Archive for the ‘Eye Issues’ Category

Acute Transverse Myelitis – A Clinical Manifestation of Lyme (That Nobody Has a Clue About Prevalence)

https://www.ncbi.nlm.nih.gov/pubmed/30622896

2018 Dec 29;15:e00479. doi: 10.1016/j.idcr.2018.e00479. eCollection 2019.

Acute transverse myelitis – A rare clinical manifestation of Lyme neuroborreliosis.

Abstract

Acute transverse myelitis (ATM) is a rare, potentially devastating neurological syndrome that has variety of causes, infectious being one of them. Lyme disease (LD) is the most common vector borne zoonosis in the United States (U.S.). While neurologic complications of LD are common, acute transverse myelitis is an exceedingly rare complication.

We present a case of a previously healthy 25-year-old man who presented with secondary erythema migrans, aseptic meningitis and clinical features of transverse myelitis including bilateral lower extremity motor and sensory deficits manifesting as weakness and numbness, urinary retention and constipation.

Despite negative serum antibodies against Borrelia burgdoferi, cerebrospinal fluid (CSF) was positive for Borrelia burgdorferi PCR.

Following treatment with methylprednisolone and ceftriaxone, he attained complete recovery apart from neurogenic bladder necessitating intermittent self-catheterization. We report rare manifestation of a common disease and emphasize the importance of considering LD in the differential diagnosis of acute transverse myelitis, particularly in residents of endemic areas.

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**Comment**

Nobody has a CLUE about how often anything is occurring in Lyme/MSIDS, when testing misses over half of all cases and folks are commonly misdiagnosed or undiagnosed for years.  Again, because words mean things, and research has been used against patients for over 40 years, a more accurate statement would be, “This is the first recorded case of ATM caused by Lyme Disease.”  And remember, just because something isn’t on record doesn’t mean it hasn’t happened.  Important distinction.

According to https://myelitis.org/living-with-myelitis/disease-information/afm/

The predominant presentation is weakness that may affect the limbs, face, oral or eye muscle. Weakness varies greatly ranging from subtle to very severe. AFM may result in total paralysis, partial paralysis, or weakness of just one limb. The combination of paralysis and how individuals present are widely variable. The limbs or muscle structures of individuals with AFM appear weak, flaccid, or limp and are not spastic as seen in classic cases of transverse myelitis. Since it is markedly the gray matter of the spinal cord that is inflamed in individuals with AFM, sensory, bowel and bladder functions can remain intact, however there are individuals that have both upper and lower motor neuron involvement.

The enterovirus (EV-D68) has been suspect in many of these cases however, it has not been definitively proven that it is this particular virus that has caused the paralysis,(1) although several cases of AFM occurred at around the same time as an outbreak of the EV-D68 virus.(2)

There has been a spike in AFM:  https://madisonarealymesupportgroup.com/2018/10/19/rise-in-acute-flaccid-myelitis-cases-and-the-link-to-vaccinations/

Within the above link, you will learn there are numerous theories on what causes AFM including viruses & vaccinations.  Lyme/MSIDS patients often have viral involvement, and reactivation of Lyme has been documented after vaccinations:  https://madisonarealymesupportgroup.com/2017/12/02/scottish-doctor-gives-insight-on-lyme-msids/, as well as Bartonella:  https://madisonarealymesupportgroup.com/2016/04/24/gardasil-and-bartonella/

https://madisonarealymesupportgroup.com/2016/11/07/connection-of-acute-flaccid-myelitis-and-vaccinations/  In this article, James Lyons Weiler states:

The US press has been pushing a view of acute flaccid paralysis as a mysterious condition of unknown etiology (unknown cause). Checking the scientific literature, however, tells us that AFP is most often Guillain Barre Syndrome (GBS), a condition that appears on the National Vaccine Injury Compensation Program as a “Table Condition” – i.e., one that the US HHS has no defense against when parents file in the NVICP for compensation for GBS as a vaccine injury in their children.  https://madisonarealymesupportgroup.com/2018/12/07/acute-flaccid-paralysis-is-most-often-guillain-barre-syndrome/

GBS is also often a player with Lyme/MSIDS:  https://madisonarealymesupportgroup.com/2019/01/09/transverse-myelitis-guillain-barre-associated-with-bartonella/

https://madisonarealymesupportgroup.com/2017/07/14/clinical-association-lyme-disease-and-guillain-barre/  In Dr. Waisbren’s book, Treatment of Chronic Lyme Disease, the majority of his 51 cases of chronic Lyme had high EBV titers.  He also states,

“As will be seen in other cases, the Epstein-Barr virus may be a candidate for a co-infection associated with LD.”  

Waisbren often treated this co-infected patients that had EBV with 1000mg of Valtrex three times a day with good success.  He also used gamma globulin (4cc twice a week).

So Lyme/MSIDS patients are at the top of the list for AFM for numerous reasons.  Personally, I had a MRI at one point due to the excruciating pain in my spine and occipital headaches.  This pain was unrelenting.  Borrelia burgdorferi (Bb) loves the brain and spinal column.  Many viruses hang out in the spine.  The MRI showed nothing abnormal and I was sent home with the same pain I came with.  While I believe proper antimicrobial treatment to be imperative, what finally relieved this pain for me was MSM:  https://madisonarealymesupportgroup.com/2018/03/02/dmso-msm-for-lyme-msids/

Along with swelling in the spine, patients can have brain swelling as well.  Within one week, I met 3 Lyme patients with Chiari, another supposed “rare” condition:  https://madisonarealymesupportgroup.com/2016/04/02/chiari/  While Chiari is often caused by structural defects in the brain and spinal cord that occur during fetal development, it can also be caused due to injury, exposure to harmful substances, or infection. 

When you study the Bb organism, along with the numerous coinfections, spine and brain swelling makes complete sense and needs to be studied further:  https://madisonarealymesupportgroup.com/2016/02/13/lyme-disease-treatment/

There is so much research begging to be done, yet main stream medicine wants to wrap Lyme into a pretty box with a bow on top.  Again, if there is any box involved with Lyme/MSIDS, it’s Pandora’s.

 

 

Scientists Weigh-in on the Seriousness of Tick-borne Illness (Video)

  Approx. 48 Min.

Published on Dec 10, 2018

In Stand4Lyme Foundation’s video, scientists tackle the Lyme disease Epidemic. Experts address the serious consequences of Lyme and tick-borne diseases, an increasing source of morbidity and mortality worldwide. Stand4Lyme makes a clear business case for pharmaceutical support and federal research funding to develop reliable diagnostic tools and accessible effective medical treatment. The goal of this video is to help educate all stakeholders from a scientific perspective and garner increased government support and funding.
They discuss:
  1. Heart issues (including Dr. Neil Spector’s case)
  2. Eye issues
  3. Cognitive issues
  4. Borrelia is complex and lurks within the body
  5. Borrelia crosses the blood/brain barrier
  6. The pathogen connection & Alzheimer’s
  7. Neurological complications of Lyme
  8. Psychiatric complications of Lyme
  9. This year, WHO has recognized Lyme can be spread Congenitally
  10. Sexual transmission was broached as well & will be researched
  11. Admission that Lyme has been neglected by the Medical Community
  12. The need for a system approach to Lyme
  13. The admission that borrelia is slow growing & sustain themselves like TB, and the fact current medications only work on cells that are dividing.  Borrelia can lie dormant.
  14. In both mouse and primate studies, doxycycline does not eradicate borrelia in the later stages of infection.
  15. The admission “WE ARE IN THE DARK” on Lyme
  16. Discussion of some current hopeful research  (scroll to 34:39 & listen until 38:30)
  17. Lyme can cause suicide
  18. Families have to sell their house, car, etc. to get help from doctors who do not accept insurance
  19. Funding for Lyme/MSIDS research is coming from private sources not the NIH
  20. 2018 – LD is in ALL 50 states and in 80 countries worldwide by CDC numbers
Want to donate & support LD Research at Stanford University?  https://www.stand4lyme.org/
Stanford Lyme Working Group:
Dr. Laura Roberts
Dr. Mark Davis
Dr. William Robinson
Dr. Irving Weissman
Dr. Frank Longo
Dr. John Aucott
Dr. Brian Fallon
Dr. Nevena Zubcevik
Dr. Monica Embers
Dr. Neil Spector
Dr. Allen Steere
**May be a partial list of SWLG and Collaborators
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**Comment**
One of the best videos I’ve personally seen.  Kudos to Taking a Stand 4 Lyme on such a groundbreaking video.  Definitely worth your time to view.

Lyme Patients – Check Your Vision

https://www.elenafridmd.com/single-post/2018/09/25/CHECK-YOUR-VISION

CHECK YOUR VISION

September 26, 2018

Elena Frid MD

Cases included:

  1. Visual floaters caused by ophthalmic artery vasculitis.

  2. Opsoclonus Myoclonus Syndrome (OMS) – dancing eyes, causing impaired reading skills and dizziness.

  3. Optic neuritis – inflammation of the optic nerve causing blurry vision and worsening visual acuity.

  4. Saccadic intrusions on smooth pursuit and conversion insufficiency – abnormal eye movements, causing difficulty tracking when reading. This is one of the most common visual disturbances I see in my practice and can be very disturbing for the patient. It can be detected during a thorough neurological exam in the office. However, I find that it is frequently missed in clinical practice.

  5. Uveitis – frequent eye infections that are a result of an impaired immune system caused by tick borne disease in the setting of Lyme disease and co-infections.

Your eyes are an extension of your brain. Its important to note and share changes (even if they are small) in your vision with your physician. Get proper testing and seek a specialist who is familiar and comfortable addressing and treating visual impairments.

In good health,

ELENA FRID, M.D. ABPN, ABCN

ADULT AND PEDIATRIC LYME EXPERT

BOARD CERTIFIED NEUROLOGIST & CLINICAL NEUROPHYSIOLOGIST

151 E 62nd, STE 1A New York, NY 10065   |   T: 212-288-8832

ELENAFRIDMD.COM   |   WWW.DRFRID.COM

Dr. Frid is a physician specializing in Lyme disease and sees patients with this condition – which is not universal among physicians. For more information about Lyme disease contact Dr. Frid follow Dr. Frid on Instagram @drelenafrid.

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For More:  https://madisonarealymesupportgroup.com/2018/09/06/ocular-manifestations-of-bartonellosis/

https://madisonarealymesupportgroup.com/2017/10/23/opthalmic-manifestations-of-bartonella-infection/

https://madisonarealymesupportgroup.com/2018/08/17/case-of-optic-neuritis-secondary-to-lyme-disease/

https://madisonarealymesupportgroup.com/2015/09/16/bizarre-symptoms-msids/

https://madisonarealymesupportgroup.com/2017/07/30/tick-inside-eye/

Ocular Manifestations of Bartonellosis

https://www.ncbi.nlm.nih.gov/m/pubmed/30124532/

Ocular manifestations of bartonellosis.

Curr Opin Ophthalmol. 2018 Aug 18. doi: 10.1097/ICU.0000000000000522. [Epub ahead of print]

Authors
Abstract

PURPOSE OF REVIEW: To review the systemic and ocular complications of Bartonella spp. infections specifically cat scratch disease, encompassing epidemiology, laboratory diagnostics, ophthalmic imagining, and treatment.

RECENT FINDINGS: Recent studies have shown that ocular manifestations occur in approximately 4.4% of cat scratch disease patients. The annual prevalence is lower than previously reported to be approximately 12 500 cases annually. Mainstay treatment continues to be oral antibiotics with and without corticosteroids and is dependent on associated systemic manifestations, age, and patient immune status. More recently anti-VEGF agents have been used for complications such as cystoid macular edema and choroidal neovascularization.

SUMMARY: Bartonella spp. infections continue to be a common cause uveitis with ophthalmic manifestations ranging from neuroretinits, vascular occlusions, to choroidal granulomas. Review of associated risk factors including contact with feline reservoirs will aid in recognition and diagnosis of this disease entity. Laboratory diagnostics continue to improve to help with the diagnosis of this entity.

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**Comment**

Thankful that more is coming out on how Bartonella affects the eyes.  This crossed my desk just last year:  https://madisonarealymesupportgroup.com/2017/10/23/opthalmic-manifestations-of-bartonella-infection/

As well as these:  https://madisonarealymesupportgroup.com/2017/07/21/bartonella-and-neuroretinitis/

https://madisonarealymesupportgroup.com/2017/04/06/ocular-bartonellosis/

What ISN’T coming across my desk is the fact many feel strongly that ticks carry and transmit Bartonella.  Mainstream medicine & researchers still mostly deny this to the demise of patients.  Bartonella alone is a formidable foe, but couple it with Lyme and other viruses and tick borne infections and you have a seriously ill patient on your hands.  Regardless if it is transmitted by ticks, there is also the potential of reactivating latent infections within the body when bitten by a tick.  So if the Bart is hanging around but the patient is asymptomatic, a tick bite could activate the latent Bart and cause a hail storm of symptoms.  In my experience testing is horrific in this area and wise doctors treat patients based upon clinical presentation.

Research is required in this area.  Doctors need to know about the potential for this pathogen to be in the mix of tick borne illnesses.  This is another reason why the mono therapy of doxycycline rarely works in patients.  They are often dealing with more than one pathogen/illness.

Until this changes people will not improve.

According to this doctor, Bartonella is the new Lyme:  https://madisonarealymesupportgroup.com/2018/05/07/fox-news-bartonella-is-the-new-lyme-disease/