Archive for the ‘Alzheimer’s’ Category

Increased Occurrence of Treponema spp. and Double-Species Infections in Patients With Alzheimer’s Disease

Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer’s disease rights and content


  • Detection of five bacterial and five viral pathogens in serum and cerebrospinal fluid.
  • An increased frequency of Alzheimer’s disease patients positive for Treponema spp.
  • A significantly higher prevalence of cases with two and more simultaneous infections.
  • The studied pathogens were widespread equally in serum and cerebrospinal fluid.
  • Paralleled analysis of multiple sample specimens provides complementary information.


Although the link between microbial infections and Alzheimer’s disease (AD) has been demonstrated in multiple studies, the involvement of pathogens in the development of AD remains unclear. Here, we investigated the frequency of the 10 most commonly cited viral (HSV-1, EBV, HHV-6, HHV-7, and CMV) and bacterial (Chlamydia pneumoniaeHelicobacter pyloriBorrelia burgdorferiPorphyromonas gingivalis, and Treponema spp.) pathogens in serum, cerebrospinal fluid (CSF) and brain tissues of AD patients. We have used an in-house multiplex PCR kit for simultaneous detection of five bacterial and five viral pathogens in serum and CSF samples from 50 AD patients and 53 healthy controls (CTRL). We observed a significantly higher frequency rate of AD patients who tested positive for Treponema spp. compared to controls (AD: 62.2 %; CTRL: 30.3 %; p-value = 0.007). Furthermore, we confirmed a significantly higher occurrence of cases with two or more simultaneous infections in AD patients compared to controls (AD: 24 %; CTRL 7.5 %; p-value = 0.029). The studied pathogens were detected with comparable frequency in serum and CSF. In contrast, Borrelia burgdorferi, human herpesvirus 7, and human cytomegalovirus were not detected in any of the studied samples. This study provides further evidence of the association between microbial infections and AD and shows that paralleled analysis of multiple sample specimens provides complementary information and is advisable for future studies.

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Dr. Alan McDonald: Lyme Links to Alzheimer’s, Cancer, Leukemia, Liver Damage, & Suicide


So thankful someone listened to the entire podcost and broke it down in this handy article.  I try to do this but sometimes get overwhelmed with the length and amount of material, and neglected to break down Dr. McDonald’s latest work.  I regret this as I consider McDonald an expert and a true help for Lyme patients.  Every word that proceeds out of this man’s mouth is informative.  Now we can all enjoy the information he presented in the podcast in the article which follows.  Enjoy!

Pioneering researcher discusses Lyme links to Alzheimer’s and more

April 4, 2023

From the Tick Boot Camp Podcast:

In this eye-opening episode, Dr. Alan McDonald unveils his latest findings, revealing the connections between Lyme disease and an array of serious health issues, including Lewy body dementia, liver damage, leukemia, brain cancer, and even suicide.

This compelling conversation underscores the urgency of broadening our understanding of Lyme disease to better support and treat patients.

Dr. McDonald’s research has led to several groundbreaking discoveries, including:

  1. Lyme Disease Triggers Lewy Body Dementia: Dr. McDonald has discovered a link between Lyme disease and Lewy body dementia, a neurodegenerative disorder that affects the brain. His research has shown that Lewy bodies contain Borrelia DNA, the bacteria responsible for Lyme disease, challenging previous assumptions about the nature of Lewy bodies.
  2. Lyme Disease Causes Liver Damage: Dr. McDonald has found that nearly 20% of acute early Lyme patients suffer from liver issues related to the disease. Early treatment of Lyme disease can help prevent liver damage and its detrimental effects on the body’s detoxification process.
  3. Lyme Disease Linked to Leukemia: Dr. McDonald’s research has also identified a connection between Lyme disease and chronic lymphocytic leukemia, opening up possibilities for improved diagnosis and treatment options for patients affected by both conditions.
  4. Lyme Disease Initiated Brain Cancer: The podcast highlights Dr. McDonald’s ongoing research on glioblastomas, a form of brain cancer, and its association with Lyme disease. This research has the potential to lead to new treatment options and a better understanding of the disease’s impact on the brain.
  5. Lyme Disease and Suicide: The podcast also addresses the crucial connection between Lyme disease and suicide, emphasizing the importance of understanding and supporting patients struggling with the psychological impact of Lyme disease.
  6. Lyme Disease Intelligently Evades Tests: Dr. McDonald’s research illustrates the Lyme bacteria’s ability to sequester itself in the body, leading to false-negative test results and leaving many Lyme patients undiagnosed and untreated.

Click here to listen.

It’s also available on Apple podcasts, Google podcast, and Spotify.



As I read this, I was again hit hard with the fact that this seriously incredible information isn’t even on the radar of mainstream research/medicine/public health.  After 40 years we haven’t budged on understanding this complex illness which typically includes far more than just Lyme, which is why many call it MSIDS or multi systemic infectious disease syndrome or Lyme and company.  Lyme alone is formidable, but add in a few coinfections just as nasty and you are one sick dog.  McDonald and a few others are the rare scientists who aren’t led by the government narrative/paradigm and who do not have conflicts of interests that obviously make them biased.  Further, they obviously look harder and don’t quit when they get the accepted result.

Hopefully the last few years have awakened many to the fact science has been hijacked; however, science has always been hijacked in many areas and Lyme/MSIDS is one of them.  I would put vaccines, cancer, autism, MS, chronic fatigue, and many others in this camp as well.  Currently, these diseases are huge money makers and the ‘powers that be’ are raking in royalties and other monies and don’t want their cash cows to stop.  Public health is the last thing on their minds.  If these diseases are in fact triggered or caused by hidden infections, they could be helped by cheap, already existing antimicrobials that could be repurposed.  As we have clearly seen with COVID, those controlling the narrative simply can’t allow this to happen.

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9 Leading Experts: RF Radiation Can Lead to Brain Damage, Alzheimer’s & Also Cancer According to Four Experts

9 Leading Experts: RF Radiation Can Lead to Brain Damage, Alzheimer’s

Research on 5G radiofrequency (RF) radiation shows it can cause brain damage and possibly lead to dementia and Alzheimer’s disease, according to nine independent experts in the RF radiation field who published a new peer-reviewed article.

This article was originally published by The Defender — Children’s Health Defense’s News & Views Website.

Research on 5G radiofrequency (RF) radiation shows it can cause brain damage and possibly lead to dementia and Alzheimer’s disease, according to nine independent experts in the RF radiation field.

In a peer-reviewed article published last week in the Annals of Clinical and Medical Case Reports, the experts called on authorities to heed the voices of the RF scientific community by establishing a “more stringent regulatory framework” on RF radiation and by halting the rollout of 5G technologies — including smart meters and 5G cell towers — until a team of “qualified scientists independent of industry” review the risks of the technology.

“The situation is absurd,” said Mona Nilsson, managing director of the Swedish Radiation Protection Foundation and lead author of the article.

Although the first two studies ever published on 5G’s effects on humans and animals reported serious adverse health effects, government authorities and telecom companies continue to put 5G cell towers and smart meters on and around people’s homes, Nilsson told The Defender.

Dr. Lennart Hardell, a leading scientist on cancer risks from radiation and co-author of the article, told the Defender, “I think it is time to have an ethical discussion.”

“What kind of society should we have?” asked Hardell, an oncologist and epidemiologist with the Environment and Cancer Research Foundation who has authored more than 100 papers on non-ionizing radiation.

“Is it possible for the government to expose people to hazardous pollution in their own homes and you can’t escape?” he asked.

From an ethical point of view, that’s a very problematic societal situation, Hardell said.

So much research and ‘still nothing happens’

Hardell, Nilsson and their co-authors are leaders of independent organizations in Norway, Sweden, Denmark and Finland that focus on RF radiation.

They said the first study on 5G’s effects showed people experienced a plethora of symptoms — including severe sleep disturbances, dizziness, skin complaints, concentration problems, tinnitus, impaired short-term memory, confusion, fatigue, tendency toward depression, heart and lung symptoms and heart palpitations — days after a 5G cell tower was installed above their apartments.

The second 5G study showed rats exposed to 5G had an increased incidence of damage to neurons and increased oxidative stress in the brain.

These effects could eventually lead to degenerative brain diseases, such as dementia, Alzheimer’s and other neurological diseases, the authors said.

Nilsson said there are many earlier studies showing detrimental effects from RF radiation on the brain and nervous system.

According to a compilation by Henry Lai, Ph.D., a professor emeritus of bioengineering at the University of Washington, 244 studies between 2007 and 2022 showed negative neurological effects from RF radiation, Nilsson said.

We have so much research and we have so many scientists that are raising their voices louder and louder — and still nothing happens because those institutions that have influenced the authorities … are captured by the industry,” Nilsson said.

Hardell and Rainer Nyberg, Ph.D., a professor emeritus of education and welfare studies at Åbo Akademi University in Finland and a co-author on the article, launched in 2017 the 5G Appeal, which asks policymakers to halt 5G deployment due to the risk of serious human health consequences until the risks have been investigated by scientists with no ties to industry.

As of Jan. 10, 430 medical doctors and scientists from around the world have signed the 5G Appeal.

Despite the accumulating scientific evidence of harmful effects, authorities “continue to ignore the increasing evidence of clear risks,” the authors said in their article.

Regulatory authorities claim current guidelines are sufficient to protect people from harm. But they rely on a “limited group of experts” — who are not representative of the scientific community at large — to support their position, according to the authors.

Moreover, the majority of these experts have “ties to the telecom companies,” the authors said.

What’s needed to fix the problem?

The authors said a new committee comprised of qualified scientists independent of the industry is urgently needed for a sound scientific evaluation of 5G.

Until then, “the 5G rollout must stop,” they said.

5G Rollout a ‘violation of human rights’

Given that 5G RF radiation levels are well above levels known to be harmful to human life and wildlife, the author considered it “a violation of human rights to impose this harmful radiation on people in their own homes without their informed consent.”

“This is a clear violation of human rights [that is] a consequence of the corruption of the science and the experts who have the role … of evaluating the science,” Nilsson said.

Hardell said he was pessimistic that regulatory authorities would heed the advice he and his co-authors offer in their latest article.

“The industry and the politicians … have decided, ‘No problem, so let’s go on,’” he said.

Nonetheless, Hardell said the article — and the 5G Appeal — are important historical documents showing that scientists warned about the health effects of 5G.

Plus, he said, it’s important that scientists continue writing on the topic — because how can they do otherwise, as ethical human beings?

The case reports published by Hardell and Nilsson on 5G’s effects showed that people had to leave their homes to get relief from their symptoms, Hardell emphasized.

“Do we really have an environmental pollutant that’s so strong or hazardous that people have to leave their own homes? I mean, how can we tolerate that?” he asked.

Hardell said he was especially concerned about those who are poor.

The individuals featured in the case reports had the means to relocate for the sake of their health, but most people don’t have the economic resources to do that, he said.

This article was originally published by The Defender — Children’s Health Defense’s News & Views Website under Creative Commons license CC BY-NC-ND 4.0. Please consider subscribing to The Defender or donating to Children’s Health Defense.


Top Scientists Find ‘Substantial Scientific Evidence’ RF Radiation Causes Cancer

Based on the results of their landmark review of the latest science, four of the world’s top experts in environmental health called for prevention and precaution when it comes to public exposure to radiofrequency radiation.

Four of the world’s top experts in environmental health are calling for prevention and precaution when it comes to public exposure to radiofrequency (RF) radiation.

The scientists — including the former director of the U.S. National Toxicology Program (NTP) — last month published a preprint review of the most recent studies on the effects of electromagnetic radiation (EMR) and RF radiation on different life forms and humans, and the epidemiological evidence for cancer due to RF radiation from cellphone use.

The authors concluded there is “substantial scientific evidence” that “RF radiation causes cancer, endocrinological, neurological and other adverse health effects” — and that the U.S. Federal Communications Commission (FCC) has failed to protect public health.

They accused the FCC of ignoring the “Precautionary Principle,” commonly used in toxicology, and also the Bradford Hill criteria, a set of principles commonly used in epidemiology for establishing a causal relationship, in evaluating the risks of RF radiation. (See link for article) 



The article states besides causing cancer, EMR/RF can cause DNA damage, adversely affect fetal development and the functions like a classic endocrine disruptor.

For more:

Reversible Dementia Caused By Lyme: Case Study

A case of reversible dementia with Lyme treatment?

Annals of Geriatric Medicine and Research (Sanchini, C., et al.) 2.6.23, published “A case of reversible dementia? Dementia vs delirium in Lyme disease.” The report describes a case of a 75-year-old man who was admitted to the Alzheimer’s Disease Care Unit of the Institute Golgi in Abbiategrasso, Italy.

According to the case report, the man had been recently discharged from a local hospital with a diagnosis of “cognitive impairment, deficit of memory, and poor capacity of criticism compatible with degenerative disease.”

The patient was a multilingual interpreter with a high school degree. He enjoyed walking in the countryside with his dog, but he had been experiencing knee pain – for about a month. The pain would worsen and migrate to his other joints. The case also reports that he had been showing minor memory deficiency and ideomotor slowdown.

A CT scan showed abnormalities, but blood tests were within normal ranges, the only thing noted was increased inflammation. As time went on, the patient became more confused and disoriented, presenting with hallucinations, aggressive behavior, and insomnia.

With the patient having arthritis, he was tested for Lyme. Lyme antibodies were detected by the western blot. Initial intravenous ceftriaxone treatments did not alleviate the patient’s symptoms. Oral doxycycline was administered as well as a brief course of quetiapine to manage the hallucinations.

Soon after 6–7 days of antibiotic therapy, delusional symptoms and hallucinations were reduced, and his insomnia improved. Urinary incontinence completely resolved. His behavioral profile also improved, with a reduction in agitation, aggression, and depression. His language became more fluent and communicative.

Read the full case study here.



This proves that antimicrobial therapy helps Lyme/MSIDS patients, unfortunately, this patient will most probably suffer relapses as this duration of therapy has been proven to be insufficient time and time again.  Herein lies one of the most glaring problems that has not changed in 40 years.  The other glaring problem is the coinfection involvement that often occurs, necessitating different medications.

But, the band plays on…..

For more:

How many more dementia/Alzheimer’s patients have undiagnosed tick-borne illness?

CoQ10: What is It & Do You Need It?

CoQ10: What is it & Do You Need It?

By Holtdorf Medical Group

Do You Need CoQ10?

As the body ages, many systems and functions begin to decline and deteriorate. Common problems associated with aging include reduced energy, cognitive troubles, fertility issues, and of course greater risk of cardiovascular and neurodegenerative disease. Many assume that these difficulties are an unavoidable part of getting older. However, this may not be the case.

Is CoQ10 the Answer?

CoQ10 is a substance that naturally occurs in the body and is an important part of healthy bodily function. As we get older, levels of CoQ10 decline, which can contribute to various difficulties and health issues associated with aging. By maintaining or restoring appropriate levels of CoQ10 through effective supplementation, you may be able to significantly reduce the risk of age-related issues and support long-term wellness. CoQ10 influences many bodily functions but perhaps its greatest impact is on energy production. CoQ10 is stored in mitochondria, which are responsible for producing cellular energy in the form of adenosine triphosphate (ATP). ATP is the most widely utilized form of energy throughout the body. CoQ10 is necessary for ATP production. Therefore, without an adequate supply of CoQ10, cells can experience a cellular energy deficit resulting in widespread dysfunction. Issues associated with poor CoQ10 levels include heart disease, fibromyalgia, neurological and neurodegenerative disorders, diabetes, muscle conditions, cancer, and others.

Getting the CoQ10 Your Body Needs

Most individuals are able to acquire enough CoQ10 to maintain healthy bodily functions. However, tissue levels of CoQ10 decline with age. Other factors including nutrient deficiencies, genetic issues, mitochondrial disease, medications such as statins, and oxidative stress can further contribute to CoQ10 deficiency. Despite CoQ10 being found in common foods including beef, chicken, fish, and whole grains, there are many individuals who suffer from a deficiency. Part of the reason may be that CoQ10 has a low absorption rate when acquired from food sources. Because of this, an individual may have poor CoQ10 levels even if they consume a high volume of foods containing CoQ10. An effective and safe solution to poor CoQ10 acquisition is supplementing with a product such as HoltraCeuticals’ CoQ10 Plus. CoQ10 Plus is a supplement that provides high-quality and easily absorbed CoQ10.

HoltraCeuticals developed the supplement with the goal of improving individual wellness and longevity. To achieve this goal, specific elements have been included in CoQ10 Plus. CoQ10 Plus utilizes soft gel capsules that improve absorption, meaning that the CoQ10 contained within is more easily utilized by the body. CoQ10 Plus also contains Vitamin E, which has been shown to work synergistically with CoQ10. Studies show that the combination of these two substances provides better absorption and greater antioxidant action than if they were to be taken separately. Greater absorption and quality ingredients make CoQ10 Plus an exceptional supplement that can be used to support long-term wellness.

Benefits of Supplementing with CoQ10

Supplementing with CoQ10 provides a wide range of benefits that support sustained wellness and longevity. Its influence can be seen in areas including metabolic activity, antioxidant action, and safeguarding heart health. Below are several areas that are benefited by supplementing with CoQ10.

Combatting Free Radical Damage

Free radicals cause oxidative damage, which is a primary contributor to issues and disorders commonly associated with aging. An excess of free radicals can cause oxidative damage, which weakens cell membranes, damages DNA, and disrupts cell function. When maintained at the appropriate volume, CoQ10 within mitochondria protects against free radicals and other agents of oxidation. Therefore, supplementing with CoQ10 may provide protection against age-related illness and dysfunction.

Protecting Against Neurological Disorders

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are triggered by a lack of energy in brain cells. As mentioned above, mitochondria are the primary producers of cellular energy. Mitochondrial function declines with age due in part to oxidation. In addition to cellular damage, oxidation triggers the production of harmful substances that disrupt neurological function. Such disruption can cause a reduction in memory, motor skills, and cognitive ability. Supplementing with CoQ10 helps protect mitochondrial function and may reduce the production of neurological-disrupting substances, thereby limiting the progression of neurodegenerative disease.

Reducing Risk of Heart Disease

A major contributor to heart disease is oxidative damage and inflammation in veins and arteries. Once these elements reach a certain threshold, they can inhibit the heart’s ability to contract and relax. This results in heart failure or stroke. There is a notable concentration of CoQ10 in the cardiovascular muscle that helps prevent oxidation and inflammation that can lead to cardiovascular episodes. Supplementing with CoQ10 can help protect heart health by combating oxidative and inflammatory agents in veins, arteries, and heart muscles.

Combatting Infertility

Supplementing with CoQ10 may be able to resolve infertility issues in both men and women. In men, sperm count and quality declines with age, due primarily to oxidative damage. Similarly, women experience a decline in egg production and quality as oxidative damage accrues. Regardless of gender, the antioxidant properties of CoQ10 help protect against oxidation that contributes to infertility.

Reducing Headaches & Migraines

Those who are deficient in CoQ10 frequently experience headaches and migraines. Poor mitochondrial activity can increase cellular uptake of calcium resulting in greater production of free radicals and reduced antioxidant activity. When the mitochondria in brain cells become damaged or disrupted due to increased oxidation, the brain becomes starved for energy. An energy deficit in the brain can trigger headaches and migraines. As a guardian of mitochondrial activity, CoQ10 safeguards cellular activity, limits inflammation, and supports energy production in the brain. The protective action of CoQ10 may help limit cognitive difficulties and reduce the occurrence of migraines or other head pains.

Support Sustained Wellness with CoQ10 Plus

Aging is a major concern for many people. Fortunately, it is possible to combat the oxidative damage that causes the many troubles associated with growing older. CoQ10 is a critical precursor enzyme produced by the body that supports and protects many systems including the heart and brain. Ensuring that the body has an adequate supply of this important substance protects against incremental oxidative damage and promotes long term wellness. Safeguard your future health by supplementing with a high-quality CoQ10 supplement such as HoltraCeuticals’ CoQ10 Plus

Holtorf Medical GroupThe Holtorf Medical Group specializes in optimizing quality of life and being medical detectives to uncover the underlying cause of symptoms, rather than just prescribing medications to cover-up the symptoms. We are experts in natural, prescription bioidentical hormone replacement and optimization, complex endocrine dysfunction, fibromyalgia, chronic fatigue syndrome and Lyme disease. We’ve dedicated our practice to providing you the best in evidenced-based, integrative medicine that’s not only safe and effective, but provides measurable results.