Archive for the ‘research’ Category

New Lyme Study Being Used to Support CDC Narrative: You Aren’t Infected, You Just Have A Simple Immune Response

https://www.nbcnews.com/health/health-news/lyme-disease-symptoms-recover-fast-others-not-rcna83340  Video Here (Approx. 4 Min)

Why some people recover from Lyme disease, while others experience months, years or even decades of chronic symptoms has long puzzled doctors. New research offers some clues to an immune system marker in the blood that is elevated among people with lingering Lyme disease symptoms, even after they’d received antibiotics.

In the new study, published on May 9 in the Center for Disease Control and Prevention’s Emerging Infectious Diseases journal, researchers found an immune system marker in the blood called interferon-alpha was elevated among people who had been treated for Lyme disease but had lingering symptoms.

Interferon-alpha is one of a handful of key signaling proteins the body makes to tell immune cells to fight off bacteria or viruses. If the blood levels are too high, the immune system can overact, causing pain, swelling and fatigue — symptoms often seen with Lyme disease.

In patients with high levels of interferon-alpha, the immune response to the Lyme bacteria may cause chronic inflammation, even once the infection is gone, said Klemen Strle, an assistant research professor of molecular biology and microbiology at Tufts University and an author of the new study.

“We think this is a possible driver of persistent symptoms,” Strle said. And since a number of drugs are already approved to lower interferon-alpha, he suggested the research could mean a possible treatment option for lingering Lyme symptoms.

The study was small, including 79 people diagnosed with Lyme disease, and found only a link between the higher interferon-alpha levels and the persistent Lyme disease symptoms, not that the immune marker was itself causing the lasting symptoms. A larger clinical trial would be needed to affirm the connection.

Male and female adult blacklegged ticks, Ixodes scapularis, on a sesame seed bun to demonstrate relative size.
Male and female adult black-legged ticks, Ixodes scapularis, on a sesame seed bun to show their relative size.CDC

Anywhere from 30,000 up to 500,000 people develop Lyme disease from a tick bite each year, according to the CDC. For most, the infection is mild and easily treated with antibiotics. About 10% experience symptoms like fatigue and brain fog along with muscle, joint and nerve pain that persists even after treatment.

The new findings represent a significant shift in understanding why some people infected with Lyme suffer chronic symptoms. Previously, some researchers believed that a specific strain of the spiral-shaped Borrelia burgdorferi bacteria that causes Lyme might be a cause. Others wondered whether undetectable low levels of infection lingered in the body after treatment. The new research suggests that the way the body reacts to the bacteria — not the bug itself — could result in long-lasting symptoms.

It’s still unclear why some people have elevated interferon-alpha, but Strle said he’s looking into a possible genetic cause.  (See link for article)

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To reiterate:

  • This study consisted of 79 people diagnosed with Lyme based off of matched serum and CSF samples.  Once again, no seronegative patients are represented.
  • A link between higher interferon-alpha levels and the persistent Lyme disease symptoms was found.  This does not prove causality.
  • This DOES NOT present a “significant shift in understanding.” It just supports the accepted, politicized CDC narrative that persistent/chronic infection doesn’t exist despite global research and reality which says it does.
  • Far more than 10% experience these depilating chronic symptoms.  They continue to regurgitate this number which only includes those diagnosed and treated early.  It doesn’t include the far larger subset of patients that are diagnosed and treated late.

Go here to read Lyme advocate Carl Tuttle’s letter to Strle where he reminds him that while interferon alpha has also been found in patients with chronic hepatitis, it wasn’t blamed for chronic hepatitis but rather was correlated with the presence of viral replication, or persistent viral infection.  He then reminds Strle of a 1995 case study on a Lyme patient who received multiple courses of IV and oral meds yet relapsed after each one and that the only way this patient stayed in remission was when kept on open ended clarithromycin.  To cinch the deal, Tuttle reminds Strle of a 2018 study of 12 Canadian Lyme patients who were culture positive for infection even after multiple years on antibiotics.  Tuttle simply but wisely asks the obvious question: would a chronic, persistent Lyme infection raise IFN-a levels?

‘The powers that be’ are desperate to continue the narrative because there’s a big Lyme “vaccine” in the pipeline that could make them lots of money.  A chronic/persistent infection would not be conducive to a vaccine.

Poland: Lyme Disease Cases up 93% in 2023

https://outbreaknewstoday.com/poland-lyme-disease-cases-up-93-to-date-in-2023/

Poland: Lyme disease cases up 93% to date in 2023

April 26, 2023

NewsDesk @bactiman63

This year, 2,753 cases of Lyme disease (a 93% increase) and 47 cases (a 236% increase) of tick-borne encephalitis have been confirmed in Poland, according to the latest data on infectious diseases.

This covers the period from January 1 to April 15 this year. During the same time in 2022, there were 1,423 cases of Lyme disease  and 14 cases of tick-borne encephalitis.

An educational campaign on the prevention of tick-borne diseases under the slogan “Don’t be attractive to ticks” has been launched.  (See link for article)

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For more:

Infection Strategies of Mycoplasmas: Unraveling the Panoply of Virulence Factors

https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1889813

Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors

Free PMC article

Mycoplasmas, the smallest bacteria lacking a cell wall, can cause various diseases in both humans and animals. Mycoplasmas harbor a variety of virulence factors that enable them to overcome numerous barriers of entry into the host; using accessory proteins, mycoplasma adhesins can bind to the receptors or extracellular matrix of the host cell. Although the host immune system can eradicate the invading mycoplasma in most cases, a few sagacious mycoplasmas employ a series of invasion and immune escape strategies to ensure their continued survival within their hosts. For instance, capsular polysaccharides are crucial for anti-phagocytosis and immunomodulation. Invasive enzymes degrade reactive oxygen species, neutrophil extracellular traps, and immunoglobulins. Biofilm formation is important for establishing a persistent infection. During proliferation, successfully surviving mycoplasmas generate numerous metabolites, including hydrogen peroxide, ammonia and hydrogen sulfide; or secrete various exotoxins, such as community-acquired respiratory distress syndrome toxin, and hemolysins; and express various pathogenic enzymes, all of which have potent toxic effects on host cells. Furthermore, some inherent components of mycoplasmas, such as lipids, membrane lipoproteins, and even mycoplasma-generated superantigens, can exert a significant pathogenic impact on the host cells or the immune system. In this review, we describe the proposed virulence factors in the toolkit of notorious mycoplasmas to better understand the pathogenic features of these bacteria, along with their pathogenic mechanisms.

For more:

Hemotropic mycoplasma is caused by bacteria from the Mycoplasma genus, which lack a cell wall and are unable to replicate by themselves. To survive they have to infect red blood cells. Like the other bacteria discussed here, emerging species are found in bats. Hemotropic mycoplasma may be a co-factor in white nose syndrome, a fungal disease that is killing bats.

Abnormal MRI Leads to Lyme Encephalitis Diagnosis

https://danielcameronmd.com/abnormal-mri-leads-to-lyme-encephalitis-diagnosis/

ABNORMAL MRI LEADS TO LYME ENCEPHALITIS DIAGNOSIS

elderly woman with lyme encephalitis laying in hospital bed

Encephalitis is a rare manifestation of Lyme disease with brain parenchymal inflammation being documented in only a handful of cases. In this study, the authors present the case of Lyme neuroborreliosis with encephalitis with “significant parenchymal inflammation on MRI imaging in an immunosuppressed patient.” [1]

In their article “Lyme neuroborreliosis with encephalitis: A rare case,” Rosendahl and colleagues describe a 74-year-old immunocompromised woman, who was admitted to the hospital with confusion, paranoid delusions, weight loss, back pains, and a history of fever and vomiting suspect of cancer and infection of unknown origin.¹

The woman had been hospitalized 4 times over a 4-month period.

She had a history of Lupus, myasthenia gravis (azathioprine and pyridostigmine treated), osteoporosis and atrial fibrillation. But did not have a history of dementia or psychiatric illness.

Initially, she was treated for possible bacterial meningitis and viral encephalitis.

The woman did not recall having a tick bite, EM rash or painful meningoradiculitis. “However, approximately three months prior the patient was efficiently treated for a non-itching universal skin rash with a topical steroid and antihistamines.”

This is the “first case of confirmed [Lyme neuroborreliosis] encephalitis with significant parenchymal MRI changes in a broadly immunosuppressed patient.”

Based on her spinal tap and MRI results, the woman was diagnosed with Lyme meningitis and treated with IV ceftriaxone followed by a week of oral doxycycline.

Her repeat spinal tap findings had improved. The hyperintensities in basal gangliae and thalamus resolved. However, she was left with cognitive problems, such as memory loss.

The authors discussed the need to consider Lyme encephalitis in a patient presenting with uncharacteristic symptoms for 3 months.

Note: This is a European case study involving a woman suspected of contracting Lyme disease from the tick species B. garinii. The results of this case may not apply to those in the U.S. involving infections from B. burgdorferi.

Researchers Had a Simple Test for Determining if an Asymptomatic Person Who Tested Positive for COVID Was Infectious – But CDC, Fauci Ignored It

https://childrenshealthdefense.org/defender/test-asymptomatic-covid-positive-person-infectious-cdc-fauci/

Researchers Had a Simple Test for Determining if an Asymptomatic Person Who Tested Positive for COVID Was Infectious — But CDC, Fauci Ignored It

Researchers at Stanford University who developed the test also determined that the vast majority of asymptomatic individuals who tested positive96% — did not transmit the virus.

A test that can accurately determine whether an individual with a positive PCR test result for COVID-19 is infectious was available as early as May 2020 — but public health authorities appear to have ignored it.

Researchers at Stanford University who developed the test also determined that the vast majority of asymptomatic individuals who tested positive — 96% — did not transmit the virus.

Investigative reporter and author David Zweig, a previous contributor to the release of the “Twitter files,” first reported on the test on his Substack.

“Transmission from asymptomatic people is far, far less common than we were led to believe,” Zweig wrote. “The novel test at Stanford that showed a very low rate of infectious asymptomatic people who had tested positive was available as early as May 2020.”

“Yet the CDC [Centers for Disease Control and Prevention] and other health authorities did nothing,” Zweig said.

Zweig appeared Thursday on The Hill’s “Rising,” where he told the show’s hosts:

“At Stanford, they developed a test in May of 2020, the very beginning of the pandemic, that actually could find out whether or not you were infectious.

“After you had taken a regular PCR test, if it showed you were positive, they could determine whether or not that positive test meant you could actually infect others or not.”

Zweig wrote that while the standard PCR test commonly administered during the COVID-19 pandemic “detects whether someone has the virus … it cannot detect whether the person is capable of infecting others.”

The test developed by Stanford researchers, however, was able to accomplish this. As Zweig explained:

“SARS-CoV-2 is a positive or ‘plus-stranded’ RNA virus. For it to replicate it must do so with a minus strand.

“Brilliantly, the Stanford test looks to see if the minus strand is present. If it is then that indicates the virus is actively replicating, which means it’s potentially infectious. If the minus strand is absent then the virus is not replicating. (It is not possible to transmit the virus if it is not replicating.)”

Benjamin Pinsky, Ph.D., medical director of Stanford’s Clinical Virology Laboratory and medical co-director for Point of Care Testing, was one of the researchers involved in the development of the test. He told Zweig the purpose of the test was to help hospital clinicians accurately determine if patients were infectious or not.

“The minus strand test gave a definitive answer one way or another,” Zweig wrote. But although the test was available as early as May 2020, the CDC did not publish the researchers’ paper about the test until February 2021.

The paper, published in the Emerging Infectious Diseases journal, stated that the analytical validation for the test was conducted “during May-June 2020.”

By publishing the paper in early 2021, federal agencies “certainly were aware that this test existed” even prior to its publication date, Zweig told “Rising.”

“This raises serious questions for those in charge of the CDC, NIH [National Institutes of Health], and NIAID [National Institute of Allergy and Infectious Diseases] for why resources were not allocated toward making this test broadly available,” Zweig wrote on his Substack, adding:

“Though the test was developed for use in hospitals, its utility outside of a medical setting is obvious.

“Regular people could have paid for the test to find out after they got over a bout of COVID whether they were still infectious or not, enabling them to go to work, visit relatives, and so on. Millions of kids could have tested out of isolation.”

Zweig told “Rising” that while it’s unclear why the paper wasn’t put out more broadly, “the fascinating part is we had this tool to give us an answer to a question that was merely conjecture for the entire pandemic.”

What’s more, according to Zweig, Stanford researchers “later looked at data from this test from July of 2020 through April 2022, and answered the question health authorities neglected to answer,” finding that “only 4% of asymptomatic SARS-CoV-2 PCR-positive patients were shown to be infectious.”

Zweig noted, however, that this percentage did decrease during the “Omicron wave,” where the infection rate among asymptomatic patients “peaked at about 25%.”

One of the researchers involved with the follow-up study, Dr. Ralph Tayyar, is an Infectious Diseases fellow at Stanford. He presented his findings at the Society for Healthcare Epidemiology of America’s conference in April and told Zweig that the effectiveness of restrictions on asymptomatic individuals was likely lower than claimed.

Using the classroom environment as an analogy, Tayyar told Zweig, “The probability of a kid in class who is not sick actually being infectious is very low.”

Tayyar noted that while public health officials did not adopt the Stanford test, Stanford itself stopped conducting admission screen testing. He said there was no evidence that this resulted in an increase in transmission of COVID-19.

“The CDC could have immediately conducted a huge study to actually answer the question health officials had only been conjecturing about — what percentage of positive people without symptoms have the capability of infecting others,” Zweig said, but opted not to.

Instead, Zweig wrote, during the first few months of the COVID-19 pandemic, “The specter of asymptomatic transmission undergirded not just policies on masks, but on distancing, and quarantines as well.”

According to Zweig, Dr. Anthony Fauci referred to the purported threat of asymptomatic spread to justify his “180 on community mask recommendations.” For instance, Fauci told The Washington Post in July 2020:

“We didn’t realize the extent of asymptotic spread … as the weeks and months came by, two things became clear: one, that there wasn’t a shortage of masks, we had plenty of masks and coverings that you could put on that’s plain cloth … so that took care of that problem.

“Secondly, we fully realized that there are a lot of people who are asymptomatic who are spreading infection. So, it became clear that we absolutely should be wearing masks consistently.”

The concept of “silent spread” was so influential that Dr. Deborah Birx, the White House Coronavirus Response Coordinator from Feb. 27, 2020, to Jan. 20, 2021, named her book “Silent Invasion: The Untold Story of the Trump Administration, Covid-19, and Preventing the Next Pandemic Before It’s Too Late” after it, Zweig said.

“The entire apparatus of our pandemic response — which, most consequentially, kept millions of healthy children out of full-time school for more than a year — was based on this notion,” Zweig wrote.

Other studies also showed that asymptomatic spread of COVID-19 was uncommon.

“In June 2020, Dr. Maria Van Kerkhove, head of the World Health Organization’s [WHO] emerging diseases and zoonosis unit, said that transmission from asymptomatic people was ‘very rare,’” a “conclusion based on a number of countries doing very detailed contact tracing,” Zweig wrote.

However, “the next day, after criticism from some health professionals, WHO officials walked back her statement, and Van Kerkhove said it was a ‘complex question,’” Zweig added.

And an editorial published in The BMJ in December 2020 stated that “Searching for people who are asymptomatic yet infectious is like searching for needles that appear and reappear transiently in haystacks.”

However, these findings were overshadowed by research claiming that a substantial percentage of COVID-19 infections were caused by asymptomatic individuals.

According to Zweig, such findings “supported the health authorities’ messaging … justified various community interventions” and were “covered everywhere.”

“[Many] of the actions we were told — or compelled — to take, including an acceptance of all those closed or half-empty schools, had little to no benefit,” Zweig wrote. “Schools — as they did in Sweden — and most of society could have simply followed the classic advice ‘if you’re sick, stay home,’ and we would have ended up in the same place.”

Zweig told “Rising” he did not want to speculate on why the Stanford study wasn’t rolled out. “I view my job as to merely bring this to light and … that’s a larger conversation,” he said. “Perhaps something even that investigators within the Congress or others can look into.”

This article was originally published by The Defender — Children’s Health Defense’s News & Views Website under Creative Commons license CC BY-NC-ND 4.0. Please consider subscribing to The Defender or donating to Children’s Health Defense.

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**Comment**

Nothing new here.  The CDC has vested interests by owning patents on testing and therefore refuses to use anyone else’s test.  In fact, the agency has bullied smaller more accurate CLIA-certified labs by name-calling them “home-brewed.”  Mainstream doctors that aren’t privy to this bullying tactic fall in line and refuse to use any testing but the abysmal 2-tiered CDC testing which misses 7086% of cases.  I mean, why even bother?  It’s a complete crap-shoot!

Lyme/MSIDS has been and continues to be tyrannically ruled by CDC testing for over 40 years.  Everyone and their dog knows these tests suck, but here we are.  There is even a lawsuit against the CDC for this testing monopoly. Dr. Sin Hang Lee has sued the CDC for suppressing direct detection tests for Lyme disease, and promoting their own newly patented, unproven metabolomics technology for diagnosis of LD. Current and former CDC representatives receive royalties as a result of working on the approval and promotion/CDC endorsement of a Lyme disease serology test.  Lee’s 16S rRNA gene sequencing was able to accurately detect early infection before antibody production.

But the CDC wants nothing to do with Lee’s test either.

You see it isn’t about accurately testing people or even caring if they are truly infectious or not.  It’s about money and power by controlling the narrative.  He who controls testing controls the narrative because they can utilize testing to give the appearance of anything they want even if it’s wrongWell the test says it so it must be right!  They can can fabricate a ‘pandemic’ out of thin air which they have done with bird flu, COVID, HIV/AIDS, and many others through testing, and then turn around and downplay a real 21st century plague (Lyme/MSIDS) also through testing.  It truly is an ingenious scheme where ‘public health’ always wins, makes boatloads of money, and patients lose.  Every. Time.

Just ask Lyme/MSIDS patients. The CDC has controlled the narrative for decades and nothing appears to be able to change this. The CDC has successfully controlled the COVID narrative despite face-planting so many times its expected, and nothing appears to be able to change this as well because few are truly paying attention and the ones that are get censored, bullied, and character assassinated. These are commonly deployed tactics that have been used many times before leaving many doctors too afraid to even treat patients.  You’d think people would catch onto it.  I mean, fool me once, shame on you.  Fool me twice, shame on me.

Understanding their tactics makes it quite easy to understand why the CDC wants nothing to do with determining infectiousness in asymptomatic patients.  They needed a boogie-man and the asymptomatic were the perfect monsters for their diabolical scheme – as well as the unvaccinated who were treated like second class citizens.  With Lyme/MSIDS it’s always been about a lucrative “vaccine,” so they need to frighten people just enough to want it, but at the same time they need to continue to deny the real problem of chronic/persistent infection because that would negate the need for a “vaccine.” It’s a tight-rope act the CDC balances perfectly.  Just continue to deny reality and world-wide research showing pathogen persistence, and only mention how bad things are right before a “vaccine” roll-out.  Now that you know their script, watch for it.