https://danielcameronmd.com/bio%ef%ac%81lms-in-lyme-disease/

ROUND BODIES, BLEBS AND BIOFILMS IN LYME DISEASE

biofilm-lyme-disease

In a recent study entitled “Pleomorphic Variants of Borreliella (syn. Borrelia) burgdorferi Express Evolutionary Distinct Transcriptomes,” investigators describe several pleomorphic forms which develop along Borrelia burgdorferi’s lifecycle. Their biological and medical relevance, however, is unknown.

In an effort to better understand their significance, Corak and colleagues “grew B. burgdorferi spirochete, round body, bleb, and biofilm-dominated cultures and recovered their transcriptomes by RNAseq profiling.” Their non-spirochete morphotypes were induced by simple changes in growth conditions.

The authors described three pleomorphic forms as follows:

  1. “Spherical B. burgdorferi cells with intact and flexible cell envelope enclosing numerous flagella are often termed as ‘round bodies.’”
  2. “The so called “bleb” morphotype, is characterized by the formation of outer membrane vesicles (OMVs) on the surface of B. burgdorferi cells.”
  3. “The B. burgdorferi biofilms are multicellular assemblies composed of spirochete, round body, and bleb cells embedded in a self-produced extracellular polysaccharide matrix.”

Corak and colleagues were able to generate these pleomorphic forms by modifying spirochetal cultures. They found that round bodies share similar expression profiles with spirochetes. Blebs and biofilms had different expression profiles with spirochetes.

“Taken together, we believe that many of the ongoing controversies related to Lyme disease pathogenesis and treatment strategies could be resolved by improving our understanding of B. burgdorferi biology and evolution, which for unclear reasons have not yet been explored.”

The authors postulated, “These regularities point to the possibility that bleb and biofilm morphotypes might be important in the dissemination and persistence of B. burgdorferi inside the mammalian host.”

They encouraged further research regarding the function of a large number of genes that might explain the pathogenesis of Lyme disease.

“Taken together, we believe that many of the ongoing controversies related to Lyme disease pathogenesis and treatment strategies could be resolved by improving our understanding of B. burgdorferi biology and evolution, which for unclear reasons have not yet been explored.”

References:
  1. Corak, et al. Pleomorphic Variants of Borreliella (syn. Borrelia) burgdorferi Express Evolutionary Distinct Transcriptomes. Int. J. Mol. Sci. 2023, 24(6), 5594; https://doi.org/10.3390/ijms24065594

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**Comment**

There are very clear reasons why pleomorphism has not been explored.  It would destroy the current and long-held paradigm that Lyme is straight-forwardly simple and only requires a simple monotherapy to cure. I’d say 40 years of reality obliterates that paradigm, unfortunately OZ behind the curtain has too many vested interests to admit the truth.  Admitting that Lyme/MSIDS is a chronic/persistent disease(s) means a “vaccine” isn’t possible and ‘the powers that be’ simply cannot admit this truth.

The “vaccine” train just keeps on a chugging.

Go here for a conflict of interest report:   https://madisonarealymesupportgroup.com/wp-content/uploads/2019/06/conflictreport.pdf

http://  Approx. 4 Min

Mistakes Were NOT Made: An Anthem for Justice (Video)

“Don’t Let Them Get Away With It”

Dr. Tess Lawrie‘s potent message for an awakening public.
Go here for the powerful video as Youtube has shown its true colors once again by censoring this message.

By JOHN LEAKE

There are notable moments in history when the overlords of this world go too far in their exercise of power and commit a crime that is a glaring expression of their arrogance. Such a crime is memorialized and becomes symbolic of their tyranny. Decent people are shocked by the spectacle of it and conclude that the overlords no longer have any legitimate claim to rule.

I woke up this morning thinking about the complicated ideas of justice, redemption, and forgiveness. The final concept, forgiveness, can only happen after those who have committed a crime are publicly identified and held accountable for it. Source  (See link for article)

Also see Margaret Anna Alice’s article, as this is the information that Dr. Lawrie shares in the powerful video above that was derived from a poem Anna Alice wrote.  The main point: COVID and all that followed was not a mistake or a blunder.  The entire poem is corroborated with sources so if you doubt the information, check it out for yourself.

For more:

It’s all planned and all related.  Every Single Bit Of It

Brought to you by Pfizer.

http://  Approx. 8 Min

FDA Director Issues Shocking Threat if You Don’t Take New Injection

4/10/23

Dr. Suneel Dhand discusses FDA Director Dr. Peter Mark’s statement that while “vaccine” mandates are not the way to go, the shot is for those who “want to save their lives,” insinuating that those who don’t take the jab don’t want to save their lives.  Dhand states that this shockingly absurd statement is indicative of the past years with COVID.  Marks freely admits that despite attempting for 10 years to produce a “vaccine” to prevent the flu, it hasn’t happened yet, and he doesn’t expect the next for COVID shot to be “too different” from what’s currently available.

  • The FDA is supposed to be a regulatory agency and has no business pushing medical therapeutics and formulating policy
  • The FDA has no evidence to support the assertion that the COVID injections will reduce hospitalization or save your life
  • This typifies the sheer arrogance of our public health ‘authorities’ and reveals they have learned nothing from COVID
  • Rather than simply reflecting upon their own mismanagement of COVID for the erosion in confidence for both public health and “vaccines,”  they will continue to blame others for ‘misinformation’
  • There are 88 bills in state legislatures to roll back or outlaw any sort of “vaccine” mandate.  Public health “vaccine” pushers simply can not fathom this and continue to falsely state that there are too many people dying of COVID – again insinuating that the COVID injections somehow stop this, which they don’t
  • Interestingly, Penny Heaton, MD, Global Therapeutic Area Head for Vaccines at J&J, is interested in moving beyond lipid nanoparticles that may be “potentially less reactogenic, potentially more immunogenic, potentially actually direct[ing] the exact immune response we want.”  This statement admits the COVID shots are reactogenic, not immunogenic, and are not giving the correct immune response.

https://childrenshealthdefense.org/defender/private-equity-healthcare-cd/

Private Equity’s Stranglehold on U.S. Healthcare Is ‘Shocking and Immoral’ — Report

Private equity’s ownership of U.S. healthcare providers is incompatible with the needs and best interests of patients and should be checked with federal legislation, according to a report published Wednesday by the consumer advocacy group Public Citizen.

This article was originally published by The Defender — Children’s Health Defense’s News & Views Website

By Brett Wilkins

Private equity’s ownership of U.S. healthcare providers is incompatible with the needs and best interests of patients and should be checked with federal legislation, according to a report published Wednesday by the consumer advocacy group Public Citizen.

Critics of for-profit care have long decried private equity‘s focus on maximizing returns through practices including slashing staff, surprising patients with astronomical bills and eschewing low-margin care upon which vulnerable populations rely.

The new report — authored primarily by Public Citizen healthcare policy advocate Eagan Kemp — examines investment firms’ impact on more than a dozen healthcare sectors, from reproductive health through end-of-life care.

“Private equity acquisitions in the healthcare sector have steadily climbed since the financial crisis in 2009, particularly in the past five years,” a summary of the report notes.

“Unlike acquisitions of hospitals, which typically occur under a public spotlight, the private equity industry’s acquisitions of physician practices and other healthcare business lines often occur with little or no disclosure or public scrutiny, hindering the ability of regulators and watchdogs to monitor the effects of private equity ownership.”

(See link for article)

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For more:

https://rawlsmd.com/health-articles/lyme-chlamydia-connection-know

The Lyme & Chlamydia Connection

The Lyme + Chlamydia Connection: What You Should Know

by Dr. Bill Rawls
Posted 1/18/19

If you’ve ever contended with chlamydia — and many of us have, considering an estimated 2.86 million Americans contract an infection each year — you likely treated it with antibiotics and considered it cured.

But like Lyme disease, chlamydia infections can become chronic, and they’ve have been associated with Lyme and other chronic illnesses, including chronic fatigue syndrome, chronic pelvic pain, arthritis, and possibly even multiple sclerosis. So is chronic chlamydia a Lyme coinfection, and if so, how can it be diagnosed and treated? Read on to learn more.

Is Chlamydia a Lyme Coinfection?

It’s not considered one, because it is not typically carried by ticks. Instead, chlamydia is transmitted from person to person through sexual contact, or from an untreated mother to her newborn baby during childbirth.

But chlamydia are very similar to mycoplasma, the most common Lyme coinfection. Like mycoplasma, chlamydia are small, gram-negative bacteria that live and reproduce inside cells of a host, and they need basic raw materials from the host to survive (known as an obligate intracellular bacteria). And as with both mycoplasma and borrelia (the bacteria associated with Lyme disease), chlamydia definitely fits the definition of a stealth microbe.

The word “stealth” reflects the microbes’ elusive nature: they have sophisticated mechanisms to hide inside cells, where they remain shielded from the body’s defense system. In a healthy host that achieves balance with the microbe, there may be no visible symptoms of their presence; stealth microbes can lie undetected and dormant for years.

For that reason, the actual incidence of chronic chlamydia infections is unknown, but it’s likely high. And if a person’s immune function declines and becomes compromised due to other illness or system disruptors like toxins, chronic stress, or a high-carbohydrate diet, chlamydia can begin to contribute to disease.

Symptoms of chronic illness are very different than the initial acute illness. Defining chronic chlamydia infection can be extremely challenging because when immune system functions become compromised, other stealth microbes such as Epstein-Barr virus, borrelia, and bartonella also reactivate. This can cause the wide range of symptoms typical of chronic illnesses such as fibromyalgia, chronic fatigue syndrome, and chronic Lyme disease.

Let’s take a closer look at the three main forms of chlamydia that can infect humans.

1. Chlamydia pneumoniae

C. pneumoniae is the most common form of chlamydia, affecting 30-60% of the population worldwide. Humans are the natural host and reservoir for this species of the bacteria.

Transmission of C. pneumoniae is by airborne droplets, meaning the pathogenic microbes become suspended in the air on dust particles and water droplets. The droplets can make contact with your mucous membranes when they are inhaled, or when they’ve landed on a surface that you happen to touch.

At first, the infection affects the respiratory tract. C. pneumoniae is associated with pharyngitis (sore throat), sinusitis, middle ear infection, and bronchitis. Most infections are mild or asymptomatic, but if your immune function isn’t up to par, a more severe infection can take hold.

In fact, C. pneumoniae infection can progress to atypical pneumonia, which is similar to infections like mycoplasma. C. pneumoniae is responsible for 20% of community-acquired pneumonia, mostly in people over the age 65.

C. pneumoniae, in particular, has been discovered within artherosclerotic plaques of the arteries (along with other microbes). It’s also has been associated with myocarditis (infection of the heart muscle) and nervous system disorders, including multiple sclerosis.

Diagnosing Chlamydia pneumoniae

Testing includes indirect testing with antibodies, and direct testing for chlamydia DNA with PCR. Also, your healthcare provider may take a sample of your phlegm or a nasal or throat swab. Often, the testing methods for detecting the stealth microbe in a chronic chlamydia infection are poor, but a detailed medical history of your symptoms may lead a doctor to suspect the presence of C. pneumoniae.

2. Chlamydia trachomatis

The only known natural host for C. trachomatis is humans. In the developed world, it is a common sexually transmitted disease. In males, it can cause urethritis (infection of the urethra) and prostatitis (infection of the prostate).

In females, it can cause urethritis, cervicitis (infection of the cervix), and pelvic inflammatory disease. If the symptoms of C. trachomatis are unrecognized and untreated, the infection can cause scarring of the fallopian tubes, with infertility, chronic pelvic pain, and chronic fatigue.

But chlamydia infections regularly go unreported because it’s often a silent infection, meaning individuals who’ve acquired it may be asymptomatic. C. trachomatis has a slow incubation period, so the initial signs of the infection may not pop up for weeks.

Additionally, newborns of mothers who have genital chlamydia can acquire the infection, and it can cause conjunctivitis that may result in blindness. For this reason, all newborns in developed countries are treated after birth with antibiotic drops. In the developing world, where sanitation and hygiene are poor, ocular chlamydia infection (called trachoma) is a common cause of blindness. C. trachomatis can also cause pneumonia in newborns from infected mothers.

Diagnosing Chlamydia trachomatis

Testing involves a vaginal, cervical, urethral smear or urine sample using nucleic acid amplification test (NAAT). The test is reliable for picking up the infection in asymptomatic individuals. PCR testing also has a high sensitivity.

3. Chlamydia psittaci

C. psittaci is a bacterial infection that typically infects birds of many varieties. Although less common, humans who have contact with birds can acquire the infection as well. The microbe exists endemically in birds without causing disease unless the birds become stressed. Humans can become infected from breathing dust from infected feces or coming in close contact with birds that are infected and ill.

People who are most susceptible to a C. psittaci infection include avian breeders, bird owners, veterinarians, and poultry farm workers, according to a review in Vector-Borne and Zoonotic Diseases. Indeed, the incidences of infection are most common in workers in the poultry industry, which is one of the reasons that antibiotic therapy is heavily used in the poultry industry.

Illness from C. psittaci consists of sudden onset of respiratory and flu-like symptoms, such as fever, headaches, muscles aches, and coughing. Initially, the symptoms may be mild, but they can quickly progress to severe pneumonia. Some people may experience complications of the heart, liver, nerves, or brain.

Diagnosing Chlamydia psittaci

Testing should be considered in any person experiencing severe, acute respiratory disease who has had close contact with birds. C. psittaci has not been associated with chronic illness, and typically, people begin to recover soon after taking antibiotics.

