LDN & CBD

 Approx. 1 Min

LDN Plus CBD

In this video Dr. Liptan explains the additive effects of CBD (cannabidiol) when taken with LDN (low dose naltrexone) in reducing neuroinflammation and fibromyalgia pain. CBD can also ease some of the side effects caused by LDN.

 

 Approx. 20 Min

CBD for Fibro Pt 1

Dr. Liptan explains the science of CBD, and its uses in the treatment of fibromyalgia. This video also covers:
  • The difference between THC and CBD
  • The effects of CBD on the body based on human and animal studies
  • CBD’s benefits for pain, muscle tension, arthritis, anxiety, insomnia, and adrenal fatigue

To purchase Dr. Liptan’s medical grade, lab tested CBD products visit https://www.fridabotanicals.com Dr. Liptan is also an author of:  “The FibroManual: A Complete Treatment Guide For You And Your Doctor” http://amzn.to/1XP7ZMV “The Fibro Food Formula” https://amzn.to/2rggeZt

**Comment**
I am not affiliated with any products nor do I make a red cent on anything related to this website or the support group; therefore, I can recommend the following product strictly from personal experience and use:  Lidtke CBD Gold:  https://lidtkecbd.com
We use the 2500mg plain.  While it’s $189.00, I only take 2-6 drops at night.  Definitely helps with sleep and pain.
cbd-gold-plain-2500mg
Their CBD Gold line of tinctures blends the full-spectrum CBD extract with supplements such as iodine, GABA, 5-HTP, L-tryptophan, and a whole-food complex of the vitamin C component. Besides, the Lidtke brand indicates that their manufacturing process is from non-GMO, herbicide and pesticide-free hemp for those seeking assurance on the possibility of additives.
We also take LDN.  You titrate up from 1.5mg.  Our ending dose is 4.5mg but some patients need higher dosages.  We found LDN helps our immune systems generally but specifically with better sleep and pain reduction.
Very informative documentary put out by the LDN Research Trust on Lyme/MSIDS.  Dr. Horowitz, Dr. Toups, Dr. Schweig, Dr. Windham, Dr. Holtorf, & Dr. Schwarzback, speak on everything from testing, to diet, to inflammation, and how LDN can help patients.

https://www.ncbi.nlm.nih.gov/pubmed/30619263

Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity.

Abstract

Lyme disease is the most prominent tick-borne disease with 300,000 cases estimated by CDC every year while ~2,000 cases of babesiosis occur per year in the United States. Simultaneous infection with Babesia microti and Borrelia burgdorferi are now the most common tick-transmitted coinfections in the U.S.A., and they are a serious health problem because coinfected patients show more intense and persisting disease symptoms. B. burgdorferi is an extracellular spirochete responsible for systemic Lyme disease while B. microti is a protozoan that infects erythrocytes and causes babesiosis. Immune status and spleen health are important for resolution of babesiosis, which is more severe and even fatal in the elderly and splenectomized patients.

Therefore, we investigated the effect of each pathogen on host immune response and consequently on severity of disease manifestations in both young, and 30 weeks old C3H mice.

At the acute stage of infection, Th1 polarization in young mice spleen was associated with increased IFN-γ and TNF-α producing T cells and a high Tregs/Th17 ratio. Together, these changes could help in the resolution of both infections in young mice and also prevent fatality by B. microti infection as observed with WA-1 strain of Babesia. In older mature mice, Th2 polarization at acute phase of B. burgdorferi infection could play a more effective role in preventing Lyme disease symptoms. As a result, enhanced B. burgdorferi survival and increased tissue colonization results in severe Lyme arthritis only in young coinfected mice. At 3 weeks post-infection, diminished pathogen-specific antibody production in coinfected young, but not older mice, as compared to mice infected with each pathogen individually may also contribute to increased inflammation observed due to B. burgdorferi infection, thus causing persistent Lyme disease observed in coinfected mice and reported in patients.

Thus, higher combined proinflammatory response to B. burgdorferi due to Th1 and Th17 cells likely reduced B. microti parasitemia significantly only in young mice later in infection, while the presence of B. microti reduced humoral immunity later in infection and enhanced tissue colonization by Lyme spirochetes in these mice even at the acute stage, thereby increasing inflammatory arthritis.

___________________
**Comment**
Glad to see more work done on the polymicrobial nature of Lyme/MSIDS as most of us out here in Lyme-land struggle with numerous pathogens, not just Lyme (borrelia).

Key Quote:  Our findings recognize that microbial infections in patients suffering from TBDs do not follow the one microbe, one disease Germ Theory as 65% of the TBD patients produce immune responses to various microbes.”

Another problem:  

83% of all commercial tests focus only on Lyme (borrelia), despite the fact we are infected with more than one microbe.

https://madisonarealymesupportgroup.com/2018/11/17/investigating-disease-severity-in-an-animal-model-of-concurrent-babesiosis-lyme-disease/  These findings suggest that B. Burgdorferi coinfection attenuates parasite growth while B. Microti presence exacerbates Lyme Disease-like symptoms in mice.

https://madisonarealymesupportgroup.com/2018/10/02/1st-documented-case-of-girl-with-blood-stream-infection-with-bartonella-with-coinfection-of-another-bartonella-strain/

https://madisonarealymesupportgroup.com/2017/05/01/co-infection-of-ticks-the-rule-rather-than-the-exception/  Our study reveals high pathogen co-infection rates in ticks, raising questions about possible co-transmission of these agents to humans or animals, and their consequences to human and animal health. We also demonstrated high prevalence rates of symbionts co-existing with pathogens, opening new avenues of enquiry regarding their effects on pathogen transmission and vector competence.

https://madisonarealymesupportgroup.com/2018/10/11/babesia-found-in-patient-with-persistent-symptoms-following-lyme-treatment/  Because the Ixodes scapularis tick can harbour and transmit multiple parasites simultaneously, the possibility of coinfection should be considered in any patient not responding to appropriate initial medical therapy.

To date, ticks can transmit 18 and counting pathogens – ALL as devastating as Lyme: https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/

https://madisonarealymesupportgroup.com/2017/10/28/lyme-wars-part-5-coinfections/  (Click on NBC link for new story.  Approx 5 Min.)  All tests came back negative.  Don’t be fooled.  This stuff ISN’T RARE!  Dr. Phillips discusses how Bartonella isn’t even on the radar and is often confused with Lyme as symptoms overlap greatly.

 

https://www.smithsonianmag.com/smart-news/did-charles-darwin-have-lyme-disease-180971189/

Did Charles Darwin Have Lyme Disease?

New study attributes British naturalist’s persistent poor health to tick-borne disease

By Meilan Solly

SMITHSONIAN.COM
JANUARY 8, 2019

Throughout his adult life, Charles Darwin was plagued by bouts of poor health, including “incessant vomiting,” trembling hands, a “swimming” head,” “singing in the ears” (likely linked with tinnitus), and “violent palpitation of the heart.” Historians have long puzzled over the exact nature of Darwin’s ailments, proposing diagnoses like Chagas disease, lactose intolerance and a mitochondrial disorder. But as George Dvorsky reports for Gizmodo, a new study identifies a previously unmentioned culprit: Lyme disease.

The findings, now published in Denisea, the official scientific journal of the Natural History Museum Rotterdam, posit that the naturalist contracted the tick-borne disease in the somewhat surprising locale of his home country, Great Britain. Although Darwin visited numerous tropical regions during his famed voyage on the H.M.S. Beagle and subsequent research expeditions, the researchers argue it’s more likely he encountered an infectious tick while roaming the expanses of England, Wales and Scotland. Despite the fact that Lyme disease wasn’t formally diagnosed until 1976, Dvorsky notes that instances of the tick-borne disease abound in late 19th- and early 20th-century European records.

Lead researcher Erwin Kompanje of Rotterdam’s Erasmus University medical centre tells the Guardian’s Ian Sample that “[Darwin] had a lot of different symptoms: involuntary twitching of muscles, swimming of the head, a shortness of breath, trembling hands.

He adds, “All of them came and went, and that is quite typical of Lyme disease.”

To analyze Darwin’s maladies, Kompanje and study co-author Jelle Reumer of the Natural History Museum Rotterdam sifted through the scientist’s copious body of correspondence and personal writings. These accounts, many of which are available through the University of Cambridge’s online Darwin portal, offer a portrait of a man beset by chronic illness. In a March 28, 1949, letter to a friend named Joseph Hooker, for example, Darwin explains,

“I was not able to do anything one day out of three, [and] was altogether too dispirited to write to you or to do anything but what I was compelled.”

According to the study, Darwin’s symptoms can be divided into three categories: dysautonomic (or related to the autonomic nervous system), neurological and psychiatric; gastrointestinal; and cutaneous (affecting the skin). The first group of ailments closely resembled what we would now call a panic disorder, with key complaints, including fatigue, dizziness and heart palpitations. Some studies have drawn on these symptoms to suggest Darwin suffered from agoraphobia, but the new study points out that his wife, Emma, once wrote “he always tells me how he … never wants to be alone”— a sentiment not likely shared by most true agoraphobics. Indeed, the authors note that recent research has linked the sudden onset of panic attacks with underlying Lyme disease. Upon receiving treatment for Lyme, some patients have reported these symptoms abated. Overall, the researchers attribute this group of symptoms to “atypical panic attacks.”

The second category of gastrointestinal symptoms—amongst others, flatulence, vomiting and nausea—has previously been attributed to Crohn’s disease or lactose intolerance. Adding to the mix, the study proposes yet another disorder: Cyclic Vomiting Syndrome, which is marked by periods of debilitating vomiting triggered by “stress, excitement and fatigue.”

Finally, in reference to Darwin’s recorded battles with rashes and eczema, the authors suggest that such skin inflammations emerged as a side effect of panic disorder, which they in turn identify as “a rare symptom of chronic borreliosis,” or Lyme disease.

As the Guardian’s Sample notes, the popular diagnosis of Chagas disease, an infection spread by insects native to the Americas, originates from Darwin’s mention of being bitten by a “great black bug of the Pampas” during an 1835 trip to Argentina. But Kompanje and Reumer say that the naturalist’s symptoms align more closely with Lyme disease, in part because certain recurring complaints appeared before the South American expedition.

The pair’s final assessment of a “complex condition with multisystem symptoms” pinpoints Lyme as Darwin’s major affliction, but as Dvorsky explains for Gizmodo, the researchers believe another illness, likely lactose intolerance, contributed to the scientist’s poor health. Combined with what the study terms Darwin’s “hypochondriac predisposition,” it’s unsurprising that his litany of illnesses continues to fascinate.

Still, not everyone is convinced: Richard Wall, a tick expert at the University of Bristol, tells the Guardian, “Borreliosis is a particularly difficult infection to diagnose symptomatically even when the patient is available … so retrospective diagnosis at a historical distance of 200 years, while interesting, must be considered as highly speculative.”

__________________

For more:  

Panic Attacks:  https://madisonarealymesupportgroup.com/2018/05/19/panic-attacks-may-be-lyme-msids/  The author describes the histories of three patients with panic-like episodes that turned out to be related to underlying, previously unsuspected tick-borne diseases.

Tinnitus, tingling, numbness, twitching:  https://madisonarealymesupportgroup.com/2015/09/16/bizarre-symptoms-msids/

Hearing Loss:  https://madisonarealymesupportgroup.com/2018/05/19/panic-attacks-may-be-lyme-msids/

Shortness of breath/air hunger:  https://madisonarealymesupportgroup.com/2018/03/22/what-is-air-hunger-anyway/

Brain fog:  https://madisonarealymesupportgroup.com/2018/03/22/what-is-air-hunger-anyway/

Heart issues:  https://madisonarealymesupportgroup.com/2018/06/03/heart-problems-tick-borne-disease/

Rashes:  https://www.sciencedaily.com/releases/2013/04/130422132507.htm?

