Archive for the ‘Viruses’ Category

Big Pharma Payola Scandal Erupts in Australia, Takes Down Six Corrupt Officials & Australian Premier. Millions of Americans Getting Fired For Not Getting a Jab That’s 3% Effective

https://www.pharmaceuticalfraud.com/2021-10-06-big-pharma-scandal-australia-berejiklian-covid-scam.

Big Pharma payola scandal erupts in Australia, takes down six corrupt officials and Australian Premier Berejiklian

10/06/2021 / By Ethan Huff

More than half a dozen staff members of New South Wales, Australia Premier Gladys Berejiklian have resigned in shame over their involvement in a massive Wuhan coronavirus (Covid-19) bribery scheme.

Berejiklian and her comrades reportedly took tens of millions of dollars from Big Pharma in exchange for pushing lockdowns and now “vaccines,” destroying countless lives and businesses in the process.

According to a former Australian member of parliament (MP), Pfizer and AstraZeneca both paid lobbyists to push vaccine mandates on the people, ensuring a steady stream of ill-gotten profits. (See link for article)

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**Comment**

The plot thickens.

Berejiklian was given a deal that she’d get off scot-free by issuing a”vaccine” mandate, which she allegedly accepted. It took a watchdog group looking into her “alleged misconduct,” to cause her to resign. Her deputy premier also resigned along with a cabinet minister and numerous parliament members.

The article states this scandal is likely only the tip of the iceberg with more sure to follow.

Important excerpt:

With these two Branch Covidians gone, New South Wales (NSW) is said to be in a state of “political disarray and chaos.” Many are wondering what will happen next, and how soon the region might be able to reach “post-Covid freedom.”

We the People must push for every last covid criminal to either resign or be removed – no exceptions.

The shock-wave of resignations that are likely coming can be found at Collapse.news.

__________________

https://www.informationliberation.com/?id=62617

Millions Of Americans Are Getting Fired For Not Taking A Jab That’s Now 3% Effective

Chris Menahan
InformationLiberation
Oct. 19, 2021

CNN is reporting that a new study involving over 600,000 veterans has found that Johnson & Johnson’s covid vaccine’s protection “fell from 88% in March to 3% in August.” (See link for article)

____________________

Important excerpt:

On the flip side, we know from another Israeli study that “vaccinated individuals had 27 times higher risk of symptomatic COVID infection compared to those with natural immunity from prior COVID disease,” as epidemiologist Martin Kulldorff noted.

The article states that data shows natural immunity is now more than 100 times more effective than the J&J shot, yet the government and businesses continue to deny it.

The “needle in every arm” mantra has drowned out the truth of natural immunity and the fact there are effective, safe, cheap treatments for COVID.

A recent study out of Israel showed:

  • recovered patients with natural immunity are 13 times less likely to be infected than those who have Pfizer jabs
  • those who were double jabbed were 5.96 times more likely to be infected and 7.13 times more likely to experience symptoms than those with natural immunity after recovery

The data is in and it is clear: natural immunity is best, the jabs are unnecessary, ineffective, dangerous, poisonous and have caused a 46-fold increase in vaccine-related deaths.

In Major Shift, NIH Admits Funding Risky Virus Research in Wuhan

https://www.vanityfair.com/news/2021/10/nih-admits-funding-risky-virus-research-in-wuhan

In Major Shift, NIH Admits Funding Risky Virus Research in Wuhan

A spokesman for Dr. Fauci says he has been “entirely truthful,” but a new letter belatedly acknowledging the National Institutes of Health’s support for virus-enhancing research adds more heat to the ongoing debate over whether a lab leak could have sparked the pandemic.
Anthony Fauci director of the National Institute of Allergy and Infectious Diseases on April 13 2021. U.S.nbsp
Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases on April 13, 2021. U.S. Photograph by Leigh Vogel / UPI / Bloomberg / Getty Images.

Excerpts of article:

On Wednesday, the NIH sent a letter to members of the House Committee on Energy and Commerce that acknowledged two facts.

  1. EcoHealth Alliance, a New York City–based nonprofit that partners with far-flung laboratories to research and prevent the outbreak of emerging diseases, did indeed enhance a bat coronavirus to become potentially more infectious to humans, which the NIH letter described as an “unexpected result” of the research it funded that was carried out in partnership with the Wuhan Institute of Virology.
  2. EcoHealth Alliance violated the terms of its grant conditions stipulating that it had to report if its research increased the viral growth of a pathogen by tenfold.

“It’s just another chapter in a sad tale of inadequate oversight, disregard for risk, and insensitivity to the importance of transparency,” said Stanford microbiologist Dr. David Relman. “Given all of the sensitivity about this work, it’s difficult to understand why NIH and EcoHealth have still not explained a number of irregularities with the reporting on this grant.”

(See link for article)

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**Comment**

The article points out the 900 pages obtained and subsequently published due to a FIOA lawsuit against the NIH which was still missing a document – the fifth and final progress report.

In Wednesday’s NIH letter, that missing progress report, which was dated August 2021 was finally included. That report described a “limited experiment,” as the NIH letter phrased it, in which laboratory mice infected with an altered virus became “sicker than those infected with” a naturally occurring one.

While career politicians continue to banter over definitions, people continue to get sick and even die, and a dangerous, unproven experimental gene therapy is being forced upon the populace – due to an intentional experiment that was released either intentionally or accidentally upon the public. Further, these same powerful people and organizations are censoring and banning treatments that would prevent a large portion of these deaths.  Their feet must be continually held to the fire.

Fauci’s spokesperson tries to weasel him out of it by stating the NIH funded experiments, “were not reasonably expected to increase transmissibility or virulence in humans.”

Oh, well now, that changes everything.  Not!

Wow.  I might expect this from a 10 year old, but not from the highest paid federal employee charged with protecting the entire nation’s (and in some sense – the world’s) public health.  This is yet another example that the nation’s health leader is either entirely deluded or evil.

The article further drives the nail into the coffin by reminding the reader of the findings of DRASTIC, a group of internet sleuths who released a leaked $14 million grant proposal that EcoHealth Alliance had submitted in 2018 to the Defense Advanced Research Projects Agency (DARPA).  The grant included the partnership between EcoHealth and the Wuhan lab for purposely constructing SARS-related bat coronaviruses that would be inserted with “human-specific cleavage sites” to “evaluate growth potential” of pathogens.  What’s crucial here is the furin cleavage site that makes the virus more infectious by allowing it to easily enter human cells – exactly what allowed the COVID ‘pandemic’ to occur.  Without this laboratory contrived capability humans would not become infected.

Although DARPA rejected the grant proposal, the former executive vice president of the Asia Society who sits on the WHO’s advisory committee on human genome editing simply but effectually states the following:

“If I applied for funding to paint Central Park purple and was denied, but then a year later we woke up to find Central Park painted purple, I’d be a prime suspect,”Jamie Metzl

Bingo.  Couldn’t have said it better.

Lastly, Fauci’s been accused of funding Frankenstein research grafting aborted babies’ body parts to mice to grow hair and organs, as well as ‘cruel’ puppy experiments where the NIH shipped part of a $375,800 grant to a lab in Tunisia to drug beagles and lock their heads in mesh cages filled with hungry sand flies so that the insects could eat them alive.

Mainstream media continually focuses on political party affiliation to divide the nation.  Don’t fall for it.  Right is right and wrong is wrong and truth is important.

For more:

COVID Coincidence & Stop Unique Patient ID

https://marilynsingletonmdjd.com/2021/10/12/covid-coincidence

By Marilyn M. Singleton, MD, JD – https://marilynsingletonmdjd.com/

“They” say there is no such thing as coincidence. They must have known about Covid-19, the political viral disease.

Is it a coincidence that the year of the Covid is also the year that scientific integrity died? Discourse is the lifeblood of science. I thought we had gotten past jailing or guillotining or dismissing as crackpots people whose scientific theories with which we disagreed. Many scientific mavericks were vilified: William Harvey describing the circulatory system, Ignaz Semmelweis’ advocating for simple hand-washing, Barry Marshall determining that H. pylori, not spicy foods caused peptic ulcers, to name a few. We have a modern day version of public humiliation and worse. Data that does not fit the “official story” is removed from popular social media sites, not reported on mainstream television channels, and hidden from easily accessed public websites.

Was it a coincidence that an all-out campaign to debunk the effectiveness of hydroxychloroquine as an early treatment for Covid-19 occurred after President Trump had good words to say about it in an election year? The denigration was relentless, despite 60 years of use in autoimmune diseases for its anti-inflammatory effects. Hydroxychloroquine was also found to have anti-blood clot effects. And with several viruses it was shown to inhibit viral entry into cells and viral replication. All of these properties would be effective in treating Covid-19 symptoms.

Another anti-parasitic medication, ivermectin, has 20 possible mechanisms of action against the SARS-CoV-2 virus, including interrupting viral entry into cells and anti-inflammatory action. Significantly, ivermectin is a protease inhibitor, that is, a substance that blocks proteins that allow viruses to reproduce themselves.

Is it a coincidence that Pfizer’s new anti-Covid pill, PF-07321332 is also a protease inhibitor? Notably, Pfizer’s drug would have to be given early after the onset Covid symptoms. This is also the recommendation for hydroxychloroquine and ivermectin—a recommendation that many studies ignored when dismissing the value of these anti-parasitic medications.

Is it a coincidence that Merck, who distributes ivermectin, is seeking fast-track approval for molnupiravir, an antiviral agent to treat Covid-19? How convenient that the U.S. government will purchase $1.2 billion worth of the yet-to-be-approved drug. And how predictable that vaccine maker Moderna’s stock fell 11 percent after the announcement. Vaccines are yesterday’s cash cow. Is it a coincidence that ivermectin costs no more than $100 dollars per treatment course and molnupirivir costs $700 per 10-day course of treatment?

Is it a coincidence that the pharmaceutical and health products industry, to keep their seat at the table, has spent $171,262,239 so far this year in lobbying and that Pfizer and Merck were among the top five clients?

Is it a coincidence that Dr. Fauci, in dismissing hydroxychloroquine and ivermectin, resurrected his same excuses for not using a drug that frontline physicians found effective for AIDS patients? Physicians begged Dr. Fauci to publicize the use of the sulfa drug, Bactrim, as prevention and treatment for PCP (Pneumocystis carinii pneumonia) in AIDS patients. According to investigative author Sean Strub, “Fauci refused to acknowledge the evidence and … even encouraged people with AIDS to stop taking treatments, like Bactrim, that weren’t specifically approved for use in people with AIDS.” Dr. Fauci told activists there was “no data to suggest PCP prophylaxis was beneficial and that it may, in fact be dangerous.” Thousands of deaths could have been avoided. This sounds chillingly familiar to his position on Covid treatments. Damn the clinical success. I don’t care if the drugs work; I’m waiting for my pet drugs with high price tags!

Is it a coincidence that Dr. Fauci’s personal favorite AIDS drug, AZT (zidovudine), was ramrodded through the FDA? And that it was toxic, didn’t work, and in fact killed people, like his favorite anti-Covid drug, remdesivir? Remdesivir’s toxic effects were known when it was tested against Ebola virus disease in 2019. By April 2020, it was known that 60 percent of Covid patients given remdesivir had adverse effects, including liver and kidney injury. Worse yet, remdesivir did not improve survival. Indeed, a few months later the World Health Organization recommended against its use, but Fauci’s National Institutes of Health (NIH) still has it on its treatment protocol at $3,120 per treatment course.

I have a broader question about why diversity of thought is squelched. Tyrants despise free thinkers. It is not coincidence that President Biden, who wants to exert more federal government control over our lives through vaccine mandates, bought all of Regeneron’s monoclonal antibody treatments that were not in short supply but were being successfully used by “red states.” He vowed that “if governors won’t help us beat the pandemic, I’ll use my power as president to get them out of the way.”

Health and Human Services framed the sequestration more kindly: “This system will help maintain equitable distribution, both geographically and temporally, across the country.” Is it a coincidence that “governmental ownership and administration of the means of production and distribution of goods” sounds like socialism?

We Demand Privacy of Personal Medical Records: Say NO To National Patient ID

Organizations like AAPS and Citizens’ Council for Health Freedom (CCHF) have for decades helped protect our medical privacy by successfully blocking the implementation of a national patient ID. But their efforts are at grave risk of being reversed.

Lyme/MSIDS patients are in grave danger if medical records are not kept private.  Due to a misunderstood illness that can cause all sorts of neurological, psychiatric, and mental problems, patients are often misunderstood, misdiagnosed, and labeled – when they have a serious underlying issue – serious infections.  These labels and the revelation of personal, medical information could have dire consequences affecting their livelihoods and futures.

Here is how CCHF explains it:

Democrat leadership in the House and Senate, working on the 2022 appropriations bill, have REMOVED the longstanding prohibition on funding the development of a Unique Patient ID (UPI) for all Americans.

This national patient tracking number (National Patient ID) was part of HillaryCare and became law in 1996 as part of HIPAA, but its creation and implementation have regularly been stopped by the efforts of Congressman Ron Paul, and now U.S. Senator Rand Paul who’ve made sure almost every appropriations bill since 1996 has prohibited funding for its creation. In 2019, CCHF’s efforts, including a letter signed by 44 other organizations [including AAPS], convinced the Republican controlled U.S. Senate to keep the ban in place.

Your help is needed ASAP! Tell your Members of Congress in the House and Senate:

STOP THE UNIQUE PATIENT ID — Put the UPI ban back into the Appropriations bill.”

Get your message on the way to Congress in a couple short clicks at:https://p2a.co/0CzCue5
Thank you for speaking out. Your voice makes a difference.

https://p2a.co/0CzCue5  Go here to get a message to Congress

‘Medical Freedom is Worth Everything to Me’: Short Film

https://films.aflds.org/films/halcomb  Video Here (Approx. 6 Min)

“Saving Lives”

Frontline Films

All three Halcombs survived COVID, including a 95 year old.  How? Watch the short video and learn about the life-saving medications that our corrupt public ‘health’ authorities and complicit media are censoring, maligning and denying.

There is complete polarization within the medical community reminiscent of Lyme/MSIDS regarding the treatment of COVID. On one hand you have mainstream doctors toeing the accepted narrative either out of ignorance, or out of fear of losing their jobs.  On the other hand you have freedom-loving doctors who are putting their necks on the chopping block as they defy the establishment and advocate for the proper treatment of patients.  The story is one Lyme/MSIDS patients know all too well.

Science and science journals have been completely compromised and are bought-out by Big Pharma.

Lyme/MSIDS patients quickly learn of the Lyme-underground where one must go in order to get appropriate help.  Now, a wider public circle is learning what we’ve contended with for over 40 years: having to go to search out “special” doctors to receive “appropriate” treatment. Hospitals have become modern day “killing fields,” with frustrated doctors splitting off forming groups separate from mainstream medicine. These brave doctors are being attacked and threatenedPoliticians and judges are now being asked to speak up for sick patients who seemingly have no recourse.

To say we are in a mess would be an understatement. The vitriol is tangible and the public is confused and being led astray – even blaming people for not succumbing to an unproven, experimental gene therapy injection utilizing a dangerous spike protein toxin which is related to thousands upon thousands of deaths, severe adverse reactions, and pathogenic priming or ADE, all of which are completely ignored by mainstream medicine and a complicit media.  One expert warns these dangerous injections may kill up to 50 million Americans.  Whistleblowers are coming out of the woodwork with crucial information:

  • CDC whistleblower lawsuit states nearly 50,000 people were killed within 14 days of a 1st or 2nd dose of a COVID-19 “vaccine”.  Deaths are severely under counted as the corrupt CDC is counting deaths within 14 days of vaccination, as unvaccinated deaths.  These statistical shennanigans have been used throughout the “plandemic” to push an accepted narrative while hiding reality. The CDC did a similar thing with the PCR test.
  • Pfizer whistleblower states the injections are bioweapons.
  • GSK whistleblower states the injections cause sterility.
  • Vaccine researcher admits the spike protein is a toxin that accumulates in the ovaries, testes, liver, spleen, bone marrow, and adrenal glands. It also crosses the blood brain barrier.
  • Vaccine expert states COVID injections drive viral mutations which will cause outbreaks.
  • Doctor testing “vaxxed” blood found COVID shots cause severe autoimmunity.
  • Pfizer scientist admits natural immunity is better than COVID shots.
  • Pfizer whistleblower reveals internal emails purposely covering up fetal cell information.
  • Medical practitioner whistleblowers admit COVID shots kill more than they save.
  • COVID injections “cause more harm than good” based on the proper scientific endpoint of “all cause severe morbidity.”
  • Microscopy is revealing graphene, metals, parasites, “mysterious discs” and living, moving “creatures” or “objects” that look and act like “Hydra Vulgaris” inside the COVID shots.
  • Doctors testing “vaxxed” blood show microclotting and other bizarre changes in the blood.
  • COVID injections are fueling mutations, causing “break-through” infections which cause more severe illness including hospitalization and death, when exposed to COVID mutations.
  • CDC continues to manipulate data to create a pandemic of the unvaccinated, and to falsely state the shots are “safe and effective,” to push their lucrative COVID shots, which they have patents on.
  • Big Tech, Big Pharma, social media, and a complicit media continue to censor reality and the fact the injections are causing severe adverse events including death and that there is no need for these dangerous injections due to safe, effective, cheap COVID treatments that have been proven to work. There were more than 500 deaths in the first year of remdesivir usage – the drug of choice by our corrupt health ‘authorities,’ vs 20 deaths in 19 years of ivermectin usage – the drug of choice from censored, maligned doctors.  Remdesivir isn’t effective for COVID, but is manufactured by Gilead Science, a CA manufacturing company which has ties to the Pentagon and has been accused of engaging in illegal bioweapon research programs in the country of Georgia. More than 100,000 pages of classified information shows that Gilead was involved in conducting military research, biological weapons research, and other clinical experiments there that resulted in the deaths of Georgian citizens.

Artemisinin From Sweet Wormwood Inhibits SARS-CoV-2 & Two New Studies Test Quercetin And COVID Outcomes

https://articles.mercola.com/sites/articles/archive/2021/10/20/artemisinin-from-sweet-wormwood-inhibits-sars-cov-2.

Artemisinin From Sweet Wormwood Inhibits SARS-CoV-2

Analysis by Dr. Joseph Mercola Fact Checked

Story at-a-glance

  • An antimalarial treatment made from the plant Artemisia annua (Sweet Wormwood) shows promise as a COVID-19 treatment
  • The drug artesunate — which contains two compounds found in Artemisia annua: artemisinin and dihydroartemisinin — is a first-line treatment for malaria
  • In a recent in vitro study, both pretreatment and treatment with artemisinin extracts, synthetic artemisinin and the drug artesunate were able to inhibit SARS-CoV-2 infection. However, artesunate was the most potent in terms of treatment, and from a clinical perspective may be the only one worth pursuing
  • Artesunate’s mechanism of action against SARS-CoV-2 is as yet unknown, but artemisinin does have confirmed antiviral activity
  • The World Health Organization has come out in opposition to artemisinin-based products, warning their use can bolster drug-resistant strains of malaria parasites. For this reason, people living in malaria-prone areas should be cautious about using this plant remedy

This article was previously published January 4, 2021, and has been updated with new information.

A second antimalarial treatment is now being seriously considered and evaluated for its efficacy against COVID-19. The treatment is made from the plant Artemisia annua, which most people know as Sweet Wormwood. Other names for this plant include Annual Sagewort and Sweet Annie.

Research over the past few decades has revealed multiple health benefits from this medicinal herb, which has a centuries-long history of use in folk medicine. In 2015, Chinese scientist Tu Youyou received a partial Nobel Prize in Physiology or Medicine for his discovery of artemisinin and dihydroartemisinin,1 both of which have potent malaria-fighting properties.

As reported by the University of Kentucky,2 “The popular malaria drug artesunate was developed from those compounds and is still used as a first-line treatment for the disease today.”

Artemisinin — A Viable COVID-19 Remedy?

Interestingly, in addition to having a long-standing history of being used as a highly effective antiparasitic, it also has anticancer properties. Additionally, artemisia annua has antiviral activity that might be helpful against SARS-CoV-2.

In an April 8, 2020, SEC filing, Mateon Therapeutics reported3 that “Artemisinin is highly potent at inhibiting the ability of the COVID-19 causing virus (SARS-CoV-2) to multiply while also having an excellent safety index.”

After testing the plant’s antiviral effects in a laboratory setting for a couple of years, University of Kentucky researchers are also exploring its use for the treatment of COVID-19,4 as are researchers in Denmark and Germany.5 According to the University of Kentucky:6

“Surprisingly, results showed that the plant’s leaves, when extracted with absolute ethanol or distilled water, provided more antiviral activity than the actual drug itself — meaning that an Artemisia annua-blended coffee or tea could possibly be more effective than taking the drug.”

Based on these findings, researchers have decided to test artemisinin in patients diagnosed with COVID-19. Some of the first human studies, set to investigate both the extract blended into coffee and tea, as well as the drug artesunate, were implemented by UK HealthCare.

University of Kentucky researchers have founded a company called ArtemiFlow to develop and manufacture the drug, in collaboration with the Kentucky Tobacco Research & Development Center.7 A sister company, ArtemiLife, is marketing Artemisia tea and coffee to raise research funds.

Mechanism of Action Remains Unknown

As for its mechanism of action, such details still remain to be discovered. C&EN explains:8

“When countering malaria, artemisinin exploits the parasite’s taste for hemoglobin in its host’s blood. As the parasite digests hemoglobin, it frees the iron-porphyrin heme complex from the protein.

Because this heme is toxic to the parasite, the organism normally converts the complex to a more benign crystalline form. ‘But artemisinin corrupts this heme-detoxification pathway,’ says Paul O’Neill, a medicinal chemist at the University of Liverpool.

If artemisinin does have any effect against SARS-CoV-2, though, it likely relies on a completely different mechanism than the one it uses against the malaria parasite, Harvard’s [malaria researcher Dyann F.] Wirth says.”

In Vitro Study Reports Positive Results

An in vitro study9,10 looking at the efficacy of artemisinin-based treatments against SARS-CoV-2, posted on the prepublication server bioRxiv, October 5, 2020, report promising results.

The study was a collaboration between researchers from Germany, Denmark and Hong Kong, led by Kerry Gilmore, Ph.D., from the Max Planck Institute for Colloids and Interfaces in Potsdam, Germany.

Three artemisinin extracts, as well as pure, synthetic artemisinin, artesunate and artemether were evaluated. During the initial screening for antiviral activity, a German SARS-CoV-2 strain obtained from Munich was used.

Later on, during the concentration-response phase of the trial, they used a Danish SARS-CoV-2 strain from Copenhagen. These two strains are said to be “more closely related to the majority of SARS-CoV-2 strains circulating worldwide than the Wuhan strain.”11,12

In summary, they found that both pretreatment and treatment with artemisinin extracts, synthetic artemisinin and the drug artesunate were able to inhibit SARS-CoV-2 infection of Vero E6 cells and human hepatoma Huh7.5 cells. That said, artesunate was the most potent in terms of treatment, and from a clinical perspective may be the only one worth pursuing.13,14

World Health Organization Warns Against Its Use

While the world is eager to add another remedy to its COVID-19 treatment list, the World Health Organization has come out in opposition to artemisinin-based products. In a May 27, 2020, article, C&EN reported:15

“One of the most high-profile advocates for using the herbal remedy against the novel coronavirus is Madagascar president Andry Rajoelina, who has been touting Covid-Organics, a tonic containing A. annua that the Malagasy Institute of Applied Research developed …

But health officials are deeply concerned about the promotion and use of these herbal remedies for three principal reasons. First, no evidence exists that A. annua extracts can prevent or cure COVID-19 …

Second, A. annua preparations such as teas, tonics, or herbal capsules also contain a cocktail of bioactive compounds in addition to artemisinin that can have side effects such as dizziness, hearing problems, and vomiting.

Third, and perhaps most worrying of all, widespread use of A. annua herbal extracts could bolster drug-resistant strains of malaria parasites such as Plasmodium falciparum.16

For people living in regions where malaria is endemic, exposure to subtherapeutic doses of artemisinin in A. annua may be enough to kill off some of the parasites in their bodies, but not all of them. Clearing out weakling parasites leaves more room for drug-resistant siblings to proliferate, rendering vital ACTs [artemisinin-based combination therapies] ineffective.”

According to Pascal Ringwald, who heads up the drug resistance and response unit of the WHO Global Malaria Program, artemisinin resistance is a significant problem in Southeast Asia, where Artemisia readily grows and is commonly used.17

That said, this risk is bound to be slight for Americans and people in many other Western countries where malaria is exceedingly rare. According to C&EN,18 “Scientists interviewed by C&EN agree that although this use is against WHO recommendations, it does not risk accelerating resistance because there are so few cases of malaria in the U.S.”

– Sources and References

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https://articles.mercola.com/sites/articles/archive/2021/10/14/quercetin-improves-covid-outcomes

Two New Studies Test Quercetin And COVID Outcomes

Analysis by Dr. Joseph Mercola Fact Checked
quercetin improves covid outcomes
Story at-a-glance
  • Two recently published studies confirm quercetin is useful as an adjunct therapy in the early outpatient treatment of mild SARS-CoV-2 infection
  • In one study, COVID patients who received quercetin in addition to analgesics and an antibiotic cleared the virus faster than those who only received analgesics and antibiotics, and a greater number of patients reported reduced symptoms
  • In the second study, daily quercetin supplementation for one month reduced the frequency and length of hospitalization, the need for noninvasive oxygen therapy, intensive care and deaths
  • Quercetin has antiviral, anti-blood clotting, anti-inflammatory and antioxidant properties, all of which are important in the treatment of SARS-CoV-2 infection
  • Quercetin also inhibits binding of specific spike proteins to your ACE2 receptors, thereby blocking the virus’ ability to infect your cells. It’s also been shown to directly neutralize viral proteins that are critical in the replication of SARS‐CoV‐2

In an August 21, 2021, newsletter,1 Dr. Michael Murray discussed the use of quercetin for respiratory infection symptoms. In November 2020, he’d suffered a “very mild and brief bout of COVID-19.”

He also recounts an anecdotal story of a friend who developed suspicious respiratory symptoms. His friend had been taking a number of supplements said to offer protection, but was still feeling awful.

As it turns out, the one thing he’d not taken was quercetin, and as soon as he did, that same day, his symptoms started to dissipate. This experience, Murray says, “is consistent with the results from two clinical trials” that were recently published.

Quercetin seems to be a safe, far less expensive, and easier-to-obtain and it works by a similar mechanism, driving zinc into the cells to stop viral replication.

Statistical Improvement in Clinical Outcomes

In the first study,2 42 COVID-19 outpatients were divided into two groups. One group of 21 patients received standard medical therapy consisting of analgesics and an antibiotic (acetaminophen 500-milligram (mg) to 1,000-mg dose if body temperature was higher than 37.5 degrees C — 99.5 F — with a maximum daily dosage of 3 grams, and 500 mg azithromycin for three consecutive days).

The other group of 21 patients received standard therapy plus the equivalent of 600 mg of quercetin per day (divided into three doses) for seven days, followed by another seven-day course of 400 mg of quercetin per day (divided into two doses).

The quercetin was used with sunflower lecithin, which has been demonstrated to increase absorption in the gut by as much as 20 times, compared to pure quercetin formulations.

The main outcomes being evaluated were virus clearance and symptoms. After one week of treatment, 16 of the 21 patients in the quercetin group tested negative for SARS-CoV-2 and 12 reported that all symptoms had diminished.

In the standard care group, only two tested negative and four had partially improved symptoms. By the end of Week 2, the five remaining patients in the quercetin group tested negative. In the standard care group, 17 of the 19 remaining patients tested negative and one had died.

“These results are impressive and hopefully additional studies will be conducted on hospitalized patients to see how quercetin might be helpful in more severe cases,” Murray wrote in his newsletter.

Can Quercetin Reduce Hospitalizations and Deaths?

The second study3 — a prospective, randomized, controlled and open-label trial — gave 152 COVID-19 outpatients a daily dose of 1,000 mg of quercetin for 30 days to evaluate its adjuvant effects in the treatment of early symptoms and the prevention of severe infection. According to the authors:

“The results revealed a reduction in frequency and length of hospitalization, in need of non-invasive oxygen therapy, in progression to intensive care units and in number of deaths. The results also confirmed the very high safety profile of quercetin and suggested possible anti-fatigue and pro-appetite properties.

QP (Quercetin Phytosome®) is a safe agent and in combination with standard care, when used in early stage of viral infection, could aid in improving the early symptoms and help in preventing the severity of COVID-19 disease. It is suggested that a double-blind, placebo-controlled study should be urgently carried out to confirm the results of our study.”

Mechanisms of Action

As noted in the first study4 above, quercetin was chosen based on the fact that it has antiviral, anti-blood clotting, anti-inflammatory and antioxidant properties, all of which are important in the treatment of SARS-CoV-2 infection. In the second study, more detailed mechanisms of action are reviewed. According to the authors:5

“SARS-CoV-2 proteases, like 3-chymotrypsin-like protease (3CLpro), papain-like pro-tease (PLpro), RNA-dependent RNA polymerase, spike (S)protein and human angiotensin-converting enzyme 2 (hACE2) are considered possible targets for developing effective anti-COVID-19 drugs.

Recently, molecular docking studies have suggested the possible binding interaction of quercetin with the 3CLpro, PLpro, and S-hACE2 complex. Some recent results, obtained by biophysical techniques, appear to support the results of the molecular docking studies.

Quercetin, a flavonol not naturally present in the human body, is the most abundant polyphenol in fruits and vegetable and is widely used as a dietary supplement to boost the immune system and promote a healthy lifestyle.

Quercetin is characterized by three crucial properties: antioxidant, anti-inflammatory and immunomodulatory. The combination of these actions allows quercetin to be a potential candidate to support all unhealthy conditions where oxidative stress, inflammation and immunity are involved.”

Initially, quercetin gained attention because it’s a zinc ionophore, meaning it shuttles zinc — which has well-known antiviral effects — into your cells just like the drug hydroxychloroquine.

Some proposed the primary reason hydroxychloroquine and quercetin worked was because of this feature. Of course, you also had to take zinc along with either of them. To effectively act as a zinc ionophore, the quercetin also needs vitamin C.

Since then, other studies, including the two reviewed here, have shown quercetin has other actions that makes it useful against SARS-CoV-2 as well. As reported by Murray in his newsletter:

“In particular, quercetin exerts significant inhibition on the binding of specific spike proteins to ACE-2 receptors, thereby blocking the ability of the virus to infect human cells. Quercetin has also been shown to directly neutralize viral proteins the are critical in the replication of SARS-CoV-2.”

In some studies, quercetin has also been shown to inhibit the release of inflammatory cytokines, which could help alleviate infection-related symptoms and suppress excessive inflammatory responses from occurring. Its antioxidant effects may also help prevent tissue damage caused by scavenging free radicals, thereby aiding in the recovery process of viral infections.6

Quercetin’s Antiviral Properties

Quercetin’s antiviral properties have been attributed to three main mechanisms of action:

  1. Inhibiting the virus’ ability to infect cells
  2. Inhibiting replication of already infected cells
  3. Reducing infected cells’ resistance to treatment with antiviral medication

For example, research7 funded by the U.S. Defense Advanced Research Projects Agency (DARPA), published in 2008, found it lowers your risk of viral illness such as influenza and boosts mental performance following extreme physical stress, which might otherwise undermine your immune function and render you more susceptible to infections.

Here, cyclists who received a daily dose of 1,000 mg of quercetin in combination with vitamin C (which enhances plasma quercetin levels8,9) and niacin (to improve absorption) for five weeks were significantly less likely to contract a viral illness after bicycling three hours a day for three consecutive days, compared to untreated controls. While 45% of the placebo group got sick, only 5% of the treatment group did.

Quercetin Works Against Many Common Viruses

Before the COVID-19 pandemic struck, several studies had highlighted quercetin’s ability to prevent and treat the common cold and seasonal influenza.10,11,12,13,14,15,16,17,18 By attenuating oxidative damage, it also lowers your risk of secondary bacterial infections,19 which is actually the primary cause of influenza-related deaths.

Importantly, quercetin increases mitochondrial biogenesis in skeletal muscle, which suggests part of its antiviral effects are due to enhanced mitochondrial antiviral signaling.20 Quercetin also works against other viruses, as demonstrated in the following studies:

A 1985 study found quercetin inhibits infectivity and replication of herpes simplex virus type 1, polio-virus type 1, parainfluenza virus type 3 and respiratory syncytial virus (RSV).21

A 2016 animal study22 found quercetin inhibited mouse dengue virus and hepatitis virus.

Other studies have confirmed quercetin’s power to inhibit both hepatitis B23 and C24 infection.

A March 2020 study25 found quercetin provides “comprehensive protection” against Streptococcus pneumoniae infection, both in vitro and in vivo, primarily by neutralizing pneumolysin (PLY),26 one of the toxins released from pneumococci that encourages S. pneumoniae infection to blossom in the first place.

Streptococcus pneumoniae is responsible not only for pneumonia, but can also be involved in some ear and sinus infections, meningitis and certain blood infections.27 As reported by the authors of this study:28

“The results indicated that quercetin significantly reduced PLY-induced hemolytic activity and cytotoxicity via repressing the formation of oligomers.

In addition, treatment with quercetin can reduce PLY-mediated cell injury, improve the survival rate of mice infected with a lethal dose of S. pneumoniae, alleviate the pathological damage of lung tissue and inhibit the release of cytokines (IL-1β and TNF-α) in bronchoalveolar lavage fluid.

Considering the importance of these events in antimicrobial resistant S. pneumoniae pathogenesis, our results indicated that quercetin may be a novel potential drug candidate for the treatment of clinical pneumococcal infections.”

How Quercetin Combats Inflammation and Boosts Immunity

Aside from its antiviral activity, quercetin is also known for boosting immunity and combating inflammation. As noted in a 2016 study29 in the journal Nutrients, mechanisms of action include (but is not limited to) the inhibition of:30

  • Lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components
  • LPS-induced mRNA levels of TNF-α and interleukin (IL)-1α in glial cells, which results in “diminished apoptotic neuronal cell death”
  • The production of inflammation-producing enzymes
  • Calcium influx into the cell, which in turn inhibits pro-inflammatory cytokine release, as well as histamine and serotonin release from intestinal mast cells31

According to this paper, quercetin also stabilizes mast cells, has cytoprotective activity in the gastrointestinal tract, and “a direct regulatory effect on basic functional properties of immune cells,” which allows it to inhibit “a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions.”32

Bioavailability

While quercetin does have potent antiviral effects, in order for it to work effectively you need sufficiently high dosages to raise the level of quercetin in your body’s tissues.

The relatively low absorption rate of quercetin is why a sunflower lecithin formulation was used.

Research33 published in the July-December 2021 issue of the Journal of Natural Health Products Research, found a quercertin matrix has the same total absorption rate as quercetin phytosome — and higher peak blood levels.

“Since both of these forms of quercetin produce similar blood levels, they should produce the same effects at equal dosages based upon quercetin content,” Murray wrote in his newsletter, adding:

“My dosage recommendation as part of a nutritional supplement program to support immune function is 250 mg twice daily.

And in patients with active Infection, my recommendation is … six capsules twice a day providing a total of 3,000 mg of quercetin. This high dosage should be taken for at least 10 days and then reduced to a maintenance dosage of 250 mg twice daily …

[This] high dosage may not be necessary. But my dosage calculations are based upon likely tissue concentrations needed to exert the strongest antiviral effects. And given the safety of quercetin, there is no harm at this level.”

Protocol Using Quercetin

One doctor who early brought quercetin into the limelight was Dr. Vladimir Zelenko. As hydroxychloroquine became difficult to obtain, Zelenko switched to recommending quercetin instead, as it’s readily available as an over-the-counter supplement. For a downloadable “cheat sheet” of Zelenko’s protocol for COVID-19, visit VladimirZelenkoMD.com.

Other Health Benefits of Quercetin

There are also other lesser known benefits and uses for quercetin, including the prevention and/or treatment of:34

High blood pressure35,36
Cardiovascular disease37
Obesity38 and metabolic syndrome39 (a cluster of conditions including high blood pressure, high blood sugar, high triglyceride levels and fat accumulation around the waist that raise your risk for Type 2 diabetes, heart disease and stroke)
Certain kinds of cancer, in particular leukemia, and to a lesser degree breast cancer40
Nonalcoholic fatty liver disease (NAFLD)41
Gout42
Arthritis43
Mood disorders44
Aluminum-induced neurodegenerative changes, such as those seen in Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS).45
Longevity, thanks to its senolytic benefits (clearing out damaged and worn-out cells)46,47

Research has also highlighted quercetin’s epigenetic influence and ability to:48

  • Interact with cell-signaling pathways
  • Modulate gene expression
  • Influence the activity of transcription factors
  • Modulate microRNAs

MicroRNAs used to be considered “junk” DNA. But far from being useless, research has revealed so-called “junk” DNA is actually microRNA and plays a crucial role in regulating genes that make the proteins that build your body.

The microRNA function as “on/off” switches for the genes. Depending on the microRNA input, a single gene can code for any of more than 200 protein products. Quercetin’s ability to module microRNA may also help explain its cytotoxic effects, and why it appears to improve cancer survival (at least in mice).

– Sources and References