Archive for the ‘Lyme’ Category

Anti-Inflammatories Help Major Depression

https://www.psychologytoday.com/us/blog/expressive-trauma-integration/201911/anti-inflammatories-help-major-depression

By Odelya Gertel Kraybill Ph.D.

Anti-Inflammatories Help Major Depression

New study suggests that anti-inflammatories can mitigate MDD symptoms

Posted Nov 11, 2019

Odelya Gertel Kraybill Expressive Trauma Integration

A new study* published in the Journal of Neurology, Neurosurgery, and Psychiatry asserts the efficacy of anti-inflammatories in treating major depression. This adds to the mounting evidence that there is a connection between emotional functioning and inflammation.

An increasing number of studies have shown that depression and/or bipolar disorder are accompanied by immune system dysregulation, inflammation, and high levels of cytokines. Researchers have found that inflammation triggers depression, almost like an allergic reaction.  (See link for full article)

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**Comment**

More and more is coming out on the role inflammation plays in chronic disease states and Lyme/MSIDS is no acceptation. These patients are full of inflammation and addressing that inflammation is an important aspect of treatment.  https://madisonarealymesupportgroup.com/2019/11/18/link-between-inflammation-mental-sluggishness-shown-how-msm-systemic-enzymes-and-melatonin-can-help/

Of course, the first step is to address the pathogens which are causing this, the second step is to aid the body in detoxifying these pathogens, and the third step is to support the body by supplementing with the things our bodies are deficient in – which varies from person to person. But, the last factor is this addressing the burgeoning inflammation caused by the war brought on by pathogens.

Here are some things that have helped me in my journey.  I pray they help someone else out there as well.

(Please read about melatonin in the first link under the comment section.  Melatonin is particularly good for the brain as it not only reduces inflammation but it protects the blood-brain barrier.)

For examples of effective Lyme disease treatment: https://madisonarealymesupportgroup.com/category/lyme-disease-treatment/  Please remember Lyme is the tip of the spear and patients are often coinfected with numerous pathogens all requiring different medications.  This is why effective treatment is overlapping in nature and given for a much longer duration than a few weeks.  This fact has not been accepted and embraced by mainstream medicine and until it is, patients are required to be treated by ILADS trained professionals who understand this complex illness.  For a great video on this:  https://madisonarealymesupportgroup.com/2019/11/21/cdc-misses-the-mark-with-chronic-lyme-disease/

 

 

 

 

Category:

Detoxing, Hemp Oil, Inflammation, Lyme, Psychological Aspects, research, Treatment

Changing of the Guard: How the Lyme Disease Spirochete Subverts the Host Immune Response

https://www.ncbi.nlm.nih.gov/pubmed/31753921?

2019 Nov 21. pii: jbc.REV119.008583. doi: 10.1074/jbc.REV119.008583. [Epub ahead of print]

Changing of the guard: How the Lyme disease spirochete subverts the host immune response.

Chaconas G1, Castellanos M2, Verhey TB2.

Abstract

Lyme disease, also known as Lyme borreliosis, is the most common tick-transmitted disease in the Northern Hemisphere. The disease is caused by the bacterial spirochete Borrelia burgdorferi and other related Borrelia species. One of the many fascinating features of this unique pathogen is an elaborate system for antigenic variation whereby the sequence of the surface-bound lipoprotein VlsE is continually modified through segmental gene conversion events. This perpetual changing of the guard allows the pathogen to remain one step ahead of the acquired immune response, enabling persistent infection. Accordingly, the vls locus is the most evolutionarily diverse genetic element in Lyme disease-causing borreliae. Small stretches of information are transferred from a series of silent cassettes in the vls locus to generate an expressed mosaic vlsE gene version that contains genetic information from several different silent cassettes, resulting in ~1040 possible vlsE sequences. Yet, despite its extreme evolutionary flexibility, the locus has rigidly conserved structural features. These include a telomeric location of the vlsE gene, an inverse orientation of vlsE and the silent cassettes, the presence of near-perfect inverted repeats of ~100 bp near the 5′ end of vlsE, and an exceedingly high concentration of G runs in vlsE and the silent cassettes. We discuss the possible roles of these evolutionarily conserved features, highlight recent findings from several studies that have used next-generation DNA sequencing to unravel the switching process, and review advances in the development of a mini-vls system for genetic manipulation of the locus.

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**Comment**

Read it again: “This perpetual changing of the guard allows the pathogen to remain one step ahead of the acquired immune response, enabling persistent infection.”

Please spread the word.

Peer-Reviewed Evidence of Persistence of Lyme:MSIDS copy

 

Category:

Lyme, research

Drug For Alcoholism Could Treat Lyme Disease

https://news.yahoo.com/father-bedbound-by-lyme-disease-is-back-on-his-feet-due-to-a-drug-for-alcoholism

Alexandra Thompson

November 22, 2019

Ciaran Hughes endured "constant pain" for months, with doctors baffled as to what was wrong. [Photo: Supplied]Ciaran Hughes endured “constant pain” for months, with doctors baffled as to what was wrong. [Photo: Supplied]

A father who was bedbound by Lyme disease is finally back on his feet due to a drug for alcoholism.

Ciaran Hughes, 31, developed “constant” pain, “laboured” movement and a loss of balance in March while working in Indonesia.

Multiple tests both abroad and in his native Northern Ireland came back clear, including one for Lyme disease…(See full story in link above)

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For more:  https://madisonarealymesupportgroup.com/2019/11/19/if-disulfiram-is-the-cure-for-lyme-disease-should-it-be-prescribed-to-all-lyme-disease-patients/

Excerpt:  Disulfiram should certainly be prescribed with caution or avoided in patients with personal and familial antecedents of psychosis. Case reports are, however, not enough to guarantee the safety of a drug. Studies at larger scales are necessary. Some questions still remain unanswered.

For more:  https://madisonarealymesupportgroup.com/2019/06/03/disulfiram-in-the-treatment-of-lyme-babesiosis-3-case-reports/

https://madisonarealymesupportgroup.com/2019/07/14/disulfiram-breakthrough-drug-for-lyme-other-tick-borne-diseases/

https://madisonarealymesupportgroup.com/2019/10/15/disulfiram-psychosis-update/

https://madisonarealymesupportgroup.com/2019/10/27/disulfiram-psychosis-update-2/

https://madisonarealymesupportgroup.com/2019/09/18/dr-liegner-interview-on-disulfiram/

 

 

 

 

 

Category:

Lyme, Treatment

Non-Toxic Tips From the Experts: Clean Up Mold and Residual Spores

https://files.constantcontact.com/5a4b6d10101/7c932321-c83c-4e51-bb60-5bc9a673ca54.pdf

Time to clean up Mold and residual spores in your home? Non-Toxic Tips from the experts.

Mold Remediation Strategy of Dr. Lee Cowden -recommended to us by Dr. Doug Phillips

A USA board-certified cardiologist and internist who is internationally known for his knowledge and skill in practicing and teaching integrative medicine. He has co-authored many books and articles on integrative medicine and has pioneered successful treatments of cancer, autism, Lyme disease and many other illnesses.

Procedure for Space that has been physically remediated- after all the water leaks are resolved and the mold contaminated building materials are replaced with new uncontaminated building materials.

Use the Concentrate Liquid EC3 in the Portable Fogger to kill mold in the air of a building AFTER you have resolved all the water and environmental issues.

CONCENTRATED MOLD SOLUTION EC3- Non-Toxic Extract

Portable Hand Held FOGGER

If the building has 8 rooms-

  • use about 2 ounces of the concentrate sprayed into each room.
  • A little more than 2 ounces for the big rooms and a little less than 2 ounces for small rooms.
  • If more than 8 rooms, you probably need to buy more than one bottle of the Concentrate.
  • All Closet Doors must be open in each room when fogging with the Ec3 concentrate.

Several Hours Later-

  • After fogging is complete, run a portable HEPA /Charcoal Filter in the house for a few days.
  • Moving it from room to room, but NOT in the bedroom where people are sleeping at night.

At the Academy we use the Austin Air Filter Health Mate Plus – a good quality Hepa/Charcoal Filter

Quite and effective- easy to move and fits well in our space.

Dr. Cowdens recommended unit – Guardian Hepa Filter

If the area continues to have issues-

  • At the Academy we like the Air Reactor by HITech Air Solutions for areas that need constant mold, fungus, virus, clearning. Especially areas where you cannot remediate fully, in basements, warehouses, school gymnasiums, etc.
  • This unit is used by many sport teams to keep equipment free of shared germs.
  • The machine is run 24/7 or when you know you will be in the room you can run it in advance.
  • If a burning smell happens when you first use it, that is positive as it is neutralizing the toxins, and make a smell during the reaction taking place. Give it time to work.
  • Please also use binders, as those with mold and fungal infections can also experience a die off reaction at first.
  • Keep windows closed for best outcome.Ordered directly from the HiTech Air Solutions(See link above for pictures of machines and more information)

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For more:  https://madisonarealymesupportgroup.com/2019/11/30/is-there-life-after-mold/

https://madisonarealymesupportgroup.com/2019/10/25/dealing-with-lyme-disease-and-mold-illness-at-the-same-time/

https://madisonarealymesupportgroup.com/2018/10/14/got-mold/

https://madisonarealymesupportgroup.com/2018/05/15/watch-the-documentary-moldy-for-free-for-a-limited-time/

https://madisonarealymesupportgroup.com/2018/03/13/are-mold-mycotoxins-compromising-your-recovery/

https://madisonarealymesupportgroup.com/2017/11/08/house-making-you-sick-mold-lyme-msids/

https://madisonarealymesupportgroup.com/2018/02/24/top-3-lyme-detox-myths-busted-dr-rawls/

Category:

Activism, Lyme, Mold, Treatment

C6 Peptide Test For Lyme Disease May Indicate Borrelia Miyamotoi Infection

https://danielcameronmd.com/c6-peptide-test-lyme-disease-borrelia-miyamotoi-infection/

C6 PEPTIDE TEST FOR LYME DISEASE MAY INDICATE BORRELIA MIYAMOTOI INFECTION

The C6 enzyme immunoassay (EIA) is often used to diagnose Lyme disease. The test is based on the C6 peptide of the Borrelia burgdorferi sl VlsE protein. But a recent study suggests the C6 peptide test may also indicate an infection with Borrelia miyamotoi, another tick-borne disease.

By

Koetsveld and colleagues examined C6 reactivity in sera from both mice infected with Borrelia miyamotoi and from 46 patients with PCR-positive Borrelia miyamotoi disease (BMD).

They found, “Cross-reactivity against the C6-peptide was confirmed in 21 out of 24 mice experimentally infected with B. miyamotoi.” And a C6 antibody response was present in 39 of 46 patients. ¹

Interestingly, another recent study “showed that in a set of 43 sera from 24 patients with [Borrelia miyamotoi disease] from the United States the C6 ELISA was also positive in the vast majority (>90%) of convalescent phase serum samples.” ²

Koetsveld warns, however, that since “BMD [Borrelia miyamotoi disease] and Lyme borreliosis are found in the same geographical locations, caution should be used when relying solely on C6-reactivity testing.”

According to a new study, the C6 peptide test used to diagnose Lyme disease may also be helpful in identifying Borrelia miyamotