Archive for the ‘Supplements’ Category

The Powerful Aspirin Alternative Your Doctor Never Told You About

http://www.greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-1?

The Powerful Aspirin Alternative Your Doctor Never Told You About

“© [Originally published: 2017-07-23, Article updated: 2019-04-11] GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.”
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Given the newly released cardiovascular disease prevention guidelines recommending against daily low-dose aspirin use, natural, safe and effective alternatives are needed now more than ever. Thankfully, one particularly therapeutic alternative has been known about by the biomedical research community for decades…

In a previous article titled “The Evidence Against Aspirin and For Natural Alternatives,” we discussed the clear and present danger linked with the use of aspirin as well as several clinically proven alternatives that feature significant side benefits as opposed to aspirin’s many known side effects.

Since writing this article, even more evidence has accumulated indicating that aspirin’s risks outweigh its benefits. Most notably, a 15-year Dutch study published in the journal Heart found that among 27,939 healthy female health professionals (average age 54) randomized to receive either 100 mg of aspirin every day or a placebo the risk of gastrointestinal bleeding outweighed the benefit of the intervention for colorectal cancer and cardiovascular disease prevention in those under 65 years of age. Most recently, last month, new cardiovascular disease prevention guidelines submitted jointly by the American College of Cardiology and the American Heart Associated and published in the Journal of the American College of Cardiology, earlier this year, contradict decades of routine medical advice by explicitly advising against the daily use of low-dose or baby aspirin (75-100 mg) as a preventive health strategy against stroke or heart attack, in most cases.

Of course, aspirin is not alone as far as dangerous side effects are concerned. The entire non-steroidal anti-inflammatory (NSAID) category of prescription and over-the-counter drugs is fraught with serious danger. Ibuprofen, for instance, is known to kill thousands each year, and is believed no less dangerous than Merck’s COX-2 inhibitor NSAID drug Vioxx which caused between 88,000-140,000 cases of serious heart disease in the five years it was on the market (1999-2004). Tylenol is so profoundly toxic to the liver that contributing writer Dr. Michael Murray recently asked in his Op-Ed piece, “Is it Time for the FDA to Remove Tylenol From the Market?” Just as serious are tylenol’s empathy destroying properties that were only identified four years ago.

Given the dire state of affairs associated with pharmaceutical intervention for chronic pain issues, what can folks do who don’t want to kill themselves along with their pain?

Pine Bark Extract (Pycnogenol) Puts Aspirin To Shame

When it comes to aspirin alternatives, one promising contender is pycnogenol, a powerful antioxidant extracted from French maritime pine bark, backed by over 40 years of research, the most compelling of which we have aggregated on GreenMedInfo.com here: Pycnogenol Research. Amazingly, you will find research indexed there showing it may have value for over 80 health conditions.

In 1999, a remarkable study published in the journal Thrombotic Research found that pycnogenol was superior (i.e. effective at a lower dosage) to aspirin at inhibiting smoking-induced clotting, without the significant (and potentially life-threatening) increase in bleeding time associated with aspirin use. The abstract is well worth reading in its entirety:

“The effects of a bioflavonoid mixture, Pycnogenol, were assessed on platelet function in humans. Cigarette smoking increased heart rate and blood pressure. These increases were not influenced by oral consumption of Pycnogenol or Aspirin just before smoking. However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg Aspirin or 100 mg Pycnogenol in 22 German heavy smokers. In a group of 16 American smokers, blood pressure increased after smoking. It was unchanged after intake of 500 mg Aspirin or 125 mg Pycnogenol. In another group of 19 American smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg Pycnogenol supplementation. This study showed that a single, high dose, 200 mg Pycnogenol, remained effective for over 6 days against smoking-induced platelet aggregation. Smoking increased platelet aggregation that was prevented after administration of 500 mg Aspirin and 125 mg Pycnogenol. Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg Aspirin as well as by a lower range of 100-125 mg Pycnogenol. Aspirin significantly (p<0.001) increased bleeding time from 167 to 236 seconds while Pycnogenol did not. These observations suggest an advantageous risk-benefit ratio for Pycnogenol.” [emphasis added]

As emphasized in bold above, pycnogenol unlike aspirin did not significantly increase bleeding time. This has profound implications, as aspirin’s potent anti-platelet/’blood thinning’ properties can also cause life-threatening hemorrhagic events. If this study is accurate and pycnogenol is more effective at decreasing pathologic platelet aggregation at a lower dose without causing the increased bleeding linked to aspirin, then it is clearly a superior natural alternative worthy of far more attention by the conventional medical establishment and research community than it presently receives.

Not Just A Drug Alternative

Pycnogenol, like so many other natural interventions, has a wide range of side benefits that may confer significant advantage when it comes to reducing cardiovascular disease risk. For instance, pycnogenol is also:

  • Blood Pressure Reducing/Endothelial Function Enhancer: A number of clinical studies indicate that pycnogenol is therapeutic for those suffering with hypertension. Pycnogenol actually addresses a root cause of hypertension and cardiovascular disease in general, namely, endothelial dysfunction (the inability of the inner lining of the blood vessels to function correctly, e.g. fully dilate).[1] It has been shown to prevent damage in microcirculation in hypertensive patients, as well as reducing the dose of blood pressure drugs in hypertensive patients,[2] including hypertensive diabetic patients.[3] It has even been found to reduce intraocular hypertension found in glaucoma patients.[4]
  • Anti-Inflammatory Effects: There is a growing appreciation among the medical community that inflammation contributes to cardiovascular disease. Several markers, including C-reactive protein are now being fore grounded as being at least as important in determining cardiovascular disease risk as various blood lipids and/or their ratios, such as low-density lipoprotein (LDL). Pycnogenol has been found to reduce C-reactive protein in hypertensive patients.[5] Pycnogenol has been found to rapidly modulate downward (inhibit) both Cox-1 and Cox-2 enzyme activity in human subjects, resulting in reduced expression of these inflammation-promoting enzymes within 30 minutes post-ingestion.[6]Another observed anti-inflammatory effect of pycnogenol is its ability to down-regulate the class of inflammatory enzymes known as matrix metalloproteinases (MMPs).[7]Pycnogenol has also been found to significantly inhibit NF-kappaB activation, a key body-wide regulator of inflammation levels whose overexpression and/or dysregulation may result in pathologic cardiovascular manifestations.[8] Finally, pycnogenol has been found to reduce fibrinogen levels, a glycoprotein that contributes to the formation of blood clots; fibrinogen has been identified as an independent risk factor for cardiovascular disease.[9]
  • The Ideal Air Travel Companion: In a previous article entitled, “How Pine Bark Extract Could Save Air Travelers Lives,” we delve into a compelling body of research that indicates pycnogenol may be the perfect preventive remedy for preventing flight-associated thrombosis, edema, and concerns related to radiotoxicity and immune suppression.

Given the evidence for pycnogenol’s pleotrophic cardioprotective properties, we hope that pycnogenol will become more commonly recommended by health care practitioners as the medical paradigm continues to evolve past its reliance on synthetic chemicals, eventually (we hope) returning to natural, increasingly evidence-based interventions. However, it is important that we don’t fall prey to the one-disease-one-pill model, convincing ourselves to focus on popping pills – this time natural ones – as simply countermeasures or ‘insurance’ against the well-known harms associated with the standard American diet, lack of exercise and uncontrolled stress. The ultimate goal is to remove the need for pills altogether, focusing on preventing cardiovascular disease from the ground up and inside out, e.g. letting high quality food, clean water and air, and a healthy attitude nourish and sustain your health and well-being.


References

[1] Ximing Liu, Junping Wei, Fengsen Tan, Shengming Zhou, Gudrun Würthwein, Peter Rohdewald. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62. PMID: 14659974

[2] Gianni Belcaro, Maria Rosaria Cesarone, Andrea Ricci, Umberto Cornelli, Peter Rodhewald, Andrea Ledda, Andrea Di Renzo, Stefano Stuard, Marisa Cacchio, Giulia Vinciguerra, Giuseppe Gizzi, Luciano Pellegrini, Mark Dugall, Filiberto Fano. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. PMID: 17000888

[3] Sherma Zibadi, Peter J Rohdewald, Danna Park, Ronald Ross Watson. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. PMID: 19083426

[4] Robert D Steigerwalt, Belcaro Gianni, Morazzoni Paolo, Ezio Bombardelli, Carolina Burki, Frank Schönlau. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18618008

[5] Maria Rosaria Cesarone, Gianni Belcaro, Stefano Stuard, Frank Schönlau, Andrea Di Renzo, Maria Giovanna Grossi, Mark Dugall, Umberto Cornelli, Marisa Cacchio, Giuseppe Gizzi, Luciano Pellegrini. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants–a controlled study. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6. Epub 2010 Jan 22. PMID: 20097689

[6] Angelika Schäfer, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdenka Duracková, Petra Högger. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2006 Jan;60(1):5-9. Epub 2005 Oct 26. PMID: 16330178

[7] Tanja Grimm, Angelika Schäfer, Petra Högger. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 14990359

[8] Tanja Grimm, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdenka Duracková, Petra Högger. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006;3:1. Epub 2006 Jan 27. PMID: 16441890

[9] G Belcaro, M R Cesarone, S Errichi, C Zulli, B M Errichi, G Vinciguerra, A Ledda, A Di Renzo, S Stuard, M Dugall, L Pellegrini, G Gizzi, E Ippolito, A Ricci, M Cacchio, G Cipollone, I Ruffini, F Fano, M Hosoi, P Rohdewald. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Redox Rep. 2008;13(6):271-6. PMID: 19017467

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For more:  https://madisonarealymesupportgroup.com/2019/04/08/three-alternative-strategies-that-can-address-severe-chronic-pain/

https://madisonarealymesupportgroup.com/2018/12/09/live-webinar-the-pain-solution-with-dr-bill-rawls/

https://madisonarealymesupportgroup.com/2019/01/10/fatigue-joint-pain-and-low-testosterone-had-lyme-podcast/

 

Folate & You: Perfect Together

https://kellybroganmd.com/folate-perfect-together/

Folate and you: Perfect Together

Methylation also helps you clear toxins such as hormones from chemicals, and rogue neurotransmitters that can cause seizures, anxiety, rage, and insomnia.

If you are extremely sensitive to medicine you probably have a methylation problem.  Cohen also states that while some of this stems from genetics, there are other reasons for it such as a lack of the following vitamins:

  • Zinc
  • B2/riboflavin
  • Magnesium
  • B6/pyridoxine
  • B12/methylcobalamin
  • Folate (from food or folinic acid)

1) Poor diet, poor probiotic status, digestive issues, medications, medical conditions like Crohn’s or Celiac, and other genetic traits may cause any or all of these nutrient deficiencies.

2) Xenobiotics – which are chemicals found in our air, water, food, home, work, schools, parks, beds, cosmetics and more.

