Archive for the ‘Herbs’ Category

Johns Hopkins Researchers: Plant Compounds May be Better Than Current Antibiotics at Treating Persistent Lyme Bacteria

Johns Hopkins researchers: Plant compounds may be better than current antibiotics at treating persistent Lyme bacteria

December 3, 2018
Oils from garlic and several other common herbs and medicinal plants show strong activity against the bacterium that causes Lyme disease, according to a study by researchers at Johns Hopkins Bloomberg School of Public Health. These oils may be especially useful in alleviating Lyme symptoms that persist despite standard antibiotic treatment, the study also suggests.

The study, published October 16 in the journal Antibiotics, included lab-dish tests of 35 essential oils–oils that are pressed from plants or their fruits and contain the plant’s main fragrance, or “essence.” The Bloomberg School researchers found that 10 of these, including oils from garlic cloves, myrrh trees, thyme leaves, cinnamon bark, allspice berries and cumin seeds, showed strong killing activity against dormant and slow-growing “persister” forms of the Lyme disease bacterium.

“We found that these essential oils were even better at killing the ‘persister’ forms of Lyme bacteria than standard Lyme antibiotics,” says study senior author Ying Zhang, MD, PhD, professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School.

There are an estimated 300,000 new cases of Lyme disease each year in the United States. Standard treatment with doxycycline or an alternative antibiotic for a few weeks usually clears the infection and resolves symptoms. However, about 10 to 20 percent of patients report persistent symptoms including fatigue and joint pain–often termed “persistent Lyme infection” or “post-treatment Lyme disease syndrome” (PTLDS) that in some cases can last for months or years.

The cause of this lingering syndrome isn’t known. But it is known that cultures of Lyme disease bacteria, Borrelia burgdorferi, can enter a so-called stationary phase in which many of the cells divide slowly or not at all. The slow-dividing or dormant cells are “persister” cells, which can form naturally under nutrient starvation or stress conditions, and are more resistant to antibiotics. Some researchers have sought other drugs or medicinal compounds that can kill persister Lyme bacteria in the hope that these compounds can be used to treat people with persistent Lyme symptoms.

Zhang and his laboratory have been at the forefront of these efforts. In 2014, his lab screened FDA-approved drugs for activity against persister Lyme bacteria and found many candidates including daptomycin (used to treat MRSA) that had better activity than the current Lyme antibiotics. In 2015, they reported that a three-antibiotic combination–doxycycline, cefoperazone and daptomycin–reliably killed Lyme persister bacteria in lab dish tests. In a 2017 study they found that essential oils from oregano, cinnamon bark, clove buds, citronella and wintergreen killed stationary phase Lyme bacteria even more potently than daptomycin, the champion among tested pharmaceuticals.

In the new study Zhang and his team extended their lab-dish testing to include 35 other essential oils, and found 10 that show significant killing activity against stationary phase Lyme bacteria cultures at concentrations of just one part per thousand. At this concentration, five of these oils, derived respectively from garlic bulbs, allspice berries, myrrh trees, spiked ginger lily blossoms and may change fruit successfully killed all stationary phase Lyme bacteria in their culture dishes in seven days, so no bacteria grew back in 21 days.

Oils from thyme leaves, cumin seeds and amyris wood also performed well, as did cinnamaldehyde, the fragrant main ingredient of cinnamon bark oil.

Lab-dish tests such as these represent an early stage of research, but Zhang and colleagues hope in the near future to continue their investigations of essential oils with tests in live animals, including tests in mouse models of persistent Lyme infection. If those tests go well and the effective doses seem safe, Zhang expects to organize initial tests in humans.

“At this stage these essential oils look very promising as candidate treatments for persistent Lyme infection, but ultimately we need properly designed clinical trials,” he says.

Please remember that both Stevia and the essential oil studies have been in vitro – or in a lab, not in the human body.  This is an important distinction because the body is far more complex and what plays out in a petri dish may or may not play out in the body.
Personally, my husband and I have tried Stevia and EO’s internally.  We relapsed on both.  We also didn’t have any noticeable herx reactions.  That isn’t to say they won’t work on someone else but for me and my husband we’ve ALWAYS responded to antibiotics with noticeable herxheimer reactions upon starting treatment.  Again, much plays into this and for us, Bartonella is a key player – perhaps more so than even Lyme when going by symptoms.  The polymicrobial nature of Lyme/MSIDS keeps this a complex, difficult to treat illness.  We are human Guinea pigs.  I will also add that we both took Tinidazole throughout our YEARS of treatment which, if you study it, you discover it is one of the few that reduces spirochetal and round body forms by ~80%-90% (Again, this is an in vitro study):
All I can say is when we took Tindy, it was noticeable.  We pulsed it on TH and F and we felt like train wrecks over the weekends.  To us it was quite powerful.

Medical Cannabis Superior to Opioids for Chronic Pain, Study Finds

Medical Cannabis Superior To Opioids for Chronic Pain, Study Finds

“© [Nov 4, 2018] GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here”

Sufferers of chronic pain have been faced with a perilous decision—risk a crippling addiction to opioids or find a way to live with the pain. A new clinical study has focused on medical cannabis as an alternative to opioids, and the results may be a turning point towards a safe, plant-based option for easing pain

A new study published in the European Journal of Internal Medicine represents hope for millions of sufferers of chronic pain. Researchers at the Cannabis Clinical Research Institute at Soroka University Medical Center, and Ben-Gurion University of the Negev (BGU), found that medical cannabis can significantly reduce chronic pain without adverse effects, particularly among adults aged 65 and older. Use of cannabis, aka medical marijuana, was found to be both safe and effective for elderly patients experiencing pain because of another medical condition, such as cancer, multiple sclerosis, Parkinson’s disease, Crohn’s disease, ulcerative colitis, and post-traumatic stress disorder.

