. 2018; 13(11): e0207067.
Published online 2018 Nov 12. doi:  [10.1371/journal.pone.0207067]
PMCID: PMC6231644
PMID: 30419059

A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn

Lisa A. Waddell, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft,1,* Judy Greig, Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing,1 L. Robbin Lindsay, Conceptualization, Methodology, Validation, Writing – review & editing,2 Alison F. Hinckley, Conceptualization, Methodology, Validation, Writing – review & editing,3 and Nicholas H. Ogden, Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing4
R. Mark Wooten, Editor

Associated Data

Supplementary Materials
Data Availability Statement
All relevant data are within the paper and its Supporting Information files.


Lyme disease (LD), caused by bacteria of the Borrelia burgdorferi sensu lato species complex, is the most common vector-borne disease in North America and Europe. A systematic review (SR) was conducted to summarize the global literature on adverse birth outcomes associated with gestational LD in humans. The SR followed an a priori protocol of pretested screening, risk of bias, and data extraction forms. Data were summarized descriptively and random effects meta-analysis (MA) was used where appropriate. The SR identified 45 relevant studies, 29 describing 59 cases reported as gestational LD in the United States, Europe, and Asia (1969–2017).

Adverse birth outcomes included

  • spontaneous miscarriage or fetal death (n = 12)
  • newborn death (n = 8)
  • newborns with an abnormal outcome (e.g. hyperbilirubinemia, respiratory distress and syndactyly) at birth (n = 16).

Only one report provided a full case description (clinical manifestations in the mother, negative outcome for the child, and laboratory detection of B. burgdorferi in the child) that provides some evidence for vertical transmission of B. burgdorferi that has negative consequences for the fetus.

The results of 17 epidemiological studies are included in this SR. Prevalence of adverse birth outcomes in an exposed population (defined by the authors as: gestational LD, history of LD, tick bites or residence in an endemic area) was compared to that in an unexposed population in eight studies and no difference was reported.

A meta-analysis of nine studies showed significantly fewer adverse birth outcomes in women reported to have been treated for gestational LD (11%, 95%CI 7–16) compared to those who were not treated during pregnancy (50%, 95%CI 30–70) providing indirect evidence of an association between gestational LD and adverse birth outcomes. Other risk factors investigated; trimester of exposure, length of LD during pregnancy, acute vs. disseminated LD at diagnosis, and symptomatic LD vs. seropositive women with no LD symptoms during pregnancy were not significantly associated with adverse birth outcomes.

This SR summarizes evidence from case studies that provide some limited evidence for transplacental transmission of B. burgdorferi. There was inconsistent evidence for adverse birth outcomes of gestational LD in the epidemiological research, and uncommon adverse outcomes for the fetus may occur as a consequence of gestational LD.

The global evidence does not fully characterize the potential impact of gestational LD, and future research that addresses the knowledge gaps may change the findings in this SR. Given the current evidence; prompt diagnosis and treatment of LD during pregnancy is recommended.



This is a perfect example of garbage in, garbage out.  The reasons are numerous:

  • Testing misses over half of all cases.
  • ALL reported numbers are low regarding tick borne illness (TBI’s).  Remember, the CDC itself increased the numbers of NEW cases per year from 30,000 to 300,000 all in one fell swoop, and even that estimate is low.  Imagine all the patients who are pregnant of that number.
  • The Cabal has flatly stated that gestational Lyme doesn’t exist.  They have had a stranglehold on research and the entire medical profession for 40 years.  Do you think any researcher who wants to pay their bills will take gestational Lyme on?  I don’t think so.
Please know that gestational Lyme happens, is far more prevalent than the literature shows, and is only going to increase.

So when you read this “literature review” please understand that every single thing is stacked against finding gestational Lyme.

But you can’t fool us.  We live this nightmare.

For more info on gestational Lyme:  A retrospective study showed 480 children with gestational Lyme/MSIDS. Diagnosis was based on clinical physical and history. Two cases of in vitro fertilization caused embryonic infection. Gustafason & Burgess demonstrated gestational Bb infection in dogs. Of the inoculated bitches, 80% became infected who then birthed mostly infected pups.  Lyme disease is an infectious disease which is not only zoonotic (tick transmission) but has been proven and even documented by Canadian Federal Health authorities to be transferred from human-to-human, mother to child. There are also valid concerns that this disease could be transmitted sexually and through the blood supply.



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