Archive for the ‘Morgellons’ Category

Morgellons in Dogs

http://www.scitechnol.com/abstract.php?abstract_id=5548

Abstract

Canine Filamentous Dermatitis Associated with Borrelia Infection

Background: Although canine clinical manifestations of Lyme disease vary widely, cutaneous manifestations are not well documented in dogs. In contrast, a variety of cutaneous manifestations are reported in human Lyme disease caused by the spirochete Borrelia burgdorferi. A recently recognized dermopathy associated with tickborne illness known as Morgellons disease is characterized by brightly-colored filamentous inclusions and projections detected in ulcerative lesions and under unbroken skin.Recent studies have demonstrated that the dermal filaments are collagen and keratin biofibers produced by epithelial cells in response to spirochetal infection. We now describe a similar filamentous dermatitis in canine Lyme disease. Methods and Results: Nine dogs were found to have cutaneous ulcerative lesions containing embedded or projecting dermal filaments. Spirochetes characterized as Borrelia spp. were detected in skin tissue by culture, histology, immunohistochemistry, polymerase chain reaction (PCR) and gene sequencing performed at five independent laboratories. Borrelia DNA was detected either directly from skin specimens or from cultures inoculated with skin specimens taken from the nine canine study subjects. Amplicon sequences from two canine samples matched gene sequences for Borrelia burgdorferi sensu stricto. PCR amplification failed to detect spirochetes in dermatological specimens from four healthy asymptomatic dogs. Conclusions: Our study provides evidence that a filamentous dermatitis analogous to Morgellons disease may be a manifestation of Lyme disease in domestic dogs.

https://www.lymedisease.org/morgellons-disease-proven-occur-dogs/

“Similar skin lesions have previously been reported in bovine digital dermatitis, an infectious disease of cattle.

Most of the owners of the study dogs were healthy and were not familiar with Morgellons disease or Lyme disease; however, two of the owners also had Morgellons disease. “In those cases, we do not have evidence of contact transmission from human to animal or animal to human,” says Dr. Stricker, “it may be that both owner and dog were exposed to the same disease vector.”

The finding of skin lesions similar to Morgellons disease, first in cattle and now in dogs, confirms that the skin disease is not a delusion, as some have maintained,” said Ms. Middelveen. “We need to learn much more about this mysterious skin condition.”

About the Charles E. Holman Morgellons Disease Foundation:
The Charles E. Holman Morgellons Disease Foundation based in Austin, TX, is a 501(c) (3) nonprofit organization committed to advocacy and philanthropy in the battle against Morgellons. Director, Cindy Casey-Holman, RN, leads the foundation, named for her husband, Charles E. Holman, a pioneer in the fight against MD. The CEHMDF is the recognized authority and primary funding source for Morgellons Disease medical-scientific research. There are neither grants, nor any other public or private funding to support research for Morgellons. Donations are tax deductible in the US. To learn more about Morgellons disease go to http://www.MorgellonsDisease.org“.

For more information on Morgellons:  https://madisonarealymesupportgroup.com/2016/06/17/morgellons-believe-it/

https://madisonarealymesupportgroup.com/2016/10/27/research-on-morgellons/

https://madisonarealymesupportgroup.com/2016/12/05/new-book-on-morgellons/

New Book on Morgellons

https://www.amazon.com/dp/B01MG9BEK4/ref=pe_385040_117923520_TE_M1DP

Morgellons: The legitimization of a disease: A Factual Guide by the World’s Leading Clinical Expert

“We have come a long way against great odds on our journey to legitimize Morgellons disease. Dr. Ginger Savely paved the earliest path on the rockiest road to make this progress possible. This book provides long-awaited answers to the vital questions being posed by thousands of patients and clinicians about this unthinkable disease. In reading Dr. Savely’s poignant narrative you will learn to separate fact from myth and rumor from reality. This book will be a valuable resource for Morgellons patients and their families and friends and will serve as a guide for health care providers who are open-minded and committed to the health of their patients”.

From the Foreword by Cindy Casey, RN, Director of the Charles E. Holman Morgellons Disease Foundation

For more information on Morgellons and the link to Tick Borne Infections, see:  https://madisonarealymesupportgroup.com/2016/10/27/research-on-morgellons/

Research on Morgellons

Morgellons Disease – Video abstract 116608  Uploaded on Sep 28, 2016
Video abstract of review paper “Morgellons disease: a filamentous borrelial dermatitis” to be published in the International Journal of General Medicine by Middelveen and Stricker.

https://www.dovepress.com/articles.php?article_id=29451
Marianne J Middelveen, Raphael B Stricker

International Lyme and Associated Diseases Society, Bethesda, MD, USA

Morgellons disease: a filamentous borrelial dermatitis

Abstract: Morgellons disease (MD) is a dermopathy characterized by multicolored filaments that lie under, are embedded in, or project from skin. Although MD was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with tickborne infection, that the filaments are composed of keratin and collagen, and that they result from proliferation of keratinocytes and fibroblasts in epithelial tissue. Culture, histopathological and molecular evidence of spirochetal infection associated with MD has been presented in several published studies using a variety of techniques. Spirochetes genetically identified as Borrelia burgdorferi sensu stricto predominate as the infective agent in most of the Morgellons skin specimens studied so far. Other species of Borrelia including Borrelia garinii, Borrelia miyamotoi, and Borrelia hermsii have also been detected in skin specimens taken from MD patients. The optimal treatment for MD remains to be determined.

Morgellons disease – Video abstract: 39017  Published on Jan 8, 2013
Video abstract of original research paper “Characterization and evolution of dermal filaments from patients with Morgellons disease” by Middelveen MJ, Mayne PJ, Kahn DG, et al.

https://www.dovepress.com/characterization-and-evolution-of-dermal-filaments-from-patients-with–peer-reviewed-article-CCID
Marianne J Middelveen,1 Peter J Mayne,1 Douglas G Kahn,2 Raphael B Stricker1

1International Lyme and Associated Diseases Society, Bethesda, MD, USA; 2Department of Pathology, Olive View–UCLA Medical Center, Sylmar, CA, USA

Characterization and evolution of dermal filaments from patients with Morgellons disease

Abstract: Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either self-implanted by patients or accidentally adhering to lesions, and conclude that patients with this disease have delusions of infestation. We present histological observations and electron microscopic imaging from representative Morgellons disease samples revealing that dermal filaments in these cases are keratin and collagen in composition and result from proliferation and activation of keratinocytes and fibroblasts in the epidermis. Spirochetes were detected in the dermatological specimens from our study patients, providing evidence that Morgellons disease is associated with an infectious process.

https://www.dovepress.com/filament-formation-associated-with-spirochetal-infection-a-comparative-peer-reviewed-article-CCID
Marianne J Middelveen, Raphael B Stricker
International Lyme and Associated Diseases Society, Bethesda, MD, USA

Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

Abstract: Bovine digital dermatitis is an emerging infectious disease that causes lameness, decreased milk production, and weight loss in livestock. Proliferative stages of bovine digital dermatitis demonstrate keratin filament formation in skin above the hooves in affected animals. The multifactorial etiology of digital dermatitis is not well understood, but spirochetes and other coinfecting microorganisms have been implicated in the pathogenesis of this veterinary illness. Morgellons disease is an emerging human dermopathy characterized by the presence of filamentous fibers of undetermined composition, both in lesions and subdermally. While the etiology of Morgellons disease is unknown, there is serological and clinical evidence linking this phenomenon to Lyme borreliosis and coinfecting tick-borne agents. Although the microscopy of Morgellons filaments has been described in the medical literature, the structure and pathogenesis of these fibers is poorly understood. In contrast, most microscopy of digital dermatitis has focused on associated pathogens and histology rather than the morphology of late-stage filamentous fibers. Clinical, laboratory, and microscopic characteristics of these two diseases are compared.

Morgellons – Believe it

https://www.lymedisease.org/new-studies-morgellons/  Two new studies presented at the recent CEHMDF annual meeting in Texas show a bacterial, infective process.

“Morgellons disease is a multi-system illness characterized by the formation of unusual, sometimes brightly colored fibers within skin. It is a debilitating, painful and life impacting condition. In addition to slowly healing skin lesions, an array of multi-system symptoms can occur, including fatigue, joint and muscle pain, intestinal problems and neurological symptoms including behavioral changes. Patients with Morgellons disease may shed unusual particles from the skin described as fibers, “sand” or seed-like black specks, or crystallized particles.”

Many medical professionals believe Morgellons sufferers suffer from delusions.

In both 2013 and 2015, international scientists contradicted this theory by showing borrelia spirochetes in skin samples.  But, similarly to MSIDS (multi systemic infectious disease syndrome or Lyme with friends) denial, most mainstream doctors deny the science.

Two additional laboratories (Oklahoma State and IGenex) have now replicated finding multiple bacterial species as well as three different species of borrelia DNA in Morgellons skin samples.

Defending Morgellon’s patients, Oklahoma State’s Dr. Wymore states,

“Collectively, the research into Morgellons disease clearly shows a bacterial, infective process in these patients. In contrast, and despite the bombastic claims of some, there is zero convincing, scientific evidence that Morgellons is a psychogenic illness.”

The CEHMDF is the recognized authority and primary funding source for Morgellons disease medical-scientific research. There are neither grants, nor any other public or private funding to support research for Morgellons. Donations are tax deductible in the US. To learn more about Morgellons disease go to www.MorgellonsDisease.org.