Archive for the ‘Biofilm’ Category

Lyme Disease & Biofilms: What You Need to Know

https://rawlsmd.com/health-articles/understanding-biofilm?

Lyme Disease + Biofilms: What You Need to Know

by Dr. Bill Rawls
Updated 3/30/21

If you’ve tried everything to get well to no avail, chances are you’re feeling frustrated, confused, and exhausted. After all, which stone could you possibly have left unturned? Many people blame their persistent symptoms of chronic Lyme disease on the slimy collections of microorganisms known as biofilms, as suggested in the recent review article in Frontiers in Neurology.

But are biofilms really what’s stopping you from getting better? Here, we’ll take a closer look at these micro-communities to understand what they are and how they contribute to certain chronic illnesses. Though biofilms are interesting, the role they actually play in chronic Lyme disease may be minor.

What Are Biofilms?

Biofilms are colonies of microbes. They chiefly contain bacteria, but biofilms can also include protozoa and fungi. Biofilms form anywhere there is moisture and a surface. In other words, everywhere — including many surfaces inside the human body. The ring inside your toilet bowl and plaque on your teeth are examples of biofilm.

Certain types of bacteria initiate biofilms that can attach to a moist surface with specialized adhesion structures called pili. Once adhered to the surface, bacteria stick together and produce a matrix of slime called extracellular polymeric substance (EPS). After the matrix has been established, other kinds of microbes can join, creating a structured community. To get a sense of how a biofilm operates, imagine a crowded dance floor with bodies squeezed together, forming a uniform mass, swaying to the rhythm of the music.

A polysaccharide shell on the biofilms’ surface protects the organisms inside from starvation, drying out, the immune system, and antibiotics. The surface can include minerals, such as calcium, and blood products, including fibrin. Safe inside the biofilm, microbes are free to mingle and exchange information. Communication between bacteria, called quorum sensing, is accomplished by signaling molecules. Once a community is formed, particular groups of microbes take on specialized roles of performing metabolic functions for the entire unit. For example, water channels develop within the biofilm for moving nutrients and signaling molecules. The biofilm grows by cell division and recruitment of new individuals.

Reasons Microbes Form Biofilms

  • Conserve nutrients and energy and avoid starvation
  • Bypass the host’s immune system
  • Avoid antibiotics
  • Join forces with other microbes and increase the chances of long-term survival

In essence, the biofilm becomes an organism unto itself. Biofilms are as ancient as any lifeform. They were likely the bridge between single-cell organisms and higher multi-cell organisms.

How Biofilms Work

Biofilms cause illness by damaging the surfaces to which they attach. Additionally, if a biofilm matures and becomes massive enough, it can cause obstructions in organs or impede the function of medical equipment such as stents or catheters. Once a biofilm reaches a certain size (maturation II stage), it disperses, allowing inhabitants to spread and colonize other surfaces. As a means of survival, bacteria in the body are always trying to form new biofilms, and the immune system is constantly working to break them down.

The following graphic illustrates the 5 stages of biofilm development:
circle map with arrows connecting five circles. 1. Initial attachment 2. Irreversible attachment 3. Maturation I 4. Maturation II 5. Dispersion

Common Biofilm Diseases

Typical biofilm diseases occur where there are surfaces and moisture present for the biofilm to form. Examples of biofilm diseases include:

  • Bacterial vaginosis: Associated with biofilm in the vaginal wall.
  • Chronic urinary tract infections: Biofilm on the bladder wall is a contributing factor.
  • Middle-ear infections: Biofilms are linked to chronic middle-ear infections.
  • Heart valve infections: Microbes may attach and form biofilms on heart valves or tissues surrounding the heart.
  • Chronic vertigo: Caused by calcium deposits in the inner ear and may be a form of biofilm.
  • Dental plaque and gingivitis: Classic examples of biofilm found in the mouth.
  • Chronic sinusitis and chronic bronchitis: Associated with biofilm in sinuses and bronchial tubes.
  • Arterial plaque buildup: Responsible for heart attacks and stroke, arterial plaques have many characteristics of biofilm and are often found to harbor bacteria.
  • Hospital infections: Indwelling devices such as catheters are associated with biofilms.

Biofilms readily occur in the intestinal tract. In fact, the formation of biofilms in the colon and appendix is quite normal and supported by the immune system.

Is There a Link Between Lyme Disease and Biofilms?

There has been a lot of talk on Lyme forums about Lyme disease being a biofilm disease. This idea stems primarily from a study done in a lab showing Borrelia, the bacteria associated with Lyme disease, could participate in forming a biofilm.

No doubt, Borrelia can form a biofilm inside a test tube. Forming and participating in biofilm is a natural trait for almost any bacteria. Indeed, if you can’t join in on a biofilm, you’re not much of a bacteria. But most of the symptoms associated with chronic Lyme disease aren’t consistent with biofilm diseases. Biofilms cause localized symptoms primarily by damaging the surface they adhere to. Symptoms of chronic Lyme disease are systemic.

White blood cells, red blood cells, and in blood stream, borrelia disrupting immune system communication.

The symptoms of chronic Lyme disease and persistence against antibiotics are best explained by the fact that Borrelia is an intracellular bacteria. When the Borrelia spirochetes enter the bloodstream, they hitch a ride inside white blood cells and travel to tissues throughout the body, including the brain. Once they arrive at targeted tissue sites — heart, brain, joints, muscles — they emerge and infect other cells. Inside the cell, they can lose their wall and become an l-form bacteria. This, and being shielded inside the cell, provide protection from antibiotics and immune system functions.

The bacteria cannibalize the cell to generate new microbes and then emerge to infect other cells.

Symptoms of chronic Lyme disease are caused not only by bacterial activity invading cells, but also by the immune system’s efforts to eliminate cells that have been infected with bacteria.

The concentrations of cells that have been infected with bacteria, compared to normal cells, is not great. Considering the bacteria are a hundred times smaller than our cells, even millions of bacteria spread out among the trillions of cells in the body isn’t a high concentration of bacteria — tissues are only lightly peppered with infected cells. To take out infected cells nestled among normal cells, the immune system targets the abnormal cells with antibodies, but in the process, there is collateral damage to normal cells. In other words, autoimmunity. Research suggests that the autoimmune phenomenon may be a significant driver of symptoms of chronic Lyme disease.

In addition, bacteria manipulating the immune system to generate cytokines and inflammation may be another contributing factor to Lyme disease symptoms. Inflammation breaks down tissues and allows the bacteria to access vital nutrients from our cells.

The fact that chronic Lyme symptoms are most consistent with Borrelia existing as an intracellular bacteria suggests that this is the primary reason as to why Borrelia is persistent in the body. Participation in biofilm and being able to form an antibiotic resistant cyst form likely also contribute to antibiotic resistance, but these may not be primary factors.

Biofilms may be most relevant to intestinal symptoms that usually accompany Lyme disease and skin diseases like Morgellons that’s sometimes associated with the tick-borne infection. Calcium deposits in the inner ear causing dizziness may also be related to biofilm.

Dealing with Biofilms

Though Lyme disease is not a standard biofilm disease per se, there’s nothing wrong with supporting the body’s ability to deal with biofilms during any illness. A healthy immune system is the best way to slow the formation of biofilm in the body. The immune system is always breaking down new biofilms that start to form — it’s part of the everyday struggle of life.

The following are my preferred herbs and supplements to supports the body’s efforts to break down biofilms:

zoomed in pineapple skin

1. Proteases

Proteases are enzymes that break down proteins. It is thought that proteases may be beneficial for breaking down the outer coating of a biofilm, especially in the gut. Common natural proteases that are available in supplement form include bromelain (from pineapple), nattokinase, and serrapeptidase. Proteases also break down immune complexes in the blood and reduce inflammation.

cell diagram of N-Acetyl Cysteine (NAC)

2. N-Acetyl Cysteine (NAC)

A potent antioxidant and anti-inflammatory, n-acetyl cysteine (NAC)is known to break up mucus and may also play a role in dissolving biofilms. It also protects nerve tissue and liver function.

three overlapping image circles. cats claw, japanese knotweed, and chinese skullcap

3. Antimicrobial Herbs

The best way to overcome chronic Lyme disease, including the possibility of biofilm formation, is persistent use of herbs with antimicrobial properties. The herbal advantage is that herbs suppress pathogens without disrupting normal flora and therefore can be used for prolonged periods of time (years) without adverse side effects. Herbs also protect cells from free radical damage and other stressors, modulate immune system functions, reduce inflammation, and erode away at biofilms. Common herbs with documented activity against Borrelia include Japanese knotweed, cat’s claw, and Chinese skullcap.

