Archive for the ‘Testing’ Category

Borrelia Miyamotoi Can Be Transmitted From Mother Ticks To Offspring

https://danielcameronmd.com/borrelia-miyamotoi-can-be-transmitted-from-mother-ticks-to-offspring/

BORRELIA MIYAMOTOI CAN BE TRANSMITTED FROM MOTHER TICKS TO OFFSPRING

borrelia-miyamotoi-ticks

Lyme disease and Borrelia miyamotoi can be transmitted from a tick to a host and vice versa (horizontal transmission). B. miyamotoi can also be transmitted from the mother to their offspring (vertical transmission).

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In their article “Borrelia miyamotoi: A Comprehensive Review. Pathogens,” Cleveland and colleagues discuss Borrelia miyamotoi as an emerging tick-borne pathogen and and how it can be transmitted from a mother tick to their offspring.

Cleveland et al. reviewed the proposed vertical transmission of B. miyamotoi.¹

  • An adult female tick infected with B. miyamotoi lays eggs.
  • The larva hatch from these eggs infected with B. miyamotoi.
  • The larva, nymph and adult ticks remain infected.

Ticks can acquire B. miyamotoi after feeding on an infected tick – called horizontal transmission.

Cleveland et al. reviewed the proposed horizontal transmission of B. miyamoti.¹

  • The larva, nymph and adult ticks acquire B. miyamoti from feeding on an infected host.
  • The larva, nymph and adult ticks remain infected.

“B. miyamotoi can be transmitted from infected ticks to naïve mice during the first 24 hours of feeding,” the authors wrote.

B. miyamotoi can be transmitted to mice initially through the salivary glands and subsequently transmitted through the midgut.

Concerns surrounding Borrelia miyamotoi

Shapiro and Wormser summarized the challenges associated with B. miyamotoi in the Journal of the American Medical Association.²

  • “This bacterium can be transmitted within the first 24 hours of tick attachment.”
  • “The probability of transmission increases with every day an infected tick is allowed to remain attached.”
  • While some patients with Lyme disease may exhibit a rash, “patients infected with B. miyamotoi in the United States typically do not have a rash.” But they may present with “a fever in conjunction with headache (96%), myalgia (84%), arthralgia (76%), and malaise/fatigue (82%).”
  • There are no diagnostic tests for B. miyamotoi infection that have been approved by the US Food and Drug Administration.
  • The fever may be relapsing.
  • “Laboratory abnormalities include leukopenia (51%) and thrombocytopenia (60%), which are rarely seen in Lyme disease.” [Editor’s note: These are also seen in Ehrlichia and Anaplasmosis.]
  • “Severely immunocompromised patients may develop chronic meningitis.”

Fortunately, doxycycline and amoxicillin have been shown to effectively treat B. miyamotoi infection in patients, including those who are immunocompromised.

Editor’s notes: Fevers are infrequent and often do not relapse. The laboratory abnormalities seen in B. miyamotoi are also seen in Ehrlichia and Anaplasmosis. Long-term outcome studies are needed.

References:
  1. Cleveland DW, Anderson CC, Brissette CA. Borrelia miyamotoi: A Comprehensive Review. Pathogens. Feb 7 2023;12(2)doi:10.3390/pathogens12020267
  2. Shapiro ED, Wormser GP. Lyme Disease in 2018: What Is New (and What Is Not). JAMA. Aug 21 2018;320(7):635-636. doi:10.1001/jama.2018.10974

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Category:

Borrelia Miyamotoi (Relapsing Fever Group), research, Testing, Ticks, Transmission

Fatal Case of Heartland Virus

https://danielcameronmd.com/fatal-case-of-heartland-virus/

FATAL CASE OF HEARTLAND VIRUS

fatal-heartland-virus

The Heartland virus (HRTV) is an emerging tick-borne illness which can be acquired through the bite of an infected Lone Star tick. The virus was first reported in 2009 in Missouri. Since then, it has spread to other states including Kansas, Oklahoma, Arkansas, Tennessee, Kentucky, Indiana, Illinois, Iowa, Georgia, Pennsylvania, New York, and North Carolina, according to the Centers for Disease Control and Prevention (CDC).

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Now, investigators have identified the Heartland virus in the Maryland and Virginia region – an area where the virus is not widely recognized.

In their article “Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States,”¹ Liu and colleagues describe the fatal case of a man in his 60’s who acquired the Heartland virus in either Maryland or Virginia.

The man was admitted to the hospital in November 2021 with a fever, diarrhea, dyspnea, myalgias, and malaise which had been ongoing for 5 days. He had a history of a splenectomy, hypertension, remote trauma, coronary artery disease, and hypertension.

The patient did not recall a tick bite and did not have an erythema migrans rash.

“The range of [Heartland virus] could be expanding in the United States.”

“An arboviral disease was the leading diagnostic consideration, but limited availability of commercial diagnostic testing for tickborne diseases delayed diagnosis,” wrote Liu et al.

The man was treated clinically for a tick-borne infection with doxycycline.

“Two days later, on day 7 after symptom onset, the patient returned to the emergency department with confusion, an unsteady gait, and new fecal and urinary incontinence,” according to the authors.

He subsequently developed encephalopathy, low sodium, abnormal liver function tests, and fatigue.

“He had acute respiratory failure, renal failure, and a cardiac arrest. He was transitioned to comfort care and died on day 13 after symptom onset,” wrote Liu et al.

An autopsy revealed that the heart, spleen, kidney, and liver samples were positive for Heartland virus.

The Virginia Department of Health conducted a drag of the man’s property and found 193 Lone Star ticks. However, none of the ticks contained HRTV.

Tick-borne diseases identified by the CDC, as of 2/26/23.²

  • Anaplasmosis
  • Babesiosis
  • Borrelia mayonii
  • Borrelia miyamotoi
  • Bourbon virus
  • Colorado tick fever
  • Ehrlichiosis
  • Heartland virus
  • Lyme disease
  • Powassan disease
  • Rocky Mountain spotted fever (RMSF)
  • STARI (Southern tick-associated rash illness)
  • Tick-borne relapsing fever (TBRF)
  • Tularemia
  • 364D rickettsiosis (Rickettsia phillipi, proposed)
Related Articles:

10 cases of Heartland virus reviewed

References:
  1. Liu S, Kannan S, Meeks M, et al. Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States. Emerg Infect Dis. Feb 23 2023;29(5)doi:10.3201/eid2905.221488
  2. Diseases Transmitted by Ticks. Centers for Disease Control and Prevention. https://www.cdc.gov/ticks/diseases/index.html Last accessed 2/26/23.

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Category:

research, Testing, Ticks, Treatment, Viruses

More Window Dressing: Blumenthal Announces New Federal Funding For Tick Research

https://www.wshu.org/connecticut-news/2023-03-24/blumenthal-announces-new-federal-funding-for-tick-research

Blumenthal announces new federal funding for tick research

WSHU | By Molly Ingram
Published March 24, 2023
Blumenthal

Molly Ingram/WSHU  U.S. Senator Richard Blumenthal holds a tick, swollen from drinking blood.

U.S. Senator Richard Blumenthal (D-CT) has announced millions of dollars in funding for research into tick-borne diseases.

Diseases caused by ticks have more than doubled in the last ten years across the Northeast.

The Connecticut Agricultural Experiment Station, located in New Haven, will receive $200,000.

Blumenthal said the money will fund vital research at the nationally recognized facility.

(See link for article)

________________

SUMMARY:

  • Money to New Haven will be used to hire staff for testing ticks
  • $26 Million will go to the corrupt CDC to study Lyme disease
  • $7 Million will go to the complicit DOD‘s Tick-borne Disease Research Program

In the words of Willy Burgdorfer, the “discoverer” of Lyme:

“The controversy in Lyme Disease research is a shameful affair.  I say that because the whole thing is politically tainted.  Money goes to people that have for the past 30 years produced the same thing.  Nothing.” ~ Dr. Willy Burgdorferi

Money lining the pockets of the same people in corrupt agencies will come to nothing.
Mark my words.

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Category:

Activism, Lyme, research, Testing, Ticks

Study: Lyme Forms May Affect Persistence

https://www.mdpi.com/1422-0067/24/6/5594

Pleomorphic Variants of Borreliella (syn. Borrelia) burgdorferi Express Evolutionary Distinct Transcriptomes

by Nina Čorak1, Sirli Anniko2,3, Christina Daschkin-Steinborn2, Viktoria Krey2,4, Sara Koska1, Momir Futo1,5,6, Tin Široki5, Innokenty Woichansky 2, Luka Opašić1, Domagoj Kifer7, Anja Tušar1, Horst-Günter Maxeiner2,8, Mirjana Domazet-Lošo5, Carsten Nicolaus2 and Tomislav Domazet-Lošo1,6,*
1Laboratory of Evolutionary Genetics, Division of Molecular Biology, Ruđer Bošković Institute, Bijenička Cesta 54, HR-10000 Zagreb, Croatia
2BCA-Research, BCA-Clinic Betriebs GmbH & Co. KG, D-86159 Augsburg, Germany
3Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK
4Physics of Synthetic Biological Systems-E14, Physics Department and ZNN, Technische Universität München, D-85748 Garching, Germany
5Faculty of Electrical Engineering and Computing, University of Zagreb, Unska 3, HR-10000 Zagreb, Croatia
6School of Medicine, Catholic University of Croatia, Ilica 242, HR-10000 Zagreb, Croatia
7Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10000 Zagreb, Croatia
8Comlamed, Friedrich-Bergius Ring 15, D-97076 Würzburg, Germany
*Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(6), 5594; https://doi.org/10.3390/ijms24065594
Received: 18 February 2023 / Revised: 7 March 2023 / Accepted: 11 March 2023 / Published: 15 March 2023
(This article belongs to the Special Issue Transcriptomics in Health and Disease)

Abstract

Borreliella (syn. Borrelia) burgdorferi is a spirochete bacterium that causes tick-borne Lyme disease. Along its lifecycle B. burgdorferi develops several pleomorphic forms with unclear biological and medical relevance. Surprisingly, these morphotypes have never been compared at the global transcriptome level. To fill this void, we grew B. burgdorferi spirochete, round body, bleb, and biofilm-dominated cultures and recovered their transcriptomes by RNAseq profiling. We found that round bodies share similar expression profiles with spirochetes, despite their morphological differences. This sharply contrasts to blebs and biofilms that showed unique transcriptomes, profoundly distinct from spirochetes and round bodies. To better characterize differentially expressed genes in non-spirochete morphotypes, we performed functional, positional, and evolutionary enrichment analyses. Our results suggest that spirochete to round body transition relies on the delicate regulation of a relatively small number of highly conserved genes, which are located on the main chromosome and involved in translation. In contrast, spirochete to bleb or biofilm transition includes substantial reshaping of transcription profiles towards plasmids-residing and evolutionary young genes, which originated in the ancestor of Borreliaceae. Despite their abundance the function of these Borreliaceae-specific genes is largely unknown. However, many known Lyme disease virulence genes implicated in immune evasion and tissue adhesion originated in this evolutionary period. Taken together, these regularities point to the possibility that bleb and biofilm morphotypes might be important in the dissemination and persistence of B. burgdorferi inside the mammalian host. On the other hand, they prioritize the large pool of unstudied Borreliaceae-specific genes for functional characterization because this subset likely contains undiscovered Lyme disease pathogenesis genes.
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**Comment**
And herein lies the age-old problem: unstudied Borreliaceae-specific genes that have not been functionally characterized, and undiscovered Lyme disease pathogenesis genes.  Everything else hinges on these unknowns.
This research is begging to be done, but has been avoided like the plague because of corrupt public health, run by one man doling out research grants whom has far too much power, and whom receives untracked, secret royalty payments.
COVID has shown the world what Lyme/MSIDS patients have been facing, only they have been in this hideous time-warp for over 40 years. Researchers are smart – they know they must cow-tow to the NIAID mafia overlord to get research funding, which means they must espouse the accepted narrative that Lyme is a simple nuisance cured with a couple weeks of a mono-therapy that hasn’t worked from the get-go.
Nobody seems to care but sick patients and a handful of ethical researchers who feverishly attempt to move a 40 year old needle that’s covered with an inch of rust.  When dissenting research finally does come out, it is retracted for flimsy reasons, in this case due to testing methods, but my educated guess is the research simply couldn’t stand because it revealed too much truth.  This is quite ironic considering the COVID ‘pandemic’ only occurred due to faulty testing insisted upon & patented by corrupt public health which quietly had to withdraw its EUA because it can’t distinguish between COVID and the regular flu.  Monopolizing medicine/disease is the CDC & FDA‘s MO and this includes testing, as virtually everything else spawns off of testing.  Control testing and you control the entire paradigm from research to drugs.
This diabolical monopoly then sets the ball rolling for the entire world, again demonstrating the frightening monopoly that must be broken.  Mainstream medicine, which is lazy, remains brain-washed and simply follows orders. And compliance is what corrupt public health is counting on.  Truth is crucified and dissenters are promptly tarred and feathered despite saving lives.  Censorship, bullying, firing and closing labs down, tossing out and manipulating data, fake science, and “disappearing” are efficiently deployed to silence any opposition.
Believe it or not, mainstream medicine still does not even believe Bb is pleomorphic.

Category:

Lyme, research, Testing

COVID Testing Company Faked Tests, Threw Samples Away While Taking $83 M in Government Funding, Says DOJ

https://www.theblaze.com/news/testing-company-federal-indictment-23

COVID testing company faked tests, threw samples away while taking $83 million in government funding, says DOJ

ANDREW CHAPADOS

March 15, 2023

Excerpts:
The co-owner of a Chicago, Illinois, company is accused of cheating the United States government out of money through a fraudulent COVID-19 testing scheme.

ABC News reports that Zishan Alvi, a 44-year-old co-owner of company Laboratory Elite, fraudulently planned to seek reimbursements for providing PCR tests and 15-minute rapid antigen tests after lying about the results.

The indictment alleges that the tests were either not performed, done in such a way that results were unreliable, or had already been paid for by customers when the company sought federal reimbursement.

Between February 2021 and February 2022, the company received over $83 million in federal funding, with some of the money allegedly transferred to the Alvi’s personal account.

Alvi also told employees to provide customers with negative results despite tests never being performed.

Alvi is charged by a federal grand jury with 10 counts of wire fraud and one count of theft of government funds.

(See link for article)

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Category:

Activism, Testing, Viruses