3) Taking medications that are drug muggers that deplete you of the nutrients in #1 above. Some of the worst offenders (in terms of stealing your methylation nutrients) are methotrexate, metformin, antacids, acid blockers, proton pump inhibitors, corticosteroids, estrogen-containing drugs and nitrous oxide.

4) Drinking alcohol will pretty much shut down your methylation and wipe out your glutathione stores.

5) Green coffee bean extract is incredibly high in catechols and those use up your methylation pathway nutrients fast!

7) If you have Lyme disease, and many people do whether they know it or not, the Borrelia burgdorferi germ uses up all your magnesium (this supplement is a unique and highly absorbable form) to make biofilms and hide. Low mag reduces your ability to methylate. As an aside, this explains why some ‘Lymies’ have bad reactions during antibiotic treatment. Those drugs kill the organism but then your body is faced with poison such as ‘dead bug parts’ as well as ammonia which spikes when Borrelia dies off. Point is, you can’t remove easily the toxins from your body and it backs up in your system (by christopher at www.dresshead.com). If this is you, then use really low doses if you have to take antibiotics, until you’ve opened up your methylation (and other detoxification) pathways.

8) If you take nutrients that deplete methyl groups (like high dose niacin, or the prescription version of that called Slo-Niacin and Niaspan).

9) Heavy metals (think mercury in your diet, or your teeth) or lead in your bloodstream, cadmium if you smoke, high copper, arsenic, etc.

10) High levels of acetylaldehyde, this is a potent neurotoxin released by Candida, and also a by-product of drinking alcohol (even red wine). Don’t drink if you’re a poor methylator. Most of you know who you are, meaning you are a lightweight when it comes to alcohol. Yep, it is likely you are a poor methylator. I will share more about the Candida toxin known as “acetylaldehyde” shortly.

12) Anxiety or a lot of stress. I’m not sure why, but a pessimist or “I can’t do it” kind of outlook seems to make things worse. I think it has to do with your belief systems and how they impact your genes. In my summary, I’ll give you some links to an author and lecturer that has clues on how to change your outlook. (Dr. Bruce Lipton).

Please see Cohen’s article for options if you suspect a methylation defect:  https://suzycohen.com/articles/methylation-problems/

 

 

 

 

Study Shows Berberine Induces Cell Death in Leukemia

https://science.news/2019-03-21-berberine-induces-cell-death-in-leukemia-cells-study.html

Berberine induces cell death in leukemia cells – study

A study published in The American Journal of Chinese Medicine revealed that a compound called berberine induces cell death in leukemia cells. In this study, the subcellular localization and the apoptotic mechanisms of berberine were investigated.

  • Berberine is an isoquinoline alkaloid found in medicinal plants used in traditional and folk medicines.
  • In the study, researchers at Nagasaki International University in Japan first treated human promyelocytic leukemia cells with berberine, then examined its antiproliferative activity.
  • Five to 15 minutes after treatment, berberine exhibited powerful antiproliferative activity in the cells.
  • Then, the researchers investigated the effect of berberine on inducing cell death and found that the compound induced cell death in leukemia cells.
In conclusion, these findings suggest that berberine can induce cell death in leukemia cells immediately after administration.

Journal Reference:

Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y. BERBERINE INDUCES APOPTOTIC CELL DEATH VIA ACTIVATION OF CASPASE-3 AND -8 IN HL-60 HUMAN LEUKEMIA CELLS: NUCLEAR LOCALIZATION AND STRUCTURE–ACTIVITY RELATIONSHIPS. The American Journal of Chinese Medicine. 6 October 2017; 45(7): 1497-1511. DOI: 10.1142/S0192415X17500811

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**Comment**

Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric.  It might cause stronger heartbeats which might help heart conditions.  It also helps regulate how the body uses sugar in the blood which may help with diabetes. It also might also be able to kill bacteria and reduce swelling.  https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine

https://draxe.com/berberine/  According to Dr. Axe, research on berberine shows benefit for the following conditions:

  • Anti-aging
  • Diabetes
  • Gastrointestinal infections
  • Heart disease
  • High cholesterol
  • Hypertension (high blood pressure)
  • Immune challenges
  • Joint problems
  • Low bone density
  • Weight control

Another great article by Dr. Mercola:  https://articles.mercola.com/sites/articles/archive/2015/06/22/berberine-benefits.aspx

Berberine was able to control blood sugar and lipid metabolism as effectively as metformin, with researchers describing berberine as a “potent oral hypoglycemic agent.”4

A separate meta-analysis also revealed “berberine has comparable therapeutic effect on type 2 DM [diabetes mellitus], hyperlipidemia and hypertension with no serious side effect.”5

There is also evidence for reducing inflammation, oxidative stress, tumor growth, & depression and helping with infections, all of which Lyme/MSIDS patients can struggle with.

The Importance of Gut Health to Healing From Chronic Illnesses Podcast- Dr. Jill Carnahan

https://livingwithlyme.us/episode-63-the-importance-of-gut-health-to-healing-from-chronic-illnesses/

Episode 63: The Importance of Gut Health to Healing from Chronic Illnesses

Cindy Kennedy, FNP, is joined by Dr. Jill Carnahan, who discusses the importance of gut health in order to heal from chronic illnesses. She offers an insight into candida and its role in “Gut Dysbiosis.”Dr. Carnahan completed her residency at the University of Illinois Program in Family Medicine at Methodist Medical Center. In 2006 she was voted by faculty to receive the Resident Teacher of the Year award and elected to Central Illinois 40 Leaders Under 40. She received her medical degree from Loyola University Stritch School of Medicine in Chicago and her Bachelor of Science degree in Bio-Engineering at the University of Illinois in Champaign-Urbana. She is dually board-certified in Family Medicine and Integrative Holistic Medicine. In 2008, Dr. Carnahan’s vision for health and healing resulted in the creation of Methodist Center for Integrative Medicine in Peoria, Illinois, where she served as the Medical Director for two years. In 2010, she founded Flatiron Functional Medicine in Boulder, Colorado, where she practices functional medicine with medical partner, Dr. Robert Rountree, author and expert speaker.

Dr. Carnahan is also 10-year survivor of breast cancer and Crohn’s disease and passionate about teaching patients how to “live well” and thrive in the midst of complex and chronic illness. She is also committed to teaching other physicians how to address underlying cause of illness rather than just treating symptoms through the principles of functional medicine. She is a prolific writer, speaker, and loves to infuse others with her passion for health & healing!

If you would like to read more about Dr. Carnahan, visit www.drcarnahan.com.

________________

For more:  https://madisonarealymesupportgroup.com/2018/10/24/herbs-habits-to-revive-your-gut/

https://madisonarealymesupportgroup.com/2018/08/15/whats-the-best-diet-for-lyme-disease-dr-rawls/

https://madisonarealymesupportgroup.com/2019/01/12/sibo-clinical-implications-natural-therapeutic-options/

https://madisonarealymesupportgroup.com/2019/02/19/germs-in-your-gut-are-talking-to-your-brain-scientists-want-to-know-what-theyre-saying/

https://madisonarealymesupportgroup.com/2019/03/29/cochrane-review-probiotics-reduce-c-diff-by-70-in-high-risk-patients-taking-antibiotics/

https://madisonarealymesupportgroup.com/2018/09/15/prebiotics-probiotics-do-they-really-work-for-gut-health/

 

How to Detox Naturally For Healthy Aging

https://vitalplan.com/blog/how-to-detox-naturally-for-healthy-aging?

how-to-detox-naturally-healthy-aging

How to Detox Naturally for Healthy Aging

By Beth Janes Posted 03-15-2019

Environmental toxins have always posed a risk to humans, even thousands of years ago. Back then, it was things like molds and other dangerous bacteria and viruses, poisonous berries and other plants, snake venom, or the sting of a jellyfish that had the biggest potential to make people ill or even kill them.

Now, however, those naturally-occurring toxins are the least of our problems. Instead, our modern world is overrun with toxins and toxicants — the proper term for man-made toxins — which are harder to avoid and much more insidious than natural ones ever were.

Some estimates suggest that more than 200,000 man-made chemicals now exist, most of which have only been developed in the past 100 years or so, says Dr. Bill Rawls, M.D., Medical Director of Vital Plan. And we’re exposed to many of them every day in the air we breathe, the food and drinks we consume, and what has contact with our skin. Here’s just a taste of what’s on that list:

  • Pollution from cars and industrial processes include particulate matter, ozone gas, and benzene.
  • Indoors, chemicals called volatile organic compounds (VOCs) are commonly released from household items like carpet, paint, and cleaning solutions.
  • In the average American diet, you’ll find pesticide and herbicide residue, BPA or other chemicals from plastics that can leach into food, plus heavy metals and arsenic in water.
  • The many personal care products we use, often with the intention of making skin and hair more healthy, can contain endocrine disruptors that have been linked to a variety of cancers.
  • Traffic jams, work deadlines, and other pressures easily trigger toxic chronic stress.
  • Refined carbohydrates, highly processed sugars and manipulated fats can also be toxic to humans’ otherwise relatively primitive systems, which were designed to run on simple plants, barks, herbs and fresh, clean water.

All of these toxins and toxicants negatively impact health on many different fronts, but one of the most serious is how they accelerate or interfere with aging. In fact, research now shows that environmental toxins play a significant role in what’s called external aging, according to a recent review in the journal Trends in Molecular Medicine. That’s the type of aging that’s driven by external factors, as opposed to the genetic and internal ones we can’t control.

As tempting as it is to want to isolate and target the worst culprits on the toxic list, there’s not necessarily one or even a few that you can vilify over others, says Dr. Rawls. “It’s all of them together — it’s this high level of insidious toxins that has never been here before on earth,” he explains. “Because our ancestors didn’t deal with them, our bodies don’t have the genetic memory or ability to properly tolerate or process all of the toxins that we’re now bombarded with daily.”

But all is not lost: It is possible to minimize toxins’ impact and significantly decelerate aging — and naturally, to boot. Here’s how.

How Cells Age — and How Toxins Interfere

How Cells Age — and How Toxins Interfere

To understand how modern toxins interfere with the aging process, it helps to first know how the body ages normally. “We are a collection of cells, and each cell is specialized to take care of other cells,” Dr. Rawls explains. “When a critical number of cells, or cells from a key organ like our lungs or heart, get sick or old or die — that’s what aging and illness is in a nutshell.”

That happens naturally over time when mitochondria, cells’ power generators, burn out, which causes cells to die or produce less healthy cells that don’t function properly. It also happens when cells are no longer able to properly communicate and coordinate with their 10 trillion peers, which all come from 200 different groups.

“That cellular coordination is remarkably important,” says Dr. Rawls. “When it doesn’t happen, the body starts breaking down and functions stop working — that’s also illness and aging.”

In many ways, our bodies aren’t that different than a machine, and just like components of a machine, our cells and systems eventually stop working as well. Toxins, however, can cause the aging of cells and breakdown of cellular communication to happen sooner than it would otherwise. “Environmental toxins strangle or suffocate or damage cells, or they disrupt chemical messengers so cells aren’t communicating, and so the body breaks down,” Dr. Rawls says.

For example, just as herbicides and pesticides mess with the chemical messenger channels in weeds and insects, they can also disrupt those in humans (which are surprisingly similar), says Dr. Rawls. Chemicals in plastics and in pesticides, meanwhile, may mimic hormones in the body. Not only does that affect signaling, it can throw your body’s hormonal balance out of whack and potentially contribute to hormonally-active cancers.

Other toxins may act as free radicals, causing inflammation and damage to cell membranes or blood vessels, Dr. Rawls says. That’s the case with many air pollutants from cars and industrial processes. When you breathe them in, they flood your respiratory and cardiovascular systems and can pass into your bloodstream.

These free radical-like toxins can interact with nerve endings, too, which then allow them to disrupt your nervous system. In fact, studies have found a clear link between high levels of airborne toxins in the environment and early death from all causes, but particularly heart disease. Decreased lung function and increased hospital admissions were also shown to be more common among those who live and work in the polluted areas.

Toxins may also directly damage DNA, the blueprint that cells use to make new cells. When that happens, the new, abnormal cells may die off — or they may continue reproducing damaged, diseased, or dysfunctional cells. For example, DNA in skin cells directly absorbs photons from UV light, which then leads to skin wrinkling and increased risk for skin cancer. Research even suggests exposure to certain toxins in pesticides and elsewhere may change DNA in a way that contributes to disease not only for those exposed, but also to their offspring and subsequent generations.

That’s all pretty scary stuff, but the good news is that you aren’t powerless. “The great thing about where we are now, is that we know more about the effects of these toxins than ever before, and we have more choices that let us better avoid or deal with them,” Dr. Rawls says.

How to Detox Naturally

Along with reducing your exposure to the more obvious and well-known toxins — such as steering clear of cigarette and cigar smoke, avoiding household chemicals, and reducing your use of plastic containers — here’s how to best protect yourself against invisible, insidious toxin exposure and equip your body to naturally filter them out and reduce the potential damage.

1. Fill Half Your Plate with Vegetables and/or Fruit

“No matter what the issue is, when it comes to improving health, the answer will almost always include eating more plants,” Dr. Rawls says. But as far as detox goes, there are specific ways veggies can help.

For one, many modern toxins are fat soluble, and, unlike meat, plants generally don’t have a lot of fat in which to store toxins. Many fruits and some veggies also have protective peels that help limit their load, plus you can find many affordable organicoptions.

People who eat a lot of produce also tend to not have excessive amounts of body fat that can store toxins. Cruciferous veggies like broccoli and cabbage in particular also help ensure proper functioning of your liver, which is one of your body’s main detox centers, Dr. Rawls says. Vegetables’ fiber plays a key role, too.

“After your liver processes a toxin to make it water soluble, it’s secreted into bile, where the molecules then need something to bind to in order to exit your body,” Dr. Rawls says. “Vegetable fiber does that better than any other type.”

Indeed, fiber intake was closely tied to what researchers called “successful aging,” according to a study in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. The researchers found that people who ate a lot of fiber were 80% less likely to have hypertension, diabetes, dementia, depression, and a functional disability.

Vegetables also ensure cell membranes are their healthiest, and these membranes are what let nutrients in and help keep toxins out. “All the fat you eat ends up in cell membranes,” Dr. Rawls explains. “If you’re eating mostly saturated fat from meat and fried foods, membranes become stiff like lard.”

Plus, fried food can actually be a toxin all on its own; cooking fat or oil over extremely high heat turns it into free radicals. “So what you’re doing then is lacing cell membranes with damaging free radicals,” he says. One study in the journal British Medical Journal found that post-menopausal women who ate one or more servings of fried food a day had an 8% higher risk of dying during the study period. The risk rose to 13% for those who ordered up fried chicken daily.

A healthy plant-based diet also contributes to a healthy vascular system and good blood flow, which also helps move toxins out of your body, Dr. Rawls adds. Bottom line: “What we eat influences aging down to the cellular level, as well as our ability to flush out toxins.”

2. Try Detoxifying Herbs and Natural Ingredients

“Everyone wants one simple detox product, but most of what’s available cause only a laxative effect,” Dr. Rawls says. “When people get constipated, they build up loads of bad bacteria in their gut, and when they get rid of it, they feel better. But those products are not actually helping remove toxins.”

One that is at the top of his list: Chlorella. A nutrient-rich freshwater green algae, chlorella is rich in chlorophyll, a pigment with antioxidant properties that binds to toxins and helps usher them out of your system.

He also points to herbs that support healthy liver function, which is highly involved in processing toxins so your body can remove them. “Herbs like milk thistle and burdock root, as well as andrographis are at the top of the list because they help protect liver cells,” Dr. Rawls says. Milk thistle, for example, contains a potent antioxidant compound that has been shown beneficial in liver disease, as well as for protecting against liver toxins and reducing liver inflammation, according to a review in Lancet Oncology.

Another herb to consider: Glutathione, an essential antioxidant found in many plants and our own bodies. Glutathione plays a key role in liver function, especially during the first stage of toxin removal — when the liver transforms the toxin from fat soluble to water soluble so it can be excreted, Dr. Rawls says.

Studies suggest glutathione can be beneficial for the liver, with a recent study in BMC Gastroenterology even showing it may help those with non-fatty liver disease. What’s notable here, though, is that along with supporting liver function, glutathione also helps protect cell mitochondria from free radical damage that contributes to aging.

Berberine and other bitter herbs that support healthy digestion also help your body detox and support healthy aging. They work by ensuring proper removal of toxins through stools, plus promote healthy, balanced gut flora. And a healthy balance of gut bugs means a strong immune system — upwards of 70% of our immune system lives in our gut — which helps strengthen your defenses against disease.

3. Get Enough Sleep

Not only does sleep help diffuse stress and its toxic effects, it is essential for your body to rid itself of toxic materials and waste. “Deep, stage-3 sleep is when your body is able to detox most effectively, and when it works the hardest to get rid of toxins,” Dr. Rawls says.

One recent study in the journal Science Advances showed how this works when it comes to the brain and toxic proteins that can build up and that have been linked to Alzheimer’s disease. Researchers found that deep sleep sets up the ideal environment for your body’s glymphatic system to work optimally. The glymphatic system is your brain’s specialized waste removal system, which uses the flow of cerebrospinal fluid to “cleanse” away toxic junk.

If you struggle with occasional sleeplessness, herbs and other natural ingredients can help here, too. A few to consider:

  • Montmorency tart cherries: They’re a natural source of melatonin, a sleep-signalling hormone. Levels are low, but you don’t need much to initiate sleep, says Dr. Rawls, and in fact the high levels (>3mg) found in many supplements may actually disrupt your normal sleep-wake cycle.
  • Magnesium: More than half of Americans don’t get enough of this essential mineral, a shortfall that’s been linked with poor sleep quality. Plus, magnesium helps promote calm and relaxation, which naturally lends to better sleep. Look for it in magnesium glycinate form, which is more easily absorbed by the body.
  • Ashwagandha and l-theanine: If stress is what’s keeping you up, consider these herbs. They can help balance the hypothalamic pituitary adrenal (HPA) axis, which regulates stress hormones like cortisol and adrenaline so you’re better able to manage stress in the face of it.
  • Bacopa, passionflower, and motherwort: Especially when taken together, these three herbs help promote a calm mind and support normal, healthy sleep.

4. Drink Plenty of (Filtered) Water

Filtering your tap H2O is a no-brainer for limiting exposure to all sorts of metals and toxic substances. For example, as many as 56 million Americans in 25 states may be drinking tap water with unsafe arsenic levels, according to the U.S. Natural Resources Defense Council.

But along with arsenic, a known carcinogen, tap water can contain trace amounts of medications, heavy metals, and other toxins that can mess with natural hormones. Bottled water, however, isn’t the answer since it may not be filtered, plus has the added risk of potentially containing BPA, a hormone-disrupting toxin in many plastics, according to a paper in the The British Medical Journal.

Just as important as filtering your water is to be sure you’re drinking enough. Adequate hydration helps flush toxins out of your system through urine, but also by keeping your GI function regular, which is another exit point for toxins, Dr. Rawls says. Check out your urine for clues as to whether you’re sipping sufficiently — it should be light yellow, like lemonade.

5. Cut Way Back on Sugar

“Excess sugar is toxic in a variety of ways,” Dr. Rawls says. First, excessive sugar promotes the growth of abnormal or pathogenic bacteria in the gut. Those gut microbes can actually create toxins that stimulate and agitate the brain, which then affects sleep and hormone levels and sets off a domino effect that impacts health and longevity at every stage, Dr. Rawls says.

Excess glucose in particular accelerates aging since it sticks to proteins in the body, which “gums up the works,” Dr. Rawls says. “Proteins make all functions in cells possible, and when you load the body with glucose, it sticks to the proteins and causes them to collapse.” One of the most visible signs of too much sugar, for example, is skin wrinkling. That’s because collagen — skin’s main support structure — is primarily made of protein.

But that’s not the only way too much sugar can be toxic. The more you eat, the more your body will become resistant to the insulin that moves glucose out of your blood and to cells that use it for energy. That can lead to elevated levels of both insulin and blood glucose, which have been linked in studies to cellular aging, including in the brain. Meanwhile, other research has found that those who eat a lot of sugar are at higher risk of dying of cardiovascular diseases, reports a study in JAMA Internal Medicine.

6. Stay Physically Active

“One of the best ways to get rid of heavy metals in your body is through exercise,” Dr. Rawls says. “It increases blood flow and promotes sweat, which is a key way your body detoxes; I think of it as blowing out your pipes.” In fact, research suggests that people exposed to higher levels of metals may sweat out just as many toxins as they release through urine, according to a review in the Journal of Environmental Public Health.

Exercise is also the most effective way to manage stress and help encourage quality sleep. “That’s important, because stress and lack of sleep disrupt hormones, which then interferes with your ability to get rid of toxins,” Dr. Rawls says. So try to be moderately active every day, by walking frequently throughout the day or using a bike to commute. And if you can regularly work up a sweat, even better.

7. Turn to Nature’s Air Purifiers

A number of plants are known to be especially effective at scrubbing indoor air of pollutants, reports a paper in the journal Environmental Health Perspectives. While all plants will help to some extent, try filling your home with air-purifying all-stars shown to significantly lower indoor levels of VOCs, including areca, lady and bamboo palms, English ivy, Boston ferns, peace lily and Ficus.

Likewise, when you’re outdoors, try to spend as much time as possible in naturally green areas and away from major roads and highways. Research suggests lusher landscapes help mitigate the effects of climate change, including improving air quality and reducing your exposure to airborne toxins. One review found decreased risk of mortality among those subjects who lived in the greenest areas.

What’s more, spending time amidst nature also significantly reduces stress, according to a study in Behavioral Sciences. If you can’t escape the city, at least seek out parks for a daily dose of nature. Research suggests urban parks and green spaces improve air quality and lower the risk of cardiovascular disease, mortality, and diabetes, according to a review chapter in the book Nature-Based Solutions to Climate Change Adaptation in Urban Areas.

8. Be Sun Safe

While most toxins do their dirty work inside your body and in ways you can’t see, ultraviolet rays from the sun age you prematurely in very visible ways: Over time, they cause skin to wrinkle, make it less elastic, and trigger hyperpigmentation (brown spots) plus rough, dry skin texture.

Researchers who studied 183 sets of twins proved just how aging sun damage can be. The twins who had had more sun exposure and a history of outdoor activities and lack of sunscreen all looked significantly older compared to their more sun-safe sibling. Ultraviolet rays are also known carcinogens that can increase your risk of skin cancer, Dr. Rawls says.

You needn’t become a vampire who ventures out only at night, however. To protect yourself, simply practice sun-safe behaviors:

  • Avoid being outdoors in the sun when rays are strongest, between 10 a.m. and 2 p.m.
  • Wear protective clothing, a wide-brim hat, and sunglasses.
  • Apply a non-toxic sunscreen to exposed skin. Look for those that list zinc oxide or titanium dioxide as active ingredients, which are inert minerals that block rays, providing natural SPF.

Ultimately, it’s impossible to completely avoid the influx of modern-day toxins and their aging effects. But with these tips, you can certainly lessen your exposure and mitigate their negative effects now and years down the road as you enter and enjoy your golden years.

References
1. Sorrentino, Jessica A. et al. “Defining the toxicology of aging.” Trends in Molecular Medicine. 2014 July; 20:7 P375-384
2. University of Michigan School of Public Health, Environmental Health Fact Sheet. 2013, November. “Air Pollution and Oxidative Stress.” Retrieved from http://mleead.umich.edu/files/Air-Pollution-and-Oxidative-Stress.pdf
3. Kelly, Frank J. “Oxidative stress: Its role in air pollution and adverse health effects.” Occupational & Environmental Medicine. 003;60:612-616
4. Ueda, K. “Effect of environmental chemicals on the genes and the gene expression.” Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan. 2009 Dec;129(12):1501-6.
5. Manikkam, Mohan et al. “Pesticide Methoxychlor Promotes the Epigenetic Transgenerational Inheritance of Adult-Onset Disease through the Female Germline.” PLoS One. 2014 Jul 24;9(7):e102091.
6. Gopinath, B. et al. “Association Between Carbohydrate Nutrition and Successful Aging Over 10 Years.” The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 2016 Oct;71(10):1335-40.
7. Kmietowicz, Zosia. “Fried food linked to increased risk of death among older US women.” BMJ. 2019; 364:1362
8. MacMillan, Amanda. “What’s in your drinking water?” NRDC. 2017, May 02. Retrieved from http://www.nrdc.org/water/drinking/qarsenic.asp
9. Kerr, Jonathan R. “Bottled water for all, all the time?” BMJ2016;352:i1214
10. Harvard Medical School, Blavatnik Institute, Neurobiology, newsletter. “Sugar on the Brain.” Retrieved from http://neuro.hms.harvard.edu/harvard-mahoney-neuroscience-institute/brain-newsletter/and-brain-series/sugar-and-brain
11. Yang, Quanhe et al. “Added Sugar Intake and Cardiovascular Diseases Mortality Among US Adults.” JAMA Internal Medicine. 2014;174(4):516-524.
12. Sears, Margaret E. et al. “Arsenic, Cadmium, Lead, and Mercury in Sweat: A Systematic Review.” Journal of Environmental and Public Health. 2012; 2012: 184745.
13. Claudio, Luz. “Planting Healthier Indoor Air.” Environmental Health Perspectives. 2011 Oct; 119(10): a426–a427.
14. James, Peter et al. “Exposure to greenness and mortality in a nationwide prospective cohort study of women.” Environmental Health Perspectives. 2016: Sep
15. Ewert, Alan and Chang, Yun. “Levels of Nature and Stress Response.” Behavioral Sciences. 2018 May; 8(5): 49.
16. Braubach M., et al 2017. “Effects of Urban Green Space on Environmental Health, Equity and Resilience.” In: Kabisch N., Korn H., Stadler J., Bonn A. (eds) Nature-Based Solutions to Climate Change Adaptation in Urban Areas. Theory and Practice of Urban Sustainability Transitions. Springer, Chem
17. Guyuron, B. et al. “Factors contributing to the facial aging of identical twins.” Plastic and Reconstructive Surgery. 2009 Apr;123(4):1321-31.
18. Hablitz, Lauren M. et al. “Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.” Science Advances. 27 Feb 2019:5, 2, eaav5447
19. Siegel, Abby B. and Stebbing, Justin. “Milk thistle: early seeds of potential.” Lancet Oncology. 2013 Sep; 14(10): 929–930.
20. Honda, Yasushi et al. “Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.” BMC Gastroenterology. 2017; 17: 96.
21. Wallace TC, McBurney M, Fulgoni VL, 3rd. Multivitamin/mineral supplement contribution to micronutrient intakes in the United States, 2007-2010. J Am Coll Nutr. 2014;33(2):94-102.