Clinical diagnosis must consider any skin rash, regardless of its resemblance to the bull’s-eye.  Many people never recall a rash or tick bite. “Researchers note that multiple textbooks and websites prominently feature the bull’s-eye image as a visual representation of Lyme disease.” They write, “This emphasis on target-like lesions may have inadvertently contributed to an underappreciation for atypical skin lesions caused by Lyme disease.”Some Visible Signs of Lyme Disease Are Easily Missed or Mistaken, Science Daily, Apr 22, 2013

“Not everything is Lyme, but Lyme can be anything.”  Dr. Hoffman RIP

 

 

https://www.blacklistednews.com/article/70210/award-winning-journalist-exposes-wifi-disaster-in-canadian-public-school-that-injured-dozens-of.html

AWARD WINNING JOURNALIST EXPOSES WIFI DISASTER IN CANADIAN PUBLIC SCHOOL THAT INJURED DOZENS OF CHILDREN

Published: January 9, 2019

“Two children have dropped dead in Simcoe County Schools since Wi-Fi was installed…” ~Rodney Palmer

Wireless technology is largely seen as benevolent and kind. Any danger to our health is typically passed off to the next generation to figure out, regardless of the consequences that have happened already. This story has played out many times in the past, whether it be DDT, cigarettes, or leaded paint. However, as Wifi proliferates throughout our schools with potential dangers for our children’s health, some are courageous enough to fight back against this under-studied science.

Rodney Palmer, an award-winning Canadian journalist and Communications Advisor at the Safe School Comittee, has been speaking out about the dangers of Wifi in public schools since at least 2010.  In a presentation to the Royal Society of Canada, he spoke about a wifi disaster at a public elementary school that injured dozens of students. The story is quite remarkable.

“When the schools installed the wifi, we found out that at least four children had erratic tachycardia [fast or irregular heart rate] that confounded their doctors and they were wearing heart monitors to school. The older children…told us they had blackouts in certain areas of the school.” – Rodney Palmer

Do children have a particularly low resistance to wireless radiation? According to Rodney Palmer, many school-aged children report a negative reaction from exposure to Wifi since its introduction to public schools. These children cite headaches, irregular heart rate, and blackouts as potential reactions to the technology.

“Anyone could make the argument that you could safely spray any amount of pesticide on any person for any amount of time, although that once thought to be okay, and that’s the current government thinking with microwave radiation.” – Rodney Palmer

If you’re an adult and you want to have Wifi in your house, you can make the decision about whether you want to use a technology that may harm your health; that’s part of what it means to be free. However, the story starts to change when we talk about children.

Most parents would do anything that they can to keep their children safe, and if getting rid of Wifi at home does the job then so be it. But when children are in places where they are forced by the government to spend most of their childhood, it’s no longer up to the parents to aid their child’s health. It’s up to a bureaucracy which likely doesn’t have the same agenda as the parent. In one school’s case, they told the parents that there was no other option.

“The Simcoe County District Schools Board said no. They said the children must be exposed to Wifi at school. Even the children who were sick and presented to the school board themselves were told no, you may not plug your computer into the wall. You must sit all day in a sea of microwave radiation.”

Because of safety code 6 in Ontario, the school board does not have to acknowledge a parent’s complaint about this issue because the code considers the radiation to be completely safe. However, appropriate long-term testing has not been done to determine whether some children are affected negatively by wireless radiation.

“So, we were right! Our kids were sick at school and nowhere else. There was no mold problem, no recent renovation, chemical building materials. Only a newly installed massive WIFI system. They measured and found that radiation created by the WIFI exceeded Safety Code 6 thermal threshold by 34%. And that explained how my son came home from school with hot ears every day. He was being cooked by microwaves.

School WIFI operates at 2.4 GHz, the same frequency as a microwave oven.

So, did they shut it down?

Evacuate the school?

Did they alert the teachers? Parents? Students?

No!” [Source]

No, the Simcoe County District School Board kept it quiet. They told no one. They downplayed the results as insignificant and failed to tell the parent who were BEGGING for answers.

Unfortunately, in many western countries, children are given few options as to where their education may take place. In the UK, laws have been introduced forcing parents to pay fines of up to £120 because of their child’s tardiness to school. This type of law appears to be popping up around the world, where parents are granted littler control over the life and health of their child.

As several children have had unexplained health issues in suspicious connection with Wifi radiation, the question should not be whether we can prove for a fact that Wifi caused the incidents, but whether we should be forcing a potential danger on the world’s children just because we can’t prove for a fact that it was not.

“The ‘weight of evidence’ model is weighted in favor of science payed for by the wireless industry. As you all know, science can be manipulated, but cardiac arrest can’t.” – Rodney Palmer

THIS ARTICLE (AWARD WINNING JOURNALIST EXPOSES WIFI DISASTER IN CANADIAN PUBLIC SCHOOL THAT INJURED DOZENS OF CHILDREN) WAS ORIGINALLY CREATED AND PUBLISHED BY WAKING TIMES AND IS PUBLISHED HERE UNDER A CREATIVE COMMONS LICENSE WITH ATTRIBUTION TO PHILLIP SCHNEIDER AND WAKINGTIMES.COM. IT MAY BE RE-POSTED FREELY WITH PROPER ATTRIBUTION, AUTHOR BIO, AND THIS COPYRIGHT STATEMENT.

**Comment**

A recent article by Dr. Mercola, “Top 19 Tips to Reduce Your EMF Exposure,” is a must read and has some videos worth watching as well:  https://articles.mercola.com/sites/articles/archive/2019/01/15/health-effects-of-emf-exposure.aspx?

STORY AT-A-GLANCE

  • Persistent exposures to microwave frequencies like those from cellphones can cause mitochondrial dysfunction and nuclear DNA damage from free radicals reacted to peroxynitrite
  • Excessive exposures to cellphones and Wi-Fi networks have been linked to chronic diseases such as cardiac arrhythmias, anxiety, depression, autism, Alzheimer’s and infertility
  • Devices that continuously emit EMF radiation at levels that damage your mitochondria include your cellphone, cellphone towers, Wi-Fi routers and modems, baby monitors and “smart” devices of all kinds, including smart meters and smart appliances
  • EMF exposure has increased about 1 quintillion times over the past 100 years. Most people experience biological impacts but have no appreciation of the damage it’s causing until it’s too late. Even then, it’s extremely difficult to link the exposure to the symptoms or the disease
  • 5G relies primarily on the bandwidth of the millimeter wave, known to penetrate 1 to 2 millimeters of human tissue and has been linked to numerous health problems, including eye and heart problems, pain and suppressed immune function

http://  Approx. 3 Min

Scientists Speaking on Health Effects of Cell Phone Wireless Radiation

https://ehtrust.org/take-action/educate-yourself/top-10-facts-about-cell-phones-and-wi-fi-2/  More videos and information within the Environmental Health Trust link.

http://  Approx. 1 Hour

Dr. Mercola Interviews Martin Pall PhD on EMFs and the mechanism of how they harm people’s health and contribute to chronic diseases.

http://  Approx. 30 Min

Potential Risks to Human health From Future Sub-MM Communication Systems:  Paul Ben-Ishai, PhD

This is from the 2017 Expert Forum on Wireless and Health. All presentations from this conference are availible at http://ehtrust.org/science/key-scient…

https://microwavenews.com/short-takes-archive/italian-decision-precaution

Italian Court Orders Public Safety Campaign

January 16, 2019

In a victory for advocates of precaution, an Italian court has order the government to launch a campaign to advise the public of the health risks from mobile and cordless phones.

The information campaign must begin by July 16.

The court reached its decision last November, but the announcement was only made yesterday.

