Archive for the ‘research’ Category

First Case Report of Pancreatitis in Lyme Disease

https://researchopenworld.com/first-case-report-of-pancreatitis-in-lyme-disease/

First Case Report of Pancreatitis in Lyme Disease

Publication history

Received: November 14, 2019
Accepted: November 21, 2019
Published: November 25, 2019

Citation

A Baisse, S Parreau, A Abdeh, N Pichon (2019) First Case Report of Pancreatitis in Lyme disease. Internal Med Res Open J Volume 4 (2): 1–2. DOI: 10.31038/IMROJ.2019423

Short Abstract

We report a case of Lyme disease, revealed by pancreatic damage in a 49-year-old man without any medical history. The Lyme disease was revealed by repeated abdominal pain for 4 weeks, a skin lesion of quadricipital region, biological and radiological results showing pancreatic abnormalities.

Case Report

A 49-year-old man, non-alcoholic forest worker, with no past medical history, consulted to the Emergency Department for fever and persistent abdominal pain for a week. The biological results including, C – reactive protein (CRP), lipase, hepatic assessment were normal as well as contrast-enhanced abdominal Computed Tomography (CT). On the day after, the evolution was favorable under symptomatic treatment including nefopam and paracetamol and the patient was discharged from the hospital. One week later, the patient was admitted to the Emergency Department with an identical symptomatology. A posterior quadricipital peeling skin lesion, appeared two weeks earlier according to the patient, was observed (Figure 1a.) A gastroscopy, a colonoscopy, other abdominal CT and biological tests were performed. An inflammation biomarker elevation was observed (CRP: 180 mg/L and hyperleukocytosis: 13.3 G/L) without other biological abnormalities (lipase: 48 UI/L, ALAT: 48 UI/L). The endoscopic examinations and abdominal CT were normal. The patient was discharged from the hospital without any treatment. Half a month later, the patient was admitted to the Emergency Department for the third time and recurrence of the abdominal pain. The clinical examination found a hemodynamic stability, an abdominal pain of the left hypochondrium associated with a cutaneous ulcerative and non-progressive skin lesion in the same region as previously mentioned (Figure 1b.). The biological assessment found a very mild inflammatory syndrome (CRP 86 mg/L, Procalcitonin < 0.2 ng/mL, leukocytes 9.5 G/L), a high lipase level at 1714 IU/L without hepatocellular abnormalities. The third abdominal CT revealed an aspect of pancreatic necrosis with a pseudocyst (6 cm) at the tail of the pancreas, in contact with the splenic hile and the posterior wall of the stomach (Figure 1c.). The patient was hospitalized in Intensive Care Department with the diagnosis of pancreatitis.

On admission, the work-ups looking for the usual causes of pancreatitis (alcohol, gallstones, medications induced, hypercalcemia, traumatic, chemical exposures, hereditary diseases, infections) were negative. Regarding the skin patient’s lesion and anamnesis, the diagnosis of Lyme disease was evoked. His Lyme serology was strongly IgM positive and confirmed by Western Blot. He was treated with ceftriaxone associated with effective analgesic therapy. The clinical and biological course was uneventful and the patient was discharged from the hospital after 3 weeks. The relationship between Lyme disease and acute pancreatitis was strongly suspected.

Discussion

Lyme disease is an endemic zoonosis, transmitted to humans by a tick bite causing a multisystemic impairment due to a Gram-negative bacillus, Borrellia burgdorferi [1]. The disease schematically includes two phases and a polymorphism in clinical manifestations: a primary phase with chronical migrans erythema and articular signs (80% of cases), a secondary phase of heterogeneous and lymphatic dissemination, inaugurated by flu-like symptoms and associating neurological, cardiac or articular signs that could become chronic [2]. Each of these attacks could be inaugural or/and isolated [3]. Concerning the anamnesis, only 30% of patients remember a tick bite [4].

The heterogeneity of presentation in Lyme disease includes the serodiagnosis as a central investigation for confirmation [5]. Hepatic impairment due to Lyme disease, including hepatitis and hepatomegaly, is inconsistent, commonly found in early stage but often asymptomatic and with plasmatic manifestations [6]. A moderate hypertransaminasemia (2 to 3 N) could be noted, predominating on the ALAT. This hepatic biologic involvement is present in 27 to 66% of cases [7]. This can be explained by a systemic, lymphatic migration of the incriminated bacteria and a secondary hepatic sequestration [8]. To our knowledge, this physiopathological evolution to explain liver disorders has never been described for pancreas but is probably similar.

Regarding the treatment of Lyme disease, the cycline are recommended for the uncomplicated forms. An antibiotic treatment with cephalosporins could be considered for cardiac, neurological or complicated cases [2]. The evolution is favorable in 85% of patients, including hepatic acute injuries [9].

In our case, the skin lesion associated with a supposed tick bite, the anamnesis, the absence of other cause of pancreatitis, the favorable evolution under antibiotic treatment and especially the strong positivity of the serology are in favor of a Borrelia burgdoferi infection.

Conclusion

The authors report the first case of pancreatitis revealing a Lyme disease. Clinical, biological and evolutionary findings support the responsibility of Lyme disease in the pathogenesis of our pancreatitis case.  (See link for article and pictures)

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**Comment**

How many patients have had this or similar issues but didn’t have the rash, had negative serology and didn’t fit the other arbitrary standards that mainstream medicine has imposed that thousands of other patients don’t fit?  God only knows.

Category:

Lyme, research, Testing, Treatment

Pandemic Preparedness & The Road to International Fascism

https://onlinelibrary.wiley.com/doi/10.1111/ajes.12531?

Pandemic preparedness and the road to international fascism

First published: 30 July 2023
https://doi.org/10.1111/ajes.12531
Read the full text

Abstract

The World Health Organization’s broad definition of health embraces physical, mental and social well-being. Expressed in its 1946 constitution alongside concepts of community participation and national sovereignty, it reflected an understanding of a world emerging from centuries of colonialist oppression and the public health industry’s shameful facilitation of fascism. Health policy would be people-centered, closely tied to human rights and self-determination. The COVID-19 response has demonstrated how these ideals have been undone. Decades of increasing funding within public-private partnerships have corroded the basis of global public health. The COVID-19 response, intended for a virus that overwhelmingly targeted the elderly, ignored norms of epidemic management and human rights to institute a regime of suppression, censorship, and coercion reminiscent of the power systems and governance that were previously condemned. Without pausing to examine the costs, the public health industry is developing international instruments and processes that will entrench these destructive practices in international law. Public health, presented as a series of health emergencies, is being used once again to facilitate a fascist approach to societal management. The beneficiaries will be the corporations and investors whom the COVID-19 response served well. Human rights and individual freedom, as under previous fascist regimes, will lose. The public health industry must urgently awaken to the changing world in which it works, if it is to adopt a role in saving public health rather than contributing to its degradation.

For more:

Category:

research, Viruses

Research Suggests Cancer Medication Could Help Fight Lyme Disease

https://www.wamc.org/news/2023-08-08/research-suggests-cancer-medication-could-help-fight-lyme-disease

Research suggests cancer medication could help fight Lyme Disease

WAMC Northeast Public Radio | By Jim Levulis
Published August 8, 2023
U.S. Dept. Of Agriculture

Research out of UMass Amherst suggests medication used to stop the spread of cancer may help fight tick-borne illnesses such as Lyme Disease. WAMC’s Jim Levulis spoke with Stephen Rich, the executive director of the New England Regional Center of Vector-borne Diseases, about the study and how it relates to existing Lyme treatments.

Rich: Generally that’s antibiotic treatments, most often doxycycline. A reasonable course of doxycycline takes care of most early detected Lyme disease cases. There other antibiotics where doxycycline is contraindicated, there are other antibiotics that work as well. Things like amoxicillin, but basically antibiotics.

(See link for article and interview)

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SUMMARY:

  • Lyme spirochetes have a dependency upon a particular pathway called glycolysis which is dependent upon lactate dehydrogenase or LDH.
  • Certain cancer cells are similarly constrained in their metabolic profiles.
  • Inhibitors of the LDH molecule have been used to treat cancerous tumors.
  • The inhibitors, when tested in the test tube against Lyme spirochetes didn’t eliminate the borrelia, but they stopped it from growing (bacteriostatic).
  • They are now going to test this in lab animals and then companion animals or people.
  • Despite it being a wet, warm July in Massachusetts, there were lots of ticks at work.

For more on Lyme treatments utilized by experienced Lyme literate doctors (LLMDs) go here.

I must add that this proves ticks are ecoadaptive and tick and disease proliferation has nothing to do with the weather or supposed ‘climate change,’ which is simply a propaganda narrative touted by climate scientists who are on a “gravy train” to secure funding via government grants.

Expert after expert has stated “there is no climate emergency.”

Further, ‘the powers that be’ are using the climate agenda to desperately push a much bigger diabolical plan:  UN’s  Our Common Agenda platform, the WHO’s Pandemic Treaty, and the WEF’s depopulation, massive surveillance, and censorship designs which will give unelected officials unlimited power with ZERO oversight.

Do not fall for the unscientific clap-trap of ‘climate change.’  It’s part of an evil dystopian plan.

Category:

Cancer, Lyme, research, Treatment

Leprosy in Florida

**UPDATE**

According to this, ticks have the potential of acting as a reservoir and/or vector of leprosy.  Mycobacterium drugs have also been found to help chronically infected Lyme/MSIDS patients.  Nobody is talking about this connection, but the following connections have been discussed:

  • Researchers in both India and the U.K. have found links between leprosy adverse events and COVID shots in people previously diagnosed with leprosy.
  • Zoonotic transmission from armadillos (but nobody’s been around them that’s infected)
  • International human migration (which doesn’t explain why Texas hasn’t been hit with leprosy)

According to the CDC, leprosy is very rare in the U.S., with fewer than 200 cases reported per year and most contracting it in a foreign country.

Dr. Robert W. Malone said he believes the sudden reporting on leprosy is “fearporn,” but added, “There is no question that being immunosuppressed is a key factor to contracting leprosy.”

He added:

“Therefore, as mRNA inoculations cause immunosuppression, it has been hypothesized that in some individuals this could pose a higher risk of contracting the disease after vaccination.”

http://  Approx. 11 Min

CDC Issues Alert on Leprosy

Aug. 4, 2023

Facts Matter with Roman Balmakov

Historically uncommon in the U.S., Leprosy, or Hansen disease is a chronic infectious disease caused by Mycobacterium leprae.  Florida accounts for 81% of leprosy cases and 159 new cases were reported in 2020.

The CDC is clueless as to transmission but states that prolonged person-to-person contact through respiratory droplets is the most likely culprit, but this has never been proven.

The strains found are the same strains found in 9-banded armadillos in the region so they hypothesize zoonotic transmission.  (Is this sounding familiar yet?)  The fly in that ointment is that these patients have had ZERO exposure to this animal.  Other research suggests international human migration.

Romanov states it is an interesting coincidence that the cases are being found either in Southern states or the sanctuary state of New York where illegal migrants have been flowing over the boarders.

While no research on this has been done on the topic of migration and leprosy in the U.S., researchers in other countries have done this work and found a direct link between migration of people from countries that have leprosy and a surge in leprosy cases.  Spanish researchers found that their spike in leprosy was not related to African migrants but from South American migrants (Brazil, Paraguay, Bolivia, and other South and Central America nationalities).

South American immigrants in North America increased from 27.6 M in 1990 to 58.7 M in 2020 so even the CDC admits the potential link to migration and leprosy cases in nonendemic areas, yet people continue to flow over the border.  According to this report, there are nefarious reasons for this.

  • Both Texas and California are allowing immigrants to be peace officers even though they know nothing about the Constitution or the Bill of Rights.
  • Texas’ Gov Abbot built a facility to house 200,000 illegals who are bringing infectious & antibiotic resistant diseases such as drug resistant TB.  Tens of thousands of cattle in Texas are now being slaughtered due to these migrants transmitting this TB to the cattle, which further reduces meat in the food supply.
  • They have also built state of the art “schools” to be used as indoctrination camps to potentially weaponize these migrants against U.S. citizens by dangling carrots
  • TrakkaSystems advanced camera technology is being used to capture imaging so journalists and freedom workers on the ground can show the public what is happening at the border and that the problem is much worse than what we are being told.
  • Elon Musk’s Starlink system is used for communications.
  • SpaceX located nearby is allowing illegals to cross that property while others cannot enter.

So what other changes have been occurring in Florida?  Don’t forget the massive release of GMO mosquitoes, i.e. Frankinbugs, which are effective dirty needles spreading disease which are now being seriously considered to “vaccinate” people. This technology goes back to 2010 when Japanese researchers genetically modified mosquitoes to produce SP15 against leishmaniasis (parasitic disease spread by sand flies).

Yes folks, it’s getting more frightening by the day.

Category:

Activism, mosquitoes, research

3 Lyme Disease Vaccines in the Pipeline: RUN AWAY FAST

https://danielcameronmd.com/3-lyme-disease-vaccines-in-the-pipeline/

3 LYME DISEASE VACCINES IN THE PIPELINE

lyme-disease-vaccine
National Geographic magazine recently published an article, “Lyme disease is spreading fast—but a vaccine may be on the way.” In it, Guynup summarizes three Lyme disease vaccines that are currently in the pipeline. [1]
By 

In 1998, the first Lyme disease vaccine was introduced by LYMErix but it was pulled from the market after 3 years due to poor sales and possible safety concerns. The FDA was never able to confirm that the vaccine caused harm despite concerns.

Only recently have drug makers resumed researching new human Lyme vaccines.

“But the challenge now is creating vaccines that will protect against the seven globally known strains of Lyme disease,” says Obadiah Plante, who leads the bacteriology team at Moderna.

Pfizer/Valneva candidate: VLA15 and Moderna are both developing vaccines that target the bacterium’s Outer Surface Protein A (OspA). The spirochete that causes Lyme disease produces OspA in the tick. The vaccine is intended to create “antibodies that prevent the organisms from suppressing OspA when the tick next feeds,” the author explains. “This will render them immobile, imprisoned within the tick’s intestine and unable to infect a human host.”

The vaccine is not expected to work after the infection enters humans, as the spirochete changes proteins from OspA to Outer Surface Protein C (OspC).

“The Pfizer/Valneva candidate, VLA15, is farthest along and is being tested in a phase three clinical trial that launched in the summer of 2022,” writes Guynup.

Two study sites (Nantucket and Martha’s Vineyard) were halted due to protocol violations. “In an email, a spokesperson for Pfizer noted that the study is expected to wrap up in December 2025,” Guynup points out.

Moderna, best known for developing a COVID-19 vaccine using mRNA technology, has been working on two Lyme disease vaccines using this same technology.

Moderna will begin human trials this summer with 800 participants in the U.S. between 18 and 70 years old.

The first vaccine, named mRNA-1982, contains a single mRNA that targets the Borrelia bacteria species that causes most cases of Lyme disease in the U.S.

The second vaccine, named mRNA-1975, contains a mixture of seven mRNAs targeting the Borrelia species that cause most cases of Lyme disease in both the U.S. and Europe.

MassBiologics is taking a different approach, using monoclonal antibody targeting OspA.

This vaccine may offer immediate protection, while it can take months for immunity to develop with the Pfizer and Moderna vaccines.

“Within days after you get the subcutaneous injection, you’ve absorbed enough of the antibody so you’re immediately immune,” says Mark Klempner, a professor of medicine and vice chancellor emeritus of MassBiologics at UMass Chan Medical School.

According to Klempner, when 20 infected ticks were placed on nonhuman primates “this antibody treatment provided 100 percent protection.”

The company hopes to apply for approval from the FDA in 2025.

Author’s Note: The safety and efficacy of these vaccines are not yet available for doctors to weigh the pros and cons of offering a vaccine. Furthermore, none of the vaccines is designed for protecting against a co-infections.

References:
  1. Lyme disease is spreading fast but a vaccine may be on the way. National Geographic. Guynup, Sharon. May 15, 2023. https://www.nationalgeographic.com/premium/article/vaccine-prevention-lyme-disease-epidemic-tick-treatment

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**Comment**

Category:

Lyme, research, vaccines