Archive for the ‘Alzheimer’s’ Category

Biological Mechanisms of Vaccine Injury

Biological Mechanisms of Vaccine Injury

by jameslyonsweiler, Nov, 2017  https://jameslyonsweiler.com/2017/11/23/biological-mechanisms-of-vaccine-injury/

When Dr. Chris Exley and his research team discovered aluminum co-localized with amyloid plaques in the brains of patients who died from Alzheimer’s, it made big news, even though a study in 1985 https://www.ncbi.nlm.nih.gov/pubmed/4065091 discussed the aluminum silicate portion of amyloid. That’s right. We’ve known since 1985 at least that amyloid plaque in the brain is partly aluminum silicate. Now, Exley’s findings completely destroy any hope that aluminum somehow stayed out of the brain,  unnamed
Aluminum, it turns out, plays a critical role in our understanding of the biological mechanisms of vaccine injury. In this article, I will review the scientific evidence of four major ways that vaccines can cause harm. These are (1) Vaccine-Induced Mitopathy; (2) Vaccine-Induced Persistent Gliosis; (3) Vaccine-Induced Endoplasmic Reticulum Damage, and (4) Vaccine-Induced Autoimmunity (to appear as a separate article). My intent and purpose is not and has never been to discourage anyone from accepting vaccines, nor to provide medical advice of any kind; rather, my intent is to make a clear path toward safer routes to artificial immunization and communicate the state of scientific knowledge about mechanisms of the pathophysiology of disease caused by vaccines, and how such human pain and suffering can be mitigated.

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(1) Vaccine-Induced Mitopathy
Individuals born with mitochondrial disorders have partially disable cellular energetics. Mutations that alter proteins in the various specific mitochondrial pathways lead to a variety of congenital conditions http://www.umdf.org/types/, including encephalomyopathy and seizures. We need mitochondria to work in all of our tissues. However, our brains consume so much energy, any weakening of mitochondrial ATP flux will almost certainly lead to neurological disorders.

Environmental damage to mitochondria is known to occur from exposure to lead and includes depletion of mitochondrial membrane potential (ΔΨ) and intracellular glutathione (GSH), elevation of caspase-3 activity, intracellular reactive oxygen species, and malondialdehyde levels, and inhibition of GSH peroxidase (GSH-Px) activity (Liu et al., 2014).

Why discuss lead-induced mitochondrial toxicity in an article on vaccine injury? In part because many individuals familiar with brain injuries and conditions that lead to brain injuries will recognize the critical role of GSH, the importance of shutting down ROS, and the potential use of malondialdehyde as a screen for brain injury following vaccination. Another reason is that 25% of the homes in Pittsburgh have higher lead levels in the water coming into the homes than the levels found in the water in Flint, MI, and individuals with mitochondrial damage due to lead are likely to be a higher risk of the toxic effects from vaccines.

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The science of the specific actions and mechanisms of mitochondrial injury from vaccines include some of these events, including recognition of aluminum as an intracellular ROS generator (Han et al., 2013). Aluminum is present in vaccines as an adjuvant in a variety of forms, most commonly aluminum hydroxide (a well-known neurotoxin https://www.ncbi.nlm.nih.gov/pubmed/?term=aluminum+neurotoxicity). Vaccine risk denialists spend a lot of time denying the massive literature on the neurotoxicity of aluminum. Nevertheless, studies show that aluminum also disrupts cytoskeletal dynamics (Lemire et al., 2009).

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Thimerosal also has damaging influences on mitochondria, including direct damage to the mitochondrial genome. Sharpe et al. (2012) found that thimerosal induced a five-fold increase in the levels of oxidant damaged mitochondrial DNA bases and increases in the levels of mtDNA nicks and blunt-ended breaks.

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Increases in DNA damage to mitochondrial DNA can only increase the likelihood of heteroplasmy (the occurrence of >1 mitotype in a tissue or a person) – and low-energy regions of the brain can result because mitochondria are inherited in soma via cellular division.

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Repeated exposures to mercury can have myriad ill effects as well. Exposure to Methyl mercury (not the type found in vaccines) shows an increase in total reactive oxygen species (ROS) over time in the brain in autoimmune encephalomyelitis (Kharizi et al., 2016). The same ROS-generating effects, along with mitochondrial DNA damage, are seen due to the exposure of ethyl mercury in thimerosal, found in vaccines (Sharpe et al., 2012).

(2) Vaccine-Induced Persistent Gliosis
Mice injected with aluminum adjuvant doses equivalent to those given to US military service personnel showed both neuroinflammation and cell loss in the spinal cord and motor cortex, with consequent memory deficits (Petrik et al., 2007).

The cause of macrophagic myofascitis (MMF) has since been identified asaluminum hydroxide from vaccines lesions (Gherardi et al., 2001; Authier et al., 2006; Gherardi et al., 2012; Rigolet M et al., 2014). Patients with MMF have an unusually long reaction at the site of injection of aluminum-containing vaccines in their muscle, and biospies show infiltration of muscle tissue by macrophages. (See: https://jameslyonsweiler.com/2015/11/16/paging-dr-offit-your-aluminum-neurotoxicity-reading-assignments-are-ready/).

Here is chilling description of the effect of aluminum when used as an adjuvant:

“…poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in the brain” (Gherardi et al., 2015).

While reading thousands of studies for “The Environmental and Genetic Causes of Autism”, I was amazed by the number and the high diversity of types of studies that showed that microglia are chronically activated in autism. Microglia are cells in the brain that normally work to help form complex many:many synapses, leaving behind an abundance of 1:1 synapses. This is reflected in the altered Inhibitory/Excitatory ratio found in ASD and other neurodevelopmental disorders. Microglia also play the role of pruners. When there is a physical injury or an infection that damages nerve cells, glutamate is released. This amino acid is a neurotransmitter, and in high concentrations, glutamate is also a signal to microglia that cellular damage exists in the brain. Local microglia respond by changing shape, becoming macrophagic, and they go to work cleaning up cellular debris. They can induce apoptosis (cell death) and destroy both dendrites and neural precursor cells.

When metals such as aluminum and mercury enter the body, they are taken up by macrophages, and they slowly accumulate in the brain. Harm to astrocytes can occur, as we have seen, via direct mutagenesis, ROS species generation, endoplasmic dysfunction, and other mechanisms (including blockage of normal functioning of cytoskeletal dynamics (coordinated actions of actin and microtubule filaments, nucleolar membrane pores). The individual or cumulative effects of these insults reduce astrocytic uptake of glutamate, causing a rise in the brain-wide concentration of glutamate, leading to excitoxicity – the activation of microglia leading to specific types of deficits and surpluses of pruning activity, and unwarranted, unhealthy microglia-mediated apoptosis (cell death). (See the Companion site “Causes”: The Environmental and Genetic Causes of Autism Reference Resource: https://envgencauses.com for relevant references).

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The destruction of dendrites, neural precursor cells and otherwise healthy nerve cells leads to the further release of glutamate – and cytokines – signaling the brain inflammasome. Astrocytic cell death leads to the re-distribution of accumulated metals to new brain cells.

The reactive microglia are induced on a repeated basis – 33 times – over the course of the first 18 months of life (See CDC schedule to 18 mos:  https://www.cdc.gov/vaccines/schedules/downloads/child/0-18yrs-child-combined-schedule.pdf). If any child has a mutation in any number of genes encoding proteins involved in cellular detoxification, downregulation of microglial activation, mitochondrial function or even synaptic transmission, these environmental exposures can lead to devastating encephalopathy. Clearly, vaccine safety science at the population level will be uninformative on the reality of specific risk in certain families.

(3) Vaccine-Induced Endoplasmic Reticulum Damage
Like mutations that reduce a person’s ability to detoxify their brains (and other tissues)

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normally, both aluminum and mercury have toxic effects on the cell’s garbage removal system – the endoplasmic reticulum. The effects of aluminum are rather dramatic – it causes the ER to “glom-up” against the nuclear membrane. This is due in part to the failure of microtubule functions, which aids in the “unfolding” and movement and function of the ER. This mechanism is independent of the P53 apoptosis pathway (Rizvi et al., 2014) – but neuronal death occurs nevertheless.

A very important study by Stamogiannos et al. (2016) showed that thimerosal specifically inhibits the protein Endoplasmic Reticulum Aminopeptidase 1 protein (ERAP1). ERAP1 is is responsible for the proper shortening of proteins on their way to functioning in the adaptive immune system. From the UNIPROT database entry for ERAP1: http://www.uniprot.org/uniprot/Q9NZ08

“Aminopeptidase … plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules”. ml6b00084  (article here)

The significance of disabling ERAP1 to immunity to pathogens cannot be underestimated. The very proteins that patients are attempting to use to protect themselves against infectious agents that cause disease are prevented from being properly trimmed – thus disrupting proper everyday immunological signaling. This may explain why patients who have received a vaccine against influenza have higher rates of non-influenza respiratory infections (Cowling et al., 2012).

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The vaccine studied (Vaxigrip) from Sanofi Pasteur includes thimerosal: http://www.wrha.mb.ca/professionals/immunization/files/05_Vaxigrip.pdf

Widespread “anecdotal” experiences by patients reporting “getting the flu” after receiving the flu vaccine are likely due to them becoming immunologically compromised by thimerosal-containing flu vaccine, allowing viruses to which they were immune prior to the vaccine to exert a pathogenic effect.

A study in 2011 found that annual vaccination of children against influenza indeed hampers the development of virus-specific CD8+ T cell immunity (Bodewes et al., 2011). Clearly, vaccination using thimerosal is not benign to human health. Patients who choose to receive vaccination as an attempt to achieve immunity against influenza can opt for the flu vaccine without thimerosal. Quite problematically, however, many doctors are not even aware that they are injecting thimerosal into patients. It is important, therefore, for patients to share all of these findings with their health care providers and their county and state health departments.

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An exciting new realization is the finding that amyloid plaques may play a direct role in severe autism with self-injury and aggression. Amyloid is made partly of aluminum. The notion that aluminum cannot cross the blood-brain barrier has been known to be false since at least 1985 (Colin et al., 1985).

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Dr. Exley’s most recent findings of record measurements of aluminum in the brains of people who died from Alzheimer’s confirms the truth: aluminum is at the very core of Alzheimer pathophysiology. The most significant source of aluminum in children from birth to three years of age is vaccination. This is reversed in adults due to increased body weights and higher amounts of aluminum in the diet. Generally speaking, humans absorb 0.2-0.3% of the aluminum present in their water and food. In contrast, every microgram of aluminum injected must be dealt with metabolically. Around 10% aluminum introduced to the body (past an epithelial layer, either by diet or by injection) makes it to the brain and stays there for decades.

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Children with severe autistic behavior and aggression have increased levels of beta-amyloid precursor protein (Sokol et al., 2006). Aluminum from all sources in their brains (water, food, vaccines) would foster the development of amyloid plaques, and should be avoided.

This knowledge is also exciting for families with loved ones with ASD who are suffering from self-injurious behavior and aggressive behavior because intranasal insulin is known to activate the enzymatic pathway that clears amyloid plaques:  https://www.ncbi.nlm.nih.gov/pubmed/27457264. Research studies on the efficacy – and safety – of intranasal insulin in ASD are needed.

It is very important to reduce the total aluminum and toxin exposures to children being vaccinated. Some water filters such as Zero Water reduce aluminum absorption from the diet; silica drops and high-silica mineral water both cause aluminum in the diet to become bound as aluminum silicate and thus pass through the digestive tract unabsorbed.

Part (4) Vaccine-Induced Autoimmunity
This section will be published in a separate article.

Solutions
Allegheny County Health Department dropped the ball on lead in the drinking water: https://jameslyonsweiler.com/2017/07/23/allegheny-county-board-of-health-flops-on-pittsburgh-water-lead-issue/, calling on a vaccine risk apologist to distract from the lead in the water coming into their homes. In a press conference, the individual pointed out that there was more lead in the soil and paint in these homes than in the water the occupants consume: https://jameslyonsweiler.com/2017/07/25/allegheny-county-sticks-their-heads-further-in-the-sand/. This was a move to try to (but failed to) deflect responsibility away from the Allegheny County Board of Health’s (ACBH) failure to address the issue of lead in the water in homes in and around Pittsburgh. However, as discussed elsewhere, ACBH should have been more, not less concerned about lead exposure from the water due to the presence of lead in the soil and paint, because toxicity is dose-related. Risk of neurodevelopmental disorder cannot be siloized by mere mention of sources of toxins that have accumulative effects and that interact with other toxins.

The ill effects of lead on the mitochondria should therefore also cause ACBH and health care workers everywhere to pause when recommending vaccination for children known to have high lead levels. Children in urban areas should be tested for lead prior to vaccinations – and those with high lead levels should be recommended to avoid vaccines with thimerosal and aluminum. The ACBH knows where these children live, and who they are. Will they alert the parents of these children to the potential for increased risk of vaccine injury due to their lead exposures?

My most ardent supporters, many of who are completely against vaccines because, in part, they see the future of immunity as stemming from healthy societies instead of artificial immunization, understand that I will never call for an end to improving means of artificial vaccination, for to do so would to be lock into place the specific vaccines that currently are causing millions to suffer from autoimmune and neurological disorders across the globe. Many of them disagree with me on this point, some quite vigorously. Vaccine industrialists take note: the flaws in your products are putting the entire immunization paradigm at risk. Those who develop the next-generation of infection-protection products should be aware that as long as you shield yourselves from liability, they will remain unacceptable to a growing segment of the general population. The public correctly believes that it is immoral to indemnify anyone against liability for flawed products, medical or otherwise. Removing the protections of yourselves and products from liability will be one gesture that could possibly restore some confidence. Conducting randomized double-blinded clinical trials large enough to detect rare adverse events, designed to include and report on those likely to suffer adverse events (at least in the math, preferably in the study design), avoiding the use of confidence intervals, not over-correcting your analyses, defining, publishing and sticking to a data analysis plan prior to conducting any analyses, reporting NNT (numbers needed to treat) and related measures (numbers needed to invite) and providing a fully transparent report of the fate all patients enrolled in the study will help restore confidence.

I join many voices from around the globe calling for the ban on the use of thimerosal at any stage of vaccine development. We have forthcoming results that show that aluminum dosing in pediatric vaccines is too high, and was not determined by dosage escalation trials in which aluminum was injected into animals. I also strongly recommend that unsafe epitopes should be identified, and excluded from all vaccines. Legislation from the people at the state level banning the sale or distribution of vaccines with mercury, aluminum and unsafe epitopes could prove to be an effective means for the people to gain control of what goes into their bodies.

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The NVCIA (42 U.S.C. §§ 300aa-1 to 300aa-34) mandated safer vaccines. I am grateful to Informed Choice Washington for this info, esp. Bernadette Pajer)

I’ve also called for biomarkers to screen people away from vaccines due to increased risk. This is consistent with the legislation that mandated the identification of individuals most susceptible to risks from vaccines.

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Doubly grateful for Informed Choice Washington for sending this information (esp. Bernadette Pajer)

Specifically, the Act mandated the identification of “the groups, categories, or characteristics of potential recipients of such vaccine who may be at significantly higher risk of major adverse reactions to such vaccine than the general population“.

Not only has that not happened, the CDC has actually taken action to weaken the available information – and for that, last December (2016), Bernadette Pajer and my joint public comments were censored: https://www.linkedin.com/pulse/cdc-censored-my-public-comment-12232016-welcome-james-lyons-weiler/, along with hundreds of other public comments. Our redacted comments and hundreds of others were made public after a brief consultation with my lawyer.

In my view, and in the view of thousands of parents, the National Childhood Vaccine Injury Act has been abrogated due to the failure of our government, vaccine manufacturers, and the medical community to do their part. They are now pushing mandates at the State level at frenzied pace with legislation designed to strip citizens of their existing liberties to opt out of vaccination. Exemptions exist in 48/50 states, and they must be defended so people who have reason to believe they, or their children are at risk of vaccine injury, can opt out.

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Under any other area of biomedical inquiry, these rational moves would come as recommendations. Under the current likely rates of vaccine injury, these steps are not mere recommendations. Under the National Childhood Vaccine Injury Act (NCVIA) of 1986 (42 U.S.C. §§ 300aa-1 to 300aa-34), they are mandated by Congress.

Religious exemptions must also be respected, in part due to the use of aborted fetal cells in the production of vaccines:  http://www.nature.com/news/medical-research-cell-division-1.13273.

The rate of death on the first day of life in the US is highest among all rich nations. Maternal deaths during pregnancy are at an all-time high, and yet CDC is still recommending Tdap vaccination, against FDA label, every pregnancy, every time. This recommendation was made with no safety studies – and the safety studies conducted since left out mothers who were at risk of complicated pregnancies, or simply excluded fetal deaths due to a lack of scientific ability to know the date of a spontaneous abortion. See the first #braintrust episode on this topic here:  https://www.facebook.com/wearevaxxed/videos/550017128678901/.

The not-for-profit I founded, IPAK, has called for a ban on vaccination in the NICU (see #nicuchallenge on social media) until studies are produced that demonstrate that vaccination in the NICU is safe. Many people don’t know that NICU’s vaccinate all of their patients at once, and have crash teams that stand by for respiratory distress, seizures, and other serious adverse events that occur due to the vaccination of low birthweight infants with 250 mcg of aluminum in the HepB vaccine. IPAK has also published a major report: http://ipaknowledge.org/NDRR-IPAK-Tech-Report-20171.php on the potential role that vaccination against HepB on the first day of life has played in preventing the bankruptcy of the medical industry in the US, Canada and the UK. It includes a call for screening programs to keep those most at risk out of harm’s way.

Reform Must Happen
I join many other voices in calls to mandate reporting of vaccine adverse events with fines for failing to report. VAERS is a failed system, capturing only between 1% and 10% of adverse events from vaccination, and users are required to acknowledge that the data are so poor they cannot be used to determine causality. The legendary VSD of CDC folklore is not available for public review and use. Professional obfuscationists currently inhabit high-ranking offices at the CDC, the NIAID, and the NIH. Their continued involvement in the areas of infectious disease, and public health insures that no reform can take place, in spite of the overwhelming evidence that vaccines are making many – if not most – recipients sick. They need to resign, accept early retirement, or get behind the movement sweeping the nation to protect our children – and ourselves – from serious adverse events and injuries. The misinformation campaign based on fear that people will stop vaccinating must be replaced by science.

As a scientist and a citizen, I am calling on every citizen, vaccine manufacturer, ACIP, the CDC and independent researchers to request funding from Congress for $1Billion in funding to be distributed to Universities to conduct immediate prospective RCTs on the safety of all vaccines currently on the market to determine if we can predict who will experience immediate, short-term and long-term adverse events and injuries from vaccines. CDC cannot be trusted, and won’t be trusted. Vaccine manufacturers have lost all credibility to a fast-growing portion of the American public, and other than joining their fellow citizens in a call for science, they should step aside and let vaccine safety science occur. Only a bought press and captured regulatory agencies are keeping the vaccine house of cards from falling apart. Moves to make the vaccination a police action are happening around the world. Dishonest moves by the likes of State Senator Richard Pan leading to the persecution of his former colleagues – medical doctors who honor requests for exemptions – show a true lack of personal character. The entire medical industry ignores the right of patients to refuse to participate in clinical trials – fully aware that the vaccines they are administering are subject to ongoing clinical safety trials.

A clause in the 21st Century Cures Act: https://www.congress.gov/bill/114th-congress/house-bill/34/ allows doctors to enroll their patients in clinical trials as long as the IRB overseeing the trial has determined that the risk to those enrolled is minimal. Clearly this act cannot possibly be relevant for vaccines, for which post-market surveillance studies are needed to determine long-term risk – the very information needed to allow this clause to be invoked. Citizens can opt out of vaccination on the basis of their refusal to be enrolled in the ongoing post-market safety studies. Citizen groups can also consider challenging and educating individual medical doctors who enroll patients in the ongoing clinical safety trials without securing informed consent.

We need outcome studies of injured vs. non-injured, and studies of rates of vaccine adverse events in genetic groups defined by the basic and translational science conducted that points to increased genetic risk of mysterious diseases with no known cause but many suspected environmental triggers. It is morally wrong to hide specific risk to identifiable subgroups in whole-population comparisons. Where is the study to determine if people with HLA genotypes with high risk of RA are at higher risk of RA due to vaccines than people with HLA genotypes with low risk of RA?

In part two of this article, I will review the evidence of autoimmunity from vaccines as the fourth mechanism of vaccine injury.

Citations

Bodewes et al., 2011. Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8+ T Cell Immunity in Children J Virol 85:11995-12000.

Cowling, BJ et al., 2012. Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine. Clin Infect Dis. 54(12):1778-83. doi: 10.1093/cid/cis307.

Gherardi RK et al., 2015. Biopersistence and brain translocation of aluminum adjuvants of vaccines. Front Neurol. 2015 Feb 5;6:4. doi: 10.3389/fneur.2015.00004. eCollection 2015.

Han, S. 2013. How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale. Cell Biol Toxicol. 29:75-84.

Kahrizi F 2016. Repeated Administration of Mercury Intensifies Brain Damage in Multiple Sclerosis through Mitochondrial Dysfunction. Iran J Pharm Res. 15:834-841.

Lemire et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J. Neurosci Res 87:1474-83

Liu G et al., 2014. Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. Hum Exp Toxicol. 33(10):1071-80. doi: 10.1177/0960327114521048.

Mizra et al., 2017. Aluminium in brain tissue in familial Alzheimer’s disease. Journal of Trace Elements in Medicine and Biology 40:30 – 36.

Petrik MS et al., 2007. Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice. Neuromolecular Med 9:83–100.

Sharpe, MA et al., 2012. Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA Journal of Toxicology Volume 2012 Article ID 373678, 12 pages

Stamogiannos, A et al., 2016. Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1 ACS Med. Chem. Lett. 7:681–685.

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For more on vaccines:  https://madisonarealymesupportgroup.com/2017/04/06/video-how-vaccines-are-made/

https://madisonarealymesupportgroup.com/2017/03/30/ty-bollinger-the-truth-about-vaccines-series/ (I highlight Dr. Gentempo’s 9 part vaccine series)

https://madisonarealymesupportgroup.com/2017/09/21/aluminum-flawed-assumptions-fueling-autoimmune-disease-and-lyme/

https://madisonarealymesupportgroup.com/2017/09/19/autism-aluminum-adjuvant-link-corroborated/

https://madisonarealymesupportgroup.com/2016/12/08/mercury-and-autism/

https://madisonarealymesupportgroup.com/2017/10/15/vaccines-and-retroviruses-a-whistleblower-reveals-what-the-government-is-hiding/

https://madisonarealymesupportgroup.com/2017/10/26/clinical-trial-shows-most-kids-with-autism-are-not-born-with-it/

https://madisonarealymesupportgroup.com/2017/09/27/strange-case-of-poul-thorsen-vaccine-data-manipulator-extraordinaire/

https://madisonarealymesupportgroup.com/2017/05/18/first-peer-reviewed-study-of-vaccinated-vs-unvaccinated-children/

https://madisonarealymesupportgroup.com/2015/06/19/a-word-on-vaccines/

Lyme Vaccine:  https://madisonarealymesupportgroup.com/2017/09/07/20268/

https://madisonarealymesupportgroup.com/2017/07/01/pbs-lyme-vaccine/

https://madisonarealymesupportgroup.com/2017/01/26/lyme-vaccine-to-be-tested-on-humans/

https://madisonarealymesupportgroup.com/2017/06/27/military-vaccines-lymemsids/

 

H.R. 4333 – Lyme Disease Research Stamp Act

For Immediate Release Contact: John Lange
Thursday, November 9, 2017 202-225-5614 | John.Lange@mail.house.gov

Faso Introduces Bipartisan Legislation to Raise Awareness and Research Funding to Combat Lyme Disease

Washington, D.C. – Congressman John Faso (R-Kinderhook) today announced the introduction of H.R. 4333, the bipartisan “Lyme Disease Research Stamp Act” alongside Congressman Collin Peterson (D-MN). The legislation would establish a United States Postal Service semipostal stamp to raise money for Lyme disease and related tick-borne illness research – at no cost to taxpayers.

Congressman Faso said, “Lyme Disease is a scourge that Upstate families know all too well. This debilitating disease stays with its victims for years, and results in immense emotional and financial hardship. Lyme disease and related tick-borne illnesses are growing rapidly, and it is critically important that as a society we do what we can to educate the public on this epidemic so our communities and families can take the necessary steps to comprehensively address this issue.” Faso continued, “The Lyme Disease Research Stamp Act is important because it will help raise awareness and money to support comprehensive research efforts to combat and prevent these devastating diseases.”

Congressman Collin Peterson (MN-7) added, “I am proud to help lead the effort to support increasing funding for Lyme disease and tick-borne illness research and raise public awareness,” Peterson said.

The Lyme Disease Research Stamp Act would establish a United States Postal Service semipostal stamp to raise money for Lyme disease and related tick-borne illness research. The stamp would operate as USPS first-class postage, which postal patrons may voluntarily purchase at a price slightly higher than regular postage to support this cause. Revenue raised would directly benefit critical Lyme disease and related tick-borne illness research at the National Institute of Allergy and Infectious Diseases (NIAID). This market-driven initiative comes at no cost to the taxpayers.

Other leaders in the fight against Lyme Disease contributed their thoughts on the Faso legislation:

“Lyme disease is the number one spreading vector borne epidemic in the U.S, and mimics other chronic diseases accounting for an increased burden of those suffering with chronic illness. It has now been reported in all 50 states, affecting more than 330,000 people a year with debilitating symptoms. Lack of accurate diagnostic testing oftentimes results in diagnoses of Chronic Fatigue Syndrome, Fibromyalgia, autoimmune diseases, unexplained pain syndromes, as well as dementia with neuropsychiatric illness. These various manifestations contribute to disability and rising health care costs. We desperately need to improve diagnostic and treatment options for Lyme and associated illnesses, as research funding to date has been inadequate, so the “Lyme Disease Research Stamp Act” is an excellent way to help raise awareness and provide critical funding for this emerging epidemic”

Dr. Richard Horowitz
NY Times Best-selling author of “Why Can’t I Get Better? Solving the Mystery of Lyme and Chronic Disease” and national best-selling author of “How Can I Get Better? An Action Plan for Treating Resistant Lyme and Chronic Disease”
“The Lyme Disease Research Stamp Act introduced by Congressman Faso enables Congress to provide an opportunity to raise much needed funds for Lyme and other tick-borne diseases research, yet it does not add to the financial burden of the federal government. It enables individuals who want to support Lyme research–so that patients can get proper diagnosis and treatment–to do so without a strain on their budgets and without an unnecessary expenditure of time. Buy a Lyme stamp, help save a life! It’s a win-win situation.”

Pat Smith
President, Lyme Disease Association, Inc.

“Great thanks to Congressman Faso for finding this unique manner to assist with NIH Funding for Lyme disease research. There’s about 80 times as much tick-borne disease as mosquito-borne disease in the USA. Yet funding for Lyme and tick-borne diseases is not commensurate with the illnesses. This legislation will help NIH to address the ticks and the diseases they transmit as is done with mosquitoes.”

Jill Auerbach
Hudson Valley Lyme Disease Association, Chairperson

“We are gratified that Congressman Faso has sought to arrange for a direct way of funding future research for tick borne disease. This epidemic has taken a back seat to mosquito diseases and this legislation will provide a necessary amount of awareness as well as some additional funding. We are grateful to Congressman Faso for his efforts in this area.”

Ira Auerbach
Hudson Valley Lyme Disease Association

“Despite the severity of the epidemic and a rapid growth in reported cases, NIH funding for Lyme disease research has remained relatively low, averaging just $25 million annually. Additional funding is desperately needed for research to develop accurate tests that work in all stages of the disease and for clinical trials to develop more effective treatments for patients with chronic Lyme disease. The Lyme Disease Research Stamp provides an opportunity to help fill this gap at no expense to taxpayers.”

