Author Archive

Inflammatory mRNA Nanoparticles Inhibit & Alter Immune Response: Preprint Study

https://www.biorxiv.org/content/10.1101/2022.03.16.484616v2.full

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

Zhen Qin, Aurélie Bouteau, Christopher Herbst, Botond Z. Igyártó
doi: https://doi.org/10.1101/2022.03.16.484616

This article is a preprint and has not been certified by peer review [what does this mean?].

ABSTRACT

Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure to the mRNA-LNP on adaptive immune responses and innate immune fitness. We found that pre-exposure to mRNA-LNPs or LNP alone led to long-term inhibition of the adaptive immune responses, which could be overcome using standard adjuvants. On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while Candida albicans decreased. The diminished resistance to Candida albicans correlated with a general decrease in blood neutrophil percentages. Interestingly, mice pre-exposed to the mRNA-LNP platform can pass down the acquired immune traits to their offspring, providing better protection against influenza. In summary, the mRNA-LNP vaccine platform induces long-term unexpected immunological changes affecting both adaptive immune responses and heterologous protection against infections. Thus, our studies highlight the need for more research to determine this platform’s true impact on human health.

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SUMMARY:

  • Many studies in mice have since found that the lipid nanoparticles (LNPs) claimed to be non-toxic and safe, are actually highly inflammatory and highly durable – lasting for a month in the body.
  • The authors speculate that the resistance to influenza is not from strengthened immunity but is a product from an alternative pathway triggered by LNPs, and it’s unknown whether this resistance will apply to other infections.  The reason for this is due to the fact the mice were more susceptible to fungal infections.
  • There have been reports of COVID-19 vaccinated individuals developing rare fungal diseases and others with worsening of pre-existing fungal diseases.
  • The mice getting the injections had lower neutrophils, the important and common first responder immune cells.
  • The study also corroborated previous findings that the more shots, the greater the adverse reactions due to the lower T and B cell responses.
  • The authors also found that if T progenitor cells were removed before the injection, and then returned after the injection, active T cell numbers were not reduced suggesting that the lipid nanoparticles directly reduce T progenitor cells and therefore the T cell response.
  • The authors speculate that reduced immunity should not be permanent, but nobody truly knows.
  • While the study showed that immunity could be passed onto offspring, particularly if both parents are immunized, the study did not address if the offspring also inherit immune weakness such as the decline in immunity against C. albicans.
  • The increased rate of disease reported to VAERS after COVID injections, as well as many reports of emerging cancers also demonstrates reduced immunity in the “vaxxed.”
    • 284 cases of breast cancer were reported after the COVID shots, while just 350 cases have been reported in the entire history of VAERS.
    • 269 cases of leukemia were reported after the COVID shots, compared to 432 cases in the entire history of VAERS.
    • 7,559 cases of shingles have been reported after the COVID shots when 28,180 cases have been reported following any vaccination – meaning around a quarter of cases occurred after the COVID shots.  The CDC has indicated that a new case or recurrence of shingles primarily occurs in people with compromised immune systems and is a sign of weakened immunity.  Source

Category:

research, vaccines, Viruses

Lyme Detox 101 Basics

https://www.treatlyme.net/guide/lyme-detoxification-101-the-basics  Video Here (Approx. 5 Min)

Updated: 6/13/22

By Dr. Marty Ross

How to Detoxify in Lyme Disease

In this video and written article, I describe basic steps a person can take to detoxify in Lyme disease. The basic steps include:

  • eating organic foods to avoid toxins
  • living in a mold free environment to prevent absorption of mold toxins
  • avoiding toxic chemicals in your home
  • supporting liver detoxification with glutathione
  • promoting regular bowel movements to eliminate toxins
  • drinking plenty of water to support kidney detox and to promote regular bowel movements
  • sweating through sauna or exercise as tolerated
  • binding toxins in the intestines with binders if needed

A Word About Feeling Toxic

Often people report they “feel toxic” in Lyme treatments.  A major cause of feeling toxic is due to excessive cytokines the immune system makes as it tries to control Lyme infection.

A good way to deal with “feeling toxic” is to lower cytokines and work to remove the toxins triggering the cytokines. Read more about how to lower cytokines in Control Cytokines: A Guide to Fix Lyme Symptoms & The Immune System. Two basic steps that support lowering cytokines are to take liposomal curcumin and to use liposomal glutathione.

The Basic Steps to Lyme Detox

Keep Toxins Out

Start with your diet – eat organic foods. These do not contain harmful poisons. For specific diets I recommend see The Best Brain, Inflammation, Pain, Energy, and Detox Diet Ever and Elimination Diet to Find Problem Foods.

Avoid toxins in your environment. This includes mold toxins. Also use green cleaning supplies. The fumes and gasses of toxic cleaning supplies get absorbed into the bloodstream through the lungs.

Support Toxin Removal by The Liver, Intestines, and Kidneys

From the blood, toxins are cleaned out of the body by the liver. The liver transforms toxins from fat-based forms to water-based forms by tagging them with water-based chemical groups. In the intestines the tagged toxins are then moved out of our bodies through the stools. However, if a person does not have regular bowel movements, bacteria in the intestines can remove the water-based tag. If this happens, the now fat-based toxins move into the blood. Fiber in the diet and water intake promote regular bowel movements. In addition, fiber can bind the fat-based toxins so that they do not get reabsorbed.

Some use coffee enemas for detox. The tannins in coffee irritate the intestine lining causing bowel movments. There is a very small effect of coffee promoting more toxin release by the liver – but this is quite small. Because they have similar effects promoting bowel movements, I find using fiber and water in the diet is easier than coffee enemas.

Fiber & Water Support Detox

Water. It is important to drink 1/2 of your ideal body weight in ounces daily (ie: a 150-pound person should drink 75 ounces of water a day). This helps to flush the kidneys and promotes regular bowel movements.

Fiber. To bind toxins in the intestines and to promote regular bowel movements have 3 or more servings a day of fiber. Foods rich in fiber are beans, legumes, and whole grains. Apples are also a good source. To determine how much to have in a serving, I advise that a clenched fist is roughly equal to two serving sizes.

Support Liver Detoxification

Liver detoxification requires glutathione. Glutathione is a very powerful antioxidant generated in all cells and used in the liver to detox fat soluble toxins. Faced with toxin excess, the liver can exhaust its glutathione supplies. Most forms of oral glutathione are poorly absorbed. However there are sources designed for improved absorption which microscopically wrap the glutathione in fats called phospholipids. This type is called liposomal glutathione. For more information see Glutathione: The Great Fixer.

In my practice, I find that glutathione is more effective at promoting detox than other products like Nutramedix Burbur and Pinella. I do not recommend these supplements, but go with glutathione instead.

Sweat to Remove Toxins

Sweating through exercise, hot baths, or using infrared saunas can help remove toxins. When you heat up and sweat, toxins move to the liver and some move to your sweat. About 80 percent are cleared by the liver and about 20 percent are removed in the sweat. For more information about saunas and hot baths see Far Infrared Sauna Detox: More Than Sweat.

Use Binders to Remove Toxins

At times it helps to bind toxins in the intestines so they cannot get absorbed into the bloodstream using binders. Binders include bentonite or zeolite clay, activated charcoal, silica, humic acid and fulvic acid. Some companies make products which contain a number of these binders together in one pill.

Probiotics and Detox

Healthy bacteria that line the intestines remove toxins. In Lyme disease it is common to have unhealthy bacteria in the intestines due to herbal or prescription antibiotics and the stress of the illness. Rebuilding the healthy lining with high quality probiotics can help with detox. For more information about probiotics see Probiotics in Lyme Treatment.

Dosages For Supplements in This Article

Glutathione

Liposomal Glutathione 400 to 500 mg 1 to 2 times a day. An example of liposomal glutathione shown to raise cell levels of glutathione is Tri-Fortify by Researched Nutritionals. (3)*

Curcumin

Liposomal Curcumin 500 mg 1 or 2 pills 3 times a day. An example of liposomal curcumin is Meriva 500 SF by Thorne.

Probiotic to Support Healthy Intestinal Function and Detox*

Multi-biome by Researched Nutritionals 1 to 2 pills 1 time a day. This product is a soil-based spore-forming probiotic that includes strains of Bacillus scientifically proven to support intestinal health. It also includes human strains of probiotics too. This product does not require refrigeration.

Binders to Support Detox*

GI Detox + by Biobotanical Research or MycoPul by Researched Nutritionals 1 to 2 pills 1 time a day. Do not take any medicines or supplements beginning 30 min before taking these binders through 2 hours after taking these binders. The reason for this is binders will bind your supplements and prescription medicines too. You can eat any time, but the best time to have a small amount of food or a meal is 30 minutes after taking the binder.

Disclaimer

The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References

  1. Pizzorno, J. The Toxin Solution: How Hidden Poisons in the Air, Water, Food, and Products We Use Are Destroying Our Health–AND WHAT WE CAN DO TO FIX IT. New York, NY: HarperCollins; 2017.
  2. Pizzorno J. Glutathione! Integrative Medicine: A Clinician’s Journal. 2014;13(1):8-12.
  3. Sinha R, Sinha L, Calcagnotto A, Trushin N, Haley JS, Schell TD, Richie Jr JP. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European Journal of Clinical Nutrition. 2018;72:105–111.
  4. Lynch, B. Dirty genes. New York, NY: HarperOne; 2018.
  5. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol. Chem. 2009;390:191–214. doi:10.1515/BC.2009.033.
  6. Gulcubuk A, et al. Effects of curcumin on proinflammatory cytokines and tissue injury in the early and late phases of experimental acute pancreatitis.. Pancreatology. 13(4):347-354.
  7. Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124(2):188-195. doi:10.1182/blood-2014-05-552729.
  8. Linus Pauling Institute, Oregon State University. Curcumin. Micronutrient Information Center; Phytochemicals website. lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/curcumin Accessed August 18, 2018.
  9. Lu SC. Glutathione synthesis. Biochimica et biophysica acta. 2013;1830:3143-3153
  10. Pall M. Approaches to curing chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia, multiple chemical sensitivity, gulf war syndrom, and possibley many others. Townsend Letter. 2010 (Feb/March) http://www.townsendletter.com/FebMarch2010/cureNO0210.html Accessed August 19, 2018
  11. Peacock BN, Gherezghiher TB, Hilario JD. et al. New insights into Lyme disease. Redox Biol. 2015;5:66–70. doi.org/10.1016/j.redox.2015.03.002.
  12. Shachar I, Karin N. The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications. J Leukoc Biol. 2013;93(1):51–61. doi: 10.1189/jlb.0612293.
  13. Zhao F, Gong Y, Hu Y, Lu, M, Wang J, Dong J, Qiu F. Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target. Molecular Medicine Reports. 2015;11:3087-3093. doi.org/10.3892/mmr.2014.3079
  14. Markowiak P, Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9(9):1021. Published 2017 Sep 15. doi:10.3390/nu9091021

Category:

Detoxing, diet and nutrition, Gut Health, Lyme, Supplements

Antimicrobial Treatment of Vector-Borne & Community-Acquired Infections – Dr. Ann Corson

https://www.betterhealthguy.com/images/stories/PDF/corson/2022%20Antimicrobial%20Treatment.pdf

Ann F. Corson, MD presented “Antimicrobial Treatment of Vector-Borne and Community-Acquired Infections” at The Forum for Integrative Medicine (TFIM) 2022 online event in March.

Dr. Corson’s slides are in the link above.  She gives specifics on treatments for tick-borne infections as well as lists the brands she trusts and has success with.

Talk with your Lyme literate doctor about these suggestions and perhaps some of them will help you as well.

Better Health Guy, Scott Forsgren has other interviews with Dr. Corson on hypercoagulation (a common problem for Lyme/MSIDS patients) as well as pregnancy in Lyme:  https://www.betterhealthguy.com/corson

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For more:

Category:

Treatment

Reminder: September Lyme Support Meeting

Just a reminder of our upcoming Lyme Support Meeting at the end of this month. For details go here: https://madisonarealymesupportgroup.com/2022/08/19/september-lyme-support-meeting/

Also, you can check the “meetings” tab in the upper right hand corner of the website anytime to learn of meetings.

Look forward to seeing all of you!

Category:

Meetings

COVID “Vaccine” Analysis Report

https://www.documentcloud.org/documents/22140176-report-from-working-group-of-vaccine-analysis-in-germany  Report Here

Working Group for COVID Analysis

This summary is a preliminary, continuously evolving presentation of our research and findings on the so-called COVID-19 vaccines, as well as the effects we found on the human body and the blood in particular. The summary is intended for the public interest and to encourage further scientific discussion.  (See link for full report)

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**Comment**

Yet another damning report for the gene therapy shots, falsely called vaccines.

Highlights:

  • Toxic substances (the majority of were metallic) were found in ALL samples without exception & can not be explained as contamination from manufacturing
  • The blood of those getting the shots showed marked changes
  • The greater the stability of the lipid nano particle envelope, the more frequent the side effects
  • The novel (never seen before) complex structures found in the injections were also found in those receiving them, and clear deformation of cell membranes of erythrocytes which are only encountered in chronically ill people and those with severe degenerative diseases were found
  • Blood clots that can occlude small vessels were also frequently seen in the vaxxed
  • The microscope does not lie. There are significant differences of the blood of the vaxxed vs the unvaxxed
  • Heavy metals can enter connective tissue and the brain and the authors state they are forced to conclude that these substances found in the shots can spread throughout the body
  • The following predominantly metallic elements were unexpectedly detected in the doses from AstraZeneca, BioNTech/Pfizer and Moderna:
    • Alkali metals: caesium (Cs), potassium (K)
    • Alkaline earth metals: calcium (Ca), barium (Ba)
    • Transition metals: cobalt (Co), iron (Fe), chromium (Cr), titanium (Ti)
    • Rare earth metals: cerium (Ce), gadolinium (Gd)
    • Mining group/metal: aluminium (Al)
    • Carbon group: silicon (Si) (partly support material/slide)
    • Oxygen group: sulphur (S)
  • Antimony (Sb), a toxic metal, was found in significant concentration in the Moderna shot.
  • Each of these findings should result in the immediate suspension of these shots which should have been stopped long ago
Please see top link for the report and microscopy findings.

For more:

Category:

research, vaccines