The Bottom Line

Ultimately, the idea that patients must aggressively hammer away at biofilms with harsh drugs and treatments to see improvements in symptoms may not be a sustainable or beneficial approach for most people. Blasting biofilms with strong chemicals and potent antibiotics has the potential to backfire because it can disrupt the balance of normal flora in the body and inadvertently suppress immune system functions.

In contrast, by supporting a healthy immune system with herbal therapy and a few select supplements, you can etch away at biofilms that may be present, while addressing other more significant underlying causes of your symptomsuntil they’re gone without setting yourself back for days or weeks at a time.

Dr. Rawls is a physician who overcame Lyme disease through natural herbal therapy. You can learn more about Lyme disease in Dr. Rawls’ new best selling book, Unlocking Lyme.

You can also learn about Dr. Rawls’ personal journey in overcoming Lyme disease and fibromyalgia in his popular blog post, My Chronic Lyme Journey.

REFERENCES
1. Supi et al, Characterization of Biofilm Formation by Borrelia burgdorferi, In Vitro, PLOS-one, Oct 24, 2012
2. Karatan E, Watnick P, Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms, Microbiology and Molecular Biology Reviews, June 2009, Vol 73 (2), P. 310-347
3. Lennox J, Biofilm Development, Biofilms: The Hypertextbook, Web, May 2011
4. Costerton, Stewart, Greenburg, Bacterial Biofilms: A Common Cause of Persistent Infections, Science, May 1999, Vol 284 (5418) p. 1318-1322
5. Sapi, MacDonald, Biofilms of Borrelia burgdorferi in chronic cutaneous borreliosis, Am J Clin Pathol, 2008, 129, p. 988-989
6. Hoyle, Costerton, Bacterial resistance to antibiotics: the role of biofilms, Prog Drug Res, 1991, 37, p. 91-105
7. Kurti, Munderloh, Ashstrand, Colony formation and morphology in Borrelia burgdorferi, J Clin Microbiol, 1987, 25, p. 2054-2058
8. Figure copyright 2006 Keith Kasnot, MA, CMI, FAMI
9. Image source: http://nutritionreview.org/2014/08/gingivitis-gum-health/
10. Di Domenico EG, Cavallo I, Bordignon V, et al. The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. Front Neurol. 2018;9:1048. Published 2018 Dec 3. doi: 10.3389/fneur.2018.01048
11. Datar A, Kaur N, Patel S, Luecke D, Sapi E. In Vitro Effectiveness of Samento and Banderol Herbal Extracts on the Different Morphological Forms of Borrelia Burgdorferi. Townsend Letter, the Examiner of Alternative Medicine. July 27, 2010.
12. Rudenko N, Golovchenko M, Kybicova K, Vancova M. Metamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persisters. Parasit Vectors. 2019;12(1):237. Published 2019 May 16. doi: 10.1186/s13071-019-3495-7
13. Markova ND. L-form bacteria cohabitants in human blood: significance for health and diseases. Discov Med. 2017 May;23(128):305-313. PMID: 28715646.
14. Rivera OJ, Nookala V. Lyme Carditis. 2020 Oct 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 31536195.
__________________________________
**Comment**
Patients often struggle with whether they should go after biofilms or not.  I had this same struggle myself and still do not have a definitive answer.  I know patients who didn’t notice a thing after treating biofilms and others who had great progress.  Herein lies the challenge: what works for one, doesn’t work for another.  We are a conundrum to treat for sure.
I’ve taken everything mentioned in Dr. Rawl’s article for various reasons throughout my journey.  The ones I’ve stuck with are NAC and proteases as both supplements do a myriad of things simultaneously.
I’ll never forget Master Herbalist Stephen Buhner’s advice in the need to find a sophisticated treatment that does many things simultaneously.  I believe he’s absolutely correct.  This saves time and money.
For more on NAC:

For more on Systemic Enzymes (proteases):

French and Australian Connections on Lyme, Inflammation and Cancer: Medicine Week 2019, Baden-Baden

https://www.linkedin.com/pulse/french-australian-connections-lyme-inflammation-cancer-yu-md/

French and Australian Connections on Lyme, Inflammation and Cancer: Medicine Week 2019, Baden-Baden

By Dr. Simon Yu, MD

Medical Director at Prevention and Healing,Inc.
______________________
Medicine Week in Germany is considered one of the biggest cutting-edge complementary medical conferences in the world and there are multiple lectures simultaneously held at the huge congress hall. I gave a lecture on Parasites, Inflammation and Immune Dysregulation in the section on “Causal Therapies for Chronic Inflammation and Chronic Infection,” sponsored by Dr. med. Rainer Mutschler from Germany.

Many of the international speakers covered cutting edge topics of Lyme, parasites, mold, inflammation and chronic infections, and different treatment modalities. Bacteriophage therapy and hemoadsorption therapy were new concepts for me take home to investigate further.

The first speaker, Louis Charles Teulieres, MD from France and England, spoke on bacteriophages in Lyme disease and diagnostics. Bacteriophages are a hot topic in the Lyme community as a means to detect and treat Lyme disease instead of heavily relying on antibiotics. Bacteriophages, a dominant viral life form existing as naked DNA with a protein coat, infect bacteria and “devour” them. They are everywhere: 50 million bacteriophage viruses are found in one milliliter of seawater.

Dr. Teulieres’ main focus: Is there a place for bacteriophages in diagnosis and treatment of Lyme disease? Can this provide an alternative treatment to antibiotics for Lyme disease, and thereby avoid post-antibiotic resistance? His lecture was highly technical, and it is still theoretical to use bacteriophages as a diagnostic tool, or to kill Borrelia Lyme bacteria with a Borrelia-specific virus. Phage Therapy is a novel idea to be tested soon. I have some skepticism about this approach which overlooks hidden dental spirochete and parasite infections, but stay tuned for more research.

Other topics included molds and fungus in chronic inflammation by Dr. Damien Downing of London, a lecture on biofilm by a doctor from Scandinavia, Lyme and co-infections by Prof. Dr. Kenny de Meirleir of Belgium, immune monitoring of hemoadsorption approaches as a new treatment option in antibiotic resistant chronic Lyme infection by Prof. Dr. Marion Schneider of Germany, and patient cases treated with hemoadsorption and extracorporeal hyperthermia by Dr. med. Rainer Mutschler of Germany.

Bacteriophage testing for Lyme disease claims it could detect direct evidence of Borrelia presence, is highly sensitive and specific, could distinguish Lyme from relapsing fever Borrelia strains, could distinguish active and non-active Borrelia presence, and could be developed to have the ability to distinguish different Borrelia sub-types.

On my last day at the Medicine Week, I met Australian researcher Jennie Burke, MSc from Sydney who gave a lecture on, Cancer and Infection. I did not attend her lecture but at the night meeting at the restaurant, she gave me her lecture slides to review.

To my delight, she presented on viral, bacterial and parasite infections as possible causative agents for the development of tumors or opportunistic inhabitants. Her slides covered controversial topics from Virginia Livingston Wheeler, Royal Rife and Dr. Milbank Johnson on BX virus and Rife frequency therapy, Dr. Laszlo K. Csatary on Newcastle virus, and included a list of bacteria and viruses associated with inducing cancer. Her list of cancer types and infections include Gallbladder carcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and Ovarian, Colorectal, Lung, Pancreatic, Breast, Prostate, Anal and Oral cancer. She listed the names of the bacterial and viral infections and development of specific cancer types.

