Back in May you may remember the article about Dr. Horowitz having success with Dapsone, a drug commonly used for Leprosy, in his MSIDS patients that didn’t respond well to conventional treatment. https://madisonarealymesupportgroup.com/2016/05/09/leprosy-drug-for-lyme/. It was reported that patients improved in all symptoms except for headache.
Recently he and Phyllis R. Freeman published on another mycobacterium drug, pyrazinamide, (PZA). https://www.jscimedcentral.com/Arthritis/arthritis-1-1008.pdf
He states in the study that co-infection is the rule and that one recent study showed 45% of ticks were co-infected with up to five different pathogens, with up to eight identified in the same tick. Patients who have Lyme (borrelia) and are co-infected are much sicker and often resistant to standard therapies and often have varied clinical presentations making them harder to diagnose and treat.
The case study has based on a woman with Borrelia burgdorferi, Borrelia hermsii, possible prior exposure to tularemia, exposure to Mycoplasma pneumonia, multiple viruses, fibromyalgia, and rheumatoid arthritis.
This poor woman had been through hell and back for years. Under Dr. Horowitz’s care she improved from 30% to 50%, but with the addition of Dapsone had a sudden fourfold increase in tularemia titers as well as Bartonella titers turning positive.
While making continuous progress the patient had ongoing joint pain which interfered with sleep as well as ongoing severe blood-filled blisters, oral/genital ulcerations, and increased granulomas.
While a rheumatologist wanted to put her on an immunosuppressive, she and Dr. Horowitz chose to try 500mg (based on body weight) of PZA twice a day combined with rifampin and minocycline. Her liver was monitored every two weeks and was helped with alpha lipoid acid 600mg and milk thistle 250mg.
Two months later she reported up to 80% of normal functioning, had improvement in her most resistant dermatological symptoms with the resolution of her oral ulcers, and stated that it was the best protocol she had done in the past 20 years.
Horowitz reports that the Dapsone and PZA protocols have been the most effective treatment additions for resistant Lyme and autoimmune symptoms, with PZA being the most effective for dermatological manifestations of Bahcet’s and arthritic/granulomatous changes.