Archive for the ‘research’ Category

The History of Lyme Disease Has a Wisconsin Chapter. It’s Still Being Written

https://wisconsinwatch.org/2022/03/the-history-of-lyme-disease-has-a-wisconsin-chapter-its-still-being-written

The history of Lyme disease has a Wisconsin chapter. It’s still being written.

From the first case documented by a Milwaukee dermatologist to ongoing research at the University of Wisconsin, the state has played a big role in Lyme disease.
Xia Lee, a postdoctoral vector biologist in the University of Wisconsin-Madison Department of Entomology, shows an adult black-legged tick, in the Susan Paskewitz Lab in Madison, Wis., on Sept. 21, 2021. Lyme disease in Wisconsin has grown as the black-legged ticks that cause the disease have spread across the state. (Coburn Dukehart / Wisconsin Watch)
Reading Time: 3 minutes Wisconsin Watch is a nonprofit newsroom that focuses on government integrity and quality of life issues. Sign up for our newsletter for more stories straight to your inbox.In 1970, a Wisconsin dermatologist first documented what would soon be called Lyme disease across the country.

Dr. Rudolph J. Scrimenti, a dermatologist in Milwaukee, reported the first case in the United States of the signature rash of early Lyme disease.

The patient had removed a tick from his skin three months earlier in north-central Wisconsin. Scrimenti treated the patient with penicillin based on medical literature he had read out of Europe.

“The patient became symptom-free within 48 hours,” he wrote in the journal article in 1970. “There has been no recurrence of symptoms for the past year.” However, Scrimenti said the cause of the disease was “uncertain.”

Scrimenti, who died in 2013, later began treating patients in Milwaukee and served on the review board of a journal on tick-borne diseases in the early 1990s.

Over the past three decades, Susan Paskewitz, a medical entomologist at University of Wisconsin-Madison, has documented the growing prevalence of ticks in Wisconsin.

Paskewitz found that deer ticks, also called black-legged ticks, have moved steadily from northwest to southwest, and then into the central and eventually slowly into the eastern and southern Wisconsin.

“They invaded our state entirely,” Paskewitz said in a 2021 Wednesday Nite @ The Lab episode. She said the regeneration of forests decimated by logging in the early 1900s and rebounding of the deer population are the main drivers in Wisconsin. Paskewitz said warming temperatures caused by climate change are expected to lengthen the tick season and accelerate their northward march into Canada.

Confirmed cases of Lyme disease per 100,000 Wisconsin residents, 2020. (Wisconsin Department of Health Services)

Xia Lee, a tick biologist in Paskewitz’s lab, has studied the insects for more than a decade. Lee is soft-spoken, but when he talks about the parasites, he marvels at their “beauty.”

Lee explained that the Lyme-bearing ticks live between two and three years. They acquire blood meals from animal hosts at each stage of life — larva, nymph and adult.

“These guys are always born uninfected, and they have to pick up the infections when they feed on their first animal (hosts),” Lee said, pointing to the lab-raised larvae.

He said that larvae pick up pathogens during their first blood meal from infected small mammals, such as the white-footed mouse. They subsequently transmit those pathogens during their second meal as nymphs and their third meal as adults.

A Yale study has found that about 20% to 30% of the black-legged tick nymphs carry the bacterium that causes Lyme disease in southern New England, while the rate of infected adult ticks is 30% to 50%. The tick can also be infected with other microbes at the same time, carrying and transmitting other pathogens and making people sick with Lyme and other tick-borne diseases such as anaplasmosis and babesiosis.

Xia Lee, a postdoctoral vector biologist in the University of Wisconsin-Madison Department of Entomology, is seen in the Susan Paskewitz Lab in Madison, Wis., on Sept. 21, 2021.  Lee hopes to develop a Lyme disease vaccine for mice, which spread the disease to ticks that feed on them and later infect humans.  (Coburn Dukehart/Wisconsin Watch)

Once an infected tick latches on a human, it falls off when full. If a tick is removed within 24 hours, the likelihood of transmission is very low, Lee said. However, when a poppy seed-sized nymphal tick firmly attaches itself to the skin, detecting and removing it is difficult, increasing the risk of infection.

Lee noted that Wisconsin never got the proper recognition as the site of the first case of the disease. That honor went to the town of Lyme in Connecticut, which remains one of the states with the highest incidence rates in the country.

“We like to joke about it and say that Wisconsin was actually the first state where Lyme disease was detected,” he said, “but we never got the glory for naming (it).”

The nonprofit Wisconsin Watch (www.WisconsinWatch.org) collaborates with WPR, PBS Wisconsin, other news media and the University of Wisconsin-Madison School of Journalism and Mass Communication. All works created, published, posted or disseminated by Wisconsin Watch do not necessarily reflect the views or opinions of UW-Madison or any of its affiliates. 

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For more:

Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016

https://wwwnc.cdc.gov/eid/article/28/6/21-1335_article

Sarah A. HookComments to Author , Seonghye Jeon, Sara A. Niesobecki, AmberJean P. Hansen, James I. Meek, Jenna K.H. Bjork, Franny M. Dorr, Heather J. Rutz, Katherine A. Feldman, Jennifer L. White, P. Bryon Backenson, Manjunath B. Shankar, Martin I. Meltzer, and Alison F. Hinckley
 
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (S.A. Hook, A.F. Hinckley); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Jeon, M.B. Shankar, M.I. Meltzer); Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA (S.A. Niesobecki, A.P. Hansen, J.I. Meek); Minnesota Department of Health, St. Paul, Minnesota, USA (J.K.H. Bjork, F.M. Dorr); Maryland Department of Health, Baltimore, Maryland, USA (H.J. Rutz, K.A. Feldman); New York State Department of Health, Albany, New York, USA (J.L. White, P.B. Backenson)

Cite This Article

Abstract

Approximately 476,000 cases of Lyme disease are diagnosed in the United States annually, yet comprehensive economic evaluations are lacking. In a prospective study among reported cases in Lyme disease–endemic states, we estimated the total patient cost and total societal cost of the disease. In addition, we evaluated disease and demographic factors associated with total societal cost. Participants had a mean patient cost of ≈$1,200 (median $240) and a mean societal cost of ≈$2,000 (median $700). Patients with confirmed disseminated disease or probable disease had approximately double the societal cost of those with confirmed localized disease. The annual, aggregate cost of diagnosed Lyme disease could be $345–968 million (2016 US dollars) to US society. Our findings emphasize the importance of effective prevention and early diagnosis to reduce illness and associated costs. These results can be used in cost-effectiveness analyses of current and future prevention methods, such as a vaccine.

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**Comment**

And here you have it. The sudden concern for costs due to the need for “prevention methods”, specifically a “vaccine,” which, BTW is the most lucrative venture for scientists – the big cash cow they are all vying for with your tax dollars.

Sorry. Not buying it. I’m so over this global propaganda that puts everyone into a box and treats everyone identically. This has never been done in medicine until now. A “vaccine” can never and will never be a magic bullet for anything – particularly Lyme/MSIDS.

While societal cost is undoubtedly high, it isn’t high enough to get an injection that to date still has OspA in itthe very thing causing illness and has been linked to severe adverse reactions. The desperate need for effective, affordable, safe treatments just isn’t interesting to researchers and our government due to the small monetary return – yet the very thing that would alleviate patient suffering around the world.

Further, studies are never done with the chronically infected so millions do not fit into the “vaccine” paradigm at all and never will. But the chronically ill just don’t matter. It’s all for the “greater good,” whoever that is.

CD4 T Cell Responses in Persistent Borrelia Burgdorferi Infection

https://www.sciencedirect.com/science/article/abs/pii/S0952791522000346

CD4 T cell responses in persistent Borrelia burgdorferi infection

1Graduate Group in Immunology, University of California Davis, One Shields Ave, Davis, CA 95616, USA
2Center for Immunology and Infectious Diseases, University of California Davis, One Shields Ave, Davis, CA 95616, USA
3Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA

Available online 9 May 2022, Version of Record 9 May 2022.

https://doi.org/10.1016/j.coi.2022.102187Get rights and content

Highlights

•Multiple immune evasion strategies support B. burgdorferi (Bb) persistent infection.
•CD4 Th1 polarization correlates with Bb-induced disease not protection.
•Neither protective Th2 nor Th17 polarization are induced to Bb infection.
•Strong Tfh induction but impaired T-dependent B cell responses after Bb infection.
•CD4 T cells may be a host cell target of Bb-induced immune evasion strategies.

Infection of mice with Borrelia burgdorferi (Bb), a tick-transmitted spirochete and the pathogen that causes Lyme disease in humans, triggers CD4 T cell activation in secondary lymphoid tissues, from which they disseminate into various infected tissues. Despite their activation and the appearance of CD4 T cell-dependent antibody responses, Bb establishes persistent infection in natural Bb reservoir hosts in the absence of overt disease, raising the question of the effectiveness of the anti-Bb T cell responses. Reviewing the existing literature, we propose that CD4 T cells might constitute a host cell target of Bb-mediated immune evasion, rendering these cells ineffective in orchestrating effective inflammatory responses and in supporting highly functional Bb-specific antibody induction. Supporting the induction of more effective CD4 T cell responses may help overcome Bb persistence.

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For more:

7 Conditions Masquerading As Dementia

https://greenmedinfo.com/blog/7-conditions-masquerading-dementia

7 Conditions Masquerading As Dementia

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.
© [5/30/22] GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here //www.greenmedinfo.com/greenmed/newsletter.

Moderna ‘Throwing 30 Million Doses in the Garbage’ As Mounting Death, Injury, and Waning Efficacy Data Pours In, But Similarly With Lyme Vaccine – Makers Predictably Blame ‘Lack of Demand’

https://www.theepochtimes.com/moderna-throwing-30-million-doses-in-the-garbage-over-dwindling-vaccine-demand-ceo  Audio Here

Moderna ‘Throwing 30 Million Doses in the Garbage,’ CEO Says

By Katabella Roberts
Updated: May 26, 2022

The CEO of pharmaceutical and biotechnology company Moderna, Stéphane Bancel, said the company is having to “throw away” millions of doses of COVID-19 vaccines because “nobody wants them.”

Bancel made the comments during an appearance at the World Economic Forum on Monday, while noting his concerns over the lack of people getting vaccinated and waning immunity among those who have had the shots but declined to get boosters.  (See link for article)

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**Comment**

Please compare that with the official word that Lymerix was also pulled off the market due to “lack of demand.”

That’s an interesting spin.

When you go down the deep, dark rabbit hole for truth you learn LYMERix can cause symptoms similar to NEUROSYPHILLIS, or tertiary syphilis, causes auto antibodies ANA, autoimmune diseases and more.  Further, PATIENTS WHO ARE HLA-DR4, are more likely to manifest reactions which means that in your immunological composition you have an antigenic marker or ALLELE DENOMINATED DR4, which is determined with a blood test and If you are a carrier, you will have more side effects.

According to this insightful article, Dr. Laptenta states:

“the LABORATORY DOES NOT KNOW OF THIS FACT, IT ALSO DID NOT KNOW THAT PATIENTS EXPOSED TO LYME DISEASE SHOULD NOT BE VACCINATED AS A RISK FACTOR, this was discovered by the VAERS system (system for reporting adverse events) and published on Jan. 31, 2001 when 1,440,000 doses of LYMErix was released.”

But, similarly to the history of Lymerix, ‘officials’ simply ignore VAERS reports for the COVID shots which show more adverse reactions and deaths than any other vaccine in the history of VAERS, yet they continue to deny any link to the gene therapy injections, just as ‘authorities’ deny any link between the Lyme-like symptoms people became saddled with after getting Lymerix.

Don’t ever accept any blame, just find a scapegoat.

Regarding COVID gene therapy injections, autopsies are showing higher viral loads in the “vaccinated” with evidence of a pathological outcome, especially in the immunocompromised.  But ‘authorities’ don’t care.  In fact, Fauci initially ordered that autopsies were not to be done on those with COVID.

https://childrenshealthdefense.org/defender/deaths-injuries-waning-efficacy-covid-vaccines

Deaths, Injuries and Waning Efficacy: The Latest Bad News on COVID Vaccines

Considering the mounting evidence of adverse effects and lack of effectiveness, some physicians and health agencies are calling for the immediate withdrawal of the COVID-19 vaccines.

Story at a glance:

  • A previously healthy 36-year-old mother of two died 11 days after receiving a Pfizer COVID-19 shot; her death was deemed to be caused by myocarditis due to the shot.
  • Emergency calls for cardiac arrest and acute coronary syndrome increased more than 25% among 16- to 39-year-olds from January to May 2021, compared to the same time period in 2019 and 2020.
  • Pfizer deliberately excluded pregnant women from COVID-19 shot trials; the recommendation that the shots are safe and effective for pregnant women was based on a 42-day study involving 44 rats.
  • Research conducted by the New York State Department of Health found the shots’ effectiveness declined rapidly among 5- to 11-year-olds, falling from 68% to just 12%.
  • Considering the adverse effects and lack of effectiveness, many have called for an immediate withdrawal of the shots.

A previously healthy 36-year-old mother of two died 11 days after receiving a Pfizer COVID-19 shot. Initially, her cause of death was deemed inconclusive, but at an inquest, pathologist Dr. Sukhvinder Ghataura explained that he believes the COVID-19 shot was to blame.

He told the coroner:

“On the balance of probabilities, she had vaccine-related problems. There is nothing else for me to hang my hat on. It is the most likely reason, in my conclusion. It is more than likely Dawn died in response to the Covid jab.”

Government officials continue to deny deaths linked to Pfizer’s mRNA COVID-19 shot.

In the U.S., they’ve acknowledged only nine deaths as causally associated with Johnson and Johnson’s COVID-19 shot as of May 10. But this case, which occurred in the U.K., highlights the potential dangers of shot-induced myocarditis.

According to Ghataura, the woman had several signs of myocarditis, or inflammation of the heart muscle, including inflammation of the heart, fluid in the lungs and a small clot in her lungs.

She had also reported menstrual irregularities, jaw pain and arm pain. When asked by a family member whether he believed the woman would still be alive today if she hadn’t received the shot, Ghataura said, “It’s a difficult question but I would say yes.”

COVID-19 shots increase heart attack risk by 25% in youth

At the conclusion of the inquest regarding the woman’s death, assistant coroner Alison McCormick stated, “I give the narrative conclusion that her death was caused by acute myocarditis, due to recent Covid-19 immunization.”

Myocarditis is a recognized adverse effect of mRNA COVID-19 shots and one that has been named in other deaths.

Dr. Neil Singh Dhalla, a CEO of a major health clinic, fell asleep four days after he got a COVID-19 booster shot — and died from a heart attack.

The autopsy stated myocarditis. He was only 48 years old and had never had heart problems in his life. In another example, epidemiologists confirmed that two teenage boys from different U.S. states died of myocarditis days after getting the Pfizer shot.

Both had received second doses of the shot. In a study that examined the autopsy findings, it’s reported that the “myocarditis” described in the boys’ deaths is “not typical myocarditis pathology”:

“The myocardial injury seen in these post-vaccine hearts is different from typical myocarditis and has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Understanding that these instances are different from typical myocarditis and that cytokine storm has a known feedback loop with catecholamines may help guide screening and therapy.”

An astounding study published in Scientific Reports further revealed that calls to Israel’s National Emergency Medical Services (EMS) for cardiac arrest and acute coronary syndrome increased more than 25% among 16- to 39-year-olds from January 2021 to May 2021, compared to the same time period in 2019 and 2020.

The researchers evaluated the association between the volume of the calls and other factors, including COVID-19 shots and COVID-19 infection, but a link was only found for the shots:

“[T]he weekly emergency call counts were significantly associated with the rates of 1st and 2nd vaccine doses administered to this age group but were not with COVID-19 infection rates.

“While not establishing causal relationships, the findings raise concerns regarding vaccine-induced undetected severe cardiovascular side-effects and underscore the already established causal relationship between vaccines and myocarditis, a frequent cause of unexpected cardiac arrest in young individuals.”

COVID shots weren’t tested on pregnant women

The U.S. Food and Drug Administration (FDA) and Pfizer attempted to hide COVID-19 shot clinical trial data for 75 years. “When I saw that, that’s when I got very vocal and said fraud has occurred. How do I know that? They won’t show us the clinical data,” former Blackrock portfolio manager Edward Dowd said.

This should be a red flag for all Americans.

Now that a lawsuit forced the FDA to release thousands of the documents, data about what they were trying to hide is coming out. Among the revelations is evidence that Pfizer deliberately excluded pregnant women from COVID-19 shot trials.

So how did they make the recommendation that the shots are safe and effective for pregnant women? This was based on a 42-day study involving 44 rats.

What’s more, a Pfizer-BioNTech rat study revealed the shot more than doubled the incidence of preimplantation loss and also led to a low incidence of mouth/jaw malformations, gastroschisis (a birth defect of the abdominal wall) and abnormalities in the right-sided aortic arch and cervical vertebrae in the fetuses.

A Centers for Disease Control and Prevention (CDC) sponsored study that was widely used to support the U.S. recommendation for pregnant women to get injected “presents falsely reassuring statistics related to the risk of spontaneous abortion in early pregnancy,” according to the Institute for Pure and Applied Knowledge (IPAK).

When the risk of miscarriage was recalculated to include all women injected prior to 20 weeks gestation, the incidence was seven to eight times higher than the original study indicated, with a cumulative incidence of miscarriage ranging from 82% to 91%.

Also buried in one of the documents is the statement, “Clinical laboratory evaluation showed a transient decrease in lymphocytes that was observed in all age and dose groups after Dose 1, which resolved within approximately one week …”

What this means is Pfizer knew that in the first week after the shot, people of all ages experienced transient immunosuppression, or put another way, a temporary weakening of the immune system, after the first dose.

Pfizer and FDA knew vaccines were not ‘safe and effective’

“It looks to me — this is not an overstatement from what I’ve seen — that this was a clinical trial that by August 2021, Pfizer and the FDA knew was failed, the vaccines were not safe and effective,” said investigative author Naomi Wolf. “That they weren’t working. That the efficacy was waning … and that they were seriously dangerous. And they rolled it out anyway.”

Regarding the shots for pregnant women, Wolf said, in an interview with Stephen Bannon on “War Room,” that a spike in severe adverse events among pregnant women coincides with the rollout of COVID-19 shots.

U.S. Department of Defense (DOD) whistleblowers datamined the DOD health database, revealing significant increases in rates of miscarriage and stillbirths, along with cancer and neurological disease, since COVID-19 jabs rolled out. “This is honestly one of the wors[t] things I’ve ever, ever seen in my 35 years as a reporter,” Wolf said.

Not only does IPAK’s data show COVID-19 injections prior to 20 weeks are unsafe for pregnant women, but 12.6% of women who received it in the third trimester reported Grade 3 adverse events, which are severe or medically significant but not immediately life-threatening.

Another 8% also reported a fever of 38 degrees C (100.4 degrees F), which can lead to miscarriage or premature labor.

Young children are also developing severe hepatitis and nobody knows why.

COVID-19 shots have been linked to cases of liver disease and liver damage following the shots has been deemed “plausible.”

Confirmed: COVID shots affect menstrual cycles

It’s clear that there are many unknowns about how COVID-19 shots affect pregnancy and reproduction, including their effects on menstrual cycles. Women around the globe have reported changes in their menstrual cycles following COVID-19 shots, and health officials have tried to brush off the reports or label them all as anecdotal.

But a study published in Obstetrics & Gynecology — and funded by the National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health’s (NIH) Office of Research on Women’s Health — confirms an association between menstrual cycle length and COVID-19 shots.

Clinical trials for COVID-19 shots did not collect data about menstrual cycles following injection, and the Vaccine Adverse Event Reporting System (VAERS) does not actively collect menstrual cycle information either, making it difficult to initially determine whether the shots were having an effect.

Anecdotal reports on social media, however, are numerous and, according to the study, “suggest menstrual disturbances are much more common …”

The Obstetrics & Gynecology study involved 3,959 individuals between the ages of 18 and 45 years. Those who had not received a COVID-19 shot noted no significant changes in cycle four during the study compared to their first three cycles.

Those who received COVID-19 shots, however, had longer menstrual cycles, typically by less than one day, when they received the shots. The longer cycles were noted for both doses of the injection, with a 0.71-day increase after the first dose and 0.91-day increase after the second dose.

While the researchers described the change as not clinically significant, meaning it’s not notable from a health standpoint, there were some women who experienced even greater menstrual changes, particularly those who received two shots in the same menstrual cycle.

These changes included a two-day increase in cycle length and, in some cases, changes in cycle length of eight days or more.

Pfizer shot only 12% effective in children

Adding insult to injury, research conducted by the New York State Department of Health shows the dismal reality about the effectiveness of COVID-19 shots in children.

From Dec. 13, 2021, to Jan. 24, 2022, they analyzed outcomes among 852,384 children aged 12 to 17 years, and 365,502 children aged 5 to 11 years, who had received two doses of the shots.

Effectiveness declined rapidly among 5- to 11-year-olds, falling from 68% to just 12%.

Protection against hospitalization also dropped, from 100% to 48%. Among 11-year-olds alone, vaccine effectiveness plunged to 11%.

The lackluster response was blamed on the dosage discrepancies among the age groups, as 5- to 11-year-olds receive two 10-microgram Pfizer shots, while 12- to 17-year-olds receive 30-microgram shots.

In the younger age group, the shots provided almost no protection at all.

And it’s not only children who are affected by the shots’ rapidly waning effectiveness.

COVID-19 booster shots also lose effectiveness rapidly, with protection plummeting by the fourth-month post-shot. One CDC-funded study involved data from 10 states collected from Aug. 26, 2021, to Jan. 22, 2022, periods during which both delta and omicron variants were circulating.

Visits to emergency rooms and urgent care facilities, as well as hospitalizations, among people seeking medical care for COVID-19, were analyzed. The study did not include milder COVID-19 cases, for which no medical attention was sought.

While initially vaccine effectiveness against COVID-19-associated emergency department or urgent care visits and hospitalizations was higher after the booster shot, compared to the second COVID-19 injection, effectiveness waned as time passed since vaccination.

Within two months of the second COVID-19 shot, protection against the emergency department and urgent care visits related to COVID-19 was at 69%. This dropped to 37% after five months post-shot. The low effectiveness five months after the initial shot series is what prompted officials to recommend a booster dose — and the third shot “boosted” effectiveness to 87%.

This boost was short-lived, however. Within four to five months post-booster, protection against the emergency department and urgent care visits decreased to 66%, then fell to just 31% after five months or more post-booster.

Considering the adverse effects and lack of effectiveness, many have called for an immediate withdrawal of the shots.

IPAK believes the data are already compelling enough to withdraw the shots for vulnerable populations, including pregnant and breastfeeding women, children and those of child-bearing age.

Janci Chunn Lindsay, Ph.D., a prominent toxicologist and molecular biologist who works with M.D. Anderson Cancer Center-Houston spoke at the CDC’s Advisory Committee on Immunization Practices meeting held on April 23, 2021, and also called for “all gene therapy vaccines” to “be halted immediately due to safety concerns on several fronts,” including fertility.

The views and opinions expressed in this article are those of the authors and do not necessarily reflect the views of Children’s Health Defense.