Archive for the ‘Syphilis’ Category

The Coming Pandemic of Lyme Dementia

https://www.psychologytoday.com/blog/iage/201705/the-coming-pandemic-lyme-dementia  by Mario D Garrett Ph.D.  May 29,2017

The Coming Pandemic of Lyme Dementia:  The increasing threat from Lyme disease

There are many known causes of dementia. One of these causes are bacteria. Bacteria are usually ignored despite its historical and current significance in dementia research.  A hundred years ago it was well known that syphilis—a bacterium—was the only known cause of dementia. The bacteria interferes with the nerves until it reaches the brain where it destroys the brain from the inside. In the end, the expression of long-term syphilis is dementia—Neurosyphilis. Alois Alzheimer wrote his post-doctoral thesis (Habilitationsschrift) entitled “Histological studies on the differential diagnosis of progressive paralysis.” on neurosyphilis before his supervisor Emil Kraepelin propelled him into the history books by defining Alzheimer’s disease as a new disease in 1911. [1]

Neurosyphilis was very common in the 1900s. Between one in four to one in ten people in mental institutions were there because of neurosyphilis. Eventually syphilis kills its victims. Before the introduction of penicillin in 1943, syphilis was a common killer. In 1929, among men, the death rate from syphilis was 28.3 per 100,000 for Whites and 97.9 per 100,000 for Blacks [2]. The similarities between syphilis and dementia were addressed repeatedly in the early literature in Alzheimer’s disease [1]. Because syphilis can now be treated easily and cheaply, it has nearly been eradicated. But there is a new bacterium threat emerging—one that can also cause dementia.

Today, the main bacterial threat to acquiring dementia comes from Lyme disease—a bacterium borrelia burgdorferi. Lyme disease is transmitted to humans mainly through the bite of infected blacklegged tick. These ticks are themselves infected by feeding off mainly diseased birds, which bring the infection from across the globe. Worldwide there are 23 different species of ticks that can carry Lyme disease or diseases that are similair to Lyme disease (e.g.  Borrelia bissettii.)

Lyme disease is the most common disease carried by animals in the northern hemisphere and it is becoming an increasingly public health concern [3]. Not only because Lyme disease is a debilitating disease, but because eventually Lyme disease has been shown to cause dementia—Lyme dementia [4]. Science has not identified the mechanism for the development of Lyme dementia. The American psychiatrist  Robert Bransfield has been documenting some of its neurological expressions, but so far there is a lack of emphasis in the research community on exploring these clinical features. 

Ernie Murakami, a retired physician, has been monitoring the spread of Lyme disease across the world. With more than 65 countries that have the blacklegged ticks which transmit Lyme disease, this is a worldwide pandemic. The prevalence of Lyme disease reporting varies dramatically. Canada reporting the lowest cases in the world, with 1 case per million, while Slovenia reports 13 cases per 10,000. In the United Sates the Centers for Disease Control and Prevention reports that more than 329,000 people are likely to be infected every year in the U.S. alone. Only one in ten cases are reported since clinicians are not looking for Lyme disease. This estimated number of annual infections is higher than hepatitis C, HIV, colon cancer, and breast cancer. Lyme disease accounts for more than 90% of all reported cases of diseases carried by animals (vector-borne illness).

With any good public health strategy there needs to be a two pronged response. One is to address the clinical effects of the disease and the other is to address the underlying cause. In the United States, although research funds to examine and explore cures for Lyme disease are minimal, this avenue is likely to see the most significant increase. But this would be folly without addressing the underlying cause of the disease. Addressing these underlying causes will however be challenging.

Harvard Medical School Center reports that areas suitable for tick habitation will quadruple by the 2080s. But there are more pressing changes that will happen in our lifetime. Deforestation and climate-induced habitat change are affecting insect which carry diseases like malaria and Lyme disease. Slow climate change, urban growth in areas next to forests, reforestation following the abandonment of agriculture, and increases in the deer, mice and squirrel populations (among many others) which harbor these ticks.

Malaria and Lyme disease are both projected to increase. Even taking a more conservative estimate (all of the USA, most of Canada, all of Europe, Middle East and China), more than half the world’s populations are likely to be exposed to Lyme disease. A proportion of these populations will become infected with Lyme disease and eventually some will develop dementia. Pure Lyme dementia exists and reacts well to antibiotics [4].  Is public health ready to address this? [5]

© USA Copyrighted 2017 Mario D. Garrett

References

[1] Garrett MD (2015) Politics of Anguish: How Alzheimer’s disease became the malady of the 21st century. Createspace. USA.

[2] Hazen H.H. (1937). A leading cause of death among Negroes: Syphilis. Journal of Negro Education, 310-321.

[3] Pearson S. (2014). Recognising and understanding Lyme disease. Nursing Standard, 29(1): 37-43.

[4] Blanc F., Philippi N., Cretin B., Kleitz C., Berly L., Jung B., … & de Seze J. (2014). Lyme Neuroborreliosis and Dementia. Journal of Alzheimer’s Disease, 41(4): 1087-93.

[5] Garrett MD, & Valle R (2015) A New Public Health Paradigm for Alzheimer’s Disease Research. SOJ Neurol 2(1), 1-9. Accessible for free from:  https://sites.google.com/site/mariodrmariogarrettcom/GARRETT_VALLE_NEUROLOGY.pdf?attredirects=0

***A few notes***

Firstly, thank you to Dr. Garrett for this important acknowledgement of Lyme Dementia.

Secondly, this addresses a concern I’ve had for some time now.  Since LD is caused by a pleomorphic bacteria that shape shifts into one of three shapes, one of which has a non cell wall that can hide for years, and since doxycycline is typically the first line drug used, which researcher Eva Sapi has found that high doses of doxy pushes the spirochete into the non-cell wall form, https://www.ncbi.nlm.nih.gov/pubmed/21753890#are we setting patients with acute Lyme up for dementia later?  

*Until more and better transmission studies are done (the ones we have have 3 inches of dust on them), it would be folly to blame Lyme solely upon the black legged tick.  I am thankful Dr. Garrett pointed out that there are numerous species of ticks that carry numerous diseases.  These diseases are as bad if not worse than Lyme, and synergistically make cases infinitely worse than if infected by a single bacterium.

*Again, until much, much more research is conducted, it’s a stab in the dark to say LD is the most common disease carried by animals.  According to Dr. Breitschwerdt (DVM), that honor would be given to Bartonella, a nasty, persistent infection that has as many strains as there are animals, that coupled with Lyme will bring a person to their knees, and can also cause endocarditis.  And hardly anyone is talking about Bart – except us patients and veterinarians!  

*It is entirely true that physicians are NOT looking for TBI’s (tick borne infections).  It’s up to you to educate yourself and others.  The numbers listed in the article for each country is abysmally low.  If you don’t think TBI’s are in Canada, go here:  https://canlyme.com and http://lymediseasecanada.com.  I assure you, TBI’s are all over Canada and everywhere but Antarctica.  And, as Dr. Bransfield has stated, give it enough time and it will be there too!

*The statistic that only 1 in10 cases are reported in the U.S. is a complete stab in the dark and likely much lower.  Doubt every number you see when it comes to TBI’s.

*I appreciate Dr. Garrett’s insistence that addressing the underlying causes of disease is as important as finding a cure.

*Please remember when folks keep beating the “Climate Change” drum, that LD, with rare cases reported since 1883, originally started out as an epidemic in Connecticut in the 70’s http://whatislyme.com/history-of-lyme-disease/.  It has since spread (much like the proverbial “classic” bulls-eye rash that hardly anyone gets) to the rest of the world and is now a pandemic.  https://madisonarealymesupportgroup.com/2017/07/08/global-warming-numbers-fudged/  Respected whistle-blowers have exposed the fraudulent changing of temperatures to make the drastic rise in temperatures proponents use to push the agenda.

Whatever has caused the Lyme/MSIDS pandemic, it probably has more to do with pathogens being tweaked in a lab and spread due to a perfect storm of events:   https://sites.newpaltz.edu/ticktalk/social-attitudes/story-by-smaranda-dumitru/

 

*Regardless of how LD started, brace yourselves for the Lyme Dementia pandemic.*

 

 

 

 

 

A Bug for Alzheimer’s?

https://aeon.co/essays/how-microbial-infections-might-cause-alzheimers-disease

Please read the article above, written by Melinda Wenner Moyer, edited by Pam Weintraub.

A brief summary:

Robert Moir, a neurologist at Massachusetts General Hospital in Boston, believes that beta-amyloid, a key player in Alzheimer’s, might be a good guy who is actually protecting the brain from pathogens.

This idea is coming from numerous corners of the world and has been labeled ‘pathogen hypothesis.’ Others pointing this out are pathologist Alan MacDonald, neuropathologist Judith Miklossy, and microbiologist Tom Grier.

Moir has published mouse studies showing that their brains create amyloid plaques within hours of contracting infections and they actually kill pathogens.

This observation flies in the face of accepted dogma about beta-amyloid and it is rarely discussed in AD groups.

A meta-analysis of 25 published studies has shown that infected folks are 10 times more likely to develop AD, leading international researchers to co-sign an editorial begging others to consider pathogens in relation to AD.

But, the cabal isn’t having it. Moir’s 2016 paper was rejected six times without even a review before finally getting the nod.  https://madisonarealymesupportgroup.com/2017/01/13/lyme-science-owned-by-good-ol-boys/

The author reminds the reader that infections in the brain are nothing new and a short list of them includes: Syphillis, Herpes simplex encephalitis, tick borne disease, HIV, Toxoplasma gondii, Chlamydia pneumoniae, HSV-1, and Zika.

https://madisonarealymesupportgroup.com/2016/04/10/bugs-causing-alzheimers/

https://madisonarealymesupportgroup.com/2016/06/03/borrelia-hiding-in-worms-causing-chronic-brain-diseases/

https://madisonarealymesupportgroup.com/2016/08/09/dr-paul-duray-research-fellowship-foundation-some-great-research-being-done-on-lyme-disease/

http://www.huffingtonpost.com/david-michael-conner/man-diagnosed-with-als-di_b_8891262.html

The journalist also points out that pathogen causation is not proven and that Alzheimer’s patients might be prone to infection but that some studies suggest the infections came first. She also says that the majority of folks suggesting the ‘pathogen hypothesis’ do not feel the infections work alone but rather can cause a domino effect that over time can accumulate causing AD.

And lastly, if beta-amyloid causes AD then removing these plaques should get rid of symptoms, but when 145 beta-amyloid-reducing drugs were tested, not one slowed progression of the disease.

Once again, proving a science cabal exists, Moir recounts how at a Korean conference, attendees were asked to raised hands if they thought infections played a part in AD and a majority of hands went up.

“Ten years ago, it would have been four guys in a corner, all huddled together, not talking to anyone else, Moir says.

https://madisonarealymesupportgroup.com/2017/01/02/fake-science/

Isn’t that sad?

Syphilis Re-emerging

These findings are important for MSIDS (multi systemic infectious disease disease syndrome  or Lyme with friends) patients because people with false positive testing results for Syphilis may have Lyme Disease.  https://www.sharecare.com/health/stds-sexually-transmitted-diseases/why-false-positive-test-syphilis

When writer of The Joy Luck Club, Amy Tan, asked her doctor to test her for Lyme he insisted she didn’t have LD because it was too rare and proceeded to test her for Syphilis. https://www.amytan.net/lyme-disease.html

http://www.nature.com/articles/nmicrobiol2016245

Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster
Natasha Arora, Verena J. Schuenemann[…]Homayoun C. Bagheri
Nature Microbiology 2, Article number: 16245 (2016)
doi:10.1038/nmicrobiol.2016.245
Published online:
05 December 2016

Abstract
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century established this devastating infectious disease as one of the most feared in human history1. Surprisingly, despite the availability of effective antibiotic treatment since the mid-twentieth century, this bacterial infection, which is caused by Treponema pallidum subsp. pallidum (TPA), has been re-emerging globally in the last few decades with an estimated 10.6 million cases in 2008 (ref. 2). Although resistance to penicillin has not yet been identified, an increasing number of strains fail to respond to the second-line antibiotic azithromycin3. Little is known about the genetic patterns in current infections or the evolutionary origins of the disease due to the low quantities of treponemal DNA in clinical samples and difficulties in cultivating the pathogen4. Here, we used DNA capture and whole-genome sequencing to successfully interrogate genome-wide variation from syphilis patient specimens, combined with laboratory samples of TPA and two other subspecies. Phylogenetic comparisons based on the sequenced genomes indicate that the TPA strains examined share a common ancestor after the fifteenth century, within the early modern era. Moreover, most contemporary strains are azithromycin-resistant and are members of a globally dominant cluster, named here as SS14-Ω. The cluster diversified from a common ancestor in the mid-twentieth century subsequent to the discovery of antibiotics. Its recent phylogenetic divergence and global presence point to the emergence of a pandemic strain cluster.

http://www.theatlantic.com/health/archive/2016/06/how-syphilis-came-roaring-back/488375/

“Perhaps most concerning, the past two years have seen a cluster of cases of syphilis of the eye, and a rise in cases of congenital syphilis—something even developing countries have been able to eliminate.

The disease is curable with antibiotics, but it’s a bit of a secret agent, transmissible through almost every sexual means and erupting as a tiny lesion about a month after exposure. At various stages of the infection, it might cause no symptoms or a puzzling array of them. If gone undiagnosed, it can cause everything from disfigurement to seizures.”

https://www.poz.com/article/secret-life-syphilis  By Daniel Wolfe

“TB, rare cancers and pneumonias — all of these were documented, if unusual, expressions of syphilis before the antibiotic era,” says Joan McKenna, a research physiologist whose 1986 article in the journal Medical Hypotheses first presented the AIDS-syphilis connection.
McKenna found an unlikely ally in Sandra Larsen, MD, then a syphilis expert at the CDC. “The clinical manifestations of syphilis, which have taken various forms over the century, have now been transformed to mimic the appearance of the opportunistic infections and cancers that may accompany HIV infection, as well as the clinical symptoms of AIDS itself,” Larsen wrote. McKenna began sending AIDS patients in for confirmatory syphilis tests, even when they’d first tested negative. “We had people showing up negative on the initial tests even when they had known infections and tertiary symptoms,” she says. These syphilis cases were being missed.”
Others interested in the AIDS-syphilis link scrapped the theory in the late ’80s, when doctors treating HIVers with IV antibiotics found that they still sickened and died. But the idea that a new form of chronic syphilis may be mistaken for HIV-related infections, has been kept alive by Toronto researcher John Scythes and colleague Colman Jones. “Repeated studies show that syphilis infection and, particularly, reinfection, may not be detected with current tests,” Jones says. So some of those we say are cured of syphilis may instead be being missed. The CDC estimated there were 325,000 cases of untreated syphilis at the end of the 1970s. Where did they go?”
New research into syphilis’ suburban cousinBorrelia burgdorferi, the spirochete that causes Lyme disease — has bolstered the case for better tests. Recently researchers have successfully cultured B. burgdorferi from the blood of Lyme disease patients supposedly cured by antibiotics and found a cyst-like form of the Lyme spirochete, adopted in response to meds, which is often missed with standard microscopy. Might syphilis similarly adapt to avoid antibiotics and detection? “There is much we do not yet know,” says Willy Burgdorfer, PhD, the Lyme spirochete’s discoverer. “But T. pallidum does behave in ways very similar to B. burgdorferi.”

http://www.environmentalevolution.org/environmentalevolution.org/Fair_Use_files/312-Roundbodies.pdf (2009)

“Far from eradicating syphilis, antibiotics are driving the disease underground and increasing the difficulty of detection. Although the incidence of disease has more than tripled since 1955, the chancre and secondary rash no longer are commonly seen. Undoubtedly, some of these lesions are being suppressed and the disease masked by the indiscriminate use of antibiotics. The ominous prospect of a widespread resurgence of the disease in its tertiary forms looms ahead” (Pereyra and Voller, 1970)…..We urge that the possible direct causal involvement of spirochetes and their round bodies to symptoms of immune deficiency be carefully and vigorously investigated.”

http://www.academia.edu/5302525/Syphilis_in_the_AIDS_Era_Diagnostic_Dilemma_and_Therapeutic_Challenge_co-authored_with_John_Scythes_

This review argues that syphilis has been underdiagnosed and under treated… we suggest that latent syphilis is a chronic active immunological condition that drives the AIDS process and that non-treponemal tests have failed to associate syphilis with immune suppression since this screening concept was developed in 1906. In light of the overwhelming association between a past history of syphilis and HIV seroconversion, more sensitive tools, including recombinant antigen-based immunological tests and direct detection (PCR) technology, are needed to adequately assess the role of latent syphilis in persons with HIV/AIDS. Repeating older syphilis reinoculation studies may help establish a successful animal model for AIDS, and resolve many paradoxes in HIV science.

https://www.cdc.gov/std/syphilis/stdfact-syphilis-detailed.htm  (Syphilis fact sheet with symptoms)

https://www.cdc.gov/std/stats15/tables/1.htm  In the US in 2015, there were nearly 75,000 cases of Syphilis.

https://www.statnews.com/2016/03/01/syphilis-las-vegas/  Syphilis has more than doubled in Las Vegas since 2012.

http://wreg.com/2016/09/21/cases-of-syphilis-on-the-rise-in-mississippi/  Health Department in Mississippi says Syphilis cases are up 60% this year.

Cases of syphilis on the rise in Mississippi

 

Chlamydia-Like Organisms Found in Ticks

http://www.mdpi.com/2076-2607/4/3/28/pdf

There are currently nine families in the order Chlamydiales. Most are familiar with the family that includes trachomatis (the most commonly reported STD) and C. pneumonia (spreads by air). The other eight families are Chlamydia-Like Organisma (CLO’s). Many of these CLO’s are found in environmental samples such as water, soil, and various animals including mammals, reptiles, fish and our common enemy, the tick, along with other arthropods.

Scientists do not yet understand how this affects human health; however, associations have been made between CLO’s and tubal factor infertility, adverse pregnancy outcome, lower respiratory tract infections, and pneumonia.

The following abstract shows that ticks can carry CLO’s as well as borrelia (the causative agent of Lyme Disease), Babesia, Bartonella, Anaplasma, B. miyamotoi, tick-borne encephalitis, Mycoplasma, and more.
http://doi.org/10.3390/microorganisms4030028

Abstract
Ticks carry several human pathogenic microbes including Borreliae and Flavivirus causing tick-born encephalitis. Ticks can also carry DNA of Chlamydia-like organisms (CLOs). The purpose of this study was to investigate the occurrence of CLOs in ticks and skin biopsies taken from individuals with suspected tick bite.

DNA from CLOs was detected by pan-Chlamydiales-PCR in 40% of adult ticks from southwestern Finland. The estimated minimal infection rate for nymphs and larvae (studied in pools) was 6% and 2%, respectively. For the first time, we show CLO DNA also in human skin as 68% of all skin biopsies studied contained CLO DNA as determined through pan-Chlamydiales-PCR.

Sequence analyses based on the 16S rRNA gene fragment indicated that the sequences detected in ticks were heterogeneous, representing various CLO families; whereas the majority of the sequences from human skin remained “unclassified Chlamydiales” and might represent a new family-level lineage. CLO sequences detected in four skin biopsies were most closely related to “uncultured Chlamydial bacterium clones from Ixodes ricinus ticks” and two of them were very similar to CLO sequences from Finnish ticks.

These results suggest that CLO DNA is present in human skin; ticks carry CLOs and could potentially transmit CLOs to humans.

Two other studies have come to the same conclusion: that there exists a high prevalence and diversity of Chlamydiales DNA in ticks and the very real possibility of human infection.  https://www.ncbi.nlm.nih.gov/pubmed/24698831 and https://www.ncbi.nlm.nih.gov/pubmed/26386066

All of this continues to demonstrate why Lyme Disease isn’t typically just Lyme Disease but MSIDS, multi systemic infectious disease syndrome, a literal menagerie of pathogens invading the human host making our cases extremely complex and difficult.

Worth mentioning again is the fact spirochetes have been detected in semen and vaginal secretions demonstrating that MSIDS is an STD and can be passed congenitally.

http://afmr.org/Western/
These narratives substantiate a study presented at the annual Western Regional Meeting of the American Federation for Medical Research, with an abstract published in the January issue of the Journal of Investigative Medicine, in which researchers tested semen samples and vaginal secretions from three groups: controls without evidence of Lyme, random subjects who tested positive for Lyme, and married heterosexual couples engaging in unprotected sex who tested positive for Lyme. The results were clear: all of the controls tested negative in semen and vaginal secretions. All women with Lyme tested positive in vaginal secretions, while about half of the men tested positive in semen. One of the heterosexual couples showed identical strains. Internist Raphael Stricker stated, “There is always some risk of getting Lyme Disease from a tickbite in the woods, but there may be a bigger risk of getting Lyme Disease in the bedroom.” Reference: The Journal of Investigative Medicine 2014;62:280-281.

http://www.scientificamerican.com/article/mothers-may-pass-lyme-disease-to-children-in-the-womb/
“Scientists have long suspected, however, that the spiral-shaped Lyme bacteria, Borrelia burgoferi, can be passed gestationally, since other “spirochetes” – most notably the syphilis bacteria – are known to be transmitted in the womb, causing a range of birth defects.”

Psychiatric Lyme/MSIDS

mpr_psychiatric_img_314906_314907

When Lyme disease and the various coinfections that come with it (MSIDS or multi infectious disease syndrome) affect the brain it is often called Lyme neuroborreliosis or Lyme encephalopathy. It can mimic any psychiatric disorder and is often compared to neurosyphilis, with symptoms capable of lying dormant for years only to surface at an opportune time. These symptoms can be so crippling that a patient won’t leave the house. Sufferers may lose intimacy with friends and family due to misunderstood rage, depression,depersonalization, anxiety, hallucinations, and other severe cognitive impairment, including memory loss. Many are extremely sensitive to light, sound, and scents, making them prisoners in their own home.

https://www.holtorfmed.com/download/chronic-fatigue-syndrome-and-fibromyalgia/Lyme_Disease_and_Psychiatric_Disorders.pdf

One-third of psychiatric inpatients showed signs of a Borrelia infection according to Holdorf Medical Group based on a 2002 published study in the Journal of Psychiatry. The severest behavioral symptoms were reversed or improved with proper treatment, but not psychiatric medications alone.

Some of these symptoms include but are not limited to:
Memory impairment or loss (“brain fog”)
Dyslexia and word-finding problems
Visual/spatial processing impairment (trouble finding things, getting lost)
Slowed processing of information
Psychosis
Seizures
Violent behavior, irritability
Rage attacks/impulse dyscontrol
Anxiety
Depression
Panic attacks
Rapid mood swings that may mimic bipolarity (mania/depression)
Obsessive compulsive disorder (OCD)
Sleep Disorders
Attention deficit/hyperactivity disorder
(ADD/ADHD)-like syndrome
Autism-like syndrome
Crying spells

Disorders of the nervous system have been found in 15-40% of late stage Lyme patients (Caliendo et al, Psychosomatics 1995;36:69-74).

http://danielcameronmd.com/16-year-old-boy-lyme-disease-presenting-depression/  Here a 16 year old boy suffered from a myriad of symptoms including depression.  After being diagnosed clinically for LD he was put on 12 weeks of IV Ceftriaxone and improved in sleep, appetite, headaches, joint pain, numbness, distractibility, short-term memory, and emotional behavior.  Depression cleared without antidepressants and his IQ improved by 22 points and school performance improved.

http://www.bio.davidson.edu/people/sosarafova/assets/bio307/meprasse/page07.html  Although the typical literature states that there are 3 stages of disease in a certain order, it’s important to remember that some patients only go through one stage while others experience all three. Some may only go through stage 3 or late stage, which may include some of the more frightening psychological aspects.

https://www.psychologytoday.com/blog/why-can-t-i-get-better/201402/antibiotics-found-effective-in-schizophrenia

LLMD, Dr. Horowtiz, goes on record stating that antibiotics are effective in Schizophrenia. With irony he points out that the authors attribute the reason minocycline helped these patients is due to its ability to affect glutamate pathways in the CNS, blocking nitric oxide-induced neurotoxicity, and inflammation in the brain. He reminds them that minocycline is a tetracycline antibiotic that very well may be treating an infection. He also emphatically states that he has had several schizophrenic patients test positive for Bb, the agent of Lyme Disease. After taking doxycycline they improved significantly and with the help of their psychiatrist, were able to reduce and in some cases eliminate all of their antipsychotic medication. It is important to note that patients remained stable on antibiotics but their symptoms returned if they stopped treatment. He says a doctor should suspect MSIDS in psychiatric patients if they have a symptom complex that has good and bad days with associated fevers, sweats and chills, fatigue, migratory joint and muscle pain, migratory neuralgias with tingling, numbness and burning sensations, a stiff neck and headache, memory and concentration problems, sleep disorders with associated psychiatric symptoms.

Horowtiz also reports the work of psychiatrist Dr. Brian Fallon who has linked Lyme Disease to paranoia, thought disorders, delusions with psychosis, schizophrenia, with or without visual, auditory or olfactory hallucinations, depression, panic attacks and anxiety, obsessive compulsive disorder, anorexia, mood lability with violent outbursts, mania, personality changes, catatonia, dementia, atypical bipolar disorder, depersonalization/derealization, conversion disorders, somatization disorders, atypical psychoses, schizoaffective disorder and intermittent explosive disorders. In children and adolescents MSIDS can mimic Specific or Pervasive Developmental Delays, Attention-Deficit Disorder (Inattentive subtype), oppositional defiant disorder and mood disorders, obsessive compulsive disorder, anorexia, Tourette’s syndrome, and pseudo-psychotic disorders.

Children suffer horrendously as often they can not adequately communicate what they are going through.

John Caudwell’s young son, Rufus, started with panic attacks and other severe psychological issues out of the blue. Once a vivacious and charismatic child, he went eight long important developmental years being tossed from one doctor to another. For his story go here: https://www.youtube.com/watch?v=Y24QL-H5ZLU&feature=youtu.be

Related to this is PANDAS or PANS – pediatric acute-onset neuropsychiatric syndrome. This relatively new disease has some doctors concluding that either an infection or trigger causes the immune system to attack the brain. But, skeptics abound, and like Lyme Disease (MSIDS) there is plenty of disbelief. For one girl’s struggle through psych wards before Stanford doctors make bold diagnosis and treatment go to:  http://www.mercurynews.com/health/ci_25600426/misdiagnosed-bipolar-one-girls-struggle-through-psych-wards?source=pkg

https://wordpress.com/post/madisonarealymesupportgroup.com/2008  A harrowing story of a little girl who was told by doctors she made up all her symptoms.  The parents were told to ignore her physical complaints.  They gave her strong immunosuppressants which exacerbated her symptoms.  The mother found a Lyme literate doctor who is also an expert in PANS/PANDAS.  She tested CDC positive for Lyme, positive for Babesia, Bartonella, Erlichia, and Mycoplasma, as well as PANS/PANDAS.

***If you don’t believe and support your child they will drown in the Lyme controversy propagated by the CDC’s horrifically outdated and abysmal guidelines of treatment of essentially 21 days of doxycycline for everyone regardless of symptoms.  One highly experienced Wisconsin Lyme literate doctor states that 80% of his patients with PANS/PANDAS has Lyme Disease, coinfections, and sometimes strep.  Doctors are not looking for this complex.***

http://mentalhealthandillness.com/tnaold.html  Psychiatrist Dr. Bransfield also has noticed patterns emerging after interviewing hundreds of patients. He estimates that aggressive behavior has been a significant issue for some, although many more have reported associated symptoms. He notes that aggression may only be present for a phase of the illness.

“In considering the behavioral symptoms, these patients can become suddenly suicidal with completed suicides attributed to Lyme disease. Homicidal ideation, urges, and behavior occur in some of these patients. Some adult patients describe struggling to not act on these urges. When these patients act on a homicidal urge, more commonly it is a child becoming assaultive to a sibling. Dissociative episodes sometimes occur with these patients occasionally accompanied with aggressive behavior and loss of memory.
Compensatory compulsions are common in an effort to compensate for the memory deficits. NPLD (neuropsychiatic lyme disease) can imitate a number of common psychiatric syndromes. It can be difficult to differentiate Lyme disease from rapid cycling Bipolar illness or Post-traumatic Stress Disorder. Eating disorders are common. Invariably these patients either gain or lose weight. Sometimes massive weight gain is also seen.

Neurological symptoms have been previously recognized as a component of Lyme disease. Cranial nerve findings begin before the cognitive changes are seen and can intensify again late in the course of the illness. There are times when the cranial nerve findings are more evident late in the day when the patient becomes tired and they acquire double vision, choke on food, or lose their ability to talk. Grand mal seizures are more significant with congenital Lyme cases, while complex partial seizures are seen in a notable percent of other NPLD patients. These seizures are effectively controlled with both anticonvulsants and antibiotics. Some neurological findings are common such as numbness, tingling, sensory loss, burning, weakness, tremors, myoclonic jerks, torticollis, and fainting. Ataxia is common in these patients who are often clumsy, which leads to frequent accidents. Myotonia is uncommon but I have been this in a few patients, and Parkinson’s syndrome caused by Lyme disease can also seen, although it is uncommon. A number of these patients have herniated discs after having Lyme disease for several years. I suspect, but cannot prove, there is a causal relationship between Lyme disease and herniated discs. Burning is quite specific to NPLD, but is also seen in herpes infections. The patient describes a sensation that a blowtorch is burning the skin. It can affect any part of the body. In some patients the burning migrates, while in others it remains in a given area. Both antibiotics and anticonvulsants relieve this symptom.”

Although Bransfield says Parkinson’s caused by Lyme disease is rare, it does happen.  I believe one reason it is considered rare is physicians are not considering or looking for tick borne infections, especially in diseases like Parkinson’s and Alzheimer’s. http://danielcameronmd.com/lyme-meningitis-manifesting-parkinsonism-fully-reversed-ceftriaxone/  This patient was misdiagnosed with Parkinson’s but had Lyme.  Treatment was successful with Ceftazidime 1g IV every 8 hours for 2 days followed by a 4-week course of Ceftriaxone 2 g IV. “Within 4 weeks of therapy, his headache had resolved and he walked independently without difficulty.” 

What is truly concerning is a recent CDC report dissuades the use if IV antibiotics for Lyme Disease.  https://madisonarealymesupportgroup.com/2017/06/23/no-bias-in-mmwr-for-any-other-infectious-disease-requiring-iv-antibiotics-except-for-lyme/  These people misdiagnosed with Parkinson’s or Alzheimer’s may not be able to get IV antibiotics due to this report which was meant to frighten doctors and keep insurance companies from having to pay for it.

53_psych316x316

Lymestats.org

Bransfield describes ten psychological issues that may be risk factors for aggression in MSIDS and include:

*Decreased frustration tolerance
*Decreased impulse control
*When the two above are mild they can be irritable.
When extreme, they can become explosively angry
*Hyposexuality and hypersexuality – both can cause interpersonal frustration
*Obsessive compulsive behaviors which results in intrusive thoughts, images, and compulsions that sometimes are aggressive
*Decreased bonding capacity
*Increased startle reflex (particularly increased acoustic startle)
*Hyper-vigilance and paranoia
*Delusions and hallucinations

http://www.igenex.com/psychological_effects.htm  Can a tick bite drive you crazy?
Doctors warn that Lyme disease may cause personality changes
By Valerie Andrews
, January 2004

“A recent European study shows that psychiatric in-patients are nearly twice as likely as the average population to test positive for Lyme.

Psychiatric Lyme has been linked with virtually every psychiatric diagnosis and can affect people of all ages and from every walk of life. A former honor roll student is diagnosed with Attention Deficit Disorder and pegged as a “problem kid” because he can’t sit still in class. A lawyer has to close her practice because she can’t concentrate and suffers from anxiety attacks. A young mother is so sensitive to noise that she can no longer tolerate her baby’s cry and is afraid that she will harm her child. A retired salesman develops a compulsive habit of writing all over everything—he covers everything from the tablecloth to matchbooks with meaningless scribbles.
Family members are baffled by these transformations; counselors and physicians are consulted, often to no avail. While these individuals may also have migrating muscles pain, headaches and problems with their joints—common signs of Lyme—these symptoms are rarely picked up in a mental health evaluation. And when traditional psychiatric medication fails to produce a cure, the patient grows more desperate.

The Search for a Diagnosis
‘Most people come to see me because they’ve got something wrong that nobody else can figure out,’ says Debra Solomon, MD, a psychiatrist who practices in North Kingston, RI. Fifteen years ago Solomon was confronted with a medical mystery. More and more patients were coming in with the same group of symptoms—fatigue, headaches, migrating joint and muscle pain, accompanied by anxiety, depression, and memory problems. When one of her patients turned out to have Lyme disease, she tested the others, and found that nearly all were positive.
Recent studies show that certain areas of Rhode Island have the highest tick population in the world. Today many of Solomon’s patients come from the island Jamestown, a small farming community where ticks are abundant. Among her cases are:
• A college student in her early twenties who started hearing voices. “She came from a good family and had no previous emotional problems,” says Solomon.
• A businesswoman who suddenly became manic-depressive. “In periods of high energy, she wouldn’t sleep and felt all-powerful. She’d start a new business and begin spending lots of money, then she’d crash.”
• A high school athlete had to drop basketball because he didn’t have the stamina and couldn’t get through his classes without falling sleep. “The teachers accused him of not paying attention, but he didn’t have the concentration to do the work.”
• A 40-year-old book editor who was gaining weight and getting lame in her left leg. “She couldn’t think or process information, and was worried about her job.”

‘Lyme affects nearly every person on this island,’ says Solomon, ‘yet each person responds to it in very different ways.’
How can a physician tell the difference between true mental illness and symptoms linked to Lyme disease?

With Lyme disease, a patient’s psychiatric symptoms don’t quite fit the textbook definition. There is usually no previous history of psychiatric illness. Symptoms often come in cycles. Patients usually do not respond well to psychiatric medication. And they often describe their problems in very physical terms.

Lyme patients often say, ‘There’s a wall in my brain and I can’t seem to move my thoughts from the back to the front.’ ‘This arises from encephalopathy, an inflammation in the brain that affects cognitive function,’ Solomon explains.
Symptoms often worsen as the Lyme bacteria grow active and begin to reproduce. At the same time, a patient may experience physical symptoms, such as fatigue, muscle pain or headaches. Flare-ups are often triggered by stress, as in the case of Bob C. who ran a shipping department for a manufacturing company. Bob had dozens of people answering to him, but Lyme disease made him anxious and unable to concentrate. Because he couldn’t think, he lost his job, and his symptoms grew more intense.
Family problems, economic changes, job loss, surgery, an auto accident, or a bad case of the flu, can send Lyme patients into a sudden tailspin. Along with antibiotics, these people need to rest—and do anything they can to lessen their emotional load.  The catch-22 is that chronic Lyme disease makes it hard to think and perform one’s daily tasks. This inevitably causes financial hardship and puts a strain on family relationships.

Effects of Lyme Disease on Marriages
‘My patients come in to talk about their marital problems and are surprised to learn that they are linked to an organic illness,’ says Virginia Sherr, MD, a psychiatrist who practices in eastern Pennsylvania, another region known for its high rate of tick-borne infections. Ninety percent of Sherr’s patients test positive for Lyme disease. She then has the job of describing to them just how this condition can affect the mind and the emotions.
Lyme disease can cause increasing irritability and dramatic flares of anger, says Sherr. ‘Suddenly you hear bone-cutting verbal assaults from people who are usually more measured and benign. They may have been harboring some small grievance for years, then that hot spot comes to life and they spew out all this venom. Such outbursts cause lasting wounds.’
While some Lyme patients become verbally abusive, others lose confidence and withdraw from social situations. Mary L. tried to explain to her husband that she no longer had the stamina for dinner parties and that she dreaded going out. The husband felt that she was faking it. ‘Mary’s husband and her internist, who knew little about Lyme disease, ganged up on her,’ Sherr reports. “The doctor said, ‘You used to be so full of life, but you’ve less yourself go completely. You’re not even trying!’
‘Physicians who don’t know that Lyme causes personality changes may be dismissive or sharply critical of the patient. Our goal should be to educate couples and help them cope.’
Sherr cites one devoted couple who are both infected with Lyme disease. ‘The man has major cognitive problems and the wife helps him with his memory. She has bouts of extreme impatience, yet he gently guides her through them.’ They have begun to weather the storm together—with the help of antibiotics and marriage counseling.

Lyme Disease and Domestic Violence
Lyme disease often strikes entire families and the result is a higher incidence of divorce, family dysfunction, and domestic violence,’ says Robert Bransfield, MD, a psychiatrist in Red Bank, New Jersey. ‘Tempers flare and you see increasing conflict.’
‘Lyme disease is like an injury of the brain,’ says Bransfield. ‘Patient are less able to think things through, and tend to act impulsively. A mother may suddenly lash out at her child and a husband may lose control and abuse his wife. We underestimate the role of infectious disease in domestic violence,’ he adds.
An aggressive response is more likely if, in addition to Lyme disease, a patient has another tick-borne infection called Babesia. More than one infection can be transmitted by the same tick, and when Babesia is added to Lyme, this may make the patient more aggressive. ’It’s like putting a match to gasoline,’ Bransfield says.
Bransfield has testified in court on behalf of such patients who have been accused of everything from assault to murder. (In one instance, a patient killed his partner, killed the family pet, then killed himself.)
People with Lyme disease alone usually don’t go to these extremes. However, they may be irritable and prone to sudden rages. Bransfield says young people are the most likely to act out. ‘I’ve seen so many straight-A kids whose grades suddenly start to slip. Then they rebel against the family and start fighting with their peers.’ They can also turn their rage against themselves. ‘I’m often on the phone with a teen in a state of crisis,’ says Bransfield, ‘Feeling suicidal comes in waves and these reactions are very hard to predict. However, these kids generally improve after being treated with antibiotics.’
Schools are becoming more enlightened about the problems caused by tick-borne diseases, Raxlen notes. In Newtown, CT, for example, teachers are asked to report any sudden dips in grades or unusual behavior that may be linked to Lyme disease. And many make special arrangements for at-home tutoring while the student convalesces.

Losing Control of Life
When Lyme disease goes undiagnosed—or isn’t treated long enough—it can bankrupt businesses and destroy whole careers.
A CEO of an insurance company was diagnosed with Lyme disease and given antibiotics—but he didn’t take them long enough. Months later, his symptoms returned with a vengeance. He had ghoulish nightmares and woke up drenched. At work, he felt anxious and couldn’t concentrate. Eventually he forgot everything he’d learned about insurance. When he neglected to send in a disability payment on his own policy, the company denied his claim. ‘This man lost tens of thousands of dollars that would have helped him through his illness,’ says Raxlen. ’In the end, he had to sell his building and disband his business.’
People with Lyme disease often have trouble keeping up with ordinary tasks—one Connecticut housewife walked into the library, dumped her dry cleaning on the counter, and waited with increasing irritation for an attendant to help her. Finally a friend walked up and asked, ‘Don’t you know where you are?’
Lyme disease can also affect the part of the brain that deals with signs and symbols—making it hard to read maps or drive from place to place. A real estate agent with Lyme disease stopped at a traffic light. When the signal turned green she didn’t move. An angry motorist yelled, ‘What’s the matter with you. Why can’t you go on the green?’ The woman replied, ‘I’ve forgotten what green means.’
‘Lyme produces a microedema, or swelling in the brain,’ says Raxlen. ‘This affects your ability to process information. It’s like finding out that there’s LSD in the punch, and you’re not sure what’s going to happen next or if you’re going to be in control of your own thoughts.’  ILADS (International Lyme and Associated Diseases Society) physicians say these symptoms can be alleviated or reversed with antibiotics, but stress that Lyme disease must be diagnosed early and treated right away.

Treating Lyme Disease
Most doctors prescribe three to four weeks of antibiotics for initial cases of Lyme disease. Yet according to the ILADS, this is not enough. The Lyme bacteria has a ‘cloaking device’ that enables it to hide in the cells and body tissues. If it’s not completely eradicated, symptoms will recur and with great intensity. To avoid relapses, ILADS recommended six to eight weeks of antibiotics.
When Lyme disease moves into a chronic stage, it’s more likely to lead to neurological or psychiatric conditions. Chronic Lyme patients are harder to cure and may need to take antibiotics—orally or intravenously—for months as a time. In this case, ILADS recommends continuing treatment for at least six to eight weeks after all symptoms are resolved.
‘Lyme disease is often misdiagnosed and it’s costing our healthcare system untold millions of dollars,’ says Raxlen. ‘No one is spared, neither young nor old and each individual can display a puzzling array of symptoms. This illness can have a wide-ranging affects on marriages, families and jobs.’”

http://vitals.nbcnews.com/_news/2012/05/22/11811061-jpmorgan-execs-lyme-infection-spotlights-need-for-quick-treatment?lite  Lyme Disease (MSIDS) is cited as a possible reason for JPMorgan Chase’s financial spiral due to an executive’s battle with it.

Dr. Otto Yang, professor of infectious diseases, David Geffen School of Medicine at the University of California, Los Angeles, states, “Which is why nobody should be surprised that people with long undiagnosed Lyme end up with lingering problems.”

Dr. Andrew Nowalk, an assistant professor of pediatrics at the Children’s Hospital of Pittsburgh at the University of Pittsburgh also states, “Just like syphilis, you can have it for years.  You give an antibiotic and you get a cure 100 percent of the time. But nobody is surprised if you end up with symptoms from syphilis for the rest of your life because it damages so many organs so dramatically. It’s the same concept with Lyme.”

