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Prevalence of Infection by Bartonella spp. in Patients With Psoriasis

Prevalence of infection by Bartonella spp. in patients with psoriasis

Under a Creative Commons license
open access
Dear Editor,

Psoriasis (Ps) is a chronic multisystem inflammatory disease that, in addition to the genetic factor, has other triggers such as emotional stress, nutritional deficit, endocrine problems, and infections. The activation of immune system cells is considered an important factor in the pathogenesis of Ps, and several infectious agents have been related to this activation. To modulate the immune response in patients with Ps, the systemic treatment of the disease may be based on immunosuppressive drugs, which facilitates the spread of opportunistic infections.1

Bacteria of the genus Bartonella are fastidious Gram-negative cocobacilli distributed worldwide (Fig. 1). Currently, the genus has 45 species and subspecies, of which at least 17 are capable of infecting humans. Most of these bacteria are transmitted by hematophagous arthropods, and some of their reservoirs are domestic animals, mainly dogs and cats. Although they have been neglected, the number of studies on Bartonella spp. is increasing, as well as the recognition of their importance. These agents have been linked to a wide spectrum of clinical manifestations, ranging from asymptomatic infection to life-threatening conditions, such as endocarditis.2

Figure 1

Figure 1. Transmission electronmicroscopy photomicrograph of a colony of Bartonella henselae (ATCC 49793) after 45 days of growth on blood-enriched agar: cocoid and electrondense bacteria with a tri-laminar wall, 50,000×.

There are no diagnostic tests with sufficiently high sensitivity and specificity. In addition, bartonellosis is not included in the diagnostic hypotheses by most physicians, which contributes to the underdiagnosis of these infections.2 This study aimed to assess the prevalence of Bartonella spp. infection through molecular and microbiological tests in Ps patients and a control group of volunteers.

The project was approved by the Institutional Research Council of the Universidade Estadual de Campinas (University of Campinas), under protocol CAAE: 48057415.5.0000.5404.

Blood samples were obtained from 30 Ps patients over 18 years of age, with mild to severe manifestations in different therapeutic regimens who agreed to participate in the study, as well as 30 volunteers – Unicamp students or employees over 18 years of age who denied clinical symptoms, were not pregnant, and agreed to participate in the study.

The samples were processed as summarized in Fig. 2. Liquid enrichment cultures and solid cultures were performed as previously described.3 From whole blood and culture samples, DNA was extracted using the QIAmp DNA Mini Kit (Qiagen®).

Figure 2

Figure 2. Flowchart of the procedures performed.

From the obtained DNA, genus-specific conventional PCRs (ITS region) and Bartonella henselae-specific PCRs were performed: double amplified PCR (nested) for the ftsZ region and real-time PCR for the gltA region. The quality of the extracted DNA and the absence of amplification inhibitors were tested using conventional PCR for the GAPDH gene.

B. henselae DNA was detected in 20% (6/30) of Ps patients and in 10% (3/30) of healthy volunteers who denied symptoms at the time of blood sample collection (Table 1). Using Fisher’s exact test, no statistical difference was observed between the two groups (p = 0.23).

Ps is a multifactorial, inflammatory, and immune-mediated disease. Although there is no consensus on the exact mechanisms of action in its pathogenesis, there is strong evidence that external factors, such as super antigens, have a great capacity to stimulate the inflammatory response of the disease.1 Microorganisms have been associated with Ps (including β-hemolytic streptococci, Staphylococcus aureus, Porphyromonas gingivalis, Candida albicans, Chlamydia psittaci, human immunodeficiency virus, and hepatitis C virus), but there is limited evidence that antimicrobial therapy has any direct benefit in crisis prevention. Ps is independently associated with a higher risk of serious infections, which is increased by the use of immunomodulatory treatments.1

Infection by Bartonella spp. was documented in 3.2% of 500 blood donors using a single conventional genus-specific PCR, from samples of liquid and solid culture.4

Bartonella spp. was detected in patients with Ps and psoriatic arthritis (PsA). One patient with Ps presented with cat-scratch disease during treatment with adalimumab, and another patient with PsA presented mesenteric lymphadenopathy and splenic abscesses. Symptomatic infection by Bartonella spp. was detected in other patients who were receiving treatment with immunobiologicals.5

One in five patients with Ps and one in ten healthy volunteers presented infection by B. henselae. Despite the lack of statistical difference when compared with the control group, this information is important when considering the high prevalence of infection in patients with Ps and even in the control group. Attention is needed for any patient who requires immunobiological treatment or other immunosuppressive drugs and who presents with possible expressions of infection by Bartonella spp., such as fever of undetermined origin, cryptogenic hepatitis, lymph node enlargement, endocarditis, sepsis, and graunlomatous or angioproliferative reactions. Further studies are needed to assess whether infection by Bartonella spp. may worsen Ps expression and the risks of this infection associated with immunosuppressive treatments.