One of the head researchers in this study, Prof. Victor Novack, M.D., is a professor of medicine in the BGU Faculty of Health Sciences (FOHS), as well as BGU’s Chair in Internal Medicine. He also heads the Soroka Cannabis Clinical Research Institute. According to Prof. Novack, M.D.:

“Older patients represent a large and growing population of medical cannabis users, [yet] few studies have addressed how it affects this particular group, which also suffers from dementia, frequent falls, mobility problems, and hearing and visual impairments.”[1]

The study surveyed 2,736 patients aged 65 years and older, at the inception of medical cannabis treatment, and throughout the 33-month study period. Surveys indicated the most common reasons for using cannabis were pain (66.6%) and cancer (60.8%). Methods of ingestion included cannabis-infused oils and smoking or vaporizing the herb. After six months of cannabis therapy, researchers provided a follow-up questionnaire which sought to determine any changes to pain intensity and quality of life, as well as any adverse events that were experienced. 901 of the original respondents replied.

After 6-months of medical marijuana treatment (all statistics are +/-):

  • 94% reported an improved overall condition, and a 50% reduction in pain
  • 60% reported improved quality of life, from “bad” or “very bad” to “good” or “very good”
  • 70% reported moderate to significant improvement in their condition
  • 20% of respondents stopped using opioids or reduced their dose

Notably, the most common side effects reported were mild: dizziness (9.7%) and dry mouth (7.1%), a far cry from the high-percentage of opioid-related deaths that are linked to chronic pain.[2] BGU researchers believe that utilizing cannabis may decrease the use of other prescription medications, including opioids, and encourage further research into this plant-based alternative, especially as it relates to an aging population.

Chronic pain is a problem that affects an estimated 100 million Americans.[3] It is also one of the most significant public health problems in the United States, with an estimated cost to society of $560-$635 billion annually, an amount equal to about $2,000 for every person living in the U.S.[4] Meanwhile, the nation’s growing opioid epidemic sees 1 of every 550 chronic opioid users dying within three years of their first opioid prescription.[5] While natural alternatives to deadly opiates are rarely offered by medical doctors, medical marijuana may be the drug that bridges this senseless gap. Research is beginning to mount that shows more promise than the medical establishment can long ignore.

Neuropathy is a type of chronic pain that presents as tingling and numbness in the hands and feet, often due to nerve damage from complications of cancer or diabetes, among other causes. A 2017 meta-analysis of prior studies on neuropathy found that cannabis, particularly selected isolates called cannabinoids, can provide analgesic benefit in patients with chronic neuropathy. Cannabis can also be used as an adjunct to other pain therapies, potentially lowering the amount of dangerous synthetic medication that is required to relieve pain. A recent study on the Opioid-Sparing Effect of Cannabinoids found that when cannabinoids were administered with opioids, specifically morphine, nearly four times less morphine was needed to achieve the same analgesic effect. This presents further evidence for cannabis as a means of reducing cases of opiate dependency and death.

While the politics of cannabis are exceedingly complex, the truth of this miraculous plant is becoming increasingly obvious: it heals the human body. The fact that it does so without the need for a black-box warning of Serious Adverse Events ensures that cannabis is the future of medicine. While clinical studies in the United States have been impeded due to cannabis’s classification as a Schedule One Controlled Substance (meaning the substance has no medicinal value), other countries have taken the lead. A UK study seeking to reduce chronic pain in advanced cancer patients not fully relieved from use of opioids, found that a cannabis extract composed of THC (Tetrahydrocannabinol) and CBD (Cannabidiol), two of the active constituents in cannabis, reduced pain by more than 30% from baseline when compared with placebo, with no serious adverse effects.

Beyond the realm of chronic pain, cannabis has been shown to positively support individuals dealing with post-traumatic stress. It has demonstrated effectiveness at calming the often-debilitating side effects of inflammatory bowel disease, aka Crohn’s disease. Isolates from the cannabis plant have shown promise at treating “incurable” diseases such as Grave’s disease and brain cancer, and work better than traditional medications for Alzheimer’s disease. With so much evidence of profound medicinal value, legislation based on old systems of control will not long hold back the tide. There are simply too many health benefits to be obtained from the cannabis plant.

For additiona research on the medical benefits of cannabis, visit the GreenMedInfo database on the subject.



[2] Service Use Preceding Opioid-Related Fatality. Olfson, Wall, Wang, Crystal, Blanco. Am J Psychiatry. 2017 Nov 28:appiajp201717070808. doi: 10.1176/appi.ajp.2017.17070808.

[3] Institute of Medicine Report from the Committee on Advancing Pain Research, Care, and Education: Relieving Pain in America, A Blueprint for Transforming Prevention, Care, Education and Research. The National Academies Press, 2011.

[4] IOM (Institute of Medicine) 2011. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education and Research, Washington, DC; The National Academies Press.

[5] Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study. Gomes, Juurlink, Antoniou, Mamdani, Paterson, van den Brink. PLoS Med. 2017 Oct 3;14(10):e1002396. doi: 10.1371/journal.pmed.1002396. eCollection 2017 Oct.



Four Essential Oils for Stopping Bartonella From Taking Over Your Brain

Four Essential Oils for Stopping Bartonella from Taking Over Your Brain

lavaPublished on October 30, 2018

Greg Lee (Founder of the Two Frogs Healing Center)

For people with neurological Bartonella symptoms of swelling and anxiety

My nephew invited us to his wedding in Hawaii. As we were booking our trip, the Kilauea volcano started spewing lava into residential neighborhoods. People had no other choice and had to evacuate as their homes and cars were burned by the spreading lava.

How is flowing lava similar to neurological Bartonella infections in people with Lyme disease?

Just like a hot lava eruption, a Bartonella infection can slowly burn through your body

Bartonella is a rod shaped, gram-negative bacteria that can be transmitted to humans via insect bites1, animal scratches and bites2, organ transplant3, needle sticks4, and blood transfusion5. At least thirteen different species of Bartonella are known to infect humans6. Bartonella has been shown to infect endothelial cells, macrophages, red blood cells7, and the lymphatic system8. Bartonella can spread through the bloodstream via the lymphatic system9. Bartonella manipulates the production of vascular endothelial growth factor10 (VEGF) and Interleukin-811 (IL-8) to make it easier for it to spread via new blood vessels through the skin and the body. Unfortunately, Bartonella can also infect the nervous system.

Bartonella has been detected in the cerebral spinal fluid of patients12

Patients with a Bartonella infection may present with multiple neurological symptoms including: confusion, encephalitis13, vision loss, neuroretinitis, optic neuropathy14, subarachnoid hemorrhage, cerebral embolism15, fever, vomiting, ataxia16, slurred speech, weakness17, convulsions18, chronic inflammatory demyelinating polyneuropathy19, depression, anxiety, mood swings, severe headaches, muscle spasms, decreased peripheral vision, diminished tactile sensation, and hallucinations20. Multiple patients have both Bartonella and Lyme disease in their nervous system21. Inflammation may play a role in Bartonella’s ability to spread into the brain.

Inflammatory compounds may help Bartonella spread into the nervous system

Patients diagnosed with Bartonella have elevated levels of IL-822, Interleukin-1023 (IL-10), and vascular endothelial growth factor24 (VEGF). Elevated levels of IL-825 and VEGF26 have been correlated with blood brain barrier increased permeability and dysfunction. Il-10 may help to protect the blood brain barrier27. Similarly, inflammatory compounds Interleukin-6 (IL-6), Interleukin- (IL-8), chemokine ligand 2 (CCL2), and CXCL13 are implicated in the spread of Lyme disease in the nervous system28. Another factor in persistent neurological infections may be due to drug resistant Bartonella strains that have been discovered.

Bartonella drug resistant strains have been discovered

Highly antibiotic resistant mutants of Bartonella bacilliformis have been found in a lab study29. Another study has found drug resistant forms of Bartonella henselae30.

Can essential oils help to reduce recurring neurological symptoms by preventing how Bartonella may spread into the nervous system?

Fortunately, there are four essential oils that lower the inflammatory compounds that Bartonella uses to spread through the body

In multiple studies, essential oils were effective at lowering inflammatory compounds and symptoms like anxiety that may be elevated in neurological Bartonella infections. Formulating these oils into microparticles called liposomes may help deliver these remedies deeper inside the brain. Many of these essential oils have been used safely for years in our food supply31. Formulating these essential oils into microparticles called liposomes may help them penetrate deeper inside of blood cells, endothelial cells and the nervous system where Bartonella likes to hide32.

Anti-Neurological Bartonella Essential Oil #1: Peppermint

In a mouse wound study, peppermint essential oil was effective at lowering VEGF and increasing IL-1033. Peppermint oil has had positive effects in reducing anxiety in human studies34. Do not apply peppermint oil undiluted to the feet of children under 12 years old, avoid large doses, it may cause heartburn, perianal burning, blurred vision, nausea and vomiting when taken internally. Peppermint essential oil use is contraindicated in children under 30 months old, and people should avoid the intake of peppermint oil with gallbladder disease, severe liver damage, gallstones, chronic heartburn35, and cases of cardiac fibrillation and in patients with a G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency36. This oil is classified as Generally Recognized as Safe (GRAS) by the FDA37. Black cumin seed oil may also help to lower VEGF.

Anti-Neurological Bartonella Essential Oil #2: Black Cumin Seed

In lab studies, black cumin seed oil down regulated the expression of VEGF in endothelial cells38. In a rat study, this oil increased levels of tryptophan and reduced anxiety levels39. Black cumin seed oil is contraindicated in pregnancy and breastfeeding. It’s use is cautioned with diabetes medications, on hypersensitive, diseased or damaged skin, and in children under 2 years of age40. Mastic gum essential oil also lowers VEGF in experiments.

Anti-Neurological Bartonella Essential Oil #3: Mastic Gum

In a mouse lab study, mastic essential oil inhibited the release of VEGF41. In an outpatient study on Crohn’s disease, mastic gum decreased IL-6 and C-reactive protein (CRP)42. Citron essential oils lowered VEGF in a lab study.

Anti-Neurological Bartonella Essential Oil #4: Citron

In a lab study, citron essential oil lowered VEGF in endothelial cells43. These essential oils alone or in combination may help to reduce neurological symptoms caused by a spreading Bartonella infection in the nervous system.

Essential oils may help to reduce the spread of inflammation caused by neurological Bartonella infection

Similar to lava that is stopped by the cold waters of the ocean, essential oils that lower Bartonella inflammatory compounds may limit it’s spread in the brain and reduce neurological symptoms. Formulating these essential oils into microparticle liposomes may enhance their ability to penetrate into cells and stop Bartonella from invading the nervous system. Since these essential oils have cautions and contraindications on their use, work with a Lyme literate essential oil practitioner to develop a proper, safe, and effective strategy for your condition.

1 Billeter, S. A., M. G. Levy, B. B. Chomel, and E. B. Breitschwerdt. “Vector Transmission of Bartonella Species with Emphasis on the Potential for Tick Transmission.” Medical and Veterinary Entomology 22, no. 1 (March 2008): 1–15.

2 “Transmission | Bartonella | CDC.” Accessed July 22, 2016.

3 Scolfaro, C., F. Mignone, F. Gennari, A. Alfarano, A. Veltri, R. Romagnoli, and M. Salizzoni. “Possible Donor-Recipient Bartonellosis Transmission in a Pediatric Liver Transplant.” Transplant Infectious Disease: An Official Journal of the Transplantation Society 10, no. 6 (December 2008): 431–33.

4 Breitschwerdt, Edward Bealmear. “Bartonellosis: One Health Perspectives for an Emerging Infectious Disease.” ILAR Journal 55, no. 1 (2014): 46–58.

5 Núñez, M. Antonieta, Karla Contreras, M. Soledad Depix, Enrique Geoffroy, Nicolás Villagra, Sandra Mellado, and Ana M. Salinas. “[Prevalence of Bartonella henselae in blood donors and risk of blood transmission in Chile].” Revista Chilena De Infectologia: Organo Oficial De La Sociedad Chilena De Infectologia 34, no. 6 (December 2017): 539–43.

6 Lamas, C., A. Curi, Mn Bóia, and Ers Lemos. “Human Bartonellosis: Seroepidemiological and Clinical Features with an Emphasis on Data from Brazil – a Review.” Memorias Do Instituto Oswaldo Cruz 103, no. 3 (May 2008): 221–35.

7 Breitschwerdt, Edward Bealmear. “Bartonellosis: One Health Perspectives for an Emerging Infectious Disease.” ILAR Journal 55, no. 1 (2014): 46–58.

8 Choi, Alexander H., Michael Bolaris, Diana K. Nguyen, Eduard H. Panosyan, Joseph L. Lasky, and Gloria B. Duane. “Clinicocytopathologic Correlation in an Atypical Presentation of Lymphadenopathy with Review of Literature.” American Journal of Clinical Pathology 143, no. 5 (May 2015): 749–54.

9 Hong, Jiehua, Yan Li, Xiuguo Hua, Yajie Bai, Chunyan Wang, Caixia Zhu, Yuming Du, Zhibiao Yang, and Congli Yuan. “Lymphatic Circulation Disseminates Bartonella Infection Into Bloodstream.” The Journal of Infectious Diseases 215, no. 2 (January 15, 2017): 303–11.

10 Kempf, V. A., B. Volkmann, M. Schaller, C. A. Sander, K. Alitalo, T. Riess, and I. B. Autenrieth. “Evidence of a Leading Role for VEGF in Bartonella Henselae-Induced Endothelial Cell Proliferations.”Cellular Microbiology 3, no. 9 (September 2001): 623–32.

11 McCord, Amy M., Sandra I. Resto-Ruiz, and Burt E. Anderson. “Autocrine Role for Interleukin-8 in Bartonella Henselae-Induced Angiogenesis.” Infection and Immunity 74, no. 9 (September 2006): 5185–90.

12 Samarkos, Michael, Vasiliki Antoniadou, Aristeidis G. Vaiopoulos, and Mina Psichogiou. “Encephalopathy in an Adult with Cat-Scratch Disease.” BMJ Case Reports 2018 (March 5, 2018).

13 Samarkos, Michael, Vasiliki Antoniadou, Aristeidis G. Vaiopoulos, and Mina Psichogiou. “Encephalopathy in an Adult with Cat-Scratch Disease.” BMJ Case Reports 2018 (March 5, 2018).

14 Habot-Wilner, Zohar, Omer Trivizki, Michaella Goldstein, Anat Kesler, Shiri Shulman, Josepha Horowitz, Radgonde Amer, et al. “Cat-Scratch Disease: Ocular Manifestations and Treatment Outcome.” Acta Ophthalmologica, March 5, 2018.

15 Yuan, Y., M. Shen, and X. G. Gao. “[Presented with subarachnoid hemorrhage and then blood culture negative infective endocarditis: a case report and literature review].” Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences 49, no. 6 (December 18, 2017): 1081–86.

16 Barnafi, Natalia, Natalia Conca, Cecilia von Borries, Isabel Fuentes, Francisca Montoya, and Elisa Alcalde. “[Central nervous system infection by Bartonella henselae associated with a choroid plexus papilloma].” Revista Chilena De Infectologia: Organo Oficial De La Sociedad Chilena De Infectologia 34, no. 4 (August 2017): 383–88.

17 Teoh, Laurence S G, Hamish H Hart, May Ching Soh, Jonathan P Christiansen, Hasan Bhally, Martin S Philips, and Dominic S Rai-Chaudhuri. “Bartonella Henselae Aortic Valve Endocarditis Mimicking Systemic Vasculitis.” BMJ Case Reports 2010 (October 21, 2010).

18 Balakrishnan, Nandhakumar, Marna Ericson, Ricardo Maggi, and Edward B. Breitschwerdt. “Vasculitis, Cerebral Infarction and Persistent Bartonella Henselae Infection in a Child.” Parasites & Vectors 9, no. 1 (2016): 254.

19 Mascarelli, Patricia E, Ricardo G Maggi, Sarah Hopkins, B Robert Mozayeni, Chelsea L Trull, Julie M Bradley, Barbara C Hegarty, and Edward B Breitschwerdt. “Bartonella Henselae Infection in a Family Experiencing Neurological and Neurocognitive Abnormalities after Woodlouse Hunter Spider Bites.”Parasites & Vectors 6 (April 15, 2013): 98.

20 Breitschwerdt, Edward B., Patricia E. Mascarelli, Lori A. Schweickert, Ricardo G. Maggi, Barbara C. Hegarty, Julie M. Bradley, and Christopher W. Woods. “Hallucinations, Sensory Neuropathy, and Peripheral Visual Deficits in a Young Woman Infected with Bartonella Koehlerae ▿.” Journal of Clinical Microbiology49, no. 9 (September 2011): 3415–17.

21 Podsiadły, Edyta, Tomasz Chmielewski, and Stanisława Tylewska-Wierzbanowska. “Bartonella Henselae and Borrelia Burgdorferi Infections of the Central Nervous System.” Annals of the New York Academy of Sciences 990 (June 2003): 404–6.

22 McCord, Amy M., Sandra I. Resto-Ruiz, and Burt E. Anderson. “Autocrine Role for Interleukin-8 in Bartonella Henselae-Induced Angiogenesis.” Infection and Immunity 74, no. 9 (September 2006): 5185–90.

23 Huarcaya, Erick, Ciro Maguina, Ivan Best, Nelson Solorzano, and Lawrence Leeman. “Immunological Response in Cases of Complicated and Uncomplicated Bartonellosis during Pregnancy.” Revista Do Instituto De Medicina Tropical De Sao Paulo 49, no. 5 (October 2007): 335–37.

24 Kempf, V. A., B. Volkmann, M. Schaller, C. A. Sander, K. Alitalo, T. Riess, and I. B. Autenrieth. “Evidence of a Leading Role for VEGF in Bartonella Henselae-Induced Endothelial Cell Proliferations.”Cellular Microbiology 3, no. 9 (September 2001): 623–32.

25 Kossmann, T., P. F. Stahel, P. M. Lenzlinger, H. Redl, R. W. Dubs, O. Trentz, G. Schlag, and M. C. Morganti-Kossmann. “Interleukin-8 Released into the Cerebrospinal Fluid after Brain Injury Is Associated with Blood-Brain Barrier Dysfunction and Nerve Growth Factor Production.” Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 17, no. 3 (March 1997): 280–89.

26 Zhang, Zheng Gang, Li Zhang, Quan Jiang, Ruilan Zhang, Kenneth Davies, Cecylia Powers, Nicholas van Bruggen, and Michael Chopp. “VEGF Enhances Angiogenesis and Promotes Blood-Brain Barrier Leakage in the Ischemic Brain.” Journal of Clinical Investigation 106, no. 7 (October 1, 2000): 829–38.

27 Lin, Ronggui, Fei Chen, Shi Wen, Tianhong Teng, Yu Pan, and Heguang Huang. “Interleukin-10 Attenuates Impairment of the Blood-Brain Barrier in a Severe Acute Pancreatitis Rat Model.” Journal of Inflammation (London, England) 15 (2018): 4.

28 Ramesh, Geeta, Peter J. Didier, John D. England, Lenay Santana-Gould, Lara A. Doyle-Meyers, Dale S. Martin, Mary B. Jacobs, and Mario T. Philipp. “Inflammation in the Pathogenesis of Lyme Neuroborreliosis.”The American Journal of Pathology 185, no. 5 (May 2015): 1344–60.

29 Gomes, Cláudia, Sandra Martínez-Puchol, Lidia Ruiz-Roldán, Maria J. Pons, Juana del Valle Mendoza, and Joaquim Ruiz. “Development and Characterisation of Highly Antibiotic Resistant Bartonella BacilliformisMutants.” Scientific Reports 6 (September 26, 2016): 33584.

30 Biswas, Silpak, Ricardo G. Maggi, Mark G. Papich, and Edward B. Breitschwerdt. “Molecular Mechanisms of Bartonella Henselae Resistance to Azithromycin, Pradofloxacin and Enrofloxacin.” Journal of Antimicrobial Chemotherapy 65, no. 3 (March 1, 2010): 581–82.

31 Hyldgaard, Morten, Tina Mygind, and Rikke Louise Meyer. “Essential Oils in Food Preservation: Mode of Action, Synergies, and Interactions with Food Matrix Components.” Frontiers in Microbiology 3 (January 25, 2012).

32 Sherry, Mirna, Catherine Charcosset, Hatem Fessi, and Hélène Greige-Gerges. “Essential Oils Encapsulated in Liposomes: A Review.” Journal of Liposome Research 23, no. 4 (December 2013): 268–75.

33 Modarresi, Mohammad, Mohammad-Reza Farahpour, and Behzad Baradaran. “Topical Application of Mentha Piperita Essential Oil Accelerates Wound Healing in Infected Mice Model.” Inflammopharmacology, July 6, 2018.

34 Stea, Susanna, Alina Beraudi, and Dalila De Pasquale. “Essential Oils for Complementary Treatment of Surgical Patients: State of the Art.” Evidence-Based Complementary and Alternative Medicine : ECAM 2014 (2014).

35 “Peppermint Safety Info | National Association for Holistic Aromatherapy.” Accessed April 1, 2017.

36 Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. 2 edition. Edinburgh: Churchill Livingstone, 2013.

37 “CFR – Code of Federal Regulations Title 21.” Accessed October 28, 2018.

38 M. Baharetha, Hussein, Zeyad Nassar, Abdalrahim Aisha, Abd Kadir M.O, Zhari Ismail, and Amin Malik Shah Abdul Majid. “Essential Oil of Nigella Sativa Inhibits Angiogenesis via Down-Regulation of VEGF Expression,” 2015.

39 Perveen, Tahira, Saida Haider, Sumera Kanwal, and Darakhshan Jabeen Haleem. “Repeated Administration of Nigella Sativa Decreases 5-HT Turnover and Produces Anxiolytic Effects in Rats.”Pakistan Journal of Pharmaceutical Sciences 22, no. 2 (April 2009): 139–44.

40 Tisserand, Robert, and Rodney Young. Essential Oil Safety: A Guide for Health Care Professionals. 2 edition. Edinburgh: Churchill Livingstone, 2013. p. 793.

41 Loutrari, Heleni, Sophia Magkouta, Anastasia Pyriochou, Vasiliki Koika, Fragiskos N. Kolisis, Andreas Papapetropoulos, and Charis Roussos. “Mastic Oil from Pistacia Lentiscus Var. Chia Inhibits Growth and Survival of Human K562 Leukemia Cells and Attenuates Angiogenesis.” Nutrition and Cancer 55, no. 1 (2006): 86–93.

42 Kaliora, Andriana C, Maria G Stathopoulou, John K Triantafillidis, George VZ Dedoussis, and Nikolaos K Andrikopoulos. “Chios Mastic Treatment of Patients with Active Crohn’s Disease.” World Journal of Gastroenterology : WJG 13, no. 5 (February 7, 2007): 748–53.

43 “Effects of Citron Essential Oils on Normal Human Epidermal Keratinocytes Stimulated with Vitamin D3 and TNF-A.” Journal of the American Academy of Dermatology 76, no. 6 (June 1, 2017): AB110.


For more on essential oils:

I have personally used 1-2 drops of DMSO in a capsule with EO’s instead of the liposomal form with success.  I can smell/taste the DMSO so I know even at that low dose it’s gone systemic, driving the EO’s deep into the body, yet, it can’t be smelled by others at this dose!  Also, I use black seed oil as a carrier as well, which is listed as #2 in the article.  If you haven’t read about the usage of DMSO, please go here and learn:


Darin Ingels ND – FREE Podcast on Lyme/MSIDS  (Go here for podcast)

Dr. Ingels is a respected leader in natural medicine with numerous publications, international lectures and more than 25 years experience in the healthcare field. He received his Bachelor of Science degree in medical technology from Purdue University and his Doctorate of Naturopathic Medicine from Bastyr University in Seattle, Washington. Dr. Ingels completed a residency program at the Bastyr Center for Natural Health.

Darin Ingels is a Naturopathic Doctor who has Lyme and shares his story of finally getting his life back. The healing path was slow and difficult, but over time he found the steps that worked for himself and his patients. He has written a book that outlines the steps to healing and discusses the process during this interview with Linda. If you have Lyme disease or even another autoimmune condition, you can benefit from this interesting and informative interview.

Review by Ken Bruce


For more:

As to sexual transmission:  All I can say is ALL my initial symptoms were gynecological and I’ve worked with numerous couples that both have Lyme.  Coincidence, regarding a pathogen that can borrow through any tissue and is a cousin to syphillis?

 I doubt it.

The podcast date says 2018, but Ingels speaks of research that came out “last week” regarding sexual transmission.  The last research I can find was in 2014….and crickets.….this is a very important issue and deserves current research.  It very well could explain why Lyme/MSIDS is growing by leaps and bounds and shows no sign of slowing down.


Essential Oils as Treatment Against Lyme Disease

GLA POV: Essential Oils as Treatment Against Lyme Disease

Global Lyme Alliance’s Director of Research and Science offers perspective on newly published research on using essential oils to treat Lyme disease

Global Lyme Alliance (GLA)-funded investigator Ying Zhang, Ph.D. (Professor at Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health) details new findings on the effectiveness of certain essential oils to treat Lyme disease; “Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi.”

Persister forms of B. burgdorferi, the bacterium that causes Lyme disease, are dormant or slow-growing, and tolerant of antibiotic treatment. It’s not clear yet whether persister bacteria, immune dysfunction, or some combination of the two is responsible for post-treatment Lyme disease syndrome (PTLDS), in which patients treated with antibiotics continue to suffer symptoms.

The search for novel compounds to kill persister bacteria has led to the discovery that essential oils (EOs), aromatic compounds produced by plants, may be promising. In an article published in Antibiotics, a peer-reviewed journal, scientists led by Dr. Ying Zhang identified 10 EOs that have strong activity against stationary phase B. burgdorferi at a low concentration of 0.1%. The study, underwritten by GLA, found that of the 10 EOs, those of garlic, allspice, and Palmarosa were active at even at 0.05% concentration. In addition, cinnamaldehyde, a major ingredient isolated from cinnamon bark, was active against both stationary phase bacteria as well as replicating B. burgdorferi at a 0.02% concentration.

A stringent test of antimicrobial activity against stationary phase bacteria is the capacity to block subcultured bacteria from growing. This means that after killing bacteria in culture with the inhibitor, a small amount of that culture is transferred to fresh growth media that lacks the inhibitor. Any regrowth indicates that the inhibitor did not completely kill all bacteria from the original culture. Under these conditions, only garlic and cinnamaldehyde were effective against the regrowth of B. burgdorferi spirochetes subcultured for 21 days.

These results indicate that certain EOs or their ingredients are potent in eliminating persister B. burgdorferi, and should be studied in greater depth to analyze their utility as potential treatments.


For more on Dr. Zhang’s work:

Herbs & Habits To Revive Your Gut

The Herbs & Habits You Need to Revive Your Gut Health

by Dr. Bill Rawls
Posted 10/19/18

“Stop eating gluten.” “Give up dairy.” “Cut out caffeine.”

Diet-related advice is always the first thing you hear when it comes to overcoming any sort of gut issue. That’s true whether you’re trying to avoid the abdominal pain or bouts of constipation or diarrhea that can come with a chronic illness like Lyme disease or fibromyalgia, or sidestep triggers for GI conditions like leaky gut syndrome or irritable bowel syndrome (IBS).

It’s good guidance, of course, but it’s not always easy – and it’s not always enough.

Fortunately, there are other effective tools you can use to help cope with digestive issues. The following four steps are additional, diet-free ways to hack common sources of GI distress. Put them into action and not only will you ease symptoms, you’ll also help prevent future ones. And as an added bonus, when you improve your gut health, you also enhance immune function and support your recovery from chronic illness.

Keep reading to learn four key habits to revive your gut health.

1. Nourish Your Gut Lining

In a healthy gut, the cells in the intestinal mucosa – which line your intestines and create a barrier to troublemakers like pathogens – fit neatly together like puzzle pieces. But over time, gut disruptors like toxins and gluten can inflame, irritate, and compromise the intestinal mucosa, allowing them to sneak across the gut-blood barrier and triggering symptoms like abdominal pain, gas, bloating, diarrhea, constipation, nausea, or indigestion (all classic signs of leaky gut).

Here are some things to try to nourish and restore your gut health:

  • Take herbs with mucilage, a demulcent that acts like the mucous barrier in your gut. These can help serve as barrier to foreign substances until you’re able to rebuild your mucosa. My favorite mucilage-containing herb is slippery elm.
  • Try carminatives. These are natural substances that lessen intestinal spasms and reduce gas. Cardamom and fennel are two excellent options to ease these troubling symptoms.
  • Drink ginger tea. It’s great for soothing the stomach, plus it offers antiviral and other antimicrobial properties if you’re fighting pathogens.
  • Avoid anti-inflammatory drugs and alcohol. This includes over-the-counter medications like ibuprofen (Advil) and naproxen (Aleve) as well as numerous prescription drugs. Both medications and alcohol contribute to ulcer formation in the stomach.

2. Enhance Sluggish Digestion

If your gut is dysfunctional and inflamed, odds are you’re producing less of the digestive enzymes and stomach acids you need to properly digest a meal. As a result, your liver gets congested, and food moves through the digestive process at an increasingly slower pace.

While you’re working to help restore your gut health, the following tips can help support digestive function until it’s back up to speed.

  • Take digestive enzymes. Supplementing with an assortment of enzymes (such as protease, amylase, alpha-galactosidase, lipase, and others) can help your body digest protein, fat, and carbs until it’s able to restore normal enzyme levels. It also promotes nutrient assimilation and conversion and excretion of waste.
  • Support normal liver and gallbladder function. To encourage healthy bile flow, take 400 mg of milk thistle daily. It contains silymarin, which is a powerful antioxidant and promoter of liver health. Additionally, the herbs andrographis and artichoke extract provide similar properties.
  • Sip apple cider vinegar (ACV). When taken with meals, ACV can help increase acidity in the stomach to support digestion, after which the acetic acid in vinegar is neutralized in the small intestine to acetate and absorbed into the bloodstream. Acetate can help dissolve calcium oxalate crystals in tissues that can contribute to kidney stone formation. Take 2 tablespoons of ACV in 6 ounces of water with a drizzle of honey with each meal. Note: If burning or discomfort occurs, use of ACV should be discontinued until gut healing is more advanced.
  • Normalize bowel function. Vitamins A, B, and C and minerals like zinc and magnesium help your body produce digestive enzymes, ease gut inflammation, and aid in the growth of beneficial bacteria. Note that excess vitamin C can be converted into oxalate, so don’t take more than 2,000 mg a day, and if it bothers you, nix it altogether.
  • Add omega-3 essential fatty acids to your diet. Found in krill oil, fish oil, flax oil, and borage oil, these beneficial oils reduce inflammation in the gut and encourage normal bowel movements.

3. Restore Bacterial Balance in the Gut

For significant intestinal dysfunction, antimicrobial supplements may be necessary to help facilitate the growth of beneficial bacteria and deter the growth of symptom-inducing microbes. Herbs with antimicrobial properties offer the advantage of inhibiting the growth of pathogenic organisms without adversely affecting normal bacterial flora. The good news is that once your gut health is reestablished, normal microbiome balance can generally be maintained with diet alone.

Here are some ways to restore bacterial balance in the gut:

  • Use herbs to reduce the pathogenic organisms. Gut-friendly herbs, including berberine, andrographis, cat’s claw, sarsaparilla, and garlic, support the growth of friendly, normal flora and suppress the growth of pathogenic bacteria. Coverage includes common pathogenic bacteria, yeast, and protozoa. These herbs can be used alone or in combination for a synergistic effect against problematic microbes.
  • Stock up on ginger. You’ll notice ginger is recommended for many aspects of gut health. Not only does it have the ability to soothe the lining of the stomach, but it offers activity against many common gut pathogens.
  • Eat prebiotic foods. Prebiotics like inulin and fructo-oligosaccharides are fibers that provide nourishment for favorable bacteria. These substances are found naturally in onions, garlic, chicory, and Jerusalem artichoke.
  • Increase your intake of fermented foods. Daily consumption of yogurt or other fermented foods is important for seeding the intestinal tract with favorable bacteria, but concentrations of bacteria in yogurt are often not adequate if significant dysbiosis, an imbalance in the gut bacteria, is present. Probiotics may provide additional support.
  • Consider probiotics. Evidence of probiotics’ benefits for various health concerns is marginal at best, but they have been shown to help folks with IBS. It’s really trial and error, however: Because every person’s gut microbiome is different, some people gain benefit from a probiotic and others do not. The best probiotic to consider for IBS is one that contains both lactobacillus and bifidobacteria species.

4. Manage Your Stress

Stubborn and overwhelming stress is often a primary driving force behind digestive dysfunction. That’s because chronic stress tells your body to stay ready to fight or flee, which in turn puts digestion on hold – it’s simply not a necessary function when you’re in survival mode.

This inhibits the movement of food from your stomach through your intestinal tract. Stress also halts the flow of bile in the liver and gallbladder, which normally aids in the digestion of fats and acts as the vehicle for carrying neutralized toxins out of the body.

As you can see, putting stress back in the box is essential for allowing the gastrointestinal tract to perform its job. Try the following tips for reining in stress and supporting normal digestion.

  • Take stress-modulating herbs. Herbs such as ashwagandha, Chinese tree bark, and l-theanine help maintain normal adrenal function, so your body is better able to handle stress. (The adrenal glands are responsible for allocating resources in the body and preparing the body for stress, including the secretion of stress hormones like adrenaline and cortisol.)
  • Practice gentle exercise and stretching. Mild forms of exercise such as yoga, qigong, and walking encourage relaxation and enhance digestion. In fact, research published in the journal Psychology, Health & Medicine found that walking twice a week helped IBS sufferers experience a decrease in overall GI symptoms and well as feelings of anxiety.
  • Prioritize sleep. If you’re not getting enough sleep, stress will remain your constant companion. Reach for herbs that promote healthy sleep, such as passion flower and motherwort. Bonus: Motherwort also helps reduce intestinal spasms.
  • Drink a mug of chamomile tea. Research suggests that sipping a cup of chamomile tea can help bring on both relaxation and sleep. It’s also excellent for calming the intestinal tract.

If you’re interested in trying an herbal approach to restoring gut health, I encourage you to learn more about my holistic gut health protocol. It includes many of the herbs I recommend above and used myself to overcome my own gut dysfunction, all in one easy-to-follow and comprehensive program.

Finally, remember that no matter where you’re at with gut health, patience and persistence pay off. With time and effort, digestive function will return to normal. You may always have to watch what you eat, but making smart lifestyle choices a central part of your everyday life will go a long way toward sustaining recovery.

Dr. Rawls is a physician who overcame Lyme disease through natural herbal therapy. You can learn more about Lyme disease in Dr. Rawls’ new best selling book, Unlocking Lyme.

You can also learn about Dr. Rawls’ personal journey in overcoming Lyme disease and fibromyalgia in his popular blog post, My Chronic Lyme Journey.


For more:  Recitas, author of “The Plan,” calls MSM the wonder supplement for your gut. It can alleviate allergy symptoms, helps with detoxification, eliminates free radicals, and improves cell permeability. She states that with given time, MSM will start to actually repair damage caused by leaky gut – a common problem with Lyme/MSIDS patients. It can also help the body’s ability to absorb nutrients from food. Many Lyme patients struggle with paralysis of the gut where the muscles of the stomach and intestines stop being efficient. MSM helps this muscle tone as well.


THC vs. CBD for Pain: The Differences & Interactions

THC vs. CBD for Pain: The Differences and Interactions


As a natural pain-relief drug, some experts consider cannabis more suitable for your body than the synthetic pharmaceuticals available.

The reasoning behind this is that the body can metabolize natural chemicals better than synthetic ones the same way it can digest natural foods better than processed ones.

Synthetic drugs, as with processed food, can create by-products, which remain as harmful toxins in the body, causing strain on the liver and kidneys. Some (medical) strains of cannabis also provide many health benefits, such as anti-oxidant, anti-depressant, anti-anxiety, pain-suppression, and anti-inflammatory effects.

Not only studies, but many users strongly support the pain-relieving properties of medical marijuana in anecdotal reports. Different types of strains, however, suit different pain conditions, so before diving into medical marijuana use, it’s important to understand the differences.

Let’s look at the difference between the strains of marijuana available, and what their effects are. With the information below, you can hopefully make an informed choice about whether it’s better to use a high-THC or high-CBD strain for your pain relief.

A Brief Overview of THC and CBD

Cannabinoids are the active ingredients specific to the cannabis plant, and they are the compounds primarily responsible for the healing effects. The two most effective and studied cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD).

There have been 70 cannabinoids identified to date, and there are several others currently being studied, such as cannabigerol (CBG) and tetrahydrocannabivarin (THCV).

They are not the only active ingredients, however, and some estimates predict a figure of over 120 active components in the plant. This richness in active compounds is one of the reasons experts consider it useful for treating several ailments.

It is worth noting that THC and CBD also only convert to an effective pain-relieving agent under heat, which is why smoking, vaporizing, or baking it is important.

Most cannabis oils and extracts, designed for direct consumption, haven’t undergone heat treatment. Without heat before ingestion, their effects may not manifest.

The Difference Between THC and CBD

Both THC and CBD contribute to the positive effects associated with marijuana. However, experts only link THC to the strong psychoactive effect known as getting high. This is one of the primary differences between the two components.

The Predominant Effects of High-THC Strains

THC is the primary psychotropic component in marijuana, that is the component responsible for an altered state of mood and perception. This effect makes THC attractive to recreational users.

But THC also contains strong anti-inflammatory and analgesic properties, so it has shown some success in the treatment of pain caused by inflammation, such as arthritis, and cancer.

THC relaxes the nervous system, which helps in spasm-related pain, such as multiple sclerosis. The altered mental state caused by THC can contribute to relieving severe pain in some cases in the same way medicine uses opiates to treat pain.

The Predominant Effects of High-CBD Strains

CBD has received recognition for its anti-carcinogenic qualities. Alongside the lack of feeling “high,” CBD has shown positive anti-inflammatory and pain relief effects. Clinical trials have proven links to suppressing pain receptors from some of the chemical reactions caused by CBD.

CBD has powerful anti-oxidant properties, which also help to support the immune system. Although not considered psychoactive, it can help with the depression, and anxiety sometimes a side-effect of chronic pain.

Cannabidiol Oil and Medical Supplements

Natural cannabis oil supplements are available in capsule and spray forms, as well as oils, which patients can smoke or consume orally. Patients should not confuse medical supplements with the synthetic pharmaceutical varieties, which mimic the effect of cannabis but are not natural. Medical supplements can be pure THC, pure CBD or, so called ‘full-spectrum products’ like CBD oil, which contain ALL the beneficial compounds found in the hemp plant.

The Effects of THC versus CBD in Pain Relief

More clinical trials have linked CBD to positive results for pain relief than THC.

For example:

Chronic Pain. A 2017 report concluded that there was substantial evidence that hih-CBD cannabis-based products are effective for treating chronic pain. Another, separate study published in 2012 in the Journal of Experimental Medicine, suggests that CBD use can lessen both pain and inflammation.

Digestive Pain. CBD has proven it also can help immensely as a digestive aid and digestive pain as well. Researchers have found evidence, as suggested in Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go? that the endocannabinoid system, digestion and CBD have all sorts of interactions. While research involving CBD to treat digestive issues is still in its early beginnings, the experts believe it has the potential to help with all sorts of digestive issues which often come with pain.

Arthritis Pain. Arthritis, which literally means inflammation of the joints, is another condition that CBD oil may be very effective for. Research published in 2016 in the European Journal of Pain found a dramatic reduction in inflammation and signs of pain, without adverse side effects in rats with arthritis after the animals were given a topical gel that contained CBD for four days.

While some studies have shown positive effects of THC on pain relief, particularly for cancer-related pain, the side effects, like altered mental states, make it a less preferred cannabinoid to CBD. Although THC is more effective in muscle-spasm-related pain.

Interactions Between THC and CBD

When looking to reduce your pain, you don’t have to make a choice between THC and CBD. In fact, it could be wise to combine the two. Researchers have found that cannabis really is a synergistic shotgun in the sense that all the compounds in the cannabis plant interact with each other.

Although the exact mechanisms for these interactions remain unclear, the most effective cannabis-based pain treatments have been found to contain a combination of both THC and CBD. So, if your laws and regulations allow, go for a cannabis-based product which contains both compounds in good amounts. Just realize that THC can produce altered mental states, which can be dangerous while doing things that require proper hand-eye coordination like driving.

Choosing a Strain

There are a large range of chemical compositions within the high-THC and high-CBD varieties of cannabis. These can produce different medical effects.

To complicate the matter, the same product can have vastly different results in different people.

When looking for a natural herbal form of cannabis, the sativa strain (cannabis sativa) generally has a higher amount of CBD, whereas the indica strain (cannabis indica) contains more THC. However, due to crossbreeding this is not always reliable. Anecdotal evidence suggests that sativa is more energizing whereas indica is more of a relaxant. This observation may explain some differences that are not specific to the THC or CBD content and why many people prefer indica for pain relief. If you want therapeutic amounts of CBD, always go for a high-CBD strain, this can either be Sativa or Indica.


In medical use for pain relief, doctors prefer the CBD varieties of cannabis extract over THC, primarily due to their lack of side effects. Supplements combining CBD and THC, such as Sativix, have shown the best results in adults in clinical trials. Although experts prefer CBD because it has no side-effects, combining both CBD and THC might be the most effective way to treat pain.

Medical marijuana has fewer risks than other pain-relief medications such as codeine. It also offers more benefit while providing similar pain-relief effects. Since the reactions are incredibly variable and risks of any adverse effect are very low, it is best to discuss options for your pain management with a medical professional and begin with a small dose as a trial. Select the most suitable option for your needs, and let the results quickly manifest themselves.

Winston Peki is a marijuana enthusiast and vaporizer expert. Born and raised in Amsterdam He is the Founder of Herbonaut, an informative vaporizer and cannabis-based products site where you can find vaporizer reviews, CBD oil reviews and more.


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