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Walgreens & CVS Join the Cannabis Race

https://www.emperorcbd.com/walgreens-and-cvs-join-the-cannabis-race/

 

Cannabidiol (CBD) has become the new hot product everyone’s talking about. Much like marijuana, you can use CBD to de-stress, reduce inflammation, or treat seizures without getting drowsy, hungry, or having the perception of time slowing down. In other words, consuming CBD won’t get you high.

CBD is extracted from the industrial hemp plant and is therefore considered part of the cannabis family. In 2018, congress passed the Farm Bill which legalized the production of hemp derived CBD. However, not all CBD is legal. Only those products compliant with the Farm Bill and approved by the FDA are considered legal by the federal government.

Nevertheless, the Farm Bill was seen as a huge win by the cannabis industry; a huge win that did not go unnoticed.

Competition has emerged from all corners of the globe. So much so, that the industry is expected to reach $22 billion by 2022. It was only a matter of time before well-known retail stores such as CVS and Wal Greens rushed to grab a piece of the pie.

Walgreens Wants In

WalGreens has announced its plans to sell CBD in almost 1500 of its stores throughout the US. As of now, they plan on selling CBD patches, creams, and sprays. However, the brand for these products has not been specified.

Due to the various state regulations regarding CBD, Walgreens will only sell CBD in nine states:

  • New Mexico
  • Colorado
  • Vermont
  • South Carolina
  • Oregon
  • Illinois
  • Tennessee
  • Indiana
  • Kentucky

Walgreens spokesperson Brian Faith shared with CNBC the reason for introducing CBD in their stores is to increase the accessibility of health and wellbeing products to better meet customer demand.

However, with the recent stocking of CBD products on CVS shelves in early March, we highly doubt meeting customer demand was the only reason Walgreens announced it would sell CBD.

CVS Takes a Leap of Faith

CVS is leading the charge for retail pharmacies by selling CBD. The giant chain store has introduced CBD salves, lotions, spray roll-ons, and creams to its line of products in a strategic move to capture a portion of the growing industry.

At the time of writing, CVS sells CBD in:

  • California
  • Illinois
  • Alabama
  • Kentucky
  • Colorado
  • Indiana
  • Maryland
  • Tennessee

Due to the FDA’s regulations, CVS has stated that it’s not selling any CBD food additives or supplements. Rather, they claimed to have partnered with CBD manufacturers that are complaint with the Farm Bill to deliver only high quality products to customers.

The CEO of Curaleaf has claimed that CVS will soon be selling its products on the CVS website and in over 800 CVS stores throughout ten states.

CVS is yet to confirm any of these claims.

Time will Tell

With the FDA frowning upon the use of CBD (especially as an additive in food or dietary supplement) many retailers are turning to CBD as a beauty product. The challenges for these two giants highly increase with the online competition completely dominating the market.

Only time will tell if consumer demand will allow CBD to become another mainstream product at retail stores.

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For more:  https://madisonarealymesupportgroup.com/2017/09/28/cbd-for-pain/

https://madisonarealymesupportgroup.com/2019/02/10/the-endocannabinoid-system-and-the-important-role-it-plays-in-human-health/

https://madisonarealymesupportgroup.com/2019/01/16/ldn-cbd/

https://madisonarealymesupportgroup.com/2017/11/14/hemp-oil-presentation/

https://madisonarealymesupportgroup.com/2019/02/09/webinar-cbd-craze-health-or-hype/

https://madisonarealymesupportgroup.com/2018/10/08/thc-vs-cbd-for-pain-the-differences-interactions/

 

FREE LDN Talk in Madison – April 25

iu-8

LDN Talk in Madison, Wisconsin

When:  April 25th, 6:30-8:00pm

Where: Door Creek Church, 6602 Dominion Drive, Madison, Wisconsin 

Who: Linda Elsegood, David Yeazel, Medical Professionals and Patients

Cost:  FREE

Register:  email  

For more on LDN:  https://madisonarealymesupportgroup.com/2016/12/18/ldn/

https://madisonarealymesupportgroup.com/2018/10/30/ldn-an-overview-of-clinical-applications/

https://madisonarealymesupportgroup.com/2017/06/12/ldn-reduced-pro-inflammatory-cytokines-in-fm-after-eight-weeks/

https://madisonarealymesupportgroup.com/2018/05/18/bullseye-low-dose-naltrexone-lyme-disease-documentary/

https://madisonarealymesupportgroup.com/2018/07/16/low-dose-naltrexone-for-lyme-living-with-lyme-podcast/

https://madisonarealymesupportgroup.com/2019/03/19/sjogrens-syndrome-clinical-benefits-of-low-dose-naltrexone-therapy/

https://madisonarealymesupportgroup.com/2019/01/16/ldn-cbd/

What is LDN, How LDN Works, Conditions LDN can Treat and Formulations of LDN: https://lnkd.in/gTCgvgC

Information Packs: https://lnkd.in/gFkN2_e

LDN Clinical Trial and Studies – can be sorted by conditions: https://lnkd.in/gjYffHy

Testimonials from Users and Medical Professionals – can be sorted by conditions: https://lnkd.in/gNSiiiC

Free Conference Presentations – 2013, 2014, and 2016: https://lnkd.in/geHGKVc

Much more is on the website: https://lnkd.in/gWfhg4H