2020 Report to Congress By the Tick-borne Disease Working Group  Report Here


  • U.S. Department of Health and Human Services
  • James J. Berger, MS, MT(ASCP), SBB
  • B. Kaye Hayes, MPA

Working Group Members

  • David Hughes Walker, MD (Co-Chair)
  • Leigh Ann Soltysiak, MS (Co-Chair)
  • Charles Benjamin (Ben) Beard, PhD
  • Scott Palmer Commins, BS, MD, PhD
  • Angel M. Davey, PhD
  • Dennis M. Dixon, PhD
  • Sam T. Donta, MD
  • Adalbeto Perez de Leon, DVM, MS, PhD
  • Kevin R. Macaluso, PhD
  • Eugene David Shapiro, MD
  • Patricia Smith, BA
  • Leith Jason States, MD, MPH
  • CAPT Scott J. Cooper, MMSc, PA-C
  • CDR Todd Myers, PhD, HCLD (ABB), MB (ASCP)

Executive Summary p. 1

Chapter 1:Background p. 4

Chapter 2: Methods of the Working Group p. 10

Chapter 3: Tick Biology, Ecology, and Control p. 14

Chapter 4: Clinical Manifestations, Diagnosis, and Diagnostics p. 28

Chapter 5: Causes, Pathogenesis, and Pathophysiology p. 44

Chapter 6: Treatment p. 51

Chapter 7: Clinician and Public Education, Patient Access to Care p. 59

Chapter 8: Epidemiology and Surveillance p. 84

Chapter 9: Federal Inventory p. 93

Chapter 10: Public Input p. 98

Chapter 11: Looking Forward Conclusion p. 103

Conclusion p. 112

For more articles on the TBDWG:
Nothing has changed in Lyme-land.  
The Cabal wins again.

Pandas & Lyme in a 7-Year Old



Hello, and welcome to another Inside Lyme Podcast. I am your host Dr. Daniel Cameron. In this podcast, I will be discussing the case of a 7-year-old child who was initially diagnosed with PANDAS and later, Lyme disease.

The article by Cross et al. entitled “Case Report: PANDAS and Persistent Lyme disease with Neuropsychiatric Symptoms: Treatment, Resolution and Recovery” was published in Frontiers in Psychiatry. [1]

The 7-year-old girl developed multiple physical and neuropsychiatric symptoms six months after travelling to a tick endemic region of the U.S. During this period, she was treated for 3 separate strep infections and was subsequently diagnosed with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS). PANDAS was considered based on classic symptoms and a history of strep, a positive ASO titer and a slightly elevated DNase B titer.

However, despite treatment, the patient’s symptoms continued to worsen. Additional testing revealed that she was also positive by CDC’s criteria for Lyme disease. The Lyme EIA and western blot IgM were positive (with 2 of 3 bands). The western blot IgG was positive for 3 of 10 bands at the IGeneX lab. Her B. henselae IgG was positive at Quest labs. Her IgG Mycoplasma and IgG Babesia duncani antibodies were positive at IGeneX.

Dr. Charles Ray Jones, co-author and treating physician, describes the patient’s broad range of symptoms.

Neuropsychiatric symptoms

On her first visit, “the patient presented with crying, anxiety, headache, joint pain, decreased cognitive functioning, fatigue, nighttime awakening and an extreme fear of sleeping alone.”

The patient’s symptoms were extensive, Jones explains, and included:

• Obsessions, compulsions
• ADHD-like behavior
• Decline in school work
• Separation anxiety
• Panic attacks
• Muscle and joint pain
• Mood lability
• Aggressive behavior
• Fatigue
• Headaches
• Difficulty sleeping
• Word selection problems
• Cognitive decline
• Irrational fears (would not sleep alone)

Functional decline 

The young girl was considered a gifted child and excelled in academics. But cognitive symptoms emerged. She reportedly told her mother, “Mom, something happened to my brain.”

“The patient regressed from being a year ahead of her class in math, to being unable to add beyond the number 10. She began having trouble comprehending more difficult reading,” the authors explain.

“During a ride home with her mother, the patient asked, ‘Who are you? What’s your name again?’ And ‘I know you are mommy but what’s your name?’”

Lyme disease, PANDAS and PANS

PANDAS may be diagnosed when a strep infection triggers multiple neurologic and psychiatric symptoms. PANS or Pediatric Acute-Onset Neuropsychiatric Syndrome, on the other hand, may be triggered by other bacterial, viral or fungal infections. Researchers believe that Borrelia burgdorferi, the bacteria that causes Lyme disease can trigger PANS in some patients.

Lyme disease, PANS and PANDAS can present with similar symptoms. Dr. Bransfield, a psychiatrist who specializes in tick-borne diseases, describes a broad range of neuropsychiatric symptoms that he has seen in his Lyme disease patients. [2]

These include: behaviors associated with developmental disorders or autism spectrum disorder, schizoaffective disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, intrusive symptoms), eating disorder, decreased libido, sleep disorder, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide, violence, anhedonia, depersonalization, dissociative episodes, derealization and other impairments.”


According to the authors, the child was treated with multiple courses of oral and IV antibiotics including: intravenous ceftriaxone, Omnicef 300 mg BID, Zithromax 250 mg BID, 500 mg BID and Tindamax 250 mg QD (Saturdays and Sundays only), Bactrim and Mepron. Despite this, her symptoms continued and the Cunningham Panel™ of tests was ordered.

Cunningham Panel™ and IVIG

“The Cunningham Panel was ordered to assess the presence of antineuronal antibodies against specific neuronal receptors,” the authors write. “If the Cunningham Panel is positive or strongly positive, that would be an indication that one has an autoimmune problem that needs to be treated with IVIG, as well as antibiotics,” explains Jones.

READ MORE: Highlights from the case report

Panel results indicated the patient had elevated levels for 3 out of 4 autoantibodies: Dopamine D1 Receptor (DRD1), Dopamine D2L Receptor (DRD2L), and Tubulin (TUB).

“Based upon the patient’s Cunningham Panel tests results, the decision was made to prescribe IVIG,” the authors write.

“Over a span of 31 consecutive months of treatment with various antimicrobials and 3 courses of IVIG she experienced complete remission and remains symptom free at the time of this publication.”


“Currently this patient appears to be fully recovered and has been discharged from the care of the pediatric Lyme disease specialist. She is asymptomatic and performing academically at the “top” of her class according to her mother,” the authors write.

According to Jones, “multiple concomitant infections may be involved and require treatment to effectively resolve symptoms. Improvement in neuropsychiatric symptoms does not typically occur unless all co-infections are addressed and resolved.”

This podcast addresses the following questions:

  1. What is Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS)?
  2. What are the typical symptoms of PANDAS?
  3. What are the similarities between Lyme disease, PANS and PANDAS?
  4. Why was Lyme disease and other tick-borne illnesses considered?
  5. Why was the name Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) introduced?
  6. What is the Cunningham Panel™ of tests and why was it ordered?
  7. What tests did the girl have that supported the diagnosis of a tick-borne illness?
  8. Can you discuss the range of symptoms this patient experienced?
  9. Can you discuss the girl’s treatment for PANS?
  10. Can you discuss the girl’s treatment for Lyme disease, Bartonella, and Babesia duncani?
    Thanks for listening to another Inside Lyme Podcast. You can read more about these cases in my show notes and on my website As always, it is your likes, comments, reviews, and shares that help spread the word about Lyme disease. Until next time on Inside Lyme.

Please remember that the advice given is general and not intended as specific advice as to any particular patient. If you require specific advice, then please seek that advice from an experienced professional.

Inside Lyme Podcast Series

This Inside Lyme case series will be discussed on my Facebook and made available on podcast and YouTube.  As always, it is your likes, comments, and shares that help spread the word about this series and our work. If you can, please leave a review on iTunes or wherever else you get your podcasts.

  1. Case Report: PANDAS and Persistent Lyme Disease With Neuropsychiatric Symptoms: Treatment, Resolution, and Recovery. Cross A., Bouboulis D., Shimasaki C., Jones C.R. Front. Psychiatry, 02 February 2021
  2. Bransfield RC. Suicide and Lyme and associated diseases. Neuropsychiatr Dis Treat. 2017;13:1575-1587. Published 2017 Jun 16. doi:10.2147/NDT.S136137.


For more:  

NY Doctor Proves Everyone Wrong About Hydroxychloroquine  Video with Dr. Zelenko Here


  • As early as March 2020, Dr. Vladimir Zelenko boasted a near-100% success rate treating COVID-19 patients with hydroxychloroquine (HCQ), azithromycin and zinc sulfate for five days
  • Zelenko has now treated 3,000 patients with COVID-19 symptoms and only three high-risk patients have died
  • Misinformation and outright lies were spun about HCQ, including fabricated research, in an apparent effort to suppress and prevent widespread use
  • Early treatment is crucial. During the first five days of SARS-CoV-2 infection, the viral load remains fairly steady. Around Day 5, it exponentially increases, potentially overwhelming your immune system. To prevent complications, treatment needs to begin within the first five days of symptom onset
  • Early treatment is also crucial to prevent “long-haul” symptoms after recovery. None of Zelenko’s patients who started their treatment within the first five days went on to develop long-haul symptoms

Many doctors around the world started using the anti-malaria drug hydroxychloroquine (HCQ) early on in the COVID-19 pandemic. Among them is Dr. Vladimir Zelenko, a practicing physician in a Jewish community in Monroe County, New York.

He garnered national attention in March 2020 when he told radio host Sean Hannity that he’d had a near-100% success rate treating COVID-19 patients with HCQ, azithromycin and zinc sulfate for five days.1 “I’ve seen remarkable results; it really prevents progression of disease, and patients get better,” he said at the time.

In response, county health officials said Zelenko’s claims were “unsubstantiated” and urged residents to listen to public health officials.2 In this interview, he explains how HCQ works against COVID-19, and discusses the lies spun about the drug to suppress its widespread use. Zelenko had a very active Twitter account and would get millions of views on his tweets, and like many other truth tellers in this crazy pandemic, he was censored and recently removed from Twitter.

“When we have a large population of people that need to be treated, it has to be oral, cheap, safe and effective,” he says. “By the way, this is not new. This information was known in 2005 — even before.

There are papers with [Dr. Anthony] Fauci’s name on it, calling [HCQ] a miracle drug. Fauci called HCQ a vaccine. There’s a paper in which he called it an absolute dream treatment and vaccine. So, it’s conveniently forgotten but that’s what it is. It’s a matter of scientific record.”

What is most impressive to me is that he, through deep research and trial and error in the trenches, determined an incredibly effective protocol, and he did this under enormous personal health challenges. During the spring of last year, he was diagnosed with a type of pulmonary sarcoma that is typically considered terminal, and although improved, he continues to be under treatment for this condition.

Finding Solutions to Avoid a Death Trap

As the SARS-CoV-2 swept through his tight-knit Jewish community, Zelenko was seeing anywhere from 50 to 250 patients per day. At this point, he’s treated more than 3,000 patients with COVID-19-related symptoms. Only one-third of them actually received the triple-drug regimen. The remaining two-thirds were in low-risk categories and did not need drug treatment.

In all, Zelenko has only had 15 patients who ended up requiring hospitalization, four of whom were intubated. All were eventually successfully extubated and recovered. The remaining 11 were admitted for intravenous antibiotics for pneumonia. In all, only three of his high-risk patients died from COVID-19, which puts the mortality rate for this treatment at just 0.3%.

“You cannot ignore that. That’s not even counting the risk stratification patients, which I chose not to treat. In other words, I was able to tell these patients, ‘I know you’re going to be fine. Go home, and you’ll be fine.’ And that has value.

If you include those, the mortality rate is even less. And this has been reproduced. You don’t have to listen to me. You can call it anecdotal all you want, but there are now Harvard professors of virology with 4,000 patient experiences.

Dr. George Fareed, for example, or Dr. Harvey Risch from Yale School of Epidemiology, who has shown that it’s absolutely statistically proven that HCQ used in the prehospital setting is absolutely effective. It’s impossible for it to be a mistake,” he says.

Click here to learn more

Why HCQ?

Zelenko tells the story of how he got started treating COVID-19 patients with HCQ:

“Hospitals were near capacity and all the outpatient services were closed. Half my staff was sick and all of a sudden I had a war zone. I basically started learning triage medicine, trying to save as many people as possible.

At that time, the whole world had been focusing on building respirators and hospital capacity [instead of putting] emphasis on prehospital care. I found that bizarre because that’s never what we do in medicine. We [use] common sense and intervene in the earliest stages.

It’s much easier to fix a small problem than a large problem. For example, someone has cancer, we don’t wait for it to become metastatic disease. We treat as soon as possible. Someone has a small infection. We put the infection out.

If you look at the CDC, they recommend starting the treatment of influenza with antiviral drugs within the first 48 hours, not the week, except when it came to COVID-19. We were told to send patients home, and when they get sicker, send them to the hospital, where there was a good chance they were going to get intubated, especially in March and April.

At that point, in the city, they had mortality rates above 80%. So, it was a death sentence. None of that made sense to me at all. So, I quickly started to brush up on my virology.

I wanted to understand how this virus works and more importantly, what I can do about it. A series on YouTube called MedCram, Episode 34, saved the world. It explains the biology behind how zinc inhibits RNA polymerase, and the fact that zinc can’t get into the cell. So, it needs help.”

Zelenko goes on to describe how he settled on HCQ, a so-called zinc ionophore, meaning it shuttles zinc into the cell. He decided to treat high-risk patients as early as possible, and this turned out to be key. Early treatment really saves lives when it comes to COVID-19. This is not a situation where the wait-and-see strategy is well-advised.

According to Zelenko, during the first five days of SARS-CoV-2 infection, the viral load remains fairly steady. Around Day 5, it exponentially increases, potentially overwhelming the immune system. This also meant he could not afford to wait for test results, which took about five days. By then, most patients would already have progressed too far.

So, if a patient exhibited symptoms, especially if they reported loss of taste or smell as well, he’d start treatment immediately. In hindsight, about 90% of the tests of people experiencing symptoms had a positive test.

The Synergy of HCQ and Zinc

Zelenko likens HCQ and zinc like a gun and a bullet. HCQ is the gun that shoots the zinc into the cell. Zinc is the silver bullet that kills the virus by inhibiting an enzyme associated with viral replication inside the cell. The antibiotic azithromycin is given to prevent bacterial pneumonia and other secondary bacterial infections that are common in COVID-19.

Today, we have even more information, of course, which means there are more tools available beside HCQ, zinc and antibiotics. Ivermectin, for example, appears very useful, especially for prevention, as do steroids and blood thinners. So, Zelenko will now tweak the treatment of individual patients based on their symptoms.

“It’s not a cookie cutter approach, but what is absolutely the same is that high-risk patients must be treated as soon as possible, within the first five days from onset of symptoms, and they all survive, he says.

The Psychological Operation Against HCQ

Unfortunately, as discussed by Zelenko, there was essentially a “psychological operation” put into place to scare people away from HCQ. A big part of that was turning it into a political issue. From the start, doctors who used the drug were threatened with the loss of their medical license, which is unheard of for a drug with such a long history of safe use.

The U.S. government made matters worse by only issuing emergency use authorization for in-hospital use and not for outpatient settings. Meanwhile, HCQ has been used for about 60 years in people with chronic conditions such as lupus and rheumatoid arthritis.

“So, the hypocrisy, the loss of common sense, the outright indoctrination killed a lot of people,Zelenko says. “The root cause of it is the way we educate people. It used to be that higher education was about teaching critical thought and deductive reasoning, analytical analysis.

Now we indoctrinate people into responding to stimuli like dogs, like automatons, like robots. Common sense no longer matters. That’s my critique of higher education and why I think many physicians fell into the trap. Also, this country was traumatized. Even if a doctor was willing to give it, patients were afraid to take it.”

The biggest reason for the fear was unfortunately due to falsified studies and trials using toxic doses. It’s difficult to not suspect an ulterior motive in light of those facts. As noted by Zelenko, a main component of pandemic response, namely prehospital or outpatient treatment, was suppressed.

The question is why? One obvious reason was that it was a presidential election year, and then-president Trump came out in support of HCQ in March 2020. His announcement sparked immediate backlash from a chronically hostile media. “There were plenty of people willing to use every possible way to vilify the president and to discredit anything that might give him a win,” Zelenko says.

Then, of course, there were financial interests at play. Millions of dollars were being invested into new drugs like remdesivir, for example — a drug that costs more than $3,000 per treatment and is only for in-hospital use.

Hospitals were also paid tens of thousands of dollars more for COVID-19 patients, so there was no lack of incentive to get people into the hospital and keep them there either. Meanwhile, Zelenko’s early outpatient treatment costs about $20.

Fraudulent Studies Fueled Distrust

As for the fraudulent and misleading studies, the first to raise alarm was a VA study in Virginia, which found HCQ didn’t prevent death. However, they only used it on late-stage patients who were already on ventilators. From there, they incorrectly extrapolated that it would not be helpful in earlier stages, which simply isn’t true. Other trials simply used the wrong dosage.

While doctors reporting success with the drug are using standard doses around 200 mg to 400 mg per day for either a few days or maybe a couple of weeks, studies such as the Bill & Melinda Gates-funded3 Recovery Trial used 2,400 mg of hydroxychloroquine during the first 24 hours — three to six times higher than the daily dosage recommended4 — followed by 400 mg every 12 hours for nine more days for a cumulative dose of 9,200 mg over 10 days.

Similarly, the Solidarity Trial,5 led by the World Health Organization, used 2,000 mg on the first day, and a cumulative dose of 8,800 mg over 10 days. These doses are simply too high. More is not necessarily better. Too much, and guess what? You might kill the patient. As noted by Zelenko, these doses are “enough to kill an elephant.”

It’s really unclear as to why these studies used such enormous doses, seeing how the dosages this drug is normally prescribed in, for a range of conditions, never go that high.

“All those studies did was prove that if you poison someone with lethal doses of a drug, they’re going to die,” Zelenko says.

Then there was the famous Lancet study that the World Health Organization used to justify essentially banning HCQ. This study was withdrawn when it was discovered that the data had been completely and utterly fabricated with falsely generated data from a fly-by-night company. It was supposed to be a meta-analysis of about 90,000 patients, which showed HCQ had lethal effects.

Unfortunately, before it was withdrawn, this fake study resulted in the WHO (or to quote Zelenko, the “world homicide organization”) putting a moratorium on the use of HCQ, which didn’t improve public trust in the drug. Even more egregious, the U.S. Food and Drug Administration used that fake paper as one of its justifications for removing the emergency use authorization for HCQ, even though the study had already been retracted.

Suppression of HCQ Needlessly Killed Tens of Thousands

According to Zelenko, “HCQ is the safest medication in the history of medicine, azithromycin is one of the most common antibiotics used in medicine, and zinc is a mineral that’s well-known and well-tolerated. These drugs were affordable and available to take at home, which was very important. And they worked.”

June 30, 2020, Zelenko and two co-authors published a study,6 showing that treating COVID-19 patients who had confirmed positive test results “as early as possible after symptom onset” with zinc, low dose HCQ and azithromycin reduced odds of hospitalization by 84% and all-cause death by 500% compared to no treatment at all.

Crazy enough, even though Zelenko went to great lengths to share his clinical findings with the White House and the National Institutes of Health, he received no support and was told they had no use for it.

“What’s happened over the last 20 years is that the academic elite and pharmaceutical industry have bred a monopoly on medical truth,” he says.

“They feel only data generated through randomized control trials, pharmaceutical sponsored trials, or those that are coming out of major academic institutions are to be viewed as truth. Anything coming from a frontline country doctor must be anecdotal.

That’s the crime here. And they created artificial barriers that prevented the flow of common sense and lifesaving information. You know which countries did take it seriously? See, this is a disease of affluence because the rich countries could afford the waste of money. The poor countries like Honduras … they had no options.

They couldn’t afford respirators. They didn’t have enough hospital capacity. So, they gravitated towards the cheap generic approaches. And those are the ones that have the best outcomes.”

Zelenko highlights Uganda, which has a population of about 50 million people, yet has recorded just 325 deaths.7I think this was a genocide against the elderly and a crime against humanity,” he says. “There are plenty of people who have blood on their hands, including the media.”

Coordinated Effort to Cause Harm

He also stresses that the pandemic response, including the suppression of HCQ, has clearly been a global coordinated effort.

“You have to ask yourself, who benefits from a destabilized world? Who benefits from chaos on the streets, from anarchy, from financial despair, from psychological trauma? … In some parts of this country, suicide rates are up 600%.

I speak to my colleagues in emergency rooms — the amount of child abuse and spousal abuse they’ve seen is absolutely ridiculous. The amount of collateral damage from preventable illnesses, like heart disease and cancer that are skyrocketing because people are not getting access to routine care.

A lot of people weren’t getting elective surgeries on time. So, there’s been a lot of collateral damage. The shutdown is killing more people than the virus. The virus is not dangerous if you approach it correctly. If you treat it in the right timeframe, it’s no different than a bad flu. You can deal with it. You don’t have to shut down the world.”

The True Agenda Coming Into Plain Sight

Indeed, the world is becoming increasingly black and white and it’s becoming easier and easier to see that global and national systems are not benefiting but, rather, enslaving the population, and how they’re doing it. As noted by Zelenko:

“I see the world now with such clarity … It’s no longer confusing. It’s a binary choice. It’s very clear who’s on what side. And here are the teams: There are those who want to live a life of God, conscious … Our lives have sanctity. They’re priceless and they should be preserved at all costs. And no one has the right to enslave another human being. That’s one approach.

The other is [internment] … an attempt to enslave, psychologically, and even more so physically, the world population. Do you want to know what’s coming? Look at Justin Trudeau statements. Justin Trudeau, the prime minister of Canada, just announced that anyone who tests positive will be quarantined in a government-run facility, until the government deems you safe to return back to society.

That’s [also] what Cuomo wants to do in New York. And I’ll tell you what I think. For what I’m about to say, I’m going to be labeled as a conspiracy theorist. But you know what? I don’t care because, eventually, the truth will come out and history will prove it right.

If you look at the United Nations and the World Economic Forum, they have a plan. They have a 30-year plan, they have 100-year plan. That’s all spelled out in their charter. Just look at it.

So there’s a plan called the 2030 plan. You can go to the World Economic Forum and look at their own words. It’s being run by Klaus Schwab and his group. He wrote a book called ‘The Great Reset.’ That’s where the term comes from.

Now, all the governments are quoting him, like Justin Trudeau, Prince Charles, the Australian prime minister. There’s a myriad of other politicians calling for the great reset. So, what is the great reset? What are they asking for?

No. 1, I mean it’s absolutely ridiculous, but they’re saying, ‘You will own nothing and you will be happy.’ That is their mission. No. 2, America will no longer be a superpower. No. 3, there will be a small group of nations that determine the direction of where the world goes. No. 4, you won’t eat meat except as an occasional treat.

No. 5, there’ll be a global tax on fossil fuels to eradicate the reliance on oil. No. 6, a billion refugees will be displaced [and] we’re going to have to incorporate them and absorb them into our society. These are their stated goals.

Now, how do you take the world’s biggest country, most powerful country, richest country and make it no longer a world superpower? Well, that’s exactly what they’re doing. The economy is in shambles.

You’ve put in a government now that is passing foreign relief aid to China, Russia, Syria, Iran, the Palestinian Authority. They’re sending billions of dollars now to financially support these countries. So, you have to ask yourself, what is going on here?

This all started many years ago, but when Trump went to Davos, in the first few years of his presidency, he said, ‘I’m not part of your globalist agenda. I’m going to put my national interest first.’ That was a poke in the eye of the globalists. That’s the point when George Soros came out and said that Trump is one of the most dangerous people on the planet and he needs to be brought down.

He was dangerous to their agenda. So, what we’re really fighting for is the soul of man. God is testing us, in my opinion. Every person is being asked one simple question, either bow down to God and have the divine presence protect you or you’re going to bow down to Bill Gates … I’m calling for Nuremberg 2.0. These people need to be brought to justice.”

There’s No Rational Justification for COVID-19 Vaccines

Zelenko also shares his views on the COVID-19 mRNA vaccines. He points out that while Gates is pushing COVID-19 vaccines, ostensibly to save lives, he’s on record saying he feels the world population needs to be reduced.

“If someone was a eugenicist and feels that the world population needs to be reduced, why would I take his vaccine for my health?” he asks. “The logical inconsistencies here are absolutely perverse.

I’m so pro-vaccine you can’t imagine. I’ve given tens of thousands of patients vaccinations. I give it to myself and to my children. However, I’m not COVID-19 vaccine positive. And I’ll tell you why: Because the majority of patients under the age of 45 have a near-100% recovery rate with a mild, runny nose from COVID-19. Why would I vaccinate someone with an experimental vaccine? The answer is not for medical reasons.

Another question, why would I give someone a vaccine, even if they are at high risk, if I can give them prophylaxis and/or early prehospital treatment and have a 100% recovery rate? Not for medical reasons.

Another question: Why would I give a vaccine to someone who’s already had COVID-19 and has antibodies? Not for medical reasons. And why would I give a very specific vaccine to someone who is going to be exposed to a ton of different variants and strains and mutations?

I wouldn’t. What I would use is an approach that inhibits RNA replication of RNA viruses, which works for all the strains, including, potentially, influenza. That’s the big dirty secret here.”

It’s Safe to Stop Living in Fear

Zelenko, who was born in a communist country and whose family suffered under communist and fascist rule, is quite sensitive to the signs of these authoritarian regimes. He recounts a story told in the book “The Gulag Archipelago” by Alexander Solzhenitsyn.

