https://www.nature.com/articles/s41598-021-03837

Neuropathogenicity of non-viable Borrelia burgdorferi ex vivo

Geetha Parthasarathy & Shiva Kumar Goud Gadila

Abstract

Even after appropriate treatment, a proportion of Lyme disease patients suffer from a constellation of symptoms, collectively called Post-Treatment Lyme Disease Syndrome (PTLDS). Brain PET scan of patients with PTLDS have demonstrated likely glial activation indicating persistent neuroinflammatory processes.

It is possible that unresolved bacterial remnants can continue to cause neuroinflammation.

In previous studies, we have shown that non-viable Borrelia burgdorferi can induce neuroinflammation and apoptosis in an oligodendrocyte cell line.

In this follow-up study, we analyze the effect of sonicated remnants of B. burgdorferi on primary rhesus frontal cortex (FC) and dorsal root ganglion (DRG) explants. Five FC and three DRG tissue fragments from rhesus macaques were exposed to sonicated B. burgdorferi and analyzed for 26 inflammatory mediators. Live bacteria and medium alone served as positive and negative control, respectively. Tissues were also analyzed for cell types mediating inflammation and overall apoptotic changes.

Non-viable B. burgdorferi induced significant levels of several inflammatory mediators in both FC and DRG, similar to live bacteria. However, the levels induced by non-viable B. burgdorferi was often (several fold) higher than those induced by live ones, especially for IL-6, CXCL8 and CCL2. This effect was also more profound in the FC than in the DRG. Although the levels often differed, both live and dead fragments induced the same mediators, with significant overlap between FC and DRG. In the FC, immunohistochemical staining for several inflammatory mediators showed the presence of multiple mediators in astrocytes, followed by microglia and oligodendrocytes, in response to bacterial remnants. Staining was also seen in endothelial cells. In the DRG, chemokine/cytokine staining was predominantly seen in S100 positive (glial) cells. B. burgdorferi remnants also induced significant levels of apoptosis in both the FC and DRG. Apoptosis was confined to S100 + cells in the DRG while distinct neuronal apoptosis was also detected in most FC tissues in response to sonicated bacteria.

Non-viable B. burgdorferi can continue to be neuropathogenic to both CNS and PNS tissues with effects likely more profound in the former. Persistence of remnant-induced neuroinflammatory processes can lead to long term health consequences.

_______________

**Comment**

An important work for sure which shows even non-viable pathogen remnants cause health problems in patients.  The fact remains; however, that unresolved infections CAN ALSO cause major health problems in patients, yet is not politically correct and therefore researched by those espousing with the current accepted narrative.

https://www.lymedisease.org/deer-tick-virus-pennsylvania/

“Unusually high” levels of deer tick virus found in Pennsylvania park

Officials report an “unusually high” infection rate of deer tick virus (DTV) detected in a Pennsylvania park.

Out of 25 ticks recently collected from Lawrence Township Recreational Park in Clearfield County, 23 carried the dangerous virus. That’s a 92% infection rate.

The previous highest DTV infection rate found at a single location in Pennsylvania was 11 percent. The highest infection rate reported nationally in scientific literature is about 25 percent.

The Pennsylvania Department of Environmental Protection’s (DEP) Vector Management Program strongly advises the public to take protective measures to reduce risk of exposure to ticks.

“Deer tick virus transfers very quickly through the bite from an infected tick, and the health outcomes from the deer tick virus are more severe than other tick-borne illnesses typically seen in Pennsylvania,” said DEP Secretary Patrick McDonnell.

The deer tick virus, which is a type of Powassan virus, is rare in the United States, but positive cases have increased in recent years. It is spread to people primarily by bites from infected ticks.

Initial symptoms of a DTV infection may include fever, headache, vomiting, and weakness. Some people who are infected with DTV experience no symptoms, and therefore infection may go undetected. However, according to the CDC, 91 percent of patients treated for DTV infections develop severe neuroinvasive disease.

Those who exhibit severe disease from deer tick virus may experience encephalitis or meningitis and require hospitalization, with symptoms including confusion, loss of coordination, difficulty speaking, or seizures.

About 12 percent of people with severe disease have died, and approximately half of survivors of severe disease have suffered long-term health impacts.

SOURCE: Pennsylvania Department of Environmental Protection

SUPPORT WISCONSIN NATURAL IMMUNITY BILLS: AB 675 AND SB 662

Dear Wisconsin NVIC Advocacy Team Members,

Two bills have passed committee and are currently before the Wisconsin state legislature: AB 675 in the Assembly and SB 662 in the Senate. These bills allow individuals to submit natural antibody tests or past infection statements in lieu of COVID-19 vaccination to employers who are mandating the vaccine. Both bills have been amended (1) to also allow a simple notarized statement from an individual attesting recovery from a past COVID-19 infection, and (2) to require employers to notify employees in writing of their right to provide proof of natural immunity when faced with a vaccine mandate.

The Assembly has scheduled a vote for AB 675 today (Tuesday, Jan. 25th) at 1:00. Please call before 1:00 if possible.  The Senate has not yet scheduled a vote for SB 662.

ACTION NEEDED:

1) Contact your Wisconsin state representative and senator and ask them to support AB 675 and SB 662! Please see talking points below to use when contacting them. If you do not know who your Wisconsin state legislators are, login to the NVIC Advocacy Portal at http://nvicadvocacy.org/. Click on “Check What is Happening in Your State” on the home page or “My State” on the STATE TEAMS tab. Your personal state legislators are listed on the right side of the page. You can click on your legislators’ names to get phone numbers, emails, and even links to their social media to connect to them. You can also find your state legislators at this link: http://maps.legis.wisconsin.gov/

2) Please share this email with family and friends, or you can tell them to go to http://nvicadvocacy.org/ and click on the alert for AB 675/SB 662.

3) Sign up to get NVIC’s Wisconsin “Heads Up” text alerts by texting “Wisconsin” to 202-618-5488.

4) Login to the NVIC Advocacy Portal OFTEN to check for updates. http://nvicadvocacy.org/. We review bills and make updates daily. Bills can change many times over the legislative process and your timely visits, calls, and emails directed at the correct legislators are critical to this process.

TALKING POINTS (Personalize to share how these bills affect you and your family):

  • Some individuals have contracted and successfully recovered from COVID-19 at home without official proof from a medical services provider.
  • Employer vaccine mandates should not be instituted in the first place. They are an intrusion into the personal autonomy of individuals to determine whether to put something into their own bodies.
  • These mandates lay the groundwork for discrimination against individuals who are simply exercising personal discretion regarding their own medical choices.
  • Vaccine mandates in the workplace shift the focus from health to vaccine status. It has been demonstrated that even vaccinated individuals are still capable of contracting and spreading COVID-19.
  • Allowing employees to provide a notarized statement of their personal acknowledgement of recovery from COVID-19 provides them with an avenue to take ownership of their medical freedom when faced with an employer vaccine mandate.
  • Symptoms of COVID-19, such as the loss of taste or smell or shortness of breath, are easily recognizable. It is perfectly feasible for someone to correctly determine that he or she had COVID-19, especially if the individual has knowledge of being around someone else who had the illness.
  • Requiring employers to notify employees of their right to provide proof of natural immunity to COVID-19 would empower workers in Wisconsin to utilize this option.

Support For Natural Immunity

In late 2021, the CDC reported that over 146 million Americans had been infected with COVID-19 and they have no evidence that any person with natural immunity due to past infection has been able to transmit the virus  to another individual.

A June 2021 preprint study conducted by the Cleveland Clinic Health System involving 52,238 employees found that “Not one of the 1,359 previously infected subjects who remained unvaccinated had a [Covid-19] infection over the duration of the study” and vaccination did not reduce the risk, and persons previously infected with SARS-CoV-2 were unlikely to benefit from COVID-19 vaccination.

An August 25, 2021 Israeli retrospective study, yet to undergo peer review, found that natural immunity “confers longer lasting and stronger protection against infection, symptomatic disease, and hospitalization caused by the Delta variant.”

Natural immunity has long been recognized as superior to vaccine induced immunity.  Vaccines have not been recommended to health care workers who have obtained natural immunity for infections such as measles, mumps, rubella,  and  chicken pox.  Survivors of the 1918 Spanish flu pandemic still had protective immunity 90 years later.

Limits on Testing Show Need for Personal Notarized Statement of Infection Recovery

Researchers, the WHO, and the New York Times, among others, have expressed concerns about the widespread use of the polymerase chain reaction (PCR) test for  producing false positive results.  Study comparisons difficult as there is NO standard number of replications (cycle thresholds) for the tests.

A positive PCR test does not confirm whether a person is currently sick or will become sick in the future, whether they are infectious or will become infectious, whether they are recovered or recovering from COVID-19, or whether the test identified a viral fragment from another coronavirus infection in the past. Tests can only report if the person has come into contact with coronavirus RNA.

PCR tests have been found to be incapable of distinguishing between live viruses and viral particles, and between SARS-CoV-2 and other viruses.

Requiring that individuals who are COVID-19 positive based on the government issued OTC test and who do not require medical care for their symptoms to seek additional testing to confirm a positive result will put additional unnecessary burdens on our healthcare system. Additionally, an infected person may spread the virus to others by leaving their home for testing, instead of staying home to recover.

Sincerely,

NVIC Advocacy Team
National Vaccine Information Center
http://NVIC.org and http://NVICAdvocacy.org
https://nvicadvocacy.org/members/Members/ContactUs.aspx

**UPDATE March, 2022**

https://www.politico.com/news/2022/03/21/cdc-email-data-walensky-00018614

This article by Politico tips the CDC’s hand by showing how they will monopolize health data in the future under the auspice of “public health.”  An internal memo asks agency employees “to drive the success of the Data Modernization Initiative’’ — a CDC plan to strengthen the health surveillance infrastructure it relies upon.  Key points of the initiative:

  • unify public health data systems at the state and federal levels
  • “help” states hire staff to work on data collection & analysis (using $3 BILLION CDC funds)
  • create a “Travelocity”-like system where a “cloud-based” framework would allow staff to quickly analyze data and understand what is happening in real-time

HHS Protect took over part of U.S. COVID data collection at the beginning of the ‘pandemic’ which has since been taken over by the CDC.

It is clearly evident that the CDC wants to monopolize data.  Do we really want the CDC to have even MORE data, power, and authority when it has bungled nearly every single thing it has touched?

Sounds like a perfect prelude to global “vaccine” passports.

https://www.politico.com/news/2022/01/21/rochelle-walensky-cdc-overhaul-public-health-covid-

‘The CDC alone can’t fix this’: Walensky calls for overhaul of U.S. public health system

If the pandemic is to turn endemic — a situation top Biden health officials say they could more easily control — the U.S. needs to overhaul the nation’s public health workforce, she said.

https://popularrationalism.substack.com/p/whats-behind-the-live-with-covid?

What’s Behind The “Live with COVID” Message?

As fast as they can, they are trying to find a rug to sweep their fascism under. Many are pathetically seeking to retain legitimacy.

Infectious healthcare workers returning to work. Boris Johnson ends all COVID-19 restrictions. Israel ends all COVID-19 restrictions. CDC says we should learn to live with COVID and says five days’ isolation is “enough”. CDC will be re-visiting the number of COVID-19 cases and deaths – looking to determine how many who have died with COVID-19 actually died from COVID-19, not just died with COVID.

Why all of sudden?

After vaccine efficacy plummeted below the FDA required 50% efficacy – defined by FDA as a 50% reduction in the risk of “laboratory-confirmed” infection by the SARS-CoV-2 virus, or a similar level of reduction in symptoms of SARS-CoV-2 infection, FDA did not revoke the EUAs.

Why not?

The data are in from all over showing negative efficacy. It started with Israel. Then the UK. Then Barnstable County. Then Gibraltar. Then Scotland.

And now, the US.

CDC has admitted that natural infection is superior to vaccination.

The so-called establishment has lost the public’s confidence – and thus, their 36-year con game on vaccine safety is coming to an end.

It’s not just COVID.

It’s the flu vaccine. It’s the MMR. It’s TDAP. It’s seizures. It’s autism. It’s ADHD.

It’s death.

But it’s also been 36 years of job loss. Parents of vaccine-injured children are left without any help from the government to care for their injured children – so one of the parents has to stay home. It’s also divorce – the stresses of vaccine injury & death – especially if one’s marriage-related relatives or even blood relatives won’t accept the vaccine as the cause of a child’s death or injury.

With COVID, the lockdowns were the last straw. Over 500,000 small businesses closed. Jobs were lost. Drug use skyrocketed, and deaths from drug overdose are not at an epidemic level.

That’s the legacy of the public health “prevention” agenda.

COVID-19 has brought the public health con game into the very bright light of widespread public pain, discomfort, and grief. Public awareness of vaccine risk – vaccine risk awareness (VRA). People’s eyes are wide open.

Step 1. Re-define COVID-19 as a disease instead of the outcome of a test.

Step 2. Require Sanger confirmation of the presence of the virus and its typology.

Step 3. Official endorsement of ambulatory care for those with COVID-19.

Step 4. Stop causes ADE via vaccination against extinct variants.

Step 5. Punishment for individuals and organizations who have maligned the character and careers of those who provided the early warning system of the public health-disaster related to COVID-19 and vaccinations in general.

Step 6. Dismantling of the National Vaccine Injury Compensation Program, which devolved into institutionalized denial of vaccine injury and death.

Step 7. Start a true, new Public Health initiative to identify and address factors causing death and illness in American citizens. I have published this as #PlanB. It decentralized public health and protects it from capture – and it includes shuttering the CDC and any other captured agency in the US government. Read about Plan B here.

Step 8. Adopt a mass mentality of enhancement of the immune system to shift away from a tendency toward autoimmunity toward a tendency toward robust innate immunity and an appropriate adaptive immune response.