Decision here:  https://www.giustiziaamministrativa.it/cdsintra/cdsintra/AmministrazionePortale/DocumentViewer/index.html?ddocname=4JM4PKAARND2ZYHVSOSK2FIQIQ&q=

Google translate:

http://translate.google.com/translate?sl=it&tl=en&u=https%3A%2F%2Fwww.repubblica.it%2Fsalute%2Fmedicina-e-ricerca%2F2019%2F01%2F16%2Fnews%2Ftar_ministeri_informino_sui_rischi_dei_telefonini-216696504%2F%3Fref%3DRHPPBT-BH-I0-C4-P9-S1.4-T1%26refresh_ce

For more:  https://madisonarealymesupportgroup.com/2019/01/14/un-secretary-general-confesses-ignorance-on-known-5g-dangers/

https://madisonarealymesupportgroup.com/2019/01/08/5g-will-blanket-earth-with-ultra-high-microwave-frequencies/

https://madisonarealymesupportgroup.com/2018/05/22/latest-on-electromagnetic-radiation/

https://madisonarealymesupportgroup.com/2018/08/24/take-back-your-power-smart-meter-documentary/

Opt Out Fees:  http://www.stopsmartmetersbc.com/wp-content/uploads/OPT-OUT-FEES.pdf  (Wisconsin not listed)

 

 

 

 

 

 

https://www.oatext.com/pdf/GMO-2-153.pdf

Effective killing of Borrelia burgdorferi in vitro with novel herbal compounds

Kati Karvonen* and Leona Gilbert

Department of Biological and Environmental Science and Nanoscience Center, PO Box 35, FI-40014, University of Jyvaskyla, Finland

 

Abstract
Introduction: The tick-borne disease Lyme Borreliosis is caused by Borrelia bacteria. The disease can persist even after treatment with antibiotics, which is why other methods of treatment are needed. Herbal compounds and phytochemicals have been recently examined in relation to eradicating Borrelia bacteria in vitro.

Objective: The possible antimicrobial effect of two novel compounds, Biocidin Liquid and LSF Broad-Spectrum Liposomal formulas, was examined in the hopes of discovering an alternative method for eradication of Borrelia bacteria.

Methods: minimum inhibitory concentrations (MICs) and minimum bacterial deaths (MBDs), as well as, time-kill effect of each compound were utilized in the study.

Results: The Liquid formula effectively killed the spirochetes with 1:10 dilution, while the MIC for the Liposomal formula was 1:25. Moreover, the MIC for both compounds with Round Bodies was 1:50 and for biofilms 1:10. Though long-term effect (MBD) was seen only with 1:5 dilutions for both formulas. Additionally, the killing effect of each compound was observed already at 10 min post-treatment.

Conclusion: The study conducted here provides new insight into the antimicrobial effect of herbal compounds. Furthermore, studies such as these are required in order to discover possible alternatives to antibiotics in the battle against Borrelia infections.

___________________

**Comment**

The work was done in vitro (in a lab setting, not the human body) and funding was, “supported by Bio-Botanical research Inc. However, the authors devised the study design, collected and analyzed the data, and prepared the manuscript without input from the company. e decision to publish was the authors.”

Bio-botanical research manufactures Biocidin.

I’ve personally used Biocidin with no noticeable effects.

This work, similar to the in vitro work on stevia and essential oils still needs to be done in vivo (the human body) to determine it’s true effect, if any.

For Stevia info:  https://madisonarealymesupportgroup.com/2017/08/11/stevia-clinical-trial-underway/

https://madisonarealymesupportgroup.com/2015/11/19/stevia-and-bb/

Essential Oil info:  https://madisonarealymesupportgroup.com/2017/10/13/oregano-cinnamon-and-clove-found-to-have-high-anti-persister-activity-for-bb/

https://madisonarealymesupportgroup.com/2018/10/26/essential-oils-as-treatment-against-lyme-disease/

Personally, my husband and I have tried Stevia and EO’s internally.  We relapsed on both.  We also didn’t have any noticeable herx reactions.  That isn’t to say they won’t work on someone else but for me and my husband we’ve ALWAYS responded to antibiotics with noticeable herxheimer reactions upon starting treatment.  

https://madisonarealymesupportgroup.com/2018/12/10/johns-hopkins-researchers-plant-compounds-may-be-better-than-current-antibiotics-at-treating-persistent-lyme-bacteria/

 

 Approx. 2.3 Min.

BBC South East Evening News – Lyme Disease

Outdoor Survival Expert tells of the dangers of Lyme Disease.

__________________

Great video reminding us of how our those working in the outdoors including search and rescue folks, police, fire, EMS, and forest workers are in harms way.  These folks are in the elements, including grassy ditches and other tick friendly habitats.

https://madisonarealymesupportgroup.com/2018/09/07/lyme-taking-toll-on-lunenburg-county-search-and-rescue-team/

Tick prevention is crucial:  https://madisonarealymesupportgroup.com/2017/05/11/tick-prevention-and-removal-2017/

https://madisonarealymesupportgroup.com/2018/05/27/study-conforms-permethrin-causes-ticks-to-drop-off-clothing/

To purchase permethrin-sprayed socks and support Wisconsin Lyme Network (WLN):  https://wisconsinlymenetwork.z2systems.com/np/clients/wisconsinlymenetwork/giftstore.jsp

https://www.hopkinsmedicine.org/news/newsroom/news-releases/schizophrenia-linked-with-abnormal-immune-response-to-epstein-barr-virus

Schizophrenia Linked with Abnormal Immune Response to Epstein-Barr Virus

01/09/2019
New research from Johns Hopkins Medicine and Sheppard Pratt Health System shows that people in the study with schizophrenia also have higher levels of antibodies against the Epstein-Barr virus (EBV), a herpes virus that causes infectious mononucleosis, so-called mono.

 

Researchers proposed two explanations for the association of heightened immune responses in patients with schizophrenia and EBV infection: schizophrenia might alter the immune systems of these patients and make them more susceptible to EBV, or EBV infection might increase the risk of schizophrenia.

The article was published online Nov. 20 in Schizophrenia Bulletin.

“We are interested in the role of infectious agents such as Epstein-Barr virus in schizophrenia and other serious psychiatric disorders, so we did this study to look at the associations,” said Robert Yolken, M.D., the Theodore and Vada Stanley Distinguished Professor of Neurovirology in pediatrics at Johns Hopkins Children’s Center and senior author of the study. Yolken cautioned that the study wasn’t designed to determine cause and effect.

Schizophrenia is a mental disorder where patients have distorted thinking, perception, emotions, language, sense of self and behavior. According to the World Health Organization, schizophrenia affects more than 21 million people worldwide.

While schizophrenia has some genetic associations, genes that have been found to date explain only a portion of the disease risk. Environmental exposures, including to some infectious agents, have also been identified in previous studies as increasing the risk for schizophrenia.

EBV initially causes fever and swollen lymph nodes, and is commonly transmitted through oral contact such as kissing. In severe cases, it can spread to the central nervous system and cause persistent infection. Researchers wanted to see the relationship between this EBV infection and schizophrenia.

The researchers conducted a study among 743 people—432 with a schizophrenia diagnosis and 311 without a history of a psychiatric disorder to serve as a control group. Around 55 percent of the participants were men.

The researchers first measured levels of antibodies against components of EBV by comparing antibody levels in healthy people with those of people who have schizophrenia. They looked at the odds of having these antibodies in the 50th, 75th and 90th percentiles and found that people with schizophrenia were 1.7 to 2.3 times more likely to have increased levels of some EBV antibodies compared with people without schizophrenia.

Then they measured the antibodies to other related viruses such as varicella/chicken pox or herpes simplex type 1/cold sore virus, and didn’t find an increase of antibodies against these viruses in people with schizophrenia. These findings suggest that only EBV was associated with increased risk of schizophrenia.

After that, the researchers sequenced a portion of the participants’ DNA to determine their genetic risk for schizophrenia. Results from the analysis showed that people who had both evidence of increased genetic risk for schizophrenia and increased antibody levels to EBV had a more than eight times higher chance of being in the schizophrenia group as compared with controls. Approximately 10 percent of the individuals with schizophrenia had increased levels of both antibodies and genetic risk as compared with slightly more than 1 percent of the controls.

“We found that individuals with schizophrenia had an unusual response to Epstein-Barr virus,” said Yolken. “This indicated that the prevention and treatment of Epstein-Barr virus might represent an approach for the prevention and treatment of serious psychiatric disorders such as schizophrenia.”

Currently, there are no treatments available for EBV approved by the Food and Drug Administration, but a number of compounds that may prevent or treat replication of the virus are under investigation. The researchers considered the development of these approaches a high priority so that people with schizophrenia or other disorders associated with susceptibility to EBV could use them. In the meantime, researchers recommend preventing EBV transmission through good hygienic practices such as hand-washing and avoiding oral contact, such as kissing, with infected people. 

The study is supported by the National Institute of Mental Health (MH-94268) and by the Stanley Medical Research Institute (07-1690).

Other authors on the study included Lorraine Jones-Brando of Johns Hopkins; Faith Dickerson, Cassie Stallings, Andrea Origoni, Emily Katsafanas, Kevin Sweeney and Sunil Khushalani from the Stanley Research Program at Sheppard Pratt; Glen Ford from VanPelt Biosciences; Giulio Genovese and Colm O’Dushlaine from Broad Institute of MIT and Harvard.

This press release is modified from a release prepared by Sheppard Pratt Health System.

_________________

**Comment**

EBV & other viruses can be key players with Lyme/MSIDS:  https://madisonarealymesupportgroup.com/2017/04/11/diagnosed-with-ebv-had-lyme/

https://madisonarealymesupportgroup.com/2018/04/25/ebv-protein-can-turn-on-genes-for-autoimmune-diseases/

https://madisonarealymesupportgroup.com/2017/11/04/24514/  (EBV – A Key player in Chronic Illness & Tips to Treat Reactivated EBV)

https://madisonarealymesupportgroup.com/2018/09/30/he-got-schizophrenia-he-got-cancer-and-then-he-got-cured/

A decade ago, Dr. Miyaoka accidentally discovered one. He treated two schizophrenia patients who were both institutionalized, and practically catatonic, with minocycline, an old antibiotic usually used for acne. Both completely normalized on the antibiotic.When Dr. Miyaoka stopped it, their psychosis returned. So he prescribed the patients a low dose on a continuing basis and discharged them.

Minocycline has since been studied by others. Larger trials suggest that it’s an effective add-on treatment for schizophrenia. Some have argued that it works because it tamps down inflammation in the brain. But it’s also possible that it affects the microbiome — the community of microbes in the human body — and thus changes how the immune system works.

https://madisonarealymesupportgroup.com/2018/09/20/schizophrenia-breakthrough-identifies-importance-of-immune-cells/

https://madisonarealymesupportgroup.com/2017/10/03/treat-the-infection-psychiatric-symptoms-get-better/  LLMD, Dr. Horowtiz, goes on record stating that antibiotics are effective in Schizophrenia. With irony he points out that the authors attribute the reason minocycline helped these patients is due to its ability to affect glutamate pathways in the CNS, blocking nitric oxide-induced neurotoxicity, and inflammation in the brain. He reminds them that minocycline is a tetracycline antibiotic that very well may be treating an infection. He also emphatically states that he has had several schizophrenic patients test positive for Bb, the agent of Lyme Disease. After taking doxycycline they improved significantly and with the help of their psychiatrist, were able to reduce and in some cases eliminate all of their antipsychotic medication. It is important to note that patients remained stable on antibiotics but their symptoms returned if they stopped treatment.

https://madisonarealymesupportgroup.com/2017/06/04/minocycline-for-ms-and-much-more/  BTW:  Mino was one of the most effective meds for my neuro issues and severe occipital headaches.  It crosses the blood brain barrier.

https://madisonarealymesupportgroup.com/2017/01/17/lymemsids-and-psychiatric-illness/  In this presentation, Dr. Markes questions if psychiatric disorders are inflammatory diseases. She lists: Autism, Alzheimer’s, Schizophrenia, Bipolar, PTSD, Depression, Stress, Sleep Deprivation, Self-harm, and Suicide Attempts. She also describes a study in England observing children for over a decade in which children with a high IL-8 at age 8 have an 81% change of developing depression by age 18 and a 2-fold chance of becoming psychotic.