Pathologist, Alan McDonnald also draws connections between spirochetal infection and Alzheimer’s, a disease known to cause severe cognitive and psychological issues.

https://m.youtube.com/watch?v=8TQj2137PGk
Dr. Alan McDonnald on Alzheimer Borreliosis Lecture London June 4, 2014

The conclusion formulated by Dr. Alan MacDonald, MD is that Alzheimer’s disease of the Subtype caused by Tertiary Neuroborreliosis demonstrates evidence by Borrelia specific DNA Probe analysis and by Microbiologic cultures of Autopsy Alzheimer’s Brain tissues producing live Borrelia in pure culture, that Alzheimer’s of the Tertiary Borreliosis type is an infectious disease. The Plaques in such cases are Borrelia biofilm communities.
https://madisonarealymesupportgroup.wordpress.com/2010/08/27/lyme-on-the-brain-by-tom-grier-part-3-a-lecture-notes/

Microbiologist, Tom Grier, asks, “Why have spirochetes been ignored as infectious agents of the human brain?”

“The short answer is that to save time and money we no longer do things old school by which I mean:
No one does brain autopsies and physically stains or cultures for the bacteria.  Instead we have gotten lazy and cheap in our research and tried to rely on blood tests and CSF fluid to give us the answers.  But those tests are wholly inadequate to detect living spirochetes sequestered inside brain cells.  The trouble with silver stains is that they cannot enter human cells. So for nearly a century it was reported that spirochetes were mostly extracellular and found outside all human cells.

Not only was this a wrong conclusion based on inadequate methods, but the consequences of not recognizing an intracellular infection was and still is dire. Why?  Because intracellular infections can be incurable or at the very least more difficult to treat; there is almost no way to determine an end point where a bacteriological cure has been obtained.

Next is that spirochetes are known to disappear by changing to cyst forms, and also by going intracellular.  So these puzzled researchers that were only seeing classical formed spirochetes in 1 in 20 MS patients, may have been seeing them all along and not realizing what they were seeing. How can we conclude this?  Researchers wanted to see if the infectious agent was still in MS lesions despite no visible spirochetes.  Researchers removed brain tissue at necropsy of human patients and inoculated the tissue into uninfected animals.  In some cases, this caused the infection to occur and show up in the brain of the animals; sometimes the classical-form spiral shaped spirochetes emerged.  All of this meticulous work was done prior to WW II, and completely untainted by today’s politics and special interests; yet this body of work is being wholly ignored.”

http://library.lymenet.org/domino/file.nsf/bbf2f15334c1f28585256613000317cc/87e8dfed931381b7852567c70012001f?opendocument

Psychiatrist Brian Fallon states:
“Lyme disease is aptly called the “new great imitator,” and it can imitate psychiatric disorders no less than medical ones…It should be borne in mind also that new clinical manifestations of Lyme disease are still being discovered and described. In cases of known Lyme disease, it is important for psychiatrists to take a comprehensive approach to treatment as so many aspects of the patient’s life-physical, emotional, cognitive, familial, sexual, social and occupational-may be significantly affected by the illness.”

If you or a loved one are suffering from psychiatric lyme/MSIDS, please go to:  www.lymenet.org/SupportGroups/

For a great article about on-line counseling:  https://www.ruschellekhanna.com/onlinetherapy

There are online support groups as well as physical support groups. Take the first step today and contact your local Lyme/MSIDS support group. You’ll be glad you did.

Hyperthermia and MSIDS

Sitting in my doctor’s office, I read an article that intrigued me but made me shudder simultaneously.  In the November 8, 2013 issue of Science pp. 684-687, I read of Plasmodium vivax, the long considered “benign” malaria parasite which threatens billions of people, but more interestingly to me as an MSIDS patient, was it’s historical usage as a cure for tertiary syphilis.  Physicians in the late 19th century believed that high fever could help cure many mental illnesses.  These poor patients were institutionalized with a dismally gruesome future of increasingly neurotic behavior and paralyzation.  They had no hope.

Austrian psychiatrist Julius Wagner-Jauregg initially used tuberculin and salmonella toxins but his fever experiments failed.  He reasoned this was due to too low of a fever, so in 1917 when a soldier fighting in the Balkans was admitted to his ward with Malaria, he tried again using his blood to inoculate nine neurosyphilis patients.  Six recovered.

Thus started the wave of malariotherapy which became the treatment for tertiary syphilis.  No one is sure how it worked but the resulting high fevers appeared to help the patients’ immune systems.  About half resumed to normal activities; many resumed independent lives.

According to Kevin Baird of the Eiikman Oxford Clinical Research Unit in Jakarta, this medicinal use of P. vivax is in part to blame for the neglect of the disease it causes as people assumed it must be harmless even though it killed as many as 15% of patients who had the treatment.

This background paves the way for what is to follow:

https://www.youtube.com/watch?v=WLYZcju9RGM&sns=em

The above youtube is not only an excellent expose on MSIDS in Australia, but also on the current usage of hyperthermia.   Australian patients, who appear to have MSIDS are ignored and told it’s all in their heads.  The video shows patients getting worse, having to quit work, and breaking down in front of the camera.

Same story, different country.  

Kudos to Dr. Schloeffel who is one Australian doctor who refuses to accept patient abuse and neglect and treats his patients clinically not basing all of his decisions on faulty testing.

Due to the lack of acceptance and treatment, many Australian MSIDS patients are heading to Germany to receive the old fashioned hyperthermia treatment at St. George Clinic.  Dr. Frederich Douwes, stumbled upon Hyperthermia as a possible cure for MSIDS while treating cancer patients.  Again, hyperthermia gives the body an artificial fever.  For over 6 hours a patient’s body is heated to 41.7 degrees.

Dauwes says he has treated over 18,000 whole body hyperthermia patients with no negative side-effects.  Other modalities for MSIDS patients are included as well such as ozone, Reiki, acupuncture, foot spa detox, magnetic and laser therapy and IV antibiotics.  It costs anywhere from $30,000 – $55,000 for treatment.

The video is approximately 23 minutes long and worth every minute of it.  Very well done.  Although published in 2014, nothing much has changed in regards to general physician knowledge either in Australia or the United States.

Lastly, this raises a question:  supposedly “between 1917 and the rise of penicillin in the 1940’s, tens of thousands of syphilis patients were infected with malaria.” p. 686.  We know for sure syphilis is spread through sexual contact.  They not only had syphilis but malaria.  What happened to those people and their off-spring?  Is there a connection between the malaria experiment on syphilis patients and MSIDS today?

And hyperthermia?  I’m just thankful they aren’t using Malaria!