Archive for the ‘Treatment’ Category

Tenenbaum Cancer Protocol

I continue to marvel at the many silver linings of the disastrous COVID era. One such silver lining is the plethora of information not only about successful cancer treatments but the truth about the very nature of it. Since a recent paper shows that chemotherapy the current poison treatment of choice that oncologists get a direct cut from, has a 97.9% failure rate in the U.S. over five years, these treatments are just in time as the American Cancer Society Projects diagnoses to exceed 2 MILLION in 2025.

Due to the fact ‘the powers that be’ have proven to be unbelievably corrupt hooligans, people have begun to realize that they in fact have a brain they can use for themselves!  

This awakening has brought many to the conclusion they can research, learn, and experiment just as well as those in a fraudulent, indoctrinated medical machine for profit which spews out mostly corrupt people with a few letters after his or her name.  (There are always rare exceptions and thank God for them!)

The world has already been regaled with the success of the Joe Tippen’s Protocol, Dr. Marik’s success, Dr. Makis’ success, Mel Gibson’s testimony of 3 friends healed of stage four cancer, a major review paper showing high dose IV vitamin C (75-100g, 2-3X week for 6-8 cycles) as a promising anti-cancer agent, and entire websites dedicated to high level guidance based on research for the layman who is interested in cancer treatments.  (COVID mania also exposed the ‘good guy’ doctors who were and continue to be tenaciously persecuted for daring to think for themselves)

Now we have the astounding success of Guy Tenenbaum, a 71 year old with stage 4 prostate cancer who was given a death sentence by all the doctors he consulted with, and who realized he had to rescue himself.  He studied the Metabolic Theory of Cancer, the work of Dr. Otto Warburg and Dr. Wilhelm Brunings [06:41], and discovered the key, autophagy, related to the work of Dr. Yoshinori Ohsumi [06:54]. Many studies built on Ohsumi’s foundational work and applied it to cancer. Autophagy, the lysosomal clean-up of cellular debris, is controlled by the mTOR pathway and is turned on by fasting.  Fasting can also enhance chemotherapy and radiation effectiveness and dramatically lessen its toxicity.  Tenenbaum wrote “My Battle Against Cancer – Survivor Protocol,” “Beat Cancer to Cure From Cancer,” and co-authored “Can We Heal From Cancer? Guy and Fred Did it…..and Here’s How.”

It appears the medical machine refuses to apply previously done work to current diseases because there isn’t any money or power in it. 
You think NIAID will give grants for that?  Think again.

Guy Tenenbaum’s Cancer Protocol

  • Fast for 42 days, consuming nothing but water and occasional coffee or tea
  • Take 1,000mg of aged garlic (scientists believe it’s responsible for 30% of his recovery). Go here for research on how aged garlic:
    • reduced stomach cancer by 52% due to reducing IGF-1, activating autophagy, suppressing a master switch controlling inflammation & cancer stem cell survival, and enhancing Natural Killer Cells by up to 300%.
    • even 17 years after stopping it, subjects still had a 34% lower cancer mortality
    • has an anti-aging effect, slows heart disease progression, improves brain health, and beats EGCG and curcumin due to its bioavailability, clinical results, and track record.
    • causes blood levels peak within hours but clinical benefits usually appear:
      • 2-4 weeks – improved blood pressure and inflammation markers
      • 3 months – max cardiovascular benefits
      • 6-12 months – cancer prevention and longevity benefits

Tenenbaum continues to take aged garlic now with meals for better absorption. After his drastic self- experiment his PSA dropped from 58 to 0.1 and scans showed his bone metastases were healing.  Six years later, he remains cancer-free.  

It’s important to note that aged garlic is quite different from regular garlic or even odorless garlic due to the proprietary aging process which converts harsh compounds into gentle, beneficial ones, which have no odor and cause no irritation.  It would require 10-20 cloves of raw garlic a day to achieve 1,000mg.  I must add as a personal side note that I actually took 16 cloves of crushed garlic daily, broken down into 4 doses when I first got Lyme/MSIDS, based on the advice of a Master Herbalist.  I did it for 2 weeks and it nearly killed me.  First, I smelled like I came straight out of Shanghai (the kids banned me from the car), and second my stomach revolted toward the end.  It was just too harsh.  I will state it made me herx initially, so it gave some benefit.

Due to Tenenbaum’s success, there are now two clinical trials now in the works testing prolonged fasting and fasting-mimicking diets in prostate cancer patients.

The following tables are helpful comparing autophagy effectiveness:

Source

This seminal work has shown there there appears to be an autophagy threshold for cancer suppression, growth factor starvation, insulin suppression, Warburg effect reversal, and sustained immune activation, which the 42 day fast meets but the 16 hour intermittent fast doesn’t.

This analysis demonstrates that dose-response matters dramatically in fasting-induced autophagy:

  • Mild fasting (16h): 20-30% tumor growth slowing ✓ (good)

  • Extended fasting (5-7d cycles): 10-25% remission rates ✓ (better)

  • Prolonged fasting (42d continuous): 100% remission rate ✓ (transformational)

Milder Ways to Induce Autophagy for the average Joe

Let’s say you don’t have cancer but you want to incorporate helpful aspects of Tennenbaum’s protocol in a more sustainable manner for prevention or other issues? 

Regarding clearing of spike proteins from those who got the COVID shots, as well as curing Dr. Marik’s Type II Diabetes:

“Autophagy can be upregulated by fasting and calorie restriction [2], especially if protein is reduced [3]. Autophagy in many instances does not require the complete cessation of food intake (protocols are available at https://COVID19criticalcare.com/treatment-protocols/, accessed on 15 April 2023). Sharply decreasing protein intake can upregulate autophagy pathways [4], and this can be accomplished while still eating, which makes this more approachable as a protocol. Regular fasting was also associated with better outcomes from acute COVID-19 [5].  Source

For Average Risk Individuals

Daily: 16:8 Time-Restricted Eating

  • Fast 16 hours (e.g., 8pm – 12pm)

  • Eat 8 hours (12pm – 8pm)

Quarterly: 4-5 Day Fasting-Mimicking Diet

  • Every 3 months (4x per year)

  • 1,100 cal day 1; 500 cal/day days 2-5

Expected Results:

  • ✅ Cancer risk reduction: 40-60%

  • ✅ Sustainability: Excellent (85-95%)

  • ✅ Evidence level: Strong (multiple human RCTs)

For High-Risk Individuals (Family History, Genetic Risk)

Daily: 18:6 Time-Restricted Eating

  • Fast 18 hours (6pm – 12pm)

  • Eat 6 hours (12pm – 6pm)

Monthly: 48-72 Hour Water Fast

  • Once per month

  • Water, tea, coffee only

Quarterly: 4-5 Day FMD

  • Every 2-3 months

Expected Results:

    • ✅ Cancer risk reduction: 50-70%

    • ✅ Sustainability: Good-Excellent (70-85%)

    • ✅ Evidence level: Very Strong

Optimal Combined Protocol (50-70% Prevention)

DAILY FOUNDATION:

  • ✅ 16:8 Time-Restricted Eating (minimum)

  • ✅ 18:6 TRE for high-risk individuals

  • ✅ Eating window: 12pm – 6pm or 10am – 6pm

  • ✅ Black coffee, tea, water allowed during fast

QUARTERLY INTENSIVE:

  • ✅ Fasting-Mimicking Diet 4 times per year

  • ✅ Day 1: 1,100 calories (plant-based)

  • ✅ Days 2-5: 500 calories/day

  • ✅ ProLon kit or DIY version

  • ✅ Schedule: Jan, April, July, October

OPTIONAL MONTHLY BOOST (High Risk):

  • ✅ 48-72 hour water fast once per month

  • ✅ Or extend one FMD to 7 days

SYNERGISTIC ADDITIONS:

  • ✅ Aged Garlic Extract 2.4g/day

  • ✅ Green tea 3+ cups/day (especially lung cancer prevention)

  • ✅ Curcumin 500mg BID with piperine

  • ✅ Whole food, plant-based diet during eating windows

Go here for source and all research studies.

Repurposed Drugs for Cancer

By Paul E. Marik, MD, FCCM, FCCP and Justus R. Hope, MD

https://imahealth.org/wp-content/uploads/2025/02/approach-to-repurposed-drugs-for-cancer.pdf

We can be extremely thankful that COVID produced some amazingly unexpected benefits in how cancer and many other disease processes is being treated.

I’ll bet the medical machine didn’t predict their tyranny would promote invention!

For more:

Category:

Activism, Cancer, diet and nutrition, Herbs, Inflammation, Prevention, research, Supplements, Treatment

ACTION: Retract Deplorable Lyme Disease CME Which Ignores Persistent Bb Part 2

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/34014349?cs_tk=A8-

Medscape Now! Interprofessional Care of Post-Treatment Lyme Disease Syndrome (Part2)

Carl Tuttle
Hudson, NH, United States
Oct 28, 2025

Follow-up email to Adrian Duncan, Group Vice President, Global Head of Education & Medical Affairs at WebMD.

First email can be found here.

———- Original Message ———-
From: CARL TUTTLE <runagain@comcast.net>
To: “aduncan@webmd.net” <aduncan@webmd.net>
Cc: “cme@medscape.net” <cme@medscape.net>, “caitlin@medlitera.com” <caitlin@medlitera.com>, “naseem@medlitera.com” <naseem@medlitera.com>, “michelle@medlitera.com” <michelle@medlitera.com>
Date: 10/28/2025 9:28 AM EDT
Subject: Re: Medscape Now! Understanding the Latest Evidence and Best Practices for Interprofessional Care of Post-Treatment Lyme Disease Syndrome

Dear Mr. Duncan,

In 2016 Dr. Paul Auwaerter, past president of the Infectious Diseases Society of America coauthored a study revealing the persister form of Borrelia burgdorferi resistant to antibiotics.

Here is a timeline of events:

2015

Standard antibiotic treatment for Lyme disease does not kill persistent Borrelia bacteria.
http://droopyyoupi.blogspot.com/2015/08/standart-antibiotic-treatment-for-lyme.html

Excerpt:

–What has tuberculosis and Borrelia burgdorferi in common? In the late stage of the disease occurs persistent (tolerant) bacteria, which essentially means that the bacteria lasts and lasts and lasts. They protect themselves against antibiotics and are difficult to treat.

–Both Borrelia burgdorferi and tuberculosis is relatively easy to cure in the early stages, even with the use of one antibiotic. In the late stage it is impossible to cure the disease with the same type of treatment in the acute phase, said Dr. Ying Zhang when he visited the year NorVect conference.

-Dr. Ying Zhang is a professor at the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health

–Two days after NorVect conference, published Dr. Ying Zhang’s latest research Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection.

2016

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library
Jie Feng 1, Wanliang Shi 1, Shuo Zhang 1, David Sullivan 1, Paul G Auwaerter 2, Ying Zhang 1
https://pubmed.ncbi.nlm.nih.gov/27242757/

Abstract

Under experimental stress conditions such as starvation or antibiotic exposure, Borrelia burgdorferi can develop round body forms, which are a type of persister bacteria that appear resistant in vitro to customary first-line antibiotics for Lyme disease. To identify more effective drugs with activity against the round body form of B. burgdorferi, we established a round body persister model induced by exposure to amoxicillin (50 μg/ml) and then screened the Food and Drug Administration drug library consisting of 1581 drug compounds and also 22 drug combinations using the SYBR Green I/propidium iodide viability assay. We identified 23 drug candidates that have higher activity against the round bodies of B. burgdorferi than either amoxicillin or doxycycline.

2022

Nitroxoline Drug Combinations Are More Active Than Lyme Antibiotic Combination and Can Eradicate Stationary-Phase Borrelia burgdorferi
Alvarez-Manzo, Hector S.1; Zhang, Yumin1; Zhang, Ying2,✉
https://journals.lww.com/imd/fulltext/2022/09000/nitroxoline_drug_combinations_are_more_active_than.7.aspx

Abstract

Lyme disease (LD), caused by Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. Despite the standard 2–4 weeks’ antibiotic treatment, approximately 10%–20% of patients will develop post treatment LD syndrome, a condition that is poorly understood. One of the probable causes is thought to be the presence of B. burgdorferi persister forms that are not effectively killed by the current LD antibiotics. In this study, we evaluated nitroxoline, an antibiotic used to treat urinary tract infections, for its activity against a stationary-phase culture enriched with persister forms of B. burgdorferi. Nitroxoline was found to be more active than doxycycline and equally active as cefuroxime (standard LD antibiotics) against B. burgdorferi. Importantly, the nitroxoline two-drug combinations nitroxoline + cefuroxime and nitroxoline + clarithromycin, as well as the nitroxoline three-drug combination nitroxoline + cefuroxime + clarithromycin, were as effective as the persister drug daptomycin-based positive control three-drug combination cefuroxime + doxycycline + daptomycin, completely eradicating stationary-phase B. burgdorferi in the drug-exposure experiments and preventing regrowth in the subculture study. Future studies should evaluate these promising drug combinations in a persistent LD mouse model.
 
Mr. Duncan…. This is the missing research that should have been conducted early in the discovery phase of the disease but as we now know, all the eggs were put into the vaccine basket while a campaign was orchestrated to discredit the sick and disabled patient population along with the courageous clinicians attempting to help these patients. What has been deceitfully established here in the US is wreaking havoc globally. Example: Lyme disease: Australians ‘being treated worse than a dog riddled with mange’, Senator John Madigan says
https://www.abc.net.au/news/2016-01-11/lyme-disease-treatment-in-australia-criticised-by-john-madigan/7080708

This research is being suppressed as the disabled Lyme patient population around the globe remain sick indefinitely. (Three decades and counting)

Carl Tuttle

______________

**Comment**

We should all be eternally grateful for Lyme patient and advocate Carl Tuttle who is like a dog with a bone when it comes to relentlessly fighting for patients.  His letter makes numerous salient points completely ignored by the medical machine which runs on ‘consensus’ based medicine auto-pilot, where doctors are nothing more than automatons and where AI is more likely to diagnose patients than doctors.

In part one he calls on patients to write letters to Adrian Duncan of Medscape/WebMD.  The medical machine needs to hear from people who live this experience.  For ideas, feel free to read the letter I wrote back in 2020 to the TBDWG which I adapted for the Medscape letter. Use your own experience and ask him to retract this harmful CME course for doctors which only entrenches the false narrative of Lyme/MSIDS.

Category:

Activism, Lyme, research, Treatment, vaccines

Rise of the Digital Health Ecosystem

https://lionessofjudah.substack.com/p/the-rise-of-the-digital-health-ecosystem?

The Rise of the Digital Health Ecosystem

How wearables, data centres and virtual “twins” are redefining Healthcare 4.0

Lioness of Judah Ministry
Oct 26, 2025

By HopeGirlBlog FTWProject

A quiet revolution in plain sight

Over the past few months, the phrase digital health ecosystem has crept into press releases, conference keynotes and policy documents. We are told that this new structure will make check-ups quicker, treatment cheaper and diagnostics sharper. Yet most people still wonder: What exactly is the digital health ecosystem, and why does every tech giant and government department seem to be racing to build it?

This article unpacks the concept, traces its technological building blocks and highlights the opportunities and threats hidden beneath the glossy marketing language.

Watch the presentation here:

Why new data centers are appearing everywhere

Drive through almost any U.S. state and you will notice enormous, window-less warehouses springing up like mushrooms. These facilities are not retail hubs or logistics depots—they are data centers.

Inside, thousands of servers will store and process electronic medical files, insurance records, tax information and, increasingly, the live sensor data produced by wearable gadgets. Without this storage backbone the digital health ecosystem could not exist; vast computational power is the “prerequisite,” as one IEEE paper argues, for Healthcare 4.0 to function.

A vast grab for personal data

Early in 2025, a high-profile Silicon Valley partnership DOGE obtained access to 19 sensitive U.S. Health and Human Services databases. The cache included electronic health records, IRS files, Social Security numbers, addresses and bank details—an unprecedented consolidation of personal information.

Why does this matter to the emerging digital health ecosystem? Because predictive medicine, AI-driven drug discovery and remote patient management all feed on comprehensive, real-time data. The richer the dataset, the more marketable (and profitable) the algorithms built on top of it.

The political push for wearables

Robert F. Kennedy, in his role as Secretary of Health and Human Services, openly stated that he wants “a wearable on every American within four years.” His position is echoed by similar pledges in Europe and Asia.

Wearables—smart watches, rings, patches and even earpieces—act as the edge devices of the digital health ecosystem. They harvest heart rate, temperature, blood-oxygen, movement and sleep metrics, forwarding them through body-area and personal-area networks to those sprawling data centers.

Operation Stargate and the AI pharmaceutical dream

Long before most people heard the term “generative AI,” government-funded programs such as Operation Stargate allocated more than $500 billion to AI-specific data centers. Oracle co-founder Larry Ellison boasted that the new architecture could design an mRNA vaccine “in 48 hours.”

These milestones reveal the deeper aim of the digital health ecosystem: a real-time feedback loop in which sensors feed data to the cloud, AI models simulate outcomes on “digital twins,” and automated factories print customized therapeutics on demand.

What the IEEE paper really says about Healthcare 4.0

A 2018 article in IEEE “INTRODUCTION TO THE SPECIAL SECTION: CONVERGENCE OF AUTOMATION TECHNOLOGY BIOMEDICA ENGINEERING AND HEALTH INFORMATICS TOWARDS THE HEALTHCARE 4.0” spells out the ingredients of Healthcare 4.0…..

(See link for article)

_________________

**Comment**

If this article doesn’t scare the bejeebers out of you, you are asleep at the wheel.  

Please read entire article in top link to educate yourself.

In short, if you believe Lyme/MSIDS is tightly controlled now, just wait for a digital health ecosystem.  It will be impossible to get treatment anywhere as everything will be tyrannically monitored and controlled.  The AMA and other sold out ‘professional’ organizations are already following ‘consensus’ based medicine – where decisions are made by consensus, rather than from reality, truth, or real science.  Similar to how it has controlled COVID (banning effective treatments, bullying people into an experimental, never used before mRNA gene therapy, and persecuting doctors trying to save lives), it will be nearly impossible to even find an independent doctor willing to think for himself/herself.

A person in the comment section from the article stated something worth repeating here:

What stands out here is the reminder that these systems are not limited to the US, they form part of a much wider global agenda that is steadily being implemented across different countries.

This website has posted many articles on the unelected global elites and their evil plans:

Category:

Activism, Treatment, vaccines, Viruses

ACTION: Retract Deplorable Lyme Disease CME

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/34006713?

Medscape Now! Interprofessional Care of Post-Treatment Lyme Disease Syndrome

Carl Tuttle
Hudson, NH, United States
Oct 25, 2025

What was deceitfully established here in the US has been propagated worldwide as signatures for this petition are coming in from 21 countries!

Let’s put our numbers to work. Consider writing an email to Adrian Duncan of Medscape/WebMD referencing this Update and demand a retraction of this deplorable and misleading CME directed to the medical community. 

Change.org Petition Update (106,796 Signatures)
https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/34006713

Medscape Now! Interprofessional Care of Post-Treatment Lyme Disease Syndrome

Adrian Duncan, Group Vice President
Global Head of Education & Medical Affairs

aduncan@webmd.net

———- Original Message ———-
From: CARL TUTTLE <runagain@comcast.net>
To: “aduncan@webmd.net” <aduncan@webmd.net>
Cc: “cme@medscape.net” <cme@medscape.net>, “caitlin@medlitera.com” <caitlin@medlitera.com>, “naseem@medlitera.com” <naseem@medlitera.com>, “michelle@medlitera.com” <michelle@medlitera.com>

Date: 10/24/2025 12:42 PM EDT
Subject: Medscape Now! Understanding the Latest Evidence and Best Practices for Interprofessional Care of Post-Treatment Lyme Disease Syndrome

Medscape Now! Understanding the Latest Evidence and Best Practices for Interprofessional Care of Post-Treatment Lyme Disease Syndrome
https://www.medscape.org/viewarticle/medscape-now-understanding-latest-evidence-and-best-2025a1000rrr
CME Author: Naseem Bazargan, MPH     Developed with AI assistance.

Excerpt:

State of the Evidence

“To date, our understanding of the pathophysiology of Lyme IACI remains limited,[4] with little to no evidence supporting chronic Borrelia infection as the underlying cause.”

Adrian Duncan, Group Vice President
Global Head of Education & Medical Affairs

Dear Mr. Duncan,

In reference to the Medscape article written by Naseem Bazargan, I asked Google’s Gemini AI the following questions:

The latest Medscape CME education claiming to be developed with AI assistance, appears to have omitted the following references:

  • 2018 Middelveen study; “Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease” identifying twelve patients who were culture positive after antibiotic treatment. Some of these patients had taken as many as eleven different types of antibiotics. Also missing is the NIH funded Embers studies of persistent Bb infection in monkeys and mice. And the Sapi study: “The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease”  Here is the positive culture report from the CDC at Fort Collins Colorado and the chronic Lyme autopsy results from the patient in the Sapi study: Page 1, 2, 3, 4, 5, 6, 7. The destructive nature of Borrelia is evident in the patient’s liver (nutmeg liver), kidneys, heart, lungs and brain. The patient died after the insurer refused additional IV antibiotic therapy.
  • Additional reference from 1990: “Chronic neurologic manifestations of Lyme disease” Dr. Allen Steere
  • In fact, there appears to be 700 references identifying persistent infection. 

Question: So, is AI participating in the collusion to suppress evidence of antibiotic resistance or chronic Lyme disease? And what about the other 700 references identifying persistent infection?

Mr. Duncan…  I will spare you the lengthy discourse and get right to the point.

Questions to AI:

1. Does a chronic relapsing seronegative disease fit the vaccine model?

AI Response:

A chronic, relapsing, seronegative disease does not fit the traditional vaccine model, which is primarily designed to prevent initial infections. The characteristics you describe present significant scientific and commercial challenges for vaccine developers.

2. Since you agreed that a chronic, relapsing, seronegative disease does not fit the traditional vaccine model this in and of itself would be the motivation to conceal any and all evidence of persistent infection wouldn’t you agree? This so-called debate is not a debate at all and deserves a criminal investigation. Who would be a suitable candidate to approach for a legal case?

AI Response: Allegations of medical fraud are typically handled as civil matters, but they can become criminal if there is evidence of gross negligence, recklessness, or intent to deceive, especially for financial gain.

Mr. Duncan,

Thirty-four years ago Dr. Allen Steere identified chronic Lyme disease which should have set off a red flag prompting an immediate search for better antimicrobials but then did a 180° as he became principal investigator (PI) of the Phase 3 clinical trial for the first Lyme disease vaccine. So all the eggs were put into the vaccine basket while a campaign was orchestrated to discredit the sick and disabled patient population along with the courageous clinicians attempting to help these patients. Apparently, a chronic relapsing seronegative disease did not fit the business model of patent royalties, vaccine development and pharmaceutical profits. This set the stage for long-term treatment denial and unimaginable pain and suffering around the world. It has been ongoing for over three decades now and the latest CME from Medscape is propagating this travesty.

Lyme disease has been grossly mishandled by our public health officials for the sake of a vaccine. A false public health narrative was enforced and any clinician who did not follow that narrative risked losing their license to practice medicine as seen in the documentary: Under our Skin. (please watch the 5min trailer)

I want to make this crystal clear; suppressing evidence of antibiotic resistance is not collaboration, it is collusion. Will you turn a blind eye to the facts/evidence I have presented?

A response to this inquiry is requested.

Respectfully submitted,

Carl Tuttle
Independent Researcher
Hudson, NH USA

Additional references:

Evidence Of Persistence Of Lyme Disease In Humans
https://www.lymedisease.org/lyme-basics/resources/evidence-of-persistence-lyme-disease-in-humans/

Go here to sign Tuttle’s petition:  https://c.org/sffxsgXrdJ

________________

For more:

Category:

Activism, Lyme, research, Treatment

Research Catching Up to Post-Acute COVID-19 ‘Vaccination’ Syndrome

https://imahealth.substack.com/p/from-fringe-to-focus-how-research?

From Fringe to Focus: How Research Is Catching Up to Post-Acute COVID-19 Vaccination Syndrome (PACVS)

PACVS (Post-Acute COVID Vaccine Syndrome) is real, and the science is finally opening up. Months ago, IMA researchers broke ground. Now, another team is validating what patients have known all along.

Independent Medical Alliance
Oct 22, 2025
Research catching up to PACVS

Those suffering from Post-Acute COVID-19 Vaccination Syndrome (PACVS) face not only debilitating symptoms but also institutional resistance to recognition, diagnosis, and care. Despite these barriers, researchers are beginning to shed light on this under-recognized condition. Those who follow IMA know we’ve been working in this space for years—seeing our peers in the research community finally open up is more than encouraging.

A recent publication by Yong et al. in Reviews in Medical Virology offers one of the most comprehensive summaries to date on PACVS (which they refer to as Post-COVID-19 Vaccination Syndrome, or PCVS). Their team, spanning 25 institutions, reviewed existing scientific literature and highlighted several important areas of progress:

*See references in https://onlinelibrary.wiley.com/doi/epdf/10.1002/rmv.70070

Key Takeaways from the Review:

Terminology

The review outlines the evolving language around this condition—from “Long Vax” to “post-vac syndrome.” At the Independent Medical Alliance, we’ve adopted Post-Acute COVID-19 Vaccination Syndrome (PACVS) as our standard terminology to reflect both the temporal and mechanistic distinctions from Long COVID.

Symptom Clusters

The article identifies hallmark symptoms that will be familiar to both clinicians and patients: fatigue, cognitive dysfunction (brain fog), and paresthesia.

*This figure for post-COVID-19 syndrome is reproduced under an Attribution-NonCommercial 4.0 International license

The image above is adapted from an earlier study on “post-COVID-19 syndrome” (long COVID). The more recent article expands on this by introducing additional system categories: autonomic, visual, auditory, gustatory**, and multi-system syndromes that highlight a broader range of physiological effects.

It introduces new symptoms, including

  • paresthesia
  • neuropathy
  • tremors
  • orthostatic hypotension
  • fluctuating blood pressure or heart rate
  • heat or cold intolerance
  • vision problems
  • tinnitus
  • taste dysfunction
  • urticaria
  • exercise intolerance.

It also adds a new section on multi-system and immune-mediated conditions such as POTS, SFN, ME/CFS, myocarditis, VITT, and ITP, framing the syndrome as a more complex, vaccine-specific condition with autonomic and immune involvement beyond the generalized symptoms in the second image.

Proposed Mechanisms

The authors explore two leading hypotheses for PACVS: one centering on spike protein–induced tissue damage and another on dysregulated immune responses. While not mutually exclusive, both warrant deeper investigation.

Treatment Landscape

Though research is still early, the paper compiles a useful snapshot of current treatment strategies—ranging from manual therapies (e.g., compression garments, vestibular rehab) to pharmaceuticals (SNRIs, modafinil) and nutraceuticals (melatonin, NADH, acetyl-l-carnitine).

📣 Call for Papers: PACVS Special Edition

Our team at the Independent Medical Alliance has made PACVS research a central focus. Now, we’re inviting submissions for a special edition of the Journal of Independent Medicine dedicated to this emerging condition. If you’re studying spike injury, vaccine-related syndromes, or chronic post-injection effects, we encourage you to submit your work or learn more here before the submission deadline of December 31, 2025.

The Yong et al. review is a welcome contribution to the growing PACVS landscape, but much more research is urgently needed. Our team recently published a complementary case series on PACVS mechanisms and treatment hypotheses, available here:

👉 Read the study in Heliyon
👉 Read the summary at IMAHealth.org

Together, let’s build the evidence base for the patients still waiting to be heard.

🔬 Explore Our Independent Research Hub

From vaccine safety and cancer care to post-COVID protocols and chronic disease, our research team and Senior Fellows are producing science that challenges the status quo. The Research Hub is where you’ll find all our published studies, reviews, and groundbreaking monographs, all organized, accessible, and free to the public.

For more:

Category:

research, Treatment, vaccines