Conventional and Natural Remedies for Chlamydia

Both C. trachomatis and C. pneumoniae respond acutely to doxycycline, azithromycin, and other antibiotics, but it’s very unlikely that antibiotics completely eradicate the microbe from the body. Remember, the microbe can stay hidden and dormant in tissues for years where it’s hard to reach. Indeed, a chronic infection with any stealth microbe typically responds poorly to antibiotic therapy.

Therefore, the most functional therapy for chronic chlamydia is long-term suppression of the microbes with antimicrobial herbs, along with restoration of immune system functions. Herbs like berberine, andrographis, cat’s claw, sarsaparilla, and garlic can suppress stealth microbes without disrupting the normal flora of your gut. To enhance the function of the immune system, consider immune-modulating herbs like ashwagandha and Chinese tree bark.

Finally, it’s vital you take steps to sidestep the system disruptors that impair your immune system and leave you vulnerable to an overgrowth of unsavory microbes. That means:

Nourishing your body with a whole-foods diet that’s rich in vegetables and low in processed foods, grain-fed meats, excess carbohydrates, and unhealthy fats.

Purifying your environment by reducing your exposure to environmental toxins. Eat organic when you can, filter your water and air, and choose non-toxic cleaning supplies and beauty products.

Calming your mind on a daily basis with stress reduction and management techniques such as doing yoga, walking, coloring, or even napping.

Activating your body. Doing gentle, restorative exercise every day (yoga, tai chi, qigong) counters the modern-day pitfall of being too sedentary.

No matter which stealth microbes you’re dealing with, healthy lifestyle practices combined with herbal therapies can be beneficial for your healing. But know in advance that you’ll need to exercise patience and persistence with herbs, and you may need to experiment with a few before you find the ones that put you on a path to recovery.

Dr. Rawls is a physician who overcame Lyme disease through natural herbal therapy. You can learn more about Lyme disease in his new best selling book, Unlocking Lyme.  You can also learn about his personal journey in overcoming Lyme disease and fibromyalgia in his popular blog post, My Chronic Lyme Journey.

REFERENCES
1. AIrborne and Direct Contact Diseases. Maine Center for Disease Control and Prevention website. https://www.maine.gov/dhhs/mecdc/infectious-disease/epi/airborne/
2. Chlamydia – CDC Fact Sheet (Detailed). Centers for Disease Control and Prevention website. https://www.cdc.gov/std/chlamydia/stdfact-chlamydia-detailed.htm
3. Elwel C, Mirrashidi K, Engel J. Chlamydia cell biology and pathogenesis. Natural Reviews Microbiology. 2016 Jun; 14(6): 385–400. doi: 10.1038/nrmicro.2016.30
4. Krawiec M, Piasecki T, Wieliczko A. Prevalence of Chlamydia psittaci and Other Chlamydia Species in Wild Birds in Poland. Vector-Borne and Zoonotic Diseases. 2015 Nov 1; 15(11): 652–655. doi: 10.1089/vbz.2015.1814
5. Psittacosis. Centers for Disease Control and Prevention website. https://www.cdc.gov/pneumonia/atypical/psittacosis/about/diagnosis-treatment-complications.html
6. Libbey JE, Cusick MF, Fujinami RS.Role of pathogens in multiple sclerosis. Int Rev Immunol. 2014 Jul-Aug;33(4):266-83.
7. Käding N et al. Growth of Chlamydia pneumoniae Is Enhanced in Cells with Impaired Mitochondrial Function. Front Cell Infect Microbiol. 2017 Dec 5;7:499.
8. Ivanova MV et al. Role of Chlamydia in Multiple Sclerosis. Bull Exp Biol Med. 2015 Sep;159(5):646-8.
9. Sriram S et al. Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis. J Infect Dis. 2005 Oct 1;192(7):1219-28. Epub 2005 Sep 2.
10. Bayram A1, Erdoğan MB, Ekşi F, Yamak B.Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction. Anadolu Kardiyol Derg. 2011 May;11(3):237-43.
For more:

Co-infecting agents can be transmitted together with Borrelia burgdorferi by tick bite resulting in multiple infections but a fraction of co-infections occur independently of tick bite. Clinically relevant co-infections are caused by Bartonella species, Yersinia enterocolitica, Chlamydophila pneumoniae, Chlamydia trachomatis, and Mycoplasma pneumoniae…..Chlamydia trachomatis primarily causes polyarthritis.  Chlamydophila pneumoniae not only causes arthritis but also affects the nervous system and the heart, which renders the differential diagnosis difficult.