Stalin wanted to dig a canal from Moscow to St. Petersburg. The work, done in the middle of winter, led to the death of 400,000 prison workers, as they weren’t given the appropriate clothes or tools. The bodies were thrown into the cement and became a permanent part of the canal.

“No ship ever used the canal because it was too shallow. So, the question was, why was this canal built? And the answer is: So that 400,000 people would die,” Zelenko says.

“I’m not attacking the vaccine. I’m attacking the need for the vaccine. I have not enough information to say it’s good or bad. And I don’t like to guess. But what I can tell you is that I know for a fact that 99.98% of young and healthy people under the age of 45 recover, with no treatment.

I also know for a fact, from my own real-world battle-tested evidence, which has been reproduced now on hundreds of thousands of patients, that if you intervene early, you essentially eliminate hospitalization and death. And, I’ve now treated two waves. I have not seen one patient who’s had COVID-19 in the first wave, get it again …

So, the need for the vaccine doesn’t exist. It’s … been artificially conflated … offering people an artificial false hope solution in order to enslave them to be codependent on government. You know why my approach is so dangerous? Because not only does it treat COVID-19, [but] it treats anxiety. It tells people you don’t need to worry.

My statement to the American people or whoever’s listening is: Return to normal living. You do not need to worry. And by the way, there are nonprescription options … that can replace HCQ if your government or doctor are too stupid or vicious to give it to you. So, you don’t have to rely on them. You can buy over-the-counter things that will save your own life. So, my point is, return back to normal life …

It’s unbelievable the crime that’s been done on the human psyche. I’m screaming to humanity: Don’t be scared! Be cautious. Be smart. Use common sense. But don’t be scared. Return back to life. Reengage in life.”

HCQ Mechanisms of Action and Alternatives

Over-the-counter alternatives to HCQ include EGCG (green tea extract) and quercetin, both of which are zinc ionophores and therefore work much like HCQ does. Quercetin works best when taken in conjunction with vitamin C, however, as the vitamin C helps activate it. Zelenko recommends taking 1,000 milligrams of vitamin C with it.

Now, HCQ does have other mechanisms of action beside being a zinc ionophore, so it’s a better choice, but if you simply cannot get it, EGCG or quercetin are viable stand-ins. Additional benefits of HCQ include:

  • Inhibiting viral entry into the cytoplasm, in part by changing the pH
  • Inhibiting cytokine storms through anti-inflammatory properties
  • Stabilizing red blood cells, which improves oxygenation

“Since it has four different mechanisms of action, it’s a very effective drug, and it has a half-life of 50 days in plasma,” Zelenko says. “But if you can’t get it, you can’t get it. So, I’ll take quercetin or EGCG.”

The caveat here is you must implement this treatment within the right timeframe. It can be helpful to recognize we are in essence dealing with two diseases, or stages of disease, here.

First, there’s the viral infection, and second, there’s the immune over-response that leads to the release of inflammatory cytokines and agents that can cause blood clots. The key is to prevent the progression from the first stage to the second.

Prescription Help Is Available

Like many others who have dared run the gauntlet that is HCQ promotion, Zelenko has been attacked from several angles. His character has been assassinated in the press, his medical credentials questioned and threatened, and his online presence silenced.

“I had had zero media experience before March 2020. I am of a quiet doctor who was taking care of his patients, living a serene life. All of a sudden, this all exploded on me …

I was on Twitter, getting 10 million impressions per tweet. They shut me down last month for platform manipulation. I’m not even sure what that means. So, I had to develop my own website. It’s free and has my protocols in 20 different languages.”

To learn more about Zelenko’s protocol, be sure to visit his website, There, you’ll find protocols not only for early treatment but also prophylaxis, along with studies that document the rationale for each of the treatment components and patient testimonials.

His website also includes access to telemedicine via “Speak With an MD,” which can overnight your medication. “So, if you live in a state that’s tyrannical, you can have a consultation with Dr. Fields,” Zelenko says. “I had to develop this because there were patients around the country who didn’t have access [to HCQ].”

HCQ should be available to most people in the U.S. at this point, but you do need a prescription, and some doctors are still unwilling or resistant to prescribe it. Other times, pharmacies can create roadblocks. “It may take some diligence but none of my patients goes without the medication written for them,” he says.

Early Treatment Prevents ‘Long Haul’ Side Effects

In closing, it’s worth noting that when you treat early, your risk of developing long-term side effects, commonly referred to as “long-haulers,” is virtually nil. Not a single one of Zelenko’s patients who received treatment within the first five days of symptom onset went on to develop long-haul symptoms afterward.

“I had patients that were long-haulers, but they came to me after that window, and they were already advanced in the inflammatory process. At that point, the cytokine storm had already taken hold. They had developed blood clots, some of them had pulmonary infarct, or strokes actually.

Others developed ARDS or catastrophic lung damage and pneumonias, and others just are not themselves. I don’t know how to describe it, but it ate away part of their souls. They’re not the same people. There’s depression, there’s lack of energy. There’s a psychological impact as well.

So, it’s not that I don’t deal with long-haulers, I do. But the way to prevent the long-hauler syndrome is to intervene within the first five days, with appropriate antiviral medication in high-risk patients. That is 100% successful,” he says.

The Light of Truth Will Prevail

Zelenko refers to the COVID-19 pandemic and everything surrounding it as an information war, a propaganda war, and his primary objective and agenda in this war is to educate and speak truth.

“There’s a lot of false narrative being pumped into the heads of people, to create fear,he says. “In the Psalms of David, it says, ‘With crooked people, you have to deal crookedly.’ It also says you should learn from a thief.

So, I learned from the enemy, and I use their tactics to counter them. The main tactic is to spread truth. By the way, it’s no longer dependent on me. I have second and third and fourth generation leaders that have taken on the mission and are really spreading the knowledge worldwide.

It’s unstoppable. They could try to slow it down, and they are. But the truth will come out. The truth is coming out. And when the truth will be revealed, the people that try to obstruct it and use lies to slaughter, will be destroyed by it, God willing.

I am now more optimistic than I’ve ever been, simply because there’s no more confusion. Life was very confusing. You didn’t know what was good, what was bad. Now, it’s very clear. There’s much more bad, that’s true. But I know where it is. I know where the enemy is. And I know where the good is. And a little light pushes away a lot of darkness.”

+ Sources and References

Vagas Nerve Podcast

Why You Should Listen

In this episode, you will learn about the vagus nerve and how to support the vagus nerve in regaining health and wellness.

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About My Guest

My guest for this episode is Dr. Eva Detko.  Eva Detko, PhD is a natural health specialist, writer, and podcaster including hosting the recent summit “The Mind, Body, and Vagus Nerve Connection”.  Her training in the field of human physiology and nutritional sciences is extensive and includes a doctorate in Physiology, Biochemistry, and Nutrition as well as a Master of Science in Human Nutrition.  She is trained in clinical and medical hypnotherapy and is a Master Practitioner of Neuro-Linguistic Psychology.  Dr. Eva  specializes in working with psycho-energetic and emotional root causes of chronic illness.  As a child, she was weak and vulnerable as the result of her mother’s loss of her sister during a pregnancy; leading to physical and emotional struggles which were exacerbated by bullying and abuse.  As a protective mechanism, she tried to control everyone and everything around her and found life unenjoyable.  The trauma and stress she experienced led to a massively dysregulated autonomic nervous system, Myalgic Encephalomyelitis (or Chronic Fatigue Syndrome), Fibromyalgia, and Hashimoto’s.  Adopting a comprehensive approach to healing the body’s biochemistry, the mind, and the biofield (which she calls the Triage of Health), she has fully recovered her health.  Today, she is grateful for her health and her life and considers it a privilege to be able to be a part of other people’s journey to health.

Key Takeaways

  • What is the vagus nerve, and why is it important in health?
  • What factors negatively impact the vagus nerve?
  • What are the two branches of the parasympathetic nervous system?
  • What symptoms and conditions may be associated with vagal nerve issues?
  • How might conditions like SIBO and constipation be associated to the vagus nerve?
  • What role does the vagus nerve play in the function of the heart, blood pressure, and glucose regulation?
  • How does the vagus nerve impact systemic inflammation?
  • Is there a connection between the vagus nerve and MCAS? Autoimmunity? POTS?
  • What is the Vagus Nerve Infection Hypothesis?
  • Do infections and toxins impacting the vagus nerve have the potential to trigger autoimmunity?

Interview Date

December 29, 2020


Transcript Disclaimer: Transcripts are intended to provide optimized access to information contained in the podcast.  They are not a full replacement for the discussion.  Timestamps are provided to facilitate finding portions of the conversation.  Errors and omissions may be present as the transcript is not created by someone familiar with the topics being discussed.  Please Contact Me with any corrections.      

Transcript not yet available.  Please check back later. 


The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today’s discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

Why You Should Listen

In this episode, you will learn about the vagus nerve and how to support the vagus nerve in regaining health and wellness.

Watch The Show

Listen To The Show

Find The Show

Key Takeaways

  • How might singing, gargling, humming, cold showers, or playing the didgeridoo support vagal tone?
  • What role does a positive emotional state or meditation have on the vagus nerve?
  • How might gratitude journaling support vagus health?
  • What are EFT and Havening?
  • How might breathwork or mouth taping support the vagus nerve?
  • Can Stanley Rosenberg’s vagal toning exercises be a helpful tool?
  • Where might sound healing or biofield tuning fit in?
  • What is the role of diet in reducing inflammation?
  • How can glial cell activation be mitigated with tools like CBD?
  • What supplements may support the vagus nerve?
  • Does structure play a role?
  • What is the connection between the microbiome and the vagus nerve?
  • Can vagal nerve stimulators play a role in healing?
  • How might limbic system retraining benefit the vagus nerve?
  • What essential oils may help improve vagal tone?


Transcript Disclaimer: Transcripts are intended to provide optimized access to information contained in the podcast.  They are not a full replacement for the discussion.  Timestamps are provided to facilitate finding portions of the conversation.  Errors and omissions may be present as the transcript is not created by someone familiar with the topics being discussed.  Please Contact Me with any corrections.      

Transcript not yet available.  Please check back later. 


The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today’s discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

  Was this helpful?  If you found this information helpful, I would very much appreciate your support in keeping the site going.  If you would like to donate to my work, I thank you in advance and send you my gratitude.