Her last slide was: Parasites in Cancer? The antiparasitic mebendazole shows survival benefit in preclinical models of glioblastoma multiforme (brain cancer). Supporting articles include: Mebendazole Monotherapy and Long Term Disease Control in Metastatic Adrenocortical Carcinoma, Mebendazole Inhibits Growth of Human Adrenocortical Carcinoma Cell Lines Implanted in Nude Mice, and Mebendazole Elicits a Potent Antitumor Effect on Human Cancer Cell Lines Both in Vitro and in Vivo.

The development of cancer, infections and environmental toxins are not a new concept, but have been largely sidelined (seduced) by the genetic mutation theory of cancer. It is time to renew infections and environmental toxins, including EMF, as the driving forces of inflammation and immune dysregulation. The end results are the imbalance of Th1, Th2, Th17 and regulatory T immune cells that can trigger autoimmune reactions or development of cancer.

I have written many articles on parasites, fungal infections and cancer connections, presenting cancer as an infectious disease as if cancer is a metabolic parasite. Dr. Tim Guilford and I published, Antiparasitic and Antifungal Medications for Targeting Cancer Cells Literature Review and Case Studies, in PubMed with extensive references. If you are suffering from cancer, get a copy and share with your oncologist. He or she may embrace and try parasite and fungal medications or scorn you and laugh at you. You have nothing to lose by trying.

Listening to French, Australian and other international speakers at Medicine Week was worthwhile, and I learn from going to Baden-Baden every year. Meeting good friends and enjoying good wine, beer, food and Roman Baths give even more incentives to attend, and expand my horizons.

Dr. Simon Yu, M.D. is a Board Certified Internist. He practices Internal Medicine with an emphasis on Integrative Medicine to use the best each has to offer. For more articles and information about integrative medicine, patient success stories, and Dr. Yu’s new book, AcciDental Blow Up in Medicine: Battle Plan for Your Life, visit his website at www.preventionandhealing.com or call Prevention and Healing, Inc., 314-432-7802. You can also attend a free monthly presentation and discussion by on Integrative Medicine at his office on the second Tuesday each month at 6:30 pm. Call to verify the date. Seating is limited, arrive early.

Mixed Borrelia Burgdorferi & Helicobacter Pylori Biofilms in Morgellons Disease Dermatological Specimens

https://www.mdpi.com/2227-9032/7/2/70

Mixed Borrelia burgdorferi and Helicobacter pylori Biofilms in Morgellons Disease Dermatological Specimens

Received: 15 March 2019 / Revised: 17 April 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Lyme Disease and Related Tickborne Infections)
PDF [3717 KB, uploaded 17 May 2019]

Abstract

Background: Morgellons disease (MD) is a dermopathy that is associated with tick-borne illness. It is characterized by spontaneously developing skin lesions containing embedded or projecting filaments, and patients may also experience symptoms resembling those of Lyme disease (LD) including musculoskeletal, neurological and cardiovascular manifestations. Various species of Borrelia and co-infecting pathogens have been detected in body fluids and tissue specimens from MD patients. We sought to investigate the coexistence of Borrelia burgdorferi(Bb) and Helicobacter pylori(Hp) in skin specimens from MD subjects, and to characterize their association with mixed amyloid biofilm development.

Methods: Testing for Bb and Hp was performed on dermatological specimens from 14 MD patients using tissue culture, immunohistochemical (IHC) staining, polymerase chain reaction (PCR) testing, fluorescent in situ hybridization (FISH) and confocal microscopy. Markers for amyloid and biofilm formation were investigated using histochemical and IHC staining.
Results: Bb and Hp were detected in dermatological tissue taken from MD lesions. Bb and Hp tended to co-localize in foci within the epithelial tissue. Skin sections exhibiting foci of co-infecting Bb and Hp contained amyloid markers including β-amyloid protein, thioflavin and phosphorylated tau. The biofilm marker alginate was also found in the sections.
Conclusions: Mixed Bb and Hp biofilms containing β-amyloid and phosphorylated tau may play a role in the evolution of MD. View Full-Text
______________________

 

Can These Essential Oils Help Lyme Patients Overcome Chronic Candida?

https://www.linkedin.com/pulse/can-essential-oils-help-lyme-disease-patients-overcome-greg-lee/

Can These Essential Oils Help Lyme Disease Patients Overcome Chronic Candida Infections?

By Greg Lee Published on

FREE-Sample-of-Essential-Oils

photo credit:  freebiesdip.com

For people diagnosed with Lyme disease that have persistent Candida infections

Have you ever been frustrated by a really slow computer? A month ago, I was making a video and it took f-o-r-e-v-e-r to edit the final version. The computer was being choked by a group of programs called “Bloatware.” These programs ate up huge amounts of disk space and processing which turned my computer into a slow moving tortoise.

How is Bloatware that slows down your computer similar to recurring Candida infections in people also diagnosed with Lyme disease?

Just like Bloatware, Candida can slow you down by eating up your valuable energy and increasing inflammation

According to the US Centers for Disease Control (CDC), Candida lives on the skin and in the digestive tract without normally causing symptoms. Candida can cause local infections in the mouth, throat, esophagus and in the vagina. Candida can also cause systemic infections which affect the blood, heart, brain, eyes, bones, and other parts of the body1. Symptoms found in persistent Candida infections can include leaky gut, irritable bowel syndrome2, chronic fatigue3, arthritis4, clinical depression5, cerebral abscesses6, neck stiffness, seizures7, fever, chills, weakness, and death8. An immune system weakened by Lyme disease may make people more vulnerable to Candida infections.

Lyme disease patients may be more susceptible to recurring Candida infections 

A Lyme disease infection may weaken the immune system and make people more susceptible to opportunistic Candida infections9. Also, many Lyme patients receive prolonged antibiotic therapy which can kill off healthy gut microbes and can lead to irritable bowel syndrome (IBS), leaky gut and Candida overgrowth10. Another theory for chronic Candida in Lyme patients is an inability to produce the necessary inflammatory compounds for eliminating yeast infections.

Chronic Candida infection patients may not be able to produce important anti-fungal inflammatory compounds

In a UK study on chronic Candida infection patients, Interleukin-2 (IL-2), Interleukin-12 (IL-12) production was significantly lower and Interleukin-6 (IL-6) production was much higher11. The study indicates that Candida patients over produce IL-6 which can lead to decreased IL-12. Lower IL-12 is correlated with the inability to clear fungal infections. Patients with gastrointestinal Candida have higher levels of Interleukin-17 (IL-17) which promotes fungal colonization12. Not only Candida, but also Lyme infections can lead to excess inflammation production.

Excess inflammatory compounds may also prevent clearing of Lyme as well as Candida

Increased IL-6 leading to decreased levels of IL-12 may enable Lyme and Candida infections to persist. In neurological Lyme patients, higher levels of inflammatory compounds including IL-6, IL-2, Interleukin-5 (IL-5), Interleukin-10 (IL-10), and CXCL13 were found in spinal fluid13. In a Borrelia infected mice study, decreased IL-12 lead to decreased arthritis and increased levels of Lyme disease in tissues14. In another study, increased IL-17 led to the development of destructive arthritis in mice infected with Borrelia15. Drug resistant strains of Candida may also lead to persistent yeast infections in Lyme patients.

Candida can persist despite multiple anti-fungal medications

In the US and Canada, multi-drug resistant strains of Candida have been found in immune compromised patients16. Candida can also produce a protective slime called a “biofilm” which may make infections up to 1000x more drug resistant17. As a result of resistant and biofilm forms of Candida, Lyme patients undergoing antibiotic therapy may experience recurring Candida infections.

Are there natural remedies that can help to reduce recurring symptoms by targeting antibiotic resistant and biofilm forms of Candida?

Fortunately, there are five essential oils that have been effective against drug resistant and biofilm forms of Candida

In a multiple studies, essential oils were effective at inhibiting drug resistant forms of Candida than anti-fungal medications. Other essential oils were highly effective at reducing Candida biofilms. Many of these essential oils have been used safely for years in our food supply18 and to help patients with Candida and Lyme disease to reduce relapsing symptoms. Microparticle “liposome” essential oils have greater penetration into organs and tissues in animal and lab studies19.

Anti-Drug Resistant Candida Essential Oil #1: Clove Bud

Clove bud essential oil demonstrated considerable anti-fungal properties against Fluconazole-resistant strains of Candida in one lab study20. In another study, clove bud exhibited anti-biofilm activity against Candida species biofilms21. In another lab study, clove bud inhibited IL-6, interleukin-1beta (IL-1β), and IL-1022.

Clove bud essential oil eradicated all Lyme disease persister cells and dissolved biofilms in a lab study23. In multiple animal and lab studies, clove bud oil has also been effective against biofilms produced by Staphylococcus aureus24, E. Coli25, and Aeromonas hydrophila26. In multiple lab studies, clove oil inhibits Salmonella typhimurium, E. coli, B. cereus, Listeria innocua, Morganella morganii, Listeria monocytogenes, Enterobacteriaceae, S. aureus, and Pseudomonas species27. This oil also posses potent anti-fungal properties against Aspergillus flavus28.

Clove bud oil use is cautioned in pregnancy. This oil has anti-coagulant properties and is cautioned with the use of diabetic medications, anticoagulant medications, after major surgery, peptic ulcer, hemophilia, and other bleeding disorders. It may interact with pethidine, MAOIs or SSRIs. It is also cautioned against using this oil on diseased or damaged, or hypersensitive skin, and with children under 2 years old This oil has US Food and Drug Administration (FDA) generally recognized as safe (GRAS) status29. Similar to clove bud oil, tea tree has excellent anti-Candida properties.

Anti-Drug Resistant Candida Essential Oil #2: Tea Tree

In lab studies, tea tree oil inhibited drug resistant Candida strains30 and was effective at inhibiting biofilm growth31. Tea tree oil was also effective against Staphylococcus epidermidis, Escherichia coli, Saccharomyces cerevisiae32, Pseudomonas aeruginosa and its biofilm,33 Aspergillus niger, Aspergillus flavus34, Aspergillus fumigatus, Penicillium chrysogenum35, Mycoplasma pneumoniae, Mycoplasma hominis and Mycoplasma fermentans36, group A streptococcus37, Fusarium graminearum, Fusarium culmorum, Pyrenophora graminea38, Alternaria alternata, Botrytis cinerea and Fusarium oxysporum39 in lab and animal studies.

In an endotoxin lab study, tea tree essential oil was effective at lowering inflammatory compounds IL-1β, IL-6 and IL-1040. In another lab study, tea tree oil decreased IL-2 and increased anti-inflammatory compound IL-441. Caution: some cases have been reported where tea tree oil caused allergic dermatitis when placed on the skin42. In five cases, high doses of this oil internally, 0.5-1.0 ml/kg, have produced central nervous system symptoms of loss of coordination, drowsiness, unconsciousness, diarrhea, and abdominal pain43. Just like tea tree, geranium essential oil has multiple anti-Candida properties.

Anti-Drug Resistant Candida Essential Oil #3: Geranium

In multiple lab studies, geranium oil inhibited Fluconazole resistant Candida strains44 and inhibited multiple Candida species biofilms45. Geranium oil was also effective at significantly decreasing inflammatory compounds IL-6, IL-10, IL-2 and COX-2 levels when exposed to Candida proteins in another lab study46. In a mouse study, this oil inhibited the degranulation of mast cells47.

The use of geranium oil is cautioned with diabetes medications, drugs metabolized by CYP2B6, and has a low risk of skin sensitization48. Just like geranium, savory reduced resistant forms of Candida.

Anti-Drug Resistant Candida Essential Oil #4: Savory

Due to their compositional similarity, winter and summer savory essential oils are grouped together here. In one lab study, winter savory essential oil was highly effective at inhibiting drug resistant strains of Candida glabrata49. In another lab study, summer savory essential oil demonstrated substantial anti-fungal activity against Candida albicans and it’s biofilms50.

Since these oils may inhibit blood clotting; use is cautioned with anticoagulant medications, major surgery, peptic ulcer, hemophilia, other bleeding disorders. Use is also cautioned with diabetic medications, use on mucous membranes due to a moderate risk of irritation and use on hypersensitive, diseased or damaged skin due to a low risk of skin irritation. Use is also cautioned in children under 2 years of age51. Similar to savory, lemon has demonstrated anti-Candida properties.

Anti-Drug Resistant Candida Essential Oil #5: Lemon

In lab studies, lemon essential oil was effective at inhibiting drug-resistant Candida species52. This oil was also 100% effective at reducing a mixed species Candida albicans and E. Coli biofilm53. If applied to the skin, skin must not be exposed to sunlight or sunbed rays for 12 hours54. These essential oils in combination may help to reduce relapsing symptoms caused by drug resistant and biofilm forms of Candida in patients with Lyme disease.

Essential oils may help to reduce recurring symptoms caused by antifungal resistant and biofilm forms of Candida

Similar to deleting the Bloatware off your computer to speed it up, a powerful combination of essential oils may help you to overcome energy draining and relapsing symptoms caused by drug resistant and biofilm forms of Candida. Formulating these remedies into microparticle liposomes may enhance the stability and extend the anti-fungal activity of these essential oils. Since these essential oils have cautions and contraindications on their use, work with a Lyme literate essential oil practitioner to develop a proper, safe, and effective strategy for your condition.

https://madisonarealymesupportgroup.com/2018/01/03/the-invisible-universe-of-the-human-microbiome-msm/

“Recitas, author of ‘The Plan,’ calls MSM the wonder supplement for your gut. It can alleviate allergy symptoms, helps with detoxification, eliminates free radicals, and improves cell permeability. She states that with given time, MSM will start to actually repair damage caused by leaky gut – a common problem with Lyme/MSIDS patients. It can also help the body’s ability to absorb nutrients from food. Many Lyme patients struggle with paralysis of the gut where the muscles of the stomach and intestines stop being efficient. MSM helps this muscle tone as well.”

https://madisonarealymesupportgroup.com/2018/05/15/overview-of-anti-inflammatory-diets/

https://madisonarealymesupportgroup.com/2017/05/20/minding-your-mitochondria/

https://madisonarealymesupportgroup.com/2018/04/18/comparative-diets-to-address-chronic-inflammation/

 

 

 

 

 

 

 

 

 

 

 

 

 

Lyme Biofilm & Efflux Pumps – Dr. Christine Green

 Approx. 17 Min.

Published on Mar 15, 2018

Dr. Christine Green on Lyme Biofilms and Efflux Pumps

Dr. Christine Green, a Lyme-treating physician who serves on the board of LymeDisease.org, recently spoke on the topic of Lyme biofilms and efflux pumps–two factors that can directly affect treatment for Lyme disease.

https://www.lymedisease.org/green-biofilms-efflux-pumps/

In this second talk, Dr. Green explains how biofilms function within our bodies. A biofilm is a jelly-like barrier created by organisms to protect against environmental stress. There are both healthy biofilms and those that contribute towards illness. The National Institutes of Health (NIH) estimates that 80% of all chronic infections are associated with biofilms.

Research shows that Borrelia burgdorferi, the pathogen that causes Lyme disease, also forms biofilm. This helps protect the bacteria from antibiotics. Adding biofilm busters to antimicrobial treatment may be one way to combat chronic Lyme disease.

In addition to biofilm, Borrelia have something called “efflux pumps” that help the bacteria survive in hostile environments. The efflux pumps push out heavy metals and other chemicals, but they can also expel antibiotics before they’ve had a chance to work. Current research is looking at ways to deal with the problem.

______________

For More:  https://madisonarealymesupportgroup.com/2017/08/18/drexel-prof-lyme-persists/

https://madisonarealymesupportgroup.com/2017/10/26/lyme-wars-part-3/

Great article on biofilm & natural biofilm agents:  https://thescienceofnutrition.me/2015/03/13/natural-anti-biofilm-agents/ (Includes: garlic, NAC, xylitol, coffee, cranberry, enzymes, chelation, & more)

MSM makes cell walls permeable which is why it helps with detoxification and is an important oral chelator:  https://madisonarealymesupportgroup.com/2018/03/02/dmso-msm-for-lyme-msids/