis, but the spleen was eventually removed and tissue tests revealed the presence of Bartonella bacilliformis. This is a species of Bartonella that is primarily transmitted by sand flies in South America. The patient, it turns out, had visited South America three years earlier.

Worldwide travel opens the door to insects and pathogens you may not find at home. It’s important to keep track of symptoms & connect them to any travel, making sure to tell your doctor.

The following article shows the various sandflies which look a bit like mosquitoes.  Please note they are found in the Southern U.S. as well.  Full Article Here with pictures

Phlebotomine sand flies are of considerable public health importance because of their ability to transmit several viral, bacterial, and protozoal disease-causing organisms of humans and other animals.

Lutzomyia shannoni Dyar is a proven vector of vesicular stomatitis virus and a suspected vector of visceral leishmaniasis and sand fly fever in Florida. It is one of the more thoroughly studied species of phlebotomine sand flies in North America.

In the United States, it has been found through the southern states from Florida to Louisiana plus Arkansas, Tennessee, South and North Carolina. This species has been found as far north as Maryland and Delaware.

At least 60 species in the Old World genus Phlebotomus or New World genus Lutzomyia are vectors of several vertebrate pathogens, including a group of parasitic flagellate protozoa, Leishmania spp., which may cause cutaneous, visceral or muco-cutaneous Leishmaniasis; the bacterium, Bartonella bacilliformis causing Oroya fever; and several arboviruses causing sand fly fever and vesicular stomatitis (Lane 1993).

University of Florida Entomology & Nematology



Bartonellosis: A Hidden Cause of Splenomegaly

Bartonellosis: A Hidden Cause of Splenomegaly