Archive for the ‘research’ Category

Research Suggests Cancer Medication Could Help Fight Lyme Disease

https://www.wamc.org/news/2023-08-08/research-suggests-cancer-medication-could-help-fight-lyme-disease

Research suggests cancer medication could help fight Lyme Disease

WAMC Northeast Public Radio | By Jim Levulis
Published August 8, 2023
U.S. Dept. Of Agriculture

Research out of UMass Amherst suggests medication used to stop the spread of cancer may help fight tick-borne illnesses such as Lyme Disease. WAMC’s Jim Levulis spoke with Stephen Rich, the executive director of the New England Regional Center of Vector-borne Diseases, about the study and how it relates to existing Lyme treatments.

Rich: Generally that’s antibiotic treatments, most often doxycycline. A reasonable course of doxycycline takes care of most early detected Lyme disease cases. There other antibiotics where doxycycline is contraindicated, there are other antibiotics that work as well. Things like amoxicillin, but basically antibiotics.

(See link for article and interview)

_________________

SUMMARY:

  • Lyme spirochetes have a dependency upon a particular pathway called glycolysis which is dependent upon lactate dehydrogenase or LDH.
  • Certain cancer cells are similarly constrained in their metabolic profiles.
  • Inhibitors of the LDH molecule have been used to treat cancerous tumors.
  • The inhibitors, when tested in the test tube against Lyme spirochetes didn’t eliminate the borrelia, but they stopped it from growing (bacteriostatic).
  • They are now going to test this in lab animals and then companion animals or people.
  • Despite it being a wet, warm July in Massachusetts, there were lots of ticks at work.

For more on Lyme treatments utilized by experienced Lyme literate doctors (LLMDs) go here.

I must add that this proves ticks are ecoadaptive and tick and disease proliferation has nothing to do with the weather or supposed ‘climate change,’ which is simply a propaganda narrative touted by climate scientists who are on a “gravy train” to secure funding via government grants.

Expert after expert has stated “there is no climate emergency.”

Further, ‘the powers that be’ are using the climate agenda to desperately push a much bigger diabolical plan:  UN’s  Our Common Agenda platform, the WHO’s Pandemic Treaty, and the WEF’s depopulation, massive surveillance, and censorship designs which will give unelected officials unlimited power with ZERO oversight.

Do not fall for the unscientific clap-trap of ‘climate change.’  It’s part of an evil dystopian plan.

Category:

Cancer, Lyme, research, Treatment

Leprosy in Florida

**UPDATE**

According to this, ticks have the potential of acting as a reservoir and/or vector of leprosy.  Mycobacterium drugs have also been found to help chronically infected Lyme/MSIDS patients.  Nobody is talking about this connection, but the following connections have been discussed:

  • Researchers in both India and the U.K. have found links between leprosy adverse events and COVID shots in people previously diagnosed with leprosy.
  • Zoonotic transmission from armadillos (but nobody’s been around them that’s infected)
  • International human migration (which doesn’t explain why Texas hasn’t been hit with leprosy)

According to the CDC, leprosy is very rare in the U.S., with fewer than 200 cases reported per year and most contracting it in a foreign country.

Dr. Robert W. Malone said he believes the sudden reporting on leprosy is “fearporn,” but added, “There is no question that being immunosuppressed is a key factor to contracting leprosy.”

He added:

“Therefore, as mRNA inoculations cause immunosuppression, it has been hypothesized that in some individuals this could pose a higher risk of contracting the disease after vaccination.”

http://  Approx. 11 Min

CDC Issues Alert on Leprosy

Aug. 4, 2023

Facts Matter with Roman Balmakov

Historically uncommon in the U.S., Leprosy, or Hansen disease is a chronic infectious disease caused by Mycobacterium leprae.  Florida accounts for 81% of leprosy cases and 159 new cases were reported in 2020.

The CDC is clueless as to transmission but states that prolonged person-to-person contact through respiratory droplets is the most likely culprit, but this has never been proven.

The strains found are the same strains found in 9-banded armadillos in the region so they hypothesize zoonotic transmission.  (Is this sounding familiar yet?)  The fly in that ointment is that these patients have had ZERO exposure to this animal.  Other research suggests international human migration.

Romanov states it is an interesting coincidence that the cases are being found either in Southern states or the sanctuary state of New York where illegal migrants have been flowing over the boarders.

While no research on this has been done on the topic of migration and leprosy in the U.S., researchers in other countries have done this work and found a direct link between migration of people from countries that have leprosy and a surge in leprosy cases.  Spanish researchers found that their spike in leprosy was not related to African migrants but from South American migrants (Brazil, Paraguay, Bolivia, and other South and Central America nationalities).

South American immigrants in North America increased from 27.6 M in 1990 to 58.7 M in 2020 so even the CDC admits the potential link to migration and leprosy cases in nonendemic areas, yet people continue to flow over the border.  According to this report, there are nefarious reasons for this.

  • Both Texas and California are allowing immigrants to be peace officers even though they know nothing about the Constitution or the Bill of Rights.
  • Texas’ Gov Abbot built a facility to house 200,000 illegals who are bringing infectious & antibiotic resistant diseases such as drug resistant TB.  Tens of thousands of cattle in Texas are now being slaughtered due to these migrants transmitting this TB to the cattle, which further reduces meat in the food supply.
  • They have also built state of the art “schools” to be used as indoctrination camps to potentially weaponize these migrants against U.S. citizens by dangling carrots
  • TrakkaSystems advanced camera technology is being used to capture imaging so journalists and freedom workers on the ground can show the public what is happening at the border and that the problem is much worse than what we are being told.
  • Elon Musk’s Starlink system is used for communications.
  • SpaceX located nearby is allowing illegals to cross that property while others cannot enter.

So what other changes have been occurring in Florida?  Don’t forget the massive release of GMO mosquitoes, i.e. Frankinbugs, which are effective dirty needles spreading disease which are now being seriously considered to “vaccinate” people. This technology goes back to 2010 when Japanese researchers genetically modified mosquitoes to produce SP15 against leishmaniasis (parasitic disease spread by sand flies).

Yes folks, it’s getting more frightening by the day.

Category:

Activism, mosquitoes, research

3 Lyme Disease Vaccines in the Pipeline: RUN AWAY FAST

https://danielcameronmd.com/3-lyme-disease-vaccines-in-the-pipeline/

3 LYME DISEASE VACCINES IN THE PIPELINE

lyme-disease-vaccine
National Geographic magazine recently published an article, “Lyme disease is spreading fast—but a vaccine may be on the way.” In it, Guynup summarizes three Lyme disease vaccines that are currently in the pipeline. [1]
By 

In 1998, the first Lyme disease vaccine was introduced by LYMErix but it was pulled from the market after 3 years due to poor sales and possible safety concerns. The FDA was never able to confirm that the vaccine caused harm despite concerns.

Only recently have drug makers resumed researching new human Lyme vaccines.

“But the challenge now is creating vaccines that will protect against the seven globally known strains of Lyme disease,” says Obadiah Plante, who leads the bacteriology team at Moderna.

Pfizer/Valneva candidate: VLA15 and Moderna are both developing vaccines that target the bacterium’s Outer Surface Protein A (OspA). The spirochete that causes Lyme disease produces OspA in the tick. The vaccine is intended to create “antibodies that prevent the organisms from suppressing OspA when the tick next feeds,” the author explains. “This will render them immobile, imprisoned within the tick’s intestine and unable to infect a human host.”

The vaccine is not expected to work after the infection enters humans, as the spirochete changes proteins from OspA to Outer Surface Protein C (OspC).

“The Pfizer/Valneva candidate, VLA15, is farthest along and is being tested in a phase three clinical trial that launched in the summer of 2022,” writes Guynup.

Two study sites (Nantucket and Martha’s Vineyard) were halted due to protocol violations. “In an email, a spokesperson for Pfizer noted that the study is expected to wrap up in December 2025,” Guynup points out.

Moderna, best known for developing a COVID-19 vaccine using mRNA technology, has been working on two Lyme disease vaccines using this same technology.

Moderna will begin human trials this summer with 800 participants in the U.S. between 18 and 70 years old.

The first vaccine, named mRNA-1982, contains a single mRNA that targets the Borrelia bacteria species that causes most cases of Lyme disease in the U.S.

The second vaccine, named mRNA-1975, contains a mixture of seven mRNAs targeting the Borrelia species that cause most cases of Lyme disease in both the U.S. and Europe.

MassBiologics is taking a different approach, using monoclonal antibody targeting OspA.

This vaccine may offer immediate protection, while it can take months for immunity to develop with the Pfizer and Moderna vaccines.

“Within days after you get the subcutaneous injection, you’ve absorbed enough of the antibody so you’re immediately immune,” says Mark Klempner, a professor of medicine and vice chancellor emeritus of MassBiologics at UMass Chan Medical School.

According to Klempner, when 20 infected ticks were placed on nonhuman primates “this antibody treatment provided 100 percent protection.”

The company hopes to apply for approval from the FDA in 2025.

Author’s Note: The safety and efficacy of these vaccines are not yet available for doctors to weigh the pros and cons of offering a vaccine. Furthermore, none of the vaccines is designed for protecting against a co-infections.

References:
  1. Lyme disease is spreading fast but a vaccine may be on the way. National Geographic. Guynup, Sharon. May 15, 2023. https://www.nationalgeographic.com/premium/article/vaccine-prevention-lyme-disease-epidemic-tick-treatment

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**Comment**

Category:

Lyme, research, vaccines

Suicidal & Homicidal Lyme Concerns Podcast

https://danielcameronmd.com/suicidal-and-homicidal-lyme-concerns/

SUICIDAL AND HOMICIDAL LYME CONCERNS

Suicidal and homicidal Lyme concerns

Welcome to another selection from my book “An Expert’s Guide on Navigating Lyme disease.” The books highlights the findings of my first 600 Lyme disease Science blogs.  In this episode, I will discuss suicidal and homicidal concerns in Lyme disease patients.

By 

Dr. Robert Bransfield from Rutgers-Robert Woods Johnson Medical School, Department of Psychiatry, has described suicidal and homicidal concerns in patients with Lyme and related tick-borne illnesses in his private practice. Likewise, in my practice I have seen patients with suicidal thinking.

SUICIDAL AND HOMICIDAL BEHAVIORS IN LYME DISEASE.

Dr. Robert Bransfield reports observing suicidal and homicidal behaviors in patients with Lyme and related tick-borne illnesses. Out of 253 patients, he found:

43% were suicidal; 32% were suicidal but not homicidal; 11% were both suicidal and homicidal. No patient was homicidal without also being suicidal. 25% had explosive anger but were not homicidal or suicidal. 10% had pre-existing depression. 97% reported depression after infection. Patients were ill an average of 8.4 years before being diagnosed and treated. Read more.

“Further disease progression contributed to him feeling desperate as a result of multiple late-stage symptoms.”

THREE PSYCHIATRISTS SHARE SUICIDAL AND HOMICIDAL CASES.

Three psychiatrists share published case reports supporting Bransfield’s concerns (Munir et al., 2017). “A 44-year-old male without any past psychiatric history presented with a third unsuccessful suicide attempt and was later diagnosed as having a Borrelia infection” (Bransfield, 2017). One month of medical therapy with intravenous ceftriaxone improved his mental status and resolution of suicidal ideation (Banerjee 2013).

Fallon described two cases in a 1995 paper. “I treated both of these patients, and in addition, I have been able to follow the status of Patient B over a span of 30 years. This patient was highly suicidal, had horrific intrusive images of killing others, and had violent impulses, which were eliminated with treatment. Patient A was also suicidal, violent, and physically assaultive to her son. Combined antibiotic and psychotropic treatment helped both patients.” Read more.

HOMICIDE, TWO ASSAULTS, AND SUICIDE IN LYME DISEASE PATIENT

An article entitled “A Fatal Case of Late Stage Lyme Borreliosis and Substance Abuse,” describes a patient exhibiting aggressiveness, violence, and homicidality. Like many Lyme disease patients, the man experienced a delay in diagnosis and treatment. (One study reports that subjects enrolling in a trial of Lyme encephalopathy were ill an average of two years before being diagnosed.)

The patient’s Lyme disease symptoms progressed. “Further disease progression contributed to him feeling desperate as a result of multiple late-stage symptoms,” wrote Bransfield et al.  According to Fallon et al., the number of Lyme disease patients who feel desperate is not clear.

Based on more than 30 years of experience treating Lyme disease patients, Dr. Bransfield previously described a wide range of neuropsychiatric symptoms in Lyme disease patients. “… neuropsychiatric symptoms, usually presenting with significant comorbidity which may include developmental disorders, autism spectrum disorders, schizoaffective disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, intrusive symptoms), eating disorders, decreased libido, sleep disorders, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide, violence, anhedonia, depersonalization, dissociative episodes, derealization and other impairments.”

“A 44-year-old male without any past psychiatric history presented with a third unsuccessful suicide attempt and was later diagnosed as having a Borrelia infection.”

The patient’s condition worsened.  “The pathophysiological effects of the infection resulted in an increased number and severity of multisystem symptoms, disability, and substance abuse,” the authors wrote. “He experimented with multiple substances in an effort for relief.”

The authors added, “During acute deterioration of his mental state from phencyclidine withdrawal, NMDA agonism increased, he committed a homicide, two assaults, and suicide.”

In an earlier study, Dr. Bransfield described substance abuse, cannabis use, and intoxication in Lyme disease patients.

Bransfield and colleagues advised prompt diagnosis and treatment of Lyme disease to help prevent addictive disorders, substance abuse, and death.

“More effective diagnosis and treatment and attention to substance abuse potential in these patients may help prevent some cases of addictive disorders, substance abuse, and death.” Read more.

988 Suicide & Crisis Lifeline

The 988 Suicide & Crisis Lifeline is a national network of local crisis centers that provides free and confidential emotional support to people 24 hours a day, 7 days a week in the United States. Anyone with the following concerns can call, text, or chat 988:

  • Mental health-related distress.
  • Thoughts of suicide.
  • Substance use crisis.
  • Emotional distress.
  • There are specialized services available for veterans, LGBTQ individuals and other groups.
  • People who are worried about a loved one who may need support also can call.
The 988 Suicide & Crisis Lifeline, available by simply dialing 988, is a 24-hour, toll-free, confidential suicide prevention helpline available to anyone in suicidal crisis or emotional distress. When someone calls the helpline, his or her call is routed to the nearest crisis center. The Lifeline’s national network, consisting of more than 250 local crisis centers, provides crisis counseling and mental health referrals day and night.
Related Articles:

Mental health in COVID-19 and Lyme disease patients

Lyme disease and depression

Lyme disease patients at risk for suicide

Category:

Lyme, Psychological Aspects, research

The Lyme Puzzle: Interview With Professor Nicole Baumgarth

https://podcast.tickbootcamp.com/episode/8bc4afa1/the-lyme-puzzle-an-interview-with-professor-nicole-baumgarth

Episode 364: The Lyme Puzzle – an interview with Professor Nicole Baumgarth

July, 2023

Introduction

  • In this episode of Tick Boot Camp, our hosts Matt Sabatello and Rich Johannesen had the opportunity to talk with the remarkable Professor Nicole Baumgarth, director of the Lyme and Tick-Borne Diseases Institute at Johns Hopkins University. Baumgarth brings a unique interdisciplinary background in veterinary medicine, immunology, microbiology, and pathology offering fresh insights into the complex world of Lyme disease and tick-borne illnesses.

Lyme Disease Research

  • Baumgarth and her team are investigating why we don’t mount an effective adaptive immune response to Lyme as we do with influenza (the flu).
  • She reveals their interesting finding about how Borrelia may alter the host’s gut microbiome to enhance its survival.
  • Baumgarth and her team are currently investigating why macrophages, immune cells that gobble up pathogens outside of our cells, don’t eat up Lyme bacteria as they do with other bacteria and viruses.
  • They are also investigating the impact Lyme has on obliterating our lymph nodes, which are critical agents in receiving signals from our body and mounting a specified immune response with targeted B cells and T cells against things like Lyme disease, as well as deploying long term memory immune cells and plasma cells which would give us long-term immunity to Lyme.
  • The Lyme and Tick-Borne Diseases Institute is focusing on investigating why mice get infected with Lyme, the infection persists, yet they never get sick from the infection.
  • If the team can identify human immune system deficits causing any of the above, they could identify immune therapies to overcome these shortcomings and treat all stages of Lyme disease.
  • Baumgarth and her team are also looking into the impact of tick-borne co-infections. They argue that it’s critical to study these diseases together rather than in isolation.

Autoimmune Responses and Lyme Disease

  • Professor Baumgarth suggests that Lyme disease may cause an autoimmune response, which can be particularly concerning for those with genetic predispositions to autoimmunity.
  • She cites several studies, both in the human model and mouse model, proving that Lyme disease creates an unnecessary increase in other antibodies from our immune system that aren’t Lyme-related, resulting in an autoimmunity phenomenon, increased inflammation, and potential immune system burnout.

Understanding Lyme Disease: A Veterinary Perspective

  • Professor Baumgarth’s veterinary background has allowed her to approach Lyme disease from a macro perspective. She emphasizes that Lyme, being a zoonotic disease, is fundamentally an infection that moves from animals to humans.
  • Lyme disease is often a natural infection in animals such as small rodents and birds, where ticks can bite them and transmit the disease.

Investigating the Human Immune Response to Lyme Disease

  • Our hosts discuss how humans’ immune responses to Lyme vary significantly. Some people are bitten by ticks multiple times without falling ill, while others suffer from chronic Lyme after just one bite.
  • This discrepancy might be due to factors such as genetic predispositions, environmental stresses, or an individual’s microbial load.

The Complexity of Eradicating Lyme

  • Eliminating Lyme is not as simple as wiping out a certain animal species, as the bacteria Borrelia can infect a variety of different rodents and even birds.
  • Borrelia is a complex bacterium that replicates slowly and requires a tick to infect a host. It’s constantly evolving and it’s not a simple task to eradicate Lyme from our ecology.

The Role of Antibiotics and Their Impact

  • Despite their potential long-term impact on our immune response, antibiotics are currently the most common form of treatment as soon as Lyme disease is diagnosed. Professor Baumgarth emphasizes a variety of risks when using antibiotics to treat Lyme disease.
  • While antibiotics can help in the short term, their effect on our long-term immunity to future infections is still unclear and Professor Baumgarth strongly warns against prolonged use of antibiotics.

Final Thoughts

  • Baumgarth is hopeful about the future of Lyme disease research. Despite the challenges and controversies, she believes that continued progress is possible with dedicated research and interdisciplinary collaboration.

Episode Wrap-up

  • Professor Nicole Baumgarth’s interview provides an enlightening look into the intricate world of Lyme disease and its complex interaction with our immune system. Her unique veterinary perspective coupled with her background in immunology, microbiology, and pathology as well as her research findings shed light on the challenges we face and offer hope for future breakthroughs in the fight against Lyme and tick-borne diseases.

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**Comment**

My husband and I probably would not be on planet earth without long-term antibiotics so I’m glad this researcher didn’t treat us.  She’s just touting the safe narrative that is expected of academics working in research institutions that get their bread and butter from government grants with many strings attached, controlled by agencies that are completely corrupt.

Nobody denies the risk of prolonged use of antibiotics; however, Lyme/MSIDS can kill you in a myriad of ways.  This never seems to be discussed in the same sentence as prolonged antibiotics.  We would all love a safe, effective, affordable treatment.  Why aren’t researchers looking into this?  I’ll answer you: there’s no money in it, and it doesn’t fit with their narrative for a lucrative cash cow in a Lyme “vaccine.”  

It’s easy to be an arm-chair quarterback when it isn’t your neck on the chopping block.  All I can say is, whatever your opinions are about antibiotics before contracting Lyme/MSIDS, I guarantee they will change as you trod this pot-holed riddled, devastating path.  I hadn’t used antibiotics for 20 years before becoming infected.  I would use ANYTHING but antibiotics.  After I got infected I literally bathed in them for years.  I’m not proud of this, but they worked for both my husband and I, and many others.

It takes savvy to treat this complex illness and while anti-microbials are a MUST, there are many other important treatments required.  Please see the first link below for many treatments that experienced LLMDs have used with success.

For more:

Category:

Lyme, research, Treatment