Bruce Fries
President, Patient Centered Care Advocacy Group

Some of Congressman Faso’s efforts to combat Lyme disease in the 115th Congress:

Sent a bipartisan letter to Acting Secretary of the Department of Health and Human Services, Eric Hargan, to follow up on report language for Fiscal Year 2018 appropriations regarding Lyme disease, to improve the measurement and tracking of the progress of federal efforts to combat the disease.
Member of the House Lyme Disease Caucus.
Voted for millions in Lyme and vector-borne disease research funding, in addition to voting for a $2 billion increase in funding to the National Institutes of Health, which conducts important Lyme research.
Sent a letter to U.S. Department of Health and Human Services Secretary Tom Price urging support for the Tick-borne Disease Working Group established under the 21stCentury Cures Act.
Met with leading medical professionals and Lyme disease prevention advocates to share information about ongoing Lyme research and education programs, as well as how private companies are working to develop vaccines.
Facts about Lyme Disease:

An estimated more than 300,000 new cases of Lyme occur annually.
It is found in half of all U.S. counties and on four continents, and it is growing rapidly.
It is transmitted by tick bites.
Symptoms may begin as flu-like but can affect the nervous system, leading to paralysis, encephalitis, seizures, and death if left untreated.
It has no known cure and is difficult to diagnose.
More than 3,000 confirmed cases in NY in 2015.
14 States, including New York, account for over 96% of reported cases.
To view the Letter to Acting Secretary of the Department of Health and Human Services, Eric Hargan, click here.
To learn more about this legislation, click here: https://faso.house.gov/uploadedfiles/lyme_disease_research_stamp_page.pdf
For the full text of the legislation, click here:  https://faso.house.gov/uploadedfiles/draft_-_lyme_disease_research_stamp.pdf

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**Comment**

Sigh……why do Lyme/MSIDS patients, their doctors, and researchers have to sell lemonade to raise money for a disease that’s affecting at least 300,000 per annum and thousands more who are chronically debilitated till they die?  https://www.cdc.gov/lyme/stats/humancases.html

Think about this for a minute.

Can you imagine breast cancer or heart disease patients needing to buy expensive stamps so they can have money for research?

I mean, don’t get me wrong, I appreciate the out of the box thinking by Representative Faso; however, patients are already paying exorbitant amounts of money for treatment that insurance will not even cover.  Then there’s the patients who have become homeless, those who forego treatment, and families who have to choose who gets treated in their family as they can’t afford to treat everyone.  I could go on and on.

According to the CDC, here’s the stats for the leading causes of death in the U.S. with corresponding links showing how LD can cause or exacerbate each of these conditions:

And while I couldn’t find a direct article link to Lyme/MSIDS and “accidents,” Lyme/MSIDS patients trip, fall, and have all sorts of accidents due to neuropathy and brain processing issues, it’s just nobody’s keeping score:  http://www.mentalhealthandillness.com/tnaold.html

According to the CDC, EVERYONE is at risk for Lyme and more folks are diagnosed with Lyme disease (329,000) each year than breast cancer (232,570), colon cancer (136,830), HIV (50,000), and Hepatitis C (18,000).

Take a peek at dollars spent on research:

HIV  $3,005

Breast Cancer  $674

Colon Cancer  $288

Hepatitis  $200

Lyme Disease  $21

*Dollars in millions and rounded. Estimated funding in 2014 by National Institutes of Health (NIH).  https://globallymealliance.org/about-lyme/, Fed funding:  https://report.nih.gov/categorical_spending.aspx

Lyme Disease occurs 6 times more often annually than HIV/AIDS, yet it receives less than 1% of the funding from the National Institutes of Health compared to HIV/AIDS. Likewise, there are 141 times as many cases of Lyme Disease than West Nile virus, yet Lyme Disease receives less than half of the funding for research. http://lymediseasechallenge.org/learn-lyme-disease/

Then there’s the 1.1 billion approved for Zika.

347 symptomatic Zika virus disease cases reported, but 342 cases were in travelers returning from affected areas
2 cases acquired through presumed local mosquito-borne transmission in Florida (N=1) and Texas (N=1)
3 cases acquired through sexual transmission  https://www.cdc.gov/zika/reporting/2017-case-counts.html

Mosquito experts have gone on record stating that mosquito transmission cycles for Zika in the U.S. is near ZERO.  https://madisonarealymesupportgroup.com/2016/07/17/zika-in-the-land-of-oz/, and https://madisonarealymesupportgroup.com/2016/09/04/cdc-report-on-zika/.

But, what about microcephally?

U.N. numbers show just 142 cases of birth defects linked to Zika outside Brazil. The article admits that the condition was initially over diagnosed.  https://madisonarealymesupportgroup.com/2016/10/26/zika-puzzling-scientists/

Call me crazy, but perhaps some reorganization within the CDC/NIH/IDSA needs to happen with proper emphasis on research spending that correlates to incidence of disease…..

Just a silly thought.

 

 

Lost Link – ALS & Lyme

https://huib.me/en/blog/item/92-the-lost-link-between-als-and-lyme-disease  by Huib Kraaijeveld, October 2017

The lost link between ALS and Lyme disease

Knowledge about emergent diseases normally increases over time. Lyme Disease seems to be an exception to this rule. Claims that governments and scientists made around 1990, seem to have been forgotten. This article explores the lost link between ALS and Lyme. ALS is also known as Motor Neurone Disorder (MND) or as Lou Gehrig’s Disease, after the famous Yankee baseball player who died from it in the 1940’s. It is still claimed there is no known cause nor cure for it. 

 

A few weeks ago I visited a friend to admire her new house. She wasn’t as happy as I’d expected. She told me that a good friend of hers (46) was just diagnosed with ALS. ALS is considered a progressive and lethal disease, without a known cure for it.

Two months earlier, her friend had sudden deterioration of her memory, impairment of cognitive function and lost the use of the muscles in one arm. I’m not medically trained myself, but found this to be a peculiar combination of symptoms for ‘ALS’.

Some clinical tests for other illnesses were checked off, no blood work was done and she was basically sent home to write her will and say goodbye to her young child and husband. Memory loss and the sudden inability to think straight were not included in the diagnosis process.

My friend asked me for some sources about a potential link between Lyme and ALS. I’d like to share these sources with you as well in this current article, as a timely example how knowledge can somehow be ‘forgotten’.

Media coverage

There is a specific reason to write this article now. This week, on October 18, a highly disputed broadcast by Zembla International called ‘deceit or Borrelia‘ seems to be repeated on Dutch TV.

It attacked a specialized German lab, using the edited stories of Danish Lyme patients, who could not get help in their own country.

The patients did not give their consent for the broadcast, and when they realized where the broadcast was heading, they found that they were unable to withdraw their cooperation. This led to a ‘counter’ documentary of their own making, which you can see below.

Tabitha, the first lady who you can see in this documentary, was also told that she would live another six months at most and should say goodbye to her young daughter. Her diagnosis was also ALS.

She found that Lyme was likely the cause of her deterioration in health, got treated for it and stopped the progression of the ‘ALS’. She’s still alive now, although hardly after the damage the original documentary had done to her care plan.

Differential diagnosis

A differential diagnosis is what specialists call ‘detective work’. Clinicians look for symptomatic and laboratory clues, have hunches, order testing and perform exams, and then rule diagnoses in or out, especially when one or more illnesses have similar symptoms or even lab findings.

Part of that detective work is simply doing diagnostics by way of treatment. If a patient does not respond to a treatment for a specific disease, too bad, but then you can exclude it. But if they do, great news! Wouldn’t you think, in case of a lethal condition?

Allan Sheppard’ story, which was featured by the BBC, tells another tale. After the UK medical system NHS kept him in Intensive Care for two years with alleged ‘ALS’ and refusing his daughter to get a Lyme test from another specialized German lab, he is now improving while being treated for Lyme. Despite the UK government trying to stop her.

The story of Eivind Markhus is even more sinister. After he was told he would die from ALS, he had an American lab test his blood and found Lyme to be the real cause of his problems. He also improved after initial treatment and the progression of his ALS symptoms stopped.

Yet instead of spending 150,000 dollar on Lyme treatments, he spent that amount on legal cases, because his Norwegian government forbade him to get treated. He lost both the lawsuit and his life.

Recently, a male Dutch ALS patient (34, with three little children), who had been previously tested – with the standard unreliable serological test – for Lyme in a so-called (ALS) ’Expert Center’, had to learn from a chronic Lyme patient and a Lyme Literate US doctor how to improve the diagnostics.

By buying antibiotics online in New Zealand and taking them for a few days, his body started to produce antibodies for Lyme. So suddenly the test was positive in another (Lyme) ‘Expert Center’, where they apparently don’t know how to do this.

He is now crowdfunding to undergo an experimental treatment, which his insurance refuses to cover as it is not considered ‘evidence based’.

The story of Dr. Martz, who is featured in the award-winning documentary ‘Under Our Skin’ is the icing on the cake. He was told he would die of ALS as well, but found out by coincidence that he actually had Lyme and a co-infection, was treated for both of them and recovered so much he could give lectures in 2011.

Ice buckets

A relationship between ALS / MND and Lyme makes sense, looking at the findings of the 1990 research that was published in the article ‘Immunological Reactivity against in Borrelia burgdorferi in Patients with Motor Neuron Disease’ by Halperin et al.

This study showed that in almost 50% of the 19 people diagnosed with ALS, Lyme was the cause. Once treated, several of these patients improved. In that same year, 1990, the CDC published its first definition about Lyme and described the complex, systemic, multi-symptom and sometimes devastating chronic disease experienced by many Lyme patients – then and still today.

Did anyone ever do a follow-up on this promising research? No. It was simply hidden away and Halperin chose to become a co-author of the 2006 IDSA Lyme Guidelines instead, which maintain that ‘Lyme is a mild disease that is hard to get, easy to treat and hardly ever becomes a chronic condition’. Any possible connection with ALS or any other of the serious and previously acknowledged debilitating or even deadly conditions was no longer mentioned. Any long-term health issues are reasoned away, using semantics rather than ‘evidence based’ science.

These 2006 IDSA Lyme Guidelines have become worldwide policy, even though they were removed from the National Guidelines Clearinghouse and named as a case of bad ‘evidence based’ guidelines by the Institute of Medicine in 2011. To this day, both the CDC and WHO wholeheartedly support them, regardless of the hundreds of scientific publications that dispute them.

Today, 27 years after the Halperin study, people with ALS are routinely not (properly) tested nor treated for Lyme. Instead, friends and families are encouraged to empty ice buckets over each other’s heads to collect money for new research for a new cure for ALS.

The patient stories mentioned above will simply be discarded as ‘anecdotical’ by both mainstream scientists, doctors and policymakers. So will the fact that Lou Gehrig actually owned a house in Old Lyme, Connecticut.

Yet, if these stories are not shared anyway, the knowledge in them will be lost and so is hope for other people like Eivind, Allan, Tabitha, my friend’s friend and their children.

Choices of media channels such as the BBC or Zembla are decisive which knowledge is made available to the public. I asked the editors of Zembla to reconsider broadcasting it again, but have not yet received a reply.

An intellectual ice bucket

Most of these diagnoses are simply words on a form, which either best fit the symptoms or simply fit the codes of the insurances. Almost all of them are based on clinical diagnoses only and can mean a life-sentence to the patients.

Yet they need to prove with 100% certainty that Lyme is the actual cause? How can they do so, with blood tests that produce over 500 times more false negatives than the current HIV tests? Even the ‘experts’ now state that they should no longer be used

The intellectual ice-bucket is that one disease (causative agent) can show up as many different ‘disease images’, fooling doctors, patients, immune systems and statistics alike. Although it happened before in history, with Syphilis, many people seem to find this idea hard to grasp.

In this current article I only used ALS, which is considered a lethal and incurable disease to all afflicted, as an example to open up your imagination. Yet I could have also used any of the other 364 known potential misdiagnoses of Lyme as well.

Odds are about 100% that you personally know people who suffer from several of these illnesses, as the list includes MS, Parkinson, Alzheimer, ME, Fibromyalgia, ADHD and so on.

This is why I wrote my book for people like my friend, as it’s much easier for her to see the scope and possibilities than for the people like her friend, who are disabled and so frightened that will tend to believe their medical ‘death sentence’.

Is Lyme always the cause? Most likely not, as with anything in life, but without a 100% reliable test we will never know for sure in how many cases it is. Can it be? Of course it can, in the current climate of ‘lost knowledge’. Here are just a few more examples.

In 1988, the Canadian Department of Health reported several cases of congenital Lyme infection. In 2017: silence.

In 2012, the WHO stated in an instruction about blood donation (p.84) that Lyme Borrelia infection can “occur after the bite of a tick, mosquito or horsefly and can survive blood storage temperatures“.

Did you know? Does your doctor? Not if they don’t stumble upon it in their private lives, as retired MD Dr. Al Miller did. He recently discovered his daughter-in-law (43) was wrongly diagnosed with – again – ALS and that her health improved, after she was (properly) tested and treated for Lyme. Dr. Miller has become very vocal about it.

Change?

Using normal human, scientific or professional logic does not really help to understand the current bias against Lyme as a potential cause for many different illnesses. It simply does not fit the current model.

So change will not come from ‘above’. Throughout history, it never has, because ‘above’ has no interests in changing a status quo. Both the CDC and the WHO are political organizations.

The main insight you may need to fully understand why a severe and widespread disease – or rather pandemic – is so systematically ignored, downplayed or simply denied to exist in the first place, is to appreciate what it means that Lyme is called a ‘political disease’.

This quote might give you a hint: “a patient cured is a customer lost”. That is why a paradigm shift entails more than just ‘finding a cure for ALS’ (or those 364 other diseases) and emptying a next bucket of ice cubes; no matter how well-intended the gesture is.

References

Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function. Garth L. Nicolson, Robert Settineri and Rita R. Ellithorpe. Functional Foods in Health and Disease 2014; 4(1):23-65 (page 23 of 65)

Lyme disease-induced polyradiculopathy mimicking amyotrophic lateral sclerosis. Burakgazi AZ1. Int J Neurosci. 2014 Nov;124(11):859-62. doi: 10.3109/00207454.2013.879582. Epub 2014 Feb 7.

Chronic or Late Lyme Neuroborreliosis: Analysis of Evidence Compared to Chronic or Late NeurosyphilisJudith Miklossy. The Open Neurology Journal. 2012; 6: 146–157.

Dr. Richard Horowitz has a section in his second book ‘How Can I Get Better?‘ (page 282) where he says “Yet, if Lyme disease, co infections and environmental toxins are the sole causes of ALS, I would expect to see even more of these patients coming in with the disease.

Huib Kraaijeveld

Author of ‘Shifting the Lyme Paradigm‘, chairman of the On Lyme Foundation and founding member of the Ad Hoc Committee for Health Equity in ICD

____________

**Comment**

Bravo Huib!

Dr. Miller:  https://madisonarealymesupportgroup.com/2017/05/11/dr-al-miller-lyme-disease-series/

https://madisonarealymesupportgroup.com/2017/10/13/dr-miller-a-new-perspective-on-lyme-disease/

Silent Epidemic of Early-Onset Alzheimer’s

http://www.thevaccinereaction.org/2017/09/the-silent-epidemic-of-early-onset-alzheimers/

The “Silent Epidemic” of Early-Onset Alzheimer’s

young woman with hands on shoulders

 

An estimated 200,000 to 275,000 people in the United States alone are believed to have early-onset Alzheimer’s disease…

A study published in the journal Surgical Neurology International in 2015 highlighted a growing trend in the onset of dementia among people under 65 years of age. The study, authored by Colin Pritchard and Emily Rosenorn-Lanng of Bournemouth University in England, found that dementia and other neurological diseases among people in 21 Western countries between the ages of 55 and 74 had dramatically increased during 1989-2010. By 2010, the average age of people developing dementia was 10 years less than in 1989.1 2 3

Dementia is increasingly being diagnosed in people in their 30s, 40s, and 50s. This phenomenon, known as “early-onset” (or “younger-onset”) dementia, has been referred to as a growing “silent epidemic” affecting younger people3 4—so much so that the media has begun to notice and report on individual cases.

People magazine recently highlighted the story of 32-year old ski instructor and photographer Becky Barletta who was diagnosed with early-onset dementia shortly after her marriage in 2015. There was the case of 29-year old mother-of-two Zoe Bottrill and the case of father-of-three Ken Dodson, also 29. The media is also reporting cases of childhood dementia, such as that of nine-year old Isobel Jeffery, two-year old Kade Gibbons, and one-year old Marian McGlocklin.5 6 7 8 9 10

An estimated 200,000 to 275,000 people in the United States alone are believed to have early-onset Alzheimer’s disease. (Alzheimer’s is the most common form of dementia.) This represents up to five percent of the estimated 5.5 million Americans with Alzheimer’s. Most people with early-onset dementia are diagnosed to have Alzheimer’s.11 12 13 14 15

The Alzheimer’s Association is projecting that by the year 2050 there will be 13.5 million Americans with Alzheimer’s.16 If the percentage of people in the U.S. with early-onset Alzheimer’s compared to the total number of people with Alzheimer’s remains constant, we may expect to have almost half a million Americans with early-onset Alzheimer’s in the next four decades. If growth trends in early-onset Alzheimer’s continue, however, we could have more than a million young to middle-aged Americans with this disease within two generations.

According to the Alzheimer’s Society, “The earlier the symptoms start, the more likely the disease is to be genetic.” This genetic form of the disease, known as “familial Alzheimer’s disease,” is caused by “rare mutations” in three genes—mutations found in 7-12 percent of people with early-onset Alzheimer’s.17 

So what accounts for the remaining roughly 90 percent of people with early-onset Alzheimer’s? The study by Pritchard and Rosenorn-Lanng suggests “environmental factors.”1 Although the study did not specify which environmental factors, some of these could include greater exposure to petrochemicals and toxic herbicides and insecticides.18 

Exposure to mercury could also be a contributing factor. In 2010, the Journal of Alzheimer’s Disease published a study showing that long-term exposure to mercury may produce Alzheimer’s-like symptoms in people.19 Neuropharmacologist Richard Deth, PhD, one of the study’s authors, concluded, “Mercury is clearly contributing to neurological problems, whose rate is increasing in parallel with rising levels of mercury. It seems that the two are tied together.”

There have also been journal studies showing exposure to aluminum could be another factor in the onset of Alzheimer’s symptoms.20 21 22 An author of one of those studies, bioinorganic chemist Chris Exley, PhD, has observed that high levels of aluminum have been found in the brains of people with early-onset Alzheimer’s. “I don’t believe [aluminum] is the only factor, but I think it is an important one which should be considered very seriously,” says Dr. Exley.22

Mercury and aluminum are found in some foods, medications, personal care products, and other consumer goods like compact fluorescent light bulbs (CFLs) and cookware. Both mercury (in the form of thimerosal) and aluminum are also used in vaccines—the former as a preservative and the latter as an adjuvant.23 24 25 26 27 28 29 30 31

 

**Comment**

There has been invaluable research in Lyme Land revealing that infections such as tick borne illness(es) including nematodes can be players in Alzheimer’s/dementia, antibiotics can often help these patients as well as anthelmintics, and due to the persistence of borrelia, we should prepare ourselves for an upcoming dementia pandemic.

https://madisonarealymesupportgroup.com/2017/01/18/a-bug-for-alzheimers/

https://madisonarealymesupportgroup.com/2016/06/09/alzheimers-byproduct-of-infection/

https://madisonarealymesupportgroup.com/2016/06/03/borrelia-hiding-in-worms-causing-chronic-brain-diseases/

https://madisonarealymesupportgroup.com/2016/08/09/dr-paul-duray-research-fellowship-foundation-some-great-research-being-done-on-lyme-disease/

https://madisonarealymesupportgroup.com/2016/11/17/antibiotics-and-alzheimers/

https://madisonarealymesupportgroup.com/2016/11/17/alzheimers-lyme/

https://madisonarealymesupportgroup.com/2017/08/18/drexel-prof-lyme-persists/

https://madisonarealymesupportgroup.com/2017/06/10/the-coming-pandemic-of-lyme-dementia/

There also has been great information coming out about the dangers of mercury and aluminum in vaccines:

https://madisonarealymesupportgroup.com/2017/09/21/aluminum-flawed-assumptions-fueling-autoimmune-disease-and-lyme/

https://madisonarealymesupportgroup.com/2016/12/08/mercury-and-autism/

https://madisonarealymesupportgroup.com/2017/09/19/autism-aluminum-adjuvant-link-corroborated/

https://madisonarealymesupportgroup.com/2017/03/30/ty-bollinger-the-truth-about-vaccines-series/

Info on the Lyme Vaccine: https://madisonarealymesupportgroup.com/2017/07/01/pbs-lyme-vaccine/
https://madisonarealymesupportgroup.com/2017/09/07/20268/ (This link has many more listed at the end of the article)

 

Autism-Aluminum Adjuvant Link Corroborated

https://medium.com/@jbhandley/new-canadian-study-autism-aluminum-adjuvant-link-corroborated-330e947f5f62

New Canadian study: Autism-Aluminum adjuvant link corroborated

BY J.B. HANDLEY September 18, 2017

In the December 2017 issue of the Journal of Inorganic Biochemistry and released online today, Dr. Christopher Shaw and colleagues at the University of British Columbia have established convincing biological evidence linking aluminum adjuvant used in vaccines to autism.

“This is the paper I have been waiting for. This paper reports measurements of cytokines in the brains of animals injected with aluminum adjuvant as neonates. The same cytokines are elevated as in human autism. IL-6 and CCL2/MCP-1 are elevated for example. Male animals are more strongly affected. It’s a perfect match to human autism.”

VANCOUVER, British Columbia — Just two weeks ago, I wrote about a study from France that raised major concerns about aluminum adjuvant used in vaccines. The French study authors wrote: “Concerns about its [aluminum adjuvant’s] safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al [aluminum]-containing vaccine administrations.”

In a nutshell, the French study found that when smaller doses of aluminum adjuvant were consistently injected over a short period of time — like during childhood vaccinations —the aluminum was more likely to end up in the brain, and the French scientists issued a stern warning about the use of aluminum adjuvant in vaccines:

In the context of massive development of vaccine-based strategies worldwide, the present study may suggest that aluminium adjuvant toxicokinetics and safety require reevaluation.


Canadian researchers establish direct link

In the December 2017 issue of the Journal of Inorganic Biochemistry and released online today, Dr. Christopher Shaw and colleagues have established convincing biological evidence linking aluminum adjuvant to autism. The study’s title alone should cause concern for parents everywhere:

Subcutaneous injections of aluminum at vaccine adjuvant levels activate innate immune genes in mouse brain that are homologous with biomarkers of autism

As the study authors state:

“It thus appears that Al [aluminum adjuvant] triggered innate immune system activation and altered cholinergic activity in male mice, observations which are consistent with those in autism. Female mice were less susceptible to Al exposure as only the expression levels of NF-κB inhibitor and TNFA were altered. Regional patterns of gene expression alterations also exhibited gender differences, as frontal cortex was the most affected area in males and cerebellum in females. Thus, Al adjuvant promotes brain inflammation and males appear to be more susceptible to Al′s toxic effects.”

It’s critical to note that the researchers found gender differences in how the mice responded, with male mice showing higher susceptibility, which is consistent with what we are seeing in autism: roughly 80% of the cases are boys.


The Canadian researchers included a diagram in their study that showed how aluminum adjuvant can contribute to an inflammatory cascade in the brain that leads to autism.


What does this mean in plain English?

Six months ago, I wrote an article about how close it appeared international scientists were to establishing a clear biological basis for how aluminum adjuvant can create autism. My article has been read more than 250,000 times, and I have heard from scientists from all over the world (most unwilling to let me quote them in public, which is its own great tragedy), including a scientist who has created a great website called Vaccine Papers. I asked “VP” about the importance of this study, and words were not minced:

This is the paper I have been waiting for.

This paper reports measurements of cytokines in the brains of animals injected with aluminum adjuvant as neonates. The same cytokines are elevated as in human autism. IL-6 and CCL2/MCP-1 are elevated for example. Male animals are more strongly affected. It’s a perfect match to human autism.

The paper includes a number of strong statements about vaccine causality.

This paper is hugely important because it shows IL-6 elevation in the brain, which of course provides a firm link to the immune activation literature. It is strong evidence supporting the al adjuvant IL-6 autism hypothesis.

Vaccines are given to babies during key phases of brain development

A Clear Hypothesis

If you would like to understand this complex issue in greater detail, I hope you will consider reading my widely read article from six months ago:

For the sake of brevity, here are the four key scientific discoveries I discussed in this lengthy article, most of which has happened in the last thirty-six months, appearing to show a clear link between aluminum adjuvant from vaccines and autism.

Discovery #1: “Maternal Immune Activation” can cause autism

Studies that support Discovery #1:

  1. Pregnancy, Immunity, Schizophrenia, and Autism.

2. Neuroglial activation and neuroinflammation in the brain of patients with autism

3. Microglial Activation in Young Adults With Autism Spectrum Disorder

4. Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6

5. Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring

6. Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors

Some helpful quotes from the above research to help contextualize Discovery #1:

“As we learn more about the connections between the brain and the immune system, we find that these seemingly independent networks of cells are, in fact, continually talking to each other. As an adult, the activation of your immune system causes many striking changes in your behavior — increased sleep, loss of appetite, less social interaction — and, of course, headaches. Conversely, stress in your life (as perceived by your brain) can influence immune function — the brain regulates immune organs, such as the spleen, via the autonomic nervous system.

Recent evidence shows that this brain-immune conversation actually starts during the development of the embryo, where the state of the mother’s immune system can alter the growth of cells in the fetal brain. As we shall see, such alterations can lead to an increased risk of schizophrenia or autism in the offspring.” — Dr. Paul Patterson, CalTech

Dr. Paul Patterson, CalTech

“There is also very striking evidence of immune dysregulation in the brain itself. Just last year, a group led by Carlos Pardo at Johns Hopkins found what they’re calling a “neural inflammation” in postmortem examination of brains of patients with autism who died between the ages of eight and 44 years. But these people weren’t infected — they died of such things as drowning or heart attacks. The study found that the microglial cells, which act as the brain’s own immune system, were activated. The study also found amazing increases of certain cytokines in the brain, and of others in the cerebro- spinal fluid. This is is a landmark paper, in my opinion. It presents the first evidence that there’s an ongoing, permanent immune-system activation in the brains of autistic people. It’s a subclinical state, because there’s no overt infection. But it’s there.” — Dr. Paul Patterson, CalTech

“In conclusion, the present PET measurements revealed marked activation of microglia in multiple brain regions of young adults with ASD. The results strongly support the contention that immune abnormalities contribute to the etiology of ASD.” — Dr. Carlos Pardo, Johns Hopkins

“Cytokines are produced by the white blood cells, and their levels in the blood increase when we get an infection…We think that maternal immune activation alters brain circuits…there’s that permanent, subclinical, altered immune state in the autistic brain — those increased cytokine levels…are they [cytokines] actually interacting with the brain in an ongoing fashion, with consequences visible in the patients’ behavior? I favor [the cytokine] hypothesis.” — Dr. Paul Patterson, CalTech

“Here we show that the cytokine interleukin-6 (IL-6) is critical for mediating the behavioral and transcriptional changes in the offspring. A single maternal injection of IL-6 on day 12.5 of mouse pregnancy causes prepulse inhibition (PPI) and latent inhibition (LI) deficits in the adult offspring.” — Dr. Paul Patterson, CalTech

“In this rhesus monkey model, MIA yields offspring with abnormal repetitive behaviors, communication, and social interactions. These results extended the findings in rodent MIA models to more human-like behaviors resembling those in both autism and schizophrenia.” — UC Davis MIND Institute

“In summary, our study supports a critical role of IL-6 elevation in modulating autism-like behaviors through impairments on synapse formation, dendritic spine development, as well as on neuronal circuit balance. These findings suggest that manipulation of IL-6 may be a promising avenue for therapeutic interventions.” —Dr. Xiaohong Li, Shanghai Jiao Tong University School of Medicine


Discovery #2: Aluminum Adjuvant causes immune activation and is far more neurotoxic than previously thought

Studies that support Discovery #2:

  1. Aluminum Adjuvant Linked to Gulf War Illness Induces Motor Neuron Death in Mice
  2. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
  3. Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations
  4. Slow CCL2-dependent translocation of biopersistent particles from muscle to brain

5. Biopersistence and brain translocation of aluminum adjuvants of vaccines

6. Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

Some helpful quotes from the above research to help contextualize Discovery #2:

“In addition, the continued use of aluminum adjuvants in various vaccines (i.e., Hepatitis A and B, DPT, and so on) for the general public may have even more widespread health implications. Until vaccine safety can be comprehensively demonstrated by controlled long-term studies that examine the impact on the nervous system in detail, many of those already vaccinated as well as those currently receiving injections may be at risk in the future. Whether the risk of protection from a dreaded disease outweighs the risk of toxicity is a question that demands urgent attention.” — Dr. Christoper Shaw, University of British Columbia

“Overall, the results reported here mirror previous work that has clearly demonstrated that aluminum, in both oral and injected forms, can be neurotoxic. Potential toxic mechanisms of action for aluminum may include enhancement of inflammation (i.e., microgliosis)…” — Dr. Christoper Shaw, University of British Columbia

“…it is somewhat surprising to find that in spite of over 80 years of use, the safety of Al adjuvants continues to rest on assumptions rather than scientific evidence.For example, nothing is known about the toxicology and pharmacokinetics of Al adjuvants in infants and children…Yet, in spite of these observations children continue regularly to be exposed to much higher levels of Al adjuvants than adults, via routine childhood vaccination programmes.” — Dr. Lucija Tomljenovic, University of British Columbia

“However, continuously escalating doses of this poorly biodegradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier…” —Dr. Josette Cadusseau, Université Paris

“Thus alum and other poorly biodegradable materials taken up at the periphery by phagocytes circulate in the lymphatic and blood circulation and can enter the brain using a Trojan horse mechanism similar to that used by infectious particles. Previous experiments have shown that alum administration can cause CNS dysfunction and damage, casting doubts on the exact level of alum safety.” — Dr. Josette Cadusseau, Université Paris

“We conclude that Alhydrogel [aluminum adjuvant] injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects. To explain this unexpected result, an avenue that could be explored in the future relates to the adjuvant size since the injected suspensions corresponding to the lowest dose, but not to the highest doses, exclusively contained small agglomerates in the bacteria-size range known to favour capture and, presumably, transportation by monocyte-lineage cells. In any event, the view that Alhydrogel neurotoxicity obeys ‘the dose makes the poison’ rule of classical chemical toxicity appears overly simplistic.” —Dr. Romain K. Gherardi, Université Paris Est Créteil (UPEC)

“In the context of massive development of vaccine-based strategies worldwide, the present study may suggest that aluminium adjuvant toxicokinetics and safety require reevaluation.” — Dr. Romain K. Gherardi, Université Paris Est Créteil (UPEC)


Discovery #3: Aluminum can increase IL-6 in the brain

Studies that support Discovery #3:

  1. Neuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling

2. Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors

Some helpful quotes from the above research to help contextualize Discovery #3:

“The results also showed that aluminum administration increased the hippocampus pro-inflammatory cytokines TNF-α by 3.8-fold, IL-6 by 4-fold, and iNOS by 3.8-fold compared to the normal control group.” —Dr. Mosaad A. Abdel-Wahhab, Cairo University

Most vaccines contain aluminum, and aluminum is a proven neurotoxin, in amounts received from vaccines. Vaccines in combination can result in toxic aluminum overload. Even the aluminum in a single vaccine can be harmful because the aluminum is in a form that is more dangerous than ingested aluminum. Specifically, vaccine aluminum is in nanoparticulate form, which is harder for the body to eliminate, and because it is transported around the body differently than ingested aluminum.

It is natural and normal to ingest small doses of aluminum from food and water. Its not good for you, but the body has adequate defenses. Absorption of ingested Al is low, about 0.3%, so about 99.7% is eliminated in feces. Ingested aluminum is in ionic form (individual charged atoms), which is readily removed by the kidneys. Also, ionic aluminum is blocked from entering the brain by the blood brain barrier. The low absorption, rapid elimination by the kidneys and barrier to brain entry adequately protects the brain from aluminum.

However, nanoparticulate aluminum from vaccines cannot be removed by the kidneys. The particles are far too large to be filtered out by the kidneys. The Al nanoparticles do dissolve slowly (converting to ionic aluminum). But long before they can dissolve completely, the Al nanoparticles are “eaten” by immune system cells called macrophages. In other words, the particles wind up inside the macrophages. Once loaded with the Al nanoparticles, the macrophages spread aluminum as they travel through the body. This is dangerous, because the Al-loaded macrophages carry Al nanoparticles to tissues (e.g. the brain) that are damaged by very small amounts of aluminum. — Vaccine Papers

“Here we show that mice with elevated IL-6 in the brain dis- play many autistic features, including impaired cognitive abilities, deficits in learning, abnormal anxiety traits and habituations, as well as decreased social interactions. IL-6 elevation caused alterations in excitatory and inhibitory synaptic formations and disrupted the balance of excitatory/inhibitory synaptic transmissions. IL-6 elevation also resulted in an abnormal change in the shape, length and distributing pattern of dendritic spines. These findings suggest that IL-6 elevation in the brain could mediate autistic-like behaviors, possibly through the imbalances of neural circuitry and impairments of synaptic plasticity.” —Dr. Xiaohong Li, Shanghai Jiao Tong University School of Medicine


Discovery #4: Hepatitis B vaccine induces IL-6 in postnatal rats

Studies that support Discovery #4:

[Author’s note: This fourth discovery was really the subject of my extensive article, because it discussed a new paper that seemed to tie everything together. The Canadian paper above ties everything together even more tightly.]

  1. Neonatal vaccination with bacillus Calmette–Guérin and hepatitis B vaccines modulates hippocampal synaptic plasticity in rats

Some helpful quotes from the above research to help contextualize Discovery #4:

“An important new study by Li et al. reports the effects of bacillus calmette-guerin (BCG) vaccine (for tuberculosis) and hepatitis B vaccine on brain development in infant rats. The study relates the observed brain changes to the type of immune activation (Th1 or Th2, explained below) stimulated by the vaccines. The BCG and hep B vaccines had opposite effects on the brain (BCG being beneficial, and hep B being detrimental), and a combination of both vaccines resulted in cancellation of the effects.

This is the first study to test the effects of immune activation by vaccination on brain development. All other studies of immune activation have used essentially pathological conditions that mimic infection and induce a strong fever. A criticism I have heard often from vaccine advocates is that the immune activation experiments are not relevant to vaccines because vaccines cause a milder immune activation than injections of poly-IC or lipopolysaccharide (two types of immune system activators).

This new study demonstrates that vaccines can affect brain development via immune activation. Hence, the immune activation experiments are relevant to vaccines…The hep B vaccine increased IL-6 in the hippocampus (the only brain region analyzed for cytokines).” — Vaccine Papers


Four discoveries, a clear path to autism

Here’s a simple graphic that I think spells out the process of triggering autism very clearly, as demonstrated by the published science I have shared with you above through the four discoveries.

The new Canadian study, just published, makes these findings even more clear, and more robust, and provides even greater detail into HOW aluminum adjuvant leads to autism.

Image created by Vaccine Papers.org

Now what?

When I published my article back in February, I heard from scientists from all over the world. I heard from pediatricians. I heard from board members at Autism Speaks. Many agreed with me: this was disturbing and important work, and it may well describe where all this autism is coming from. What’s happened since that time? Nothing.

There’s no mechanism for reviewing or putting all this published science together. The scientists doing this great work are perpetually nervous that they will lose their funding source or get “Wakefielded.” There’s no group responsible for putting all these published scientists in a room and figuring out what we do about this giant mess, and what all this information means. Every minute, a new child is diagnosed with autism, and every minute, it strikes me that autism may be completely AVOIDABLE. If you’re reading this, all I can ask is that you share the information widely, and that if you happen to be in a position of influence, please help save our kids.

In my opinion, we are much, much closer to understanding how autism has been triggered in so many children, and I hope this article is another step on the path to the truth. And, for so many of you out there doing everything you can to help you son or daughter with autism live the best possible life, perhaps a clearer understanding of how their autism was triggered will improve their chances for recovery.


Addendum

For those of you interested in hearing from Dr. Shaw directly, here’s a video excerpt (just under 2 minutes) from the movie The Greater Good where Dr. Shaw discusses an earlier study he and his colleagues conducted looking at aluminum adjuvant (Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration):


J.B. Handley is the father of a child with Autism. He and his wife co-founded Generation Rescue, a national autism charity. He spent his career in the private equity industry and received his undergraduate degree with honors from Stanford University. He is also the author of “The Only Vaccine Guide a New Parent Will Ever Need” , An Angry Father’s Guide to Vaccine-Autism Science”, and “7 reasons CDC employees should be “crying in the hallways” Mr. Handley has started a podcast called “How to End the Autism Epidemic” — you might enjoy his first six interviews:

 

**Comment**

I’m posting this because it should be important to everyone; however, whenever you talk about the immune system and cytokines, Lyme/MSIDS patients should sit up and take notice.  Due to a pathogen storm, we have a cytokine storm, confusing our immune systems and giving us boatloads of pain among other horrific symptoms.  This is also a sound warning about receiving any vaccinations while infected as they are designed to introduce many foreign substances into the body so the body mounts a response.  Our immune systems are already confused by a pathogen invasion.  In fact, the question truly begs to be asked, are vaccines ever safe for infected patients?  Also, it is important to point out that it is believed that children can get infected congenitally, which means they come out of the shoot compromised.  What does vaccination do to them?

