Archive for the ‘Treatment’ Category

Piperacillin Kills Lyme Bacteria in Mice, Leaves Gut Microbiome Alone

https://www.lymedisease.org/piperacillan-kills-lyme/

Piperacillin kills Lyme bacteria in mice, leaves gut microbiome alone

From Northwestern University:

Lyme disease, a disease transmitted when deer ticks feed on infected animals like deer and rodents, and then bite humans, impacts nearly half a million individuals in the U.S. annually.

Even in acute cases, Lyme can be devastating; but early treatment with antibiotics can prevent chronic symptoms like heart and neurological problems and arthritis from developing.

Scientists from Northwestern University have identified that piperacillin, an antibiotic in the same class as penicillin, effectively cured mice of Lyme disease at 100-times less than the effective dose of doxycycline, the current gold standard treatment.

At such a low dose, piperacillin also had the added benefit of “having virtually no impact on resident gut microbes,” according to the study, in the journal Science Translational Medicine.

Doxycycline and other generic antibiotics, on the other hand, wreak havoc on the microbiome, killing beneficial bacteria in the gut and causing troubling side effects even as it kills the Borrelia bacteria that causes Lyme.

In addition to its negative impact on the gut, doxycycline also fails to help between 10 and 20% of individuals who take it, and it is not approved for use in young children — who are at the highest risk of tick bites, and therefore, of developing Lyme.

More effective, or at least more specific, treatment options are needed as climate change extends tick seasons and Lyme becomes more prevalent.

The need for customized medicine

“Powerful, broad-spectrum antibiotics that kill extracellular bacteria are seen as the most effective medication because physicians want to just kill the bacterium and don’t care how,” said Brandon L. Jutras, who led the research.

“This is certainly a reasonable approach, but I think the future for Lyme disease patients is bright in that we are approaching an era of customized medicine, and we can potentially create a particular drug, or a combination to treat Lyme disease when other fail. The more we understand about the various strains and species of Lyme disease-causing Borrelia, the closer we get to a custom approach.”

Jutras is an associate professor in the microbiology-immunology department of Northwestern University Feinberg School of Medicine, and a member of Northwestern’s Center for Human Immunobiology.

Jutras’s lab was recently named a Phase 3 winner in LymeX Diagnostics, the Steven & Alexandra Cohen Foundation’s $10 million competition to accelerate the development of Lyme disease diagnostics, and in 2021 he won the Bay Area Lyme Foundation Emerging Leader Award.

Piperacillin has already been FDA-approved as a safe treatment for pneumonia.

To reach the conclusion that the penicillin relative would be the most effective and targeted treatment, the team screened nearly 500 medicines in a drug library, using a molecular framework to understand potential interactions between antibiotics and the Borrelia bacteria.

Once the group had a short list of potentials, they performed additional physiological, cellular and molecular tests to identify compounds that did not impact other bacteria.

Prevents bacteria from growing

They found that piperacillin exclusively interfered with the unusual cell wall synthesis pattern common to Lyme bacteria, preventing the bacteria from growing or dividing and ultimately leading to its death.

Historically, piperacillin has been administered as part of a two-drug cocktail to treat severe strep infections because strep can break down beta-lactams (piperacillin’s class of antibiotics) unless accompanied by tazobactam, which is an inhibitor of the enzyme that inactivates piperacillin.

Jutras wondered if using the same two medications, rather than piperacillin alone, would be a more effective bacteria killer.

“Bacteria are clever,” Jutras said. “Strep and some other bacteria combat antibiotics by secreting beta-lactamases that inactivate piperacillin. We found the approach is totally irrelevant in the context of Lyme disease and another way that makes piperacillin more specific. Adding the beta-lactamase inhibitor doesn’t improve the therapy because Lyme Borrelia don’t produce beta-lactamase, but the cocktail does negatively impact the microbiome by becoming more broadly functional against beneficial residents.”

The study was supported by the Bay Area Lyme Foundation and United States Department of Agriculture (VA-160113), the Dennis Dean Research Grant (Virginia Tech), the National Institutes of Allergy and Infectious Disease (R01AI173256, R01AI178711), the Steven & Alexandra Cohen Foundation and the Global Lyme Alliance.

Click here for more about the study.

SOURCE: Northwestern University

_______________

**Comment**

A few points:

  1. Early treatment CAN prevent neurological problems, arthritis, & other chronic symptoms, but fails to do so in a subset of patients.
  2. Doxycycline does has a negative impact upon the gut, but far more than 10-20% go on to suffer long-term symptoms (chronic Lyme), with one researcher estimating the percentage to be more like 60%.  A little factoid: the current research which comes up with 10-20% doesn’t include patients who are diagnosed and treated late, and this is somewhere between 30-40% of patients!
  3. Independent research has proven the climate has nothing to do with tick and disease proliferation.  Further, the entire climate narrative is fraught with fraud and deceit and many experts continue to state there is no climate crisis, atmospheric CO2 emissions can not cause ‘global warming’, and that green energy policies have made the climate worse. Researchers really need to cease and desist with the climate mantra.  
    1. But this ‘tell’ reveals that those doling out federal research grants hold all the cards, and researchers know they must comply with the narrative to get the dollars. These same public health ‘experts’ and politicians also own patents on the very things (drugs, tests, vaccines, etc) they are entrusted to protect the public from as well as set treatment guidelines.
  4. Researcher Kim Lewis out of Northeastern University has also identified compounds that are highly active and selective against Lyme disease in the mouse model. Going all the way back to 2015, he found hygromycin A to be highly effective against Lyme, yet here we are in 2025 with nadda.
  5. Lewis also proved what Dr. Burrascano clinically discovered – that by treating with antibiotics for a period and then stopping for a period (cycling) – if they did this four times, they discovered no bacteria in the petri dishes.
    1. Burrascano and Dr. Alan McDonald also proved patients can test negative but still be actively infected as well as the fact that dosage makes a difference as well.  Mainstream research and medicine are clueless about these nuances and just continue to use a completely antiquated and faulty paradigm.
    2. This is why I hold little hope in any research that is federally funded.  While advocates continue to bemoan lack of federal funding, I say good riddance.  Nothing good ever comes from that quarter anyway.  As long as federal funding is involved, the fraudulent Lyme narrative will taint everything that is done.
    3. Further, the federal government is complicit in tick research that purposely weaponized ticks to deliver deadly bacteria to be incapacitating and dropped them out of airplanes.  Hello!
  6. Don’t believe me?  Listen to Willy Burgdorfer, the “discoverer” of Lyme disease himself:

“The controversy in Lyme disease research is a shameful affair. I say that because the whole thing is politically tainted. Money goes to people that have for the past 30 years produced the same thing. Nothing.  Serology or serology plus has to be started from scratch with people that don’t know beforehand the results of their research.

BOOM.

Sadly, the current research above is taking the same old tack that people are simply struggling with inflammation (PTLDS) – not an active infection.  While this is always true, it is often only a partial truth, with active infection being the driver to the inflammation.  In other words, treat the infection and symptoms get better or go away entirely.  If only inflammation is treated, symptoms will continue until the infection(s) is/are dealt with.  And this brings up another point entirely dismissed by mainstream research and medicine: this is commonly a polymicrobial issue – meaning more than one infectious organism is involved requiring yet more savvy, complex treatments.  

Until these issues are addressed, I don’t want another dime of my money going to the same people that have done nothing for the past 40 years.

For more:

http://  Approx. 3 Min

Could Piperacillin Be the Lyme Breakthrough We Need?

Dr. Danial Cameron

May 6, 2025

Category:

Activism, Lyme, research, Ticks, Treatment

Targeting the “Motor” That Helps Lyme Spread Through the Body

https://www.lymedisease.org/motor-behind-lyme-and-syphilis/

Targeting the “motor” that helps Lyme spread through the body

By Stephen D’Angelo, Cornell Research & Innovation

3/31/25

Researchers have identified a new way to fight infections like Lyme disease and syphilis by disrupting the bacteria’s ‘motor,’ preventing it from spreading through the body.

The findings could have wide-ranging impacts on the treatment of infections in the future as concern about antibiotic-resistant strains grows. The study was published in ACS Chemical Biology.

“Many types of bacteria must be able to move to infect their host organisms, including humans,” said Brian Crane, director of the Weill Institute for Cell and Molecular Biology, corresponding author on the publication.

“Motility can be important to move between hosts—ticks to humans, for example—and also for disseminating within the host, colonizing the most advantageous tissue, and evading the immune system.”

Disrupting the ability to move

In the study, funded by the National Institutes of Health and the Bay Area Lyme Foundation, the researchers exploited a crucial relationship in the bacteria’s movement system by disrupting the germ’s ability to propel itself through tissues, and significantly weakening its chances to spread and infect.

,

Click to open gallery view

Credit:Credit Chunhao Li
Click here to see video of the Lyme Disease bacterial spirochete in action. 

Spirochetes are thin, corkscrew-shaped bacteria that spiral through body tissues using a hidden propeller-like motor, protected by a membrane that shields it from the host’s immune system.

Central to its ability to accelerate is a long strand called a flagella that is joined by a hook to the organism’s motion-generating machinery. Built from self-assembled protein subunits called FlgE, the hook is tightly held together by molecular bridges known as lysinoalanine (LAL) cross-links.

“When LAL formation is disrupted, a spirochetes’ flagella hook and motor are unable to work together to move effectively. This, in turn, prevents the spirochete from swimming through body tissues and significantly reduces the ability to spread and infect,” said Michael Lynch, research associate in the Crane Group (A&S), a Cornell Weill Institute lab, and the study’s first author.

After testing a collection of existing, clinically approved drug compounds, the researchers identified three—hexachlorophene, triclosan, and dichlorophene—that could be used as inhibitors to interfere with the connections between LAL molecules and the flagella hook.

A new way to fight infections

In one experiment on the spirochete linked to gum disease, treatment with hexachlorophene significantly reduced the bacteria’s ability to move, demonstrating that stopping their motility could be a powerful new way to fight infections.

Spirochetes, including Borrelia (Lyme disease), Treponema (syphilis), and Leptospira (leptospirosis, a bacterial infection that causes mild flu-like illness to severe kidney or liver damage), are highly invasive and capable of penetrating virtually every tissue in the human body, even crossing the blood-brain barrier.

According to the researchers, many of these infections are persistent, difficult to diagnose early, and sometimes resistant to standard medicines. Current treatments rely primarily on antibiotics, which target bacteria and cells indiscriminately, affecting both harmful and beneficial bacteria.

“In contrast, our approach is highly specific, targeting the formation of LAL in flagella within pathogenic spirochetes—the only known bacteria that catalyze the formation of LAL cross-links between flagella subunits,” Lynch said. “This specificity has the potential to reduce collateral damage to beneficial bacteria, such as microbiota in the gut microbiome, which is a significant advantage over conventional antibiotic treatments.”

Antibiotic resistence

According to the researchers, the need for novel antimicrobial strategies to combat spirochetes is pressing, as antibiotic-resistant strains evolve and emerge. This puts available drug options for individuals, and even public health efforts combating certain diseases, at risk, they said.

The researchers’ approach focusing on bacteria mobility could expand the number of targets for antibiotic drug development, helping to address the challenge that disease-causing bacteria are developing resistance to today’s common antibiotics.

“While bacterial motility has been studied extensively, this is the first research to target LAL cross-links in the flagella hook as an antimicrobial strategy,” Crane said. “Ultimately, because motility is widely recognized as an enhancement in pathogenic spirochetes’ ability to cause disease, our results establish LAL cross-linking as a legitimate target for antimicrobial therapeutic development.”

SOURCE: Cornell Research & Innovation

_____________

For More:

Category:

Activism, Lyme, research, Treatment

The History of Howard Alliger – Pioneer of Chlorine Dioxide Therapies

https://pierrekorymedicalmusings.com/p/the-history-of-howard-alliger-pioneer?

The History Of Howard Alliger – Pioneer Of Chlorine Dioxide Therapies

In the 1970’s, Howard Alliger, a scientist, inventor, and entrepreneur recognized the therapeutic potential of chlorine dioxide to treat human skin, nasal, and oral diseases (among many other uses).

Pierre Kory, MD, MPA
Apr 01, 2025

Although I am going ever deeper into the “rabbit hole” of chlorine dioxide, I again want to emphasize that I am not writing as a doctor recommending a treatment. I consider this work to be in the vein of an amateur investigative science journalist trying to compile all the evidence necessary to guide and promote the research needed to establish chlorine dioxide as a viable therapy for all. Subscribe now to not miss critical upcoming posts on this topic.

HISTORY OF THE MODERN CHLORINE DIOXIDE PIONEERS

To recap, although chlorine dioxide has been widely used since the 1940’s in multiple industries such as water purification and as a disinfectant and bleaching agent, it was not until 1985 that oral ingestion was discovered to have therapeutic properties at much lower and safely tolerated concentrations.

The 1985 water treatment incident in Nigeria was relayed to me by an anonymous translational scientist with high-level security clearances (now 85 years old), who, in that post, I identified only by his old nickname, “Colonel Mondragon (CM).”

To be fair, I would say we don’t really know when its therapeutic potential as an orally ingested therapeutic was first discovered because CM found that soon after his discovery of its efficacy against malaria in Nigeria, he learned of Mexican and Central American doctors that were using it to cure other diseases as well (but not malaria).

Soon after the Nigeria incident, CM was assigned to support the aid teams sent by Ronald Reagan to assist the Russians in their response to the Chernobyl nuclear accident. In that follow-up post, I provided granular details about that mission and how it led to CM meeting Vladimir Pasechnik, a Soviet scientist who later became an international whistleblower on the Russian Bioweapons program. It was Pasechnik who informed CM that chlorine dioxide was a “universal antidote against bioweapons.” Pasechnik also told CM that the Soviets had been studying it in the treatment of disease and that he was curing TB with it. That was in 1985. And that information has, as far as I know, been classified by the Russians to this day. Here is a timeline of the oral and topical chlorine dioxide pioneers…. (See link for article)

______________

**Comment**

Kory goes through Alliger’s contributions to the science and development of numerous therapeutic applications of CD.

Important quote:

We found that the chlorine dioxide in our products kills all bacteria, virus, spores, yeast, all microorganisms within a minute in vitro, which is hard to believe, but it does that. And we put it on a wound, it did something even more than that. It oxidized free radicals and cytokines. ~ Howard Alliger, Founder of Frontier Pharma

For more:

Category:

Activism, Treatment, Viruses

Lyme Disease Crisis Addressed During HHS Hearing

https://www.globallymealliance.org/news/rfk-jr-endorses-lyme-focus-during-congressional-hearing-for-hhs-position?

Lyme Disease Crisis Addressed During HHS Hearing

by Admin at Global Lyme Alliance on March 17, 2025

<span id="hs_cos_wrapper_name" class="hs_cos_wrapper hs_cos_wrapper_meta_field hs_cos_wrapper_type_text" style="" data-hs-cos-general-type="meta_field" data-hs-cos-type="text" >Lyme Disease Crisis Addressed During HHS Hearing</span>
Robert F. Kennedy Jr. & Senator Collins discuss the Lyme disease crisis  during HHS confirmation hearing

“I’ve had Lyme disease. I’ve lived in the epicenter of Lyme disease. Every member of my immediate family has had Lyme disease. I had a son whose face was paralyzed for a year, and I have a son today who has been suffering from the devastating effects of Lyme disease for two years. There is nobody who will fight harder to find a vaccine or a treatment for Lyme disease than me.”

Read the transcript:

Senator Susan Collins (R-ME): The state of Maine has seen a steady and disturbing increase in Lyme disease cases over the past decade. We talked a little bit about this in my office. In 2023, Maine had a record number of Lyme disease cases—nearly 3,000 reported cases. Fortunately, there is a promising vaccine trial for Lyme disease underway at Maine Health in Portland. Access to a Lyme disease vaccine would be a monumental step forward in reducing the burden of this disease, which can have lifelong effects. I’ve seen it in members of my own family. As HHS Secretary, if confirmed, what influence would you exercise over new vaccine approvals, such as one for Lyme disease?

Robert F. Kennedy Jr.: Senator, you and I have talked about this issue. I’ve had Lyme disease. I’ve lived in the epicenter of Lyme disease. Every member of my immediate family has had Lyme disease. I had a son whose face was paralyzed for a year, and I have a son today who has been suffering from the devastating effects of Lyme disease for two years. There is nobody who will fight harder to find a vaccine or a treatment for Lyme disease than me.

Senator Collins: I very much appreciate that. I’m sorry that your own family has been so adversely affected. In Maine, we have a lot of people who work outside and in the woods, and ticks are everywhere. So this is a very important issue to me.

Global Lyme Alliance
________________
**Comment**
When you truly understand Lyme/MSIDS, then you truly understand that a ‘vaccine’ is not the answer.  It simply won’t work.  I have my serious doubts about ALL ‘vaccines,’ but Lyme/MSIDS is a complicated monster typically involving more than one pathogen with the ability to go dormant that was purposely created to evade antimicrobials.  You can’t vaccinate moving targets.
Please read:

Category:

Activism, Lyme, Treatment, vaccines

Peter Marks Gets the Boot: A Post Mortem of His FDA Legacy

Pharma Stocks tumbled after Peter Marks, M.D., Ph.D., director of the agency within the U.S. Food and Drug Administration (FDA) responsible for authorizing vaccines, resigned under pressure from his new boss, Health and Human Services (HHS) Secretary Robert F. Kennedy Jr.

“If Peter Marks does not want to get behind restoring science to its golden standard and promoting radical transparency, then he has no place at FDA under the strong leadership of Secretary Kennedy,” an HHS official said in a statement.  Source

The Washington Post reported a sweeping purge of agencies that oversee government health programs. Top officials were put on administrative leave or offered reassignment to the Indian Health Service. (Indians should protest)

Democratic attorneys general and governors have filed a lawsuit against HHS and the HHS Secretary for the department’s sudden rollback of $12 billion in public health funding.

“The COVID-19 pandemic is over, and HHS will no longer waste billions of taxpayer dollars responding to a non-existent pandemic that Americans moved on from years ago. HHS is prioritizing funding projects that will deliver on President Trump’s mandate to address our chronic disease epidemic and Make America Healthy Again,” the US Department of Health and Human Services said in a statement Wednesday.  Source

The vaccine cabal is also shouting that ‘the sky is falling’ due to HHS canceling hundreds of vaccine grants.

https://popularrationalism.substack.com/p/a-postmortem-on-peter-marks-fda-legacy?

A Postmortem on Peter Marks’ FDA Legacy: False Positives Killed Untold Numbers of People — and Marks Was Warned

We saw his decisions. We raised concerns, issued warnings, and watched them go unheeded. Marks answered not to science, but to those who saw objectivity as optional. The tone-deafness remains obvious.

 
James Lyons-Weiler
Mar 30, 2025
 

Dr. Peter Marks, former director of the FDA’s Center for Biologics Evaluation and Research (CBER), resigned on March 28, 2025, with an overly dramatic letter (see below) citing conflicts with Health and Human Services Secretary Robert F. Kennedy Jr. over vaccine misinformation. His tenure was marked by significant controversies, particularly concerning the approval and oversight of COVID-19 diagnostics and vaccines.

The PCR Catastrophe: False Positives, Fear, and Fatal Protocols

Under Dr. Marks’ leadership, the FDA authorized the widespread use of RT-PCR tests for COVID-19 diagnosis. Concerns arose regarding their specificity and the potential for false-positive results, especially in low-prevalence settings.​ Marks oversaw the deployment of high-cycle RT-PCR testing without adequate controls or interpretive guidance.

To this day, the public largely confuses False Positive Rate (FPR) with False Discovery Rate (FDR)—a distinction crucial to understanding the magnitude of harm. While the FPR is the proportion of truly negative tested samples that test positive (usually low), the FDR is the proportion of positive results that are false. In low-prevalence settings, even a highly specific test with low FPR can yield an FDR exceeding 50%, meaning that most positive test results are wrong.

And that’s exactly what happened.  

(See link for article)

_______________

Bulletpoint summary:

  • Marks was silent when Fauci selectively amplified HCQ results to give the predetermined outcome it was ineffective, permitting a distorted narrative that shut down scientific inquiry.
  • Under Marks, the FDA expedited approval of COVID shots despite studies showing waning immunity, breakthrough infections, negative efficacy, adverse events, and links to cancer, autoimmune disorders, and deadly kidney failure.
  • Under Marks, the FDA faced criticism for delays and redactions in releasing clinical trial data, and for the agency’s inconsistent messaging.
  • Despite failure to meet primary endpoints in phase 3 trials, under Marks, the FDA granted accelerated approval of other gene therapies.
  • In his resignation letter Marks conflates MMR data with broader vaccine safety claims which redirects and misleads the debate as not all vaccines have been studied for associations with neurodevelopmental outcomes.
  • Throughout Marks’ tenure, dissenting experts were continually sidelined.
  • Marks misled the public on Paxlovid and boosters and forced Gruber and Krause to resign when they blew the whistle on the Biden admin for insisting on the COVID booster before the agency even approved it.
  • Marks pushed unethical vaccine mandates.

For more:

Category:

Activism, Treatment, vaccines, Viruses