Each of us has a responsibility to act, every day, without relenting, to both open minds and to enact reform in who has control over our medical options from which we have to choose.

_______________

In this eye-opening expose’, US politicians have been profiteering on the pandemic.  With insider information, they transacted around $290 million because they know the future.

This is a perfect example of why public health has failed us.

**UPDATE Feb. 18, 2022**

http://  Approx. 13 Min

CDC Changes Vaccine Definition & Calls it ‘Normal’

Kim Iversen discusses what was posted here previously: The CDC changed the definition of a “vaccine” to validate the COVID mRNA gene therapies.

  • Prior to August 26, 2021, they defined a “vaccine” as a “product that stimulates a person’s immune system to produce immunity to a specific disease, protecting the person from that disease.”
  • Then they changed this to a “preparation that is used to stimulate the body’s immune response against diseases.” The difference is subtle but distinct:

The first one defined a vaccine as something that will “produce immunity.” The second one covers the mRNA jabs since they don’t “produce immunity,” but supposedly lessen the degree of infection – but many claim they don’t even do that.

But interestingly, Iversen must admit the truth: NO VACCINE is 100% perfect and breakthrough infections happen with ANY VACCINE.  She stumbles about, but it’s right there in purple crayon and important to remember. The next discussion of course, is that no vaccine is completely ‘safe and effective.’

https://www.theblaze.com/news/cdc-definition-fully-vaccinated-boosters?utm_source=theblaze-breaking

“And what we really are working to do is pivot the language to make sure that everybody is as up to date with their COVID-19 vaccines as they personally could be, should be, based on when they got their last vaccine,” Walensky said during Friday’s press briefing from the White House COVID-19 response team.

“So, importantly, right now, we’re pivoting our language,” Walensky added. “We really want to make sure people are up to date.”

Walensky defined “up to date” as: “That means if you recently got your second dose, you’re not eligible for a booster, you’re up to date. If you are eligible for a booster and you haven’t gotten it, you’re not up to date and you need to get your booster in order to be up to date.”

Only weeks ago, Walensky said the CDC is not changing the definition of what it means to be fully vaccinated.

(See link for article)

_____________________

**Comment**

Well, this was completely predictable.

It comes on the heels of data once again showing that natural immunity is best (which it always is), that repeated boosters are unsustainable, and likely weaken the immune system.

New Zealand is a fascinating a real-world experiment on COVID injection safety. After locking down from the rest of the world and strictly eliminating COVID as a variable, they went about with a mass “vaccination” campaign. NZ prime minister Jacinda Ardern’s ‘draconian measures’ are a ‘futile delaying tactic,’ and New Zealanders are “starting to work out that cornavirus is not going to be eliminated.” This is what happened:

  • they had a surge in all-cause mortality in the 60+ cohort that almost perfectly correlates with “vaccine” delivery intensity.More jabs = more deaths and fewer jabs = fewer deaths.
  • we’re being “trickle truthed” as the world comes to the realization that not only don’t two jabs work very well against omicron, but neither do three jabs and now four jabs.
  • Experts state repeated boosters are unsustainable and likely weaken the immune system.
  • While the U.S. mainstream media still hews to a stale campaign of trying to whip up more concern and fear over omicron, even the CDC has had to admit that omicron is a lot less deadly and far milder than delta.
  • The narrative is now fully shredded, but the agenda marches on. But for how much longer? People are waking up and the first large demonstration to defeat the “vaccine” mandates occurred in the U.S. on Jan 23 in Washington DC.
  • Go here to read “What’s Behind the ‘Live With COVID’ Message.” Weiler gives 8 steps needed to restore public health.

Then, there’s Quebec, where 90% are “vaccinated” yet have had some of the strictest COVID lockdown measures in the world, including a curfew that lasted FIVE months. Promised freedom if only 70% got the jabs, the opposite occurred. When Delta hit, when 9 out of 10 were “vaccinated,” they were hit with a “vaccine” passport system which also didn’t give them freedom when Omicron hit and everything was closed again.  Despite the fact that studies show Omicron is much weaker than previous variants, Quebec doubled down on the restrictions in full effect right now:

  • All private gatherings are banned
  • All public events are canceled, including sporting events
  • All restaurants, bars, and casinos are closed
  • All places of worship are closed (funerals are limited to 25 people)
  • All gyms are closed, extracurricular activities are canceled, most sporting activities are banned
  • All schools were closed until January 17th. Youth sports are banned.
  • All spas and saunas are closed
  • Mask mandate in all public places. Schoolchildren as young as 6 years old must wear masks in school at all times, including during phys ed.
  • Vaccine passports are required in ski resorts

But truth be damned.  Keep those shots rolling.

The CDC is constantly ‘pivoting’ language.