So much is unknown and unproven.  Our children are too important not to search out the answers as inconvenient as they may be.

Every Lyme/MSIDS patient I know has regressed after a vaccination.  Food for thought.

For more on vaccines:  https://madisonarealymesupportgroup.com/2017/03/30/ty-bollinger-the-truth-about-vaccines-series/

https://wordpress.com/post/madisonarealymesupportgroup.com/17421  Dark Ages of Immunization Medicine Are NOW

https://madisonarealymesupportgroup.com/2017/07/21/class-and-race-profiling-in-the-vaccine-culture-war/

Info on the Lyme Vaccine:  https://madisonarealymesupportgroup.com/2017/07/01/pbs-lyme-vaccine/

https://madisonarealymesupportgroup.com/2017/09/07/20268/  (This link has many more listed at the end of the article)

 

MS Cure?

Photo Credit: UK Business Weekly

https://www.healthnutnews.com/this-scientist-is-on-the-verge-of-curing-multiple-sclerosis-for-2-3-million-patients/  by Erin Elizabeth, Health Nut News, Aug. 31, 2017

Multiple sclerosis is a terrible and debilitating disease where the body’s immune system is directed against the central nervous system. When that happens, according to the National MS Society:1

  • Within the CNS, the immune system attacks myelin — the fatty substance that surrounds and insulates the nerve fibers — as well as the nerve fibers themselves.
  • The damaged myelin forms scar tissue (sclerosis), which gives the disease its name.
  • When any part of the myelin sheath or nerve fiber is damaged or destroyed, nerve impulses traveling to and from the brain and spinal cord are distorted or interrupted, producing a wide variety of symptoms.

Currently, there is no cure. Medication can often help make symptoms like double vision, blindness, as well as psychological or muscle issues more bearable but ultimately it robs people of their lives and shortens life expectancies. But that may all be changing.

Dr. Su Metcalfe believes that the attack on the nerve cells can be stopped thanks to a new medical development her company LIFNano has created. 2

She said in an interview:

“Some people get progressive MS, so go straight to the severe form of the disease, but the majority have a relapsing or remitting version.

It can start from the age of 30, and there’s no cure, so all you can do is suppress the immune response, but the drugs that do that have side effects, and you can’t repair the brain. The cost of those drugs is very high, and in the UK there are a lot of people who don’t get treated at all.” 3

Using the stem cell particle LIF, which is a part of the immune cell and is able to control and confine the attack on our bodies, she found a “small binary switch” which is able to regulate itself INSIDE the immune cell to NOT attack our body. However, it can attack when it needs to.

She went on to say,

“That LIF, in addition to regulating and protecting us against attack, also plays a major role in keeping the brain and spinal cord healthy. In fact it plays a major role in tissue repair generally, turning on stem cells that are naturally occurring in the body, making it a natural regenerative medicine, but also plays a big part in repairing the brain when it’s been damaged.” 4

Much more research needs to be done but this breakthrough seems quite promising and the team has set their sights on having found the cure by 2020.

Dr. Metcalfe also believes she and her team might be able to tackle dementia as well because LIF is a “major health factor for the brain.5 Therefore, if they can get into the brain and protect it, it serves that they could prevent dementia.

**Comment**

This is indeed great news for Lyme/MSIDS patients due to the fact many with MS, dementia, and Alzheimer’s are initially misdiagnosed with those labels but are actually infected and vice versa.  All in all, many autoimmune diseases will potentially benefit from this treatment.

https://madisonarealymesupportgroup.com/2017/06/26/important-example-of-iv-antibiotics-for-lymemsids/

https://madisonarealymesupportgroup.com/2016/04/10/bugs-causing-alzheimers/

https://madisonarealymesupportgroup.com/2017/01/04/aluminum-alzheimers-ld/

Iowan, Jack Gordon, is a case discovery of 2 diseases NEVER found together before on 11.22.2015: Lewy Body Dementia, causing violent hallucinations, and Lyme Disease/MSIDS. Using his medical files, he was bitten by a tick 35 yrs. ago, but the doctors never acknowledged it by diagnosing or treating him.

You may recognize Lewy Body Dementia as what Robin Williams’ autopsy revealed:  https://madisonarealymesupportgroup.wordpress.com/2016/03/28/did-robin-williams-have-lyme/
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-90
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551238/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399390/
https://www.scientificamerican.com/article/controversial-new-push-to-tie-microbes-to-alzheimer-s-disease/

 

Drexel Prof: Lyme Persists

https://newsblog.drexel.edu/2017/07/18/qa-what-happens-when-lyme-disease-is-not-treated-early/ by Lauren Ingeno July 18, 2017

Original Title: I.pacificus(F)_55sRGBBlacklegged ticks are known vectors for the bacteria Borrelia burgdorferi, which is the pathogen responsible for Lyme disease. Summer is tick season. (CDC / James Gathany)

Pennsylvania is the Lyme disease epicenter, with over 7,000 cases diagnosed in 2015.

The disease is caused by the spirochete bacteria Borrelia burgdorferi, which is carried by ticks and then transmitted to humans. When treated early, antibiotics can cure most patients. But making a diagnosis is often challenging, and chronic symptoms — such as memory problems, digestive issues and joint conditions — can linger for years, even after treatment.

Chronic Lyme is a controversial issue, dividing frustrated patients and some in the medical community who do not view their disease as a persistent infection. The Infectious Diseases Society of America, for instance, does not recommend longer courses of antibiotics even when symptoms continue.

Garth Ehrlich, PhD, a professor of microbiology and immunology at Drexel University College of Medicine, studies how chronic bacterial pathogens prevail after antibiotic therapy, and he was recently quoted in an Associated Press story about a Lehigh Valley woman who contracted the disease.

Below, he weighs in about chronic Lyme disease and why it is so hard to eliminate.

 What is the connection between your research and Lyme disease?
Lyme disease, in its persistent form, is most likely due to the bacteria forming a biofilm. I study bacterial biofilms, which are multicellular forms of bacteria, providing for increased resistance to antibiotics. If Lyme disease patients are not treated early enough or long enough, then it is possible the bacteria will form biofilms, and their acute disease will become chronic.

How is Lyme disease currently treated, and does that treatment work?
In many cases, Lyme can be treated by antibiotics, but it does not necessarily mean the disease won’t become chronic. There are many factors that contribute to the course of the disease, including the overall health and immune status of the patient, as well as the particular strain of the Lyme disease bacteria that they contract.

Why is there disagreement among the medical and scientific communities about chronic Lyme disease?
A few physicians involved in characterizing the disease in the early stages of its recognition staked their reputations on the fact that it only had an acute phase. But the bacteria that causes Lyme is a spirochete, and spirochetes are primarily associated with chronic infections, like gum disease and syphilis.

How is Lyme disease diagnosed? What are the challenges?
There is a huge problem with diagnosing it, and there are many reasons why it is difficult. There are two stages for the standard testing: an ELISA (enzyme-linked immunosorbent assay) is used to detect antibodies against B. burgdorferi proteins and a Western blot (used to separate and identify specific antibody proteins), which is more specific and used for confirmation of the ELISA.

Scientists are working to develop DNA-based tests, but they are not widely available yet, and they won’t be perfect. The problem with both types of testing is that there is enormous variability among the bacterial strains that cause the disease. Thus, an assay based on one strain might very well miss variant strains. And different individuals mount more or less of an immune response to the infection. If the infection becomes focal, then you might not be able to detect it with a DNA blood test.

What do we need to do to better combat Lyme disease?
The most important thing is to develop better diagnostics. And the next most important thing is better therapeutics. My lab is trying to develop drugs against biofilm bacteria.

For media inquiries, contact Lauren Ingeno at lingeno@drexel.edu or 215.895.2614.

________________________________________________________________________________________

**Comment**

Fantastic article revealing Oz behind the curtain:  biofilms.

I appreciate the careful wording about treating early – that it can cure most patients; however, the caveat is that treatment has to be early enough AND long enough.  I would add, and smart enough.  https://madisonarealymesupportgroup.com/2016/02/13/lyme-disease-treatment/

That said, there is an elephant in the room.  Since Eva Sapi discovered in vitro that doxycycline throws the spirochete into the cyst form, is it hiding out to reemerge later?  Many think so, and believe Lyme can be contributing to dementia and Alzheimer’s which means treatment should also include not only something that addresses biofilms, but something that addresses the non-cell wall form (even in acute cases).  For more:  https://madisonarealymesupportgroup.com/2016/06/03/borrelia-hiding-in-worms-causing-chronic-brain-diseases/

https://madisonarealymesupportgroup.com/2016/08/09/dr-paul-duray-research-fellowship-foundation-some-great-research-being-done-on-lyme-disease/

https://madisonarealymesupportgroup.com/2017/06/10/the-coming-pandemic-of-lyme-dementia/

The other elephant standing by the first is the prevalence of coinfections.  Research is absent on the compounding factors of coinfections.  For more:

https://madisonarealymesupportgroup.com/2017/05/01/co-infection-of-ticks-the-rule-rather-than-the-exception/

https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/