Archive for the ‘Testing’ Category

The Bear Metaphor & Your DNA

https://naomiwolf.substack.com/p/facing-the-beast

Facing the Beast

Can We Really Confront the Biggest Crime in Human History?

Excerpts:

I was relaxing in our screened porch in our little cottage in the forest, feeling rather pleased with myself. It had been an arduous week of the usual combat for liberty, but there had been victories.

Then I heard a “thump” about eight feet away behind my head.

I glanced behind me and saw the enormous ears and forehead of a sizable brown bear, who was ducking insolently, clearly aware of me, to lower himself behind the trash cans.

My heart pounded as I realized that he was not leaving; he continued pacing and circling, no matter where I went.

He was here because — I had done nothing to stop him. He was here because I let him slowly take over our home.

This all, of course, really happened. But that does not mean it is not also a metaphor.

The same week that this happened, I also finalized my reporting about the Pfizer vaccines, showing — what I knew for months I would eventually find.

The heart of the manufacture and distribution of millions of doses of the MRNA vaccines that are causing such a swath of death and destruction throughout North America and Western Europe, is enmeshed with the plans, methods and manufacturing infrastructure of our existential adversary.

The enemy is within our very bodies.

(See link for article)

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SUMMARY:

  • Wolf believes this isn’t just about a greedy pharmaceutical company and a corrupt regulatory agency but a massive act of war.
    • Doubling of neonatal deaths, 34% above normal stillbirths and spontaneous abortions for “vaxxed” moms
    • 40% increase in death rates, shocking rise in disability
  • 2021 Hong Kong study (answerable to the CCP) showed when mice got the second dose of the booster, it resulted in visibly enlarged hearts with white patches, cytokine storms and liver damage seen by the naked eye.  The study concluded: “Post-vaccination myopericarditis is reported after immunization with coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines.” 

  • Pfizer/BioNTech is a German-Chinese company and has an MOU with Fosun Pharmaceuticals, a major CCP-linked pharmaceutical company based in Shanghai, to make the Pfizer/BioNTech MRNA “vaccines”.  A SEC filing shows that the MOU with Fosun includes an equity investment by Fosun in BioNTech. In other words, the CCP is an equity investor in BioNTechFosun is not separate from the CCP; it is the CCP.
  • Fosun Pharma did not stay in China.  It came here. Fosun Pharmaceuticals is now also Fosun Pharmaceuticals USA, with branches for R and D and product formulation in Boston, MA and Princeton, NJ.
    • Fosun produces products in the US for distribution here and around the world and has has built a “global operation strategy” for the manufacture of COVID-19 vaccines, COVID-19 PCR tests and COVID-19 antigen tests. (These tests were the primary metric that determined the ‘pandemic’ and thus the lock downs. So a CCP-run company, and a CCP product decides who can go to work, school, and travel.)
    • A lawsuit has been filed in NY surrounding COVID testing because commercial labs get DNA, which then goes to Fulgent Genetics, which states they’re going to destroy all the samples and that they aren’t selling them to 3rd parties.
      • But a House Intel Committee Member warns that DNA test kits could lead to targeted bioweapons.
      • The LA County Sheriff’s Department announced they will not work with a China-linked genetics firm hired by the county to conduct COVID testing and registration because the FBI shared “very concerning information” about Fulgent Genetics Corporation – which was awarded a no-bid contract for the work.  LASD states DNA data from COVID testing is not guaranteed to be safe and secure from foreign governments and “will likely be shared with the Republic of China.”
        • China just happens to be quietly building the worlds largest DNA database.  All those COVID tests results will come in handy.
        • The FBI is shocked to find that China’s offer to build $100 Million ‘garden’ in DC just might be for espionage purposes.
        • There is growing concern over Chinese interests purchasing large swaths of land, particularly farmland, in the U.S. – including one sensitive parcel in North Dakota in the proximity of a military installation.
        • While Americans are paying $5 per gallon of gas, DOE docs show the Biden admin has sold nearly 6 million barrels of oil from the U.S. strategic reserve to an entity tied the CCP (Sinopec, parent org of Unipec through BHR Partners), which in turn has ties to Hunter Biden. The Biden admin. has also shipped more natural gas to Europe than promised.
    • Fosun obtained the Medicines Patent Pool (MPP)’s license to produce and supply the generic versions of:
      • Merck’s oral COVID-19 treatment Molnupiravir 
      • Pfizer’s oral COVID-19 treatment Nirmatrelvir
      • Pfizer’s Nirmatrelvir and Ritonavir
    • Fosun, a CCP-owned hybrid entity is making millions off of Pfizer injections, Monupiravir, and Paxlovid, so when Biden does a deal with Pfizer with our tax dollars, and gets billions in omnibus bills for PPE, including millions for PCR and antigen tests, he is writing checks to China.
    • A 2018 whistleblower broke a scandal revealing that Fosun Pharmaceuticals had “massively” faked its data and bribed regulators. The FDA wrote them a stern letter.

Important quote:

So take all of the above, and map it against the 150,000 plus adverse events in the Pfizer documents, the deadly harms to reproduction, the Western baby die-off, the babies in seizures; map it against the population drop, the rise in disabilities, map it against the rigid, cruel vaccine mandates aimed at Western defense forces (Canada’s, and Australia’s and all of Western Europe’s, as well as at the most powerful military in the world, that of the United States) — map it against the vaccine mandates aimed at our police, our health care workers, our firefighters, our pilots, our first responders, our kids, our babies — all this done by a White House captive, via Hunter Biden’s laptop, to the CCP.

This all means, of course, that we are staring into the abyss right now.

Traumatized or not, we all need to snap out of denial.

We let our adversary come too close to us. Into our very bloodstreams.

We need to save each other.

We need to turn and face the ravening beast.

COVID Risks May Be Heightened by History of Lyme Disease

https://www.news-medical.net/news/20220717/COVID-19-risks-may-be-heightened-by-history-of-Lyme-disease

COVID-19 risks may be heightened by history of Lyme disease

In a recent study published on the preprint server Research Square*, researchers report that individuals with a history of Borrelia infection, otherwise known as Lyme disease, caused by tick bites are at a higher risk of severe coronavirus disease 2019 (COVID-19).

Study: Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp. Image Credit: Kateryna Kon / Shutterstock.com

(See link for article)

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SUMMARY:

  • Serological testing is not sufficient to differentiate between recent and past infections because antibodies persist in the blood – even after treatment.  What the article doesn’t say is that THIS, RIGHT HERE, is why current CDC 2-tiered testing should never be used solely to diagnose patients and why doctors need to be educated to make correct clinical judgments. 
  • What started the whole ball of wax is a case report of a patient infected with Lyme who was unsuccessfully treated with one round of antibiotics and who then got COVID.  The patient’s Lyme was suppressed (lower IgG test) due to the anti-COVID meds (umifenovir, hydroxychloroquine, azithromycin, and ceftriaxone).
  • The study included:
    • 31 severely ill & hospitalized patients who were either required non-invasive or invasive ventilation.
    • 28 COVID positive patients who had either mild or asymptomatic cases who were either treated at home or unaware of infection.
    • 28 seronegative controls
  • Serum samples were collected for COVID and Borrelia infections
    • A multi-antigen microblot-array utilizing 19 antigens revealed Lyme in all hospitalized COVID patients. 
    • Of the 28 mild or asymptomatic patients, 19 had Lyme, whereas in the control group of 28, 8 had Lyme.
    • Severe COVID patients also had significantly higher levels of antibodies targeting Anaplasma.
  • Regarding seropositivity for IgM antibodies (1st antibodies to show up after infection that stay for a short period of time):
    • 24 of the 31 hospitalized patients had Lyme antibodies
    • 13 of the 28 mild/asymptomatic patients had Lyme antibodies
    • 15 of the 28 in the control group had Lyme antibodies
  • Risk of COVID-related hospitalizations increased with each positive IgG (antibodies produced later on in infection and can remain after infection resolves. Having high IgG can be indicative of chronic Lyme), but was not observed for IgM.
  • Post-hoc analysis of selected antigens (Osp proteins, p41, and VlsE) was also
    included; multivariate analysis showed that odds of hospitalization increased with increasing levels of:
    • IgG antibodies targeting OspB, OspC B. burgdorferi sensu stricto, and OspC
      B. spielmanii
    • For IgM antibodies, the same association was observed for antibodies targeting OspC B. spielmanii and OspE
  • Interestingly, the authors state that they observed in many patients antibodies targeting different species (e.g. B. burgdorferi sensu stricto, and at the same time
    B. afzelii, and/or B. garinii) which may reflect cross-reactivity but also may result from coinfections with more than one species.
  • Previous exposure to Lyme and other tick-borne diseases can increase risk of severe COVID and this is the first observation that suggests links between Lyme disease and COVID-19 prognostics.
  • The authors state that screening of anti-Borrelia antibodies in COVID patients could identify high-risk patients and improve their management.
Journal reference:
  • Szewczyk-Dabrowska, A., Budziar, W., Harhala, M., et al. (2022). Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp. Research Square. doi:10.21203/rs.3.rs-1799732/v1.

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**Comment**

This is a very interesting study but I come up with slightly different take-aways.  The first of which is – don’t let this article frighten you.  1) there are cheap, effective, safe treatments for COVID.  Far safer & cheaper than Lyme/MSIDS treatment! 2) it only makes logical sense that those with Lyme/MSIDS are sitting ducks for pretty much everything including highly contagious viruses (if that’s what this even is). Lyme/MSIDS patients already struggle with EBV, Herpes, cytomegalovirus, and much, much more.  You are not a hopeless, helpless victim. There are answers and actions you can take to protect yourself and treat yourself should you contract COVID.:

  • The case study states that the person’s Lyme was suppressed due to anti-COVID meds, yet list antibiotics (ceftriaxone & azithromycin) that are used often for Lyme – which would explain the suppression.  Suppression doesn’t mean the Lyme goes away, it just means it isn’t being picked up on the test – a common, well-known problem patients deal with on a daily basis.
  • HCQ was used, which is also used for Babesia, a coinfection they didn’t look for but is known to cause much more severe Lyme for a greater duration IF the patient has both infection concurrently.
  • And Umifenovir is a broad‐spectrum antiviral, which while it doesn’t treat Lyme directly, could assist by beating back other viruses like herpes, EBV, and others – all of which are big players in Lyme.  Treating Lyme/MSIDS is a balancing act.  Giving appropriate treatment to beat back infections and supporting your immune system to handle what’s there without freaking out is more in line than a “cure” of erradicating everything within you.  We are covered in germs/viruses and most are held in check by our immune system.  A tick/insect bite changes that balance (or other modes of transmission such as congenital or sexual, etc)
  • They looked for 19 antigens which is unheard of for average folk!
  • They found Lyme (antibodies) in nearly everyone – even the controls!  This, to me, is the real finding. 
  • Their suggestion to “screen for anti-Borrelia antibodies in COVID patients” to identify potential “high risk” patients only has one flaw:  testing sucks and is not to be trusted!

FDA Still Working to Stifle Lab Testing Options

https://anh-usa.org/fda-working-to-stifle-lab-testing-options/

FDA Working to Stifle Lab Testing Options

FDA Working to Stifle Lab Testing Options

Another dangerous policy has been slipped into legislation that must pass Congress by the end of September. Action Alert!

For months now, we’ve been telling you about the dangers of mandatory product registration for supplements; one key threat is that this policy has been snuck into the reauthorization of drug user fees which must be approved by the end of September. Another bad policy has been tacked on to this must-pass legislation. It represents another attempt by the FDA to extend its power over laboratory developed tests (LDTs). This is a critical threat, as LDTs are crucial tools used in personalized medicine because labs can create custom diagnostic tests for all sorts of diseases. We cannot allow the FDA to stifle innovation in this sector and regulate these tests out of existence.

LDTs are diagnostic tests developed and performed by local labs. They are widely used—thousands of different LDTs are available—and include genetic tests, tests for rare conditions, companion diagnostics, and also diseases like COVID-19.

The LDT policy that has been snuck into PDUFA is the VALID Act. It creates a risk-based framework for the FDA to regulate LDTs in which “high-risk” LDTs would undergo premarket review, whereas LDTs determined to be “low-risk” would have less scrutiny and could qualify for exemptions to premarket review. High-risk tests are those for which an inaccurate result has a high likelihood of resulting in serious harm or death to patients or is likely to delay life-supporting treatment. The policy allows FDA to revoke pre-market exemptions if new information comes to light indicating greater risks to patients. Generally, LDTs currently being offered are grandfathered in and would not need to undergo premarket review, though they would need to adhere to the bill’s other requirements.

Premarket review for these tests is a big mistake. We saw this in stark relief during the COVID-19 pandemic. At the beginning of the pandemic, labs were held up from developing their own COVID tests because they needed to get emergency use authorization—in essence, pre-approval—to deploy their tests. This was a major missed opportunity; accurate testing is important, but the FDA prioritized red tape over getting people reasonably accurate means of testing for COVID that could have helped reduce transmission rates and hospitalizations at an earlier date.

Premarket review for LDTs will also stifle innovation in an exciting medical sector. Regulators are often suspicious of new products. The agency is also more influenced by older firms offering old technology. Protecting them can also lead to lucrative jobs after leaving government. This is the old crony capitalist conundrum.

The policy comes with a litany of other requirements for LDTs. For example, the FDA can require labeling, advertising, post market surveillance, and other things it deems necessary to detect and mitigate adverse events. Like Sen. Durbin’s mandatory product listing for supplements, the policy also requires all LDTs to register with the FDA—a requirement that will pose a significant time and personnel burden on laboratories that are already stretched thin and short-staffed.

The policy also calls for the development of a user fee program whereby testing companies pay the FDA to review their tests. This is another bad idea, as it privileges large, commercial test developers over smaller labs (non-profit labs, academic labs, etc.).

The FDA has tried before to put LDTs under its thumb. It claims to have some statutory authority over LDTs, but for decades chose not to regulate them as other diagnostic devices. LDTs have historically been regulated by the Centers for Medicare and Medicaid Services (CMS). But in 2014, the FDA issued a draft guidance saying it would regulate LDTs as medical devices. Congress pushed back, with some legislators arguing that the FDA’s approach to LDTs was “redundant, [would] raise costs and stifle innovation, and [would] require additional taxpayer funding to the FDA.”

To us, it seemed clear that the FDA wants to take over LDTs in order to maintain the monopoly enjoyed by hospitals together with two companies: LabCorp and Quest Diagnostics. Given new authorities over LDTs, the agency would likely approve only those tests that big companies have a legal right to perform and are inclined to offer, and which insurance companies and Medicare will pay for.

LDTs are the future of medicine. People are already able to test for and spot cancers long before they manifest themselves using current methods. These tests are improving at a rapid rate. Testing can already help prevent diabetes, heart and blood vessel illness, prostate cancer, and other diseases. LDTs are not only the future of general medicine—they are also the future of individualized medicine, which is an exciting and important development. Integrative doctors use these tests to gather information that aids them in identifying the root causes of their patients’ illnesses—this information could not be gathered and analyzed otherwise.

We cannot let the FDA regulate these tests out of existence.

Action Alert! Write to Congress and tell them to oppose the VALID Act’s inclusion in the FDA user fee reauthorization bill. Please send your message immediately.

Go to top link to fill out a form to send to your representatives.

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**Comment**

Hopefully the past few years have clearly demonstrated the problem with centralized, monopolized, government sanctioned testing under the auspice of “public health” that can and will be used to take away your freedoms and rights. This faulty testing has kept people from working, going to school, and partaking in society in general.

Lyme-land has similarly been in a testing juggernaut for 40 years – clearly showing the outcome of CDC/FDA propaganda and the underlying conflicts of interest that drives everything about public health.  Similarly to COVID, Lyme testing was created (and is still being used) that eliminated the most specific band for Lymedue to vaccine development.  A case definition (also still being used) was created to fit this faulty, unscientific paradigm that has ruled like an Iron Curtain ever since.  Truthcures has met with the FDA in an attempt to ameliorate this but 40 years is a long time to suffer with no change.

And speaking of testing corruption: A NYC company, owned by family who donated $300K to NY governor Hochul, paid $637 MILLION to manufacture at home COVID tests without considering bids from competing manufacturers and without a contract.

The FDA has been coming after CLIA-certified labs such as IgeneX since it opened its doors.  The CDC also has maligned these smaller specialized labs from the top down.  Their website used to have a paragraph that called them “home-brewed” tests.  I actually heard a pediatrician speak at the Wisconsin state capital who used this exact phrase.  Doctors have been brain-washed that these CLIA-certified labs, which undergo far more rigorous lab requirements than Lab Corp or Quest, are quackery.  The pediatrician’s statement is indicative of this propaganda process.

Ask yourself one question: why won’t doctors in mainstream medicine utilize Galaxy or IgeneX testing? 

The answer is clear: they’ve been told not to.  Who is telling them?  The CDC/FDA and other government agencies are monopolizing medicine through the CARES Act, which in turn controls doctors like puppets.  This is why people are not being treated with ivermectin, HCQ/zinc, IV vitamin C, and other known, effective treatments and why people are resorting to the court system to save their loved ones in the nick of time.

This exact scenario plays out in Lyme-land on a daily basis.

Lyme/MSIDS, similarly to COVID, has become so politicized that doctors are afraid to treat patients. Instead, they fearfully toe the CDC/FDA line by using their sanctioned tests, treatments, and guidelines – all of which are completely and utterly worthless.

Our only hope are brave, independent doctors who have chosen to step outside the corrupt, fraudulent medical monopoly to do what they started out to do: uphold the Hippocratic oath by treating patients as they see fit according to their medical training and experience, and defying the corrupt professional organizations that are in bed with the government. These doctors are being harassed, censored, and threatened at every turn but refuse to be silenced. 

Dr. Steven Harris – IgeneX Testing Explained

http://  Approx. 34 Min

Dr. Steve Harris – IgeneX Testing Explained

For more:

How Prevalent is Bartonella?

https://www.lymedisease.org/bartonella-prevalent-lyme-disease/

How prevalent is Bartonella in people who have Lyme disease?

July 15, 2022

By Lonnie Marcum

At a meeting of the federal Tick-Borne Disease Working Group on March 1, Ben Beard, PhD of the CDC made a highly significant statement that passed without remark at the time.

Beard’s statement was in reply to a comment by Monica Embers, PhD, also a member of the working group. Embers noted that several slides from Beard’s Clinical Presentation and Pathogenesis subcommittee mentioned neuropsychiatric illness and neuropathic manifestations of Lyme disease.

“We’re seeing a lot more neuropsychiatric disease associated with Bartonella,” said Embers. “I’m wanting to hear more about your thought process and your recommendation with respect to bartonellosis?”

Bartonella’s “significant impact”

Beard replied:

“In my view Bartonella is ubiquitous. There are multiple different Bartonella species. A lot of people are exposed to cats and fleas, and Bartonella henselae–or cat scratch disease–is pretty common. Our group looked at it as an illness that is associated with people with other tick-borne illnesses. Not necessarily agreeing that it’s tick-borne—for me the jury is still out for that—but I’m perfectly convinced that it is very common, and that it may be confounding the diagnosis, and that it is an important co-infection. We need not get side-tracked on whether or not it’s tick-borne. We need to agree that it’s a common infection, commonly seen in patients with other illnesses, and it can have a significant impact on clinical outcome and presentation.”

This is actually a showstopper of a comment.
The CDC has long declined to categorize bartonellosis as tick-borne and has not considered it a co-infection of Lyme.

Even today, the CDC website states: “Ticks may carry some species of Bartonella bacteria, but there is currently no causal evidence that ticks can transmit Bartonella infection to people through their bites.”

Yet, as Beard observed, Bartonella is very common in people with Lyme disease.

What the data says

In MyLymeData, LymeDisease.org’s patient-led research project, 60% of patients with chronic symptoms of Lyme disease report co-infections. A previously published LymeDisease.org survey of over 3,000 patients found that over 50% had co-infections, with 30% of patients reporting two or more. Bartonella (28%) was the second most commonly reported co-infection associated with chronic Lyme disease. (Johnson, L., et al., 2014)

Bartonella does not respond to standard treatment for Lyme disease, and it is notoriously difficult to detect through standard tests. Moreover, Bartonella is not included in standard surveillance testing for ticks, and cases of the disease are not tracked by the CDC

Which leads me to the elephant in the room: nobody knows how many cases of bartonellosis there are in the US—or anywhere else for that matter.

What is bartonellosis?

Bartonellosis is caused by one of many species of the bacterium Bartonella. It is harbored in wild and domestic animals, and can be transmitted to humans through a number of different pathways including fleas, flies, lice, animal bites, animal scratches, ticks, bedbugs, and possibly through maternal fetal transmission. (Maggi RG, et al., 2015; Reis C, et al., 2011)

First identified in 1990, Bartonella henselae bacteria is the most common cause of bartonellosis in humans. Bartonella henselae infection, also called cat scratch disease, is frequently caused by flea bites or the scratch of an infected cat. The primary reservoirs for B. henselae across the world are domestic and stray cats, and the primary vector is the cat flea (ctenophalides felis). (Breitschwerdt, E.B., 2017)

Prior to 1990, there were only two diseases known to be caused by Bartonella bacteria. One was “Carrion’s disease,” endemic to parts of South America, caused by Bartonella bacilliformis. The other was “trench fever,” which infected many soldiers during World War I, caused by Bartonella quintana.  Though the illness was first described in 1915, Bartonella quintana was not  molecularly identified as its cause until 1961. (Breitschwerdt, E.B., 2017)

We now know that these bacteria have been infecting humans for thousands of years. Researchers discovered Bartonella quintana in a 4,000-year-old human tooth in France. (Drancourt M., et al., 2005)

Today, at least 40 different species of Bartonella have been identified.  About half of them are known to cause symptoms in humans or animals.

Bartonella is a stealth pathogen

At a recent conference, Dr. Ed Breitschwerdt, DVM, a leading expert in the field,  explained how Bartonella can invade and “literally affect every system in the body.” This includes the: cutaneous, muscular, skeletal, endocrine, cardiovascular and nervous systems.

He reviewed several recent studies implicating Bartonella infection in the brain in relation to several neuropsychiatric and autoimmune manifestations.

According to Breitschwerdt, these bacteria are extremely difficult to find in humans because they are slow growing and can hide within cells.

He explained how Bartonella, which are intracellular bacteria, have the ability to:

  • invade red blood cells, wall themselves off, and hide from the immune system (immune evasion)
  • migrate into the nervous system via macrophages (Trojan horse)
  • penetrate the blood brain barrier via endothelial cells and pericytes
  • persist within the brain via microglial cells.

Considering the number of different species and different methods of contracting Bartonella, Dr. Breitschwerdt ponders, “Is Bartonellosis a modern-day hidden epidemic?” (Breitschwerdt E.B., 2014)

Symptoms of bartonellosis

The symptoms of bartonellosis can range from mild to life-threatening, depending on the Bartonella species and the health of those infected. Furthermore, a growing body of evidence links Bartonella to neuropsychological symptoms.

The most commonly reported neurological symptoms include sleep disorders, mental confusion, memory loss, brain fog, irritability, rage, anxiety, panic attacks, depression, migraines, tremors, hallucinations, psychosis and postural orthostatic tachycardia (POTS).

Additional symptoms common to bartonellosis are swollen lymph nodes (especially around the head, neck and arm pits), bone pain (especially shins), pain in the soles of the feet, low grade fever in the morning, night sweats, tender nodules along the extremities, gastrointestinal pain, and skin markings (striae) that resemble stretch marks.

The table below lists the known species of Bartonella associated with human disease, the most common symptoms as well as the reservoir host and vector.

bartonella symptoms

How a stealth pathogen may prolong your chronic illness

In individuals with strong immune systems, Bartonella infection is often mild or asymptomatic. However, in those with an impaired immune system, Bartonella can wreak havoc on the body.

In fact, Bartonella henselae was discovered in the 1990s during the AIDS epidemic. Because  the HIV virus causes an acquired immune deficiency, these patients were extremely susceptible to new infections and reactivation of latent infections. In this patient population, Bartonella caused a distinctive skin lesion called bacillary angiomatosis (BA), and a type of liver disease called peliosis hepatis. (Breitschwerdt, E.B., 2017)

Advanced, disseminated disease is more likely to occur in immunocompromised patients or those taking immunosuppressive drugs. Without proper treatment, the infection can spread systemically throughout the body. The result is sometimes fatal.

When the co-infection becomes the main infection

Data from multiple animal studies shows that Borrelia burgdorferi suppresses the immune system. (Buffen K, et al., 2016; Tracy KE, Baumgarth N., 2017)

This makes me wonder. How many people with chronic Lyme disease had a latent Bartonella infection that was re-activated when their immune system became impaired?

I believe this was the case with my daughter. We live on a farm with lots of animals, including cats. Veterinarians, cat owners, and people who live or work on farms are at increased risk for Bartonella.

It wasn’t until my child became deathly ill after contracting Ehrlichia chaffeensis that her Bartonella symptoms began.

The symptoms that stood out were the constant migraine/headache, memory loss, bone pain, painful soles of feet, relapsing fever, insomnia, nighttime hallucinations that made everything look like Whoville, POTS, skin marks (striae) that resembled stretch marks, swollen lymph nodes, and an immune system so impaired it led to a temporary misdiagnosis of HIV. What a horrific experience for all of us!

Diagnosis & Treatment

Because  Bartonella may hide inside of cells and only emerge periodically, you may need to test multiple times to find a confirmatory diagnosis. And in patients who are immunocompromised, the test may not turn positive until after treatment has begun.

Research led by Ricardo Maggi, Ed Breitschwerdt and colleagues has led to the development of a new digital PCR that is much more sensitive to Bartonella. Even still, Dr. Maggi recommends running multiple types of tests (IFA serology, PCR, culture, and microscopy).

According to Dr. Joseph Burrascano, one should consider bartonellosis when symptoms persist after treatment for Lyme disease. Especially when the neurological symptoms are out of proportion to the common symptoms of disseminated Lyme disease.

Just as with Lyme disease, the longer Bartonella goes untreated, the more difficult it is to treat.  Furthermore, the standard treatment for Lyme (doxycycline) is ineffective against Bart. As Dr. Breitschwerdt famously said, “You cannot float humans or horses in enough doxycycline to kill this bacteria.”

According to the CDC: “A number of antibiotics are effective against Bartonella infections, including azithromycin, penicillins, tetracyclines, cephalosporins, aminoglycosides, and macrolides. More than one antibiotic is often used. Consult with an expert in infectious diseases regarding treatment options.”

Dr. Burrascano says, treating Bartonella-like organisms “can be difficult, as drug resistance can rapidly develop to macrolides and fluoroquinolones when used as a single agent and solo courses of tetracyclines are ineffective.”

Moving forward with Bartonella research

In 2021, a new Bartonella Research Consortium was formed with a $4.8 million grant from The Steven & Alexandra Cohen Foundation.

The consortium includes Ed Breitschwerdt and Ricardo Maggi of North Carolina State University, Monica Embers of Tulane University, and Timothy Haystead of Duke University, who is continuing the work of the late Dr. Neal Spector.

The team is actively working towards creating a targeted treatment for bartonellosis and quickly getting the drug to the marketplace for use in both animals and humans.

It’s time medicine moves beyond the one-pathogen-one-disease model. Let’s face it, ticks are full of toxic soup. Because each pathogen interacts with the host in unique ways, extensive research is needed to understand all factors surrounding co-infections and Lyme disease. (Moutailler S, et al., 2016)

Understanding the complex nature of these pathogens, how they impact the immune system, and how other bacterial and viral factors shape illness, will be key in improving public health. (Cheslock, M. A., & Embers, M. E., 2019)

It’s time for the CDC, NIH, HHS, the Tick-Borne Disease Working Group and other researchers to start looking deeper into the prevalence of Bartonella infections–not just in patients with Lyme disease but in all patients with poorly-defined chronic illnesses.

Resources

More information about testing/diagnosis of Bartonellosis see:

Free Bartonella CME Course:

LymeSci is written by Lonnie Marcum, a Licensed Physical Therapist and mother of a daughter with Lyme. She has served two terms on a subcommittee of the federal Tick-Borne Disease Working Group. Follow her on Twitter: @LonnieRhea  Email her at: lmarcum@lymedisease.org.

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**Comment**

Excellently written.  Bartonella is a real problem out here, but the CDC is just sipping on margaritas.

For more: