Background: Biomarkers to predict Coronavirus disease-19 (COVID-19) outcome early at infection are urgently needed to improve prognosis and treatment. Zinc balances immune responses and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with more severe COVID-19 outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression and thus might represent a useful biomarker.
Methods: We run a retrospective observational study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel we have studied SARS-CoV2 replication in the Vero E6 cell line modifying zinc concentrations.
Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 mcgg/dl at admission correlated with worse clinical presentation, longer time to reach stability and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV2 infected cells.
Interpretation: SZC is a novel biomarker to predict COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.
While this is awaiting peer review, it’s not a novel concept nor is it surprising; however, our public ‘authorities’ would rather rivet on mask wearing (which doesn’t work and gives a false sense of security), their expensive antiviral Remdesivir (which has been shown to be of little to no benefit), and their expensive, experimental vaccine (which has caused all sorts of side-effects already in human volunteers).
The best and safest approach is always prevention.
Please learn all you can on how to make your body a tough target for disease. Start by eating a whole-food diet, reducing your stress, getting adequate sleep, and exercising. Then, work with your medical practitioner to determine your imbalances/weaknesses and appropriately supplement using reputable products.
Caution: zinc is a fat-soluble vitamin and will build up in the body. Testing is needed to determine your level and how much to take.
For a great read on all things vitamin D including how much to take, various important nuances, and necessary testing: https://madisonarealymesupportgroup.com/2018/03/12/the-importance-of-vitamin-d-k-and-magnesium-for-lyme-msids-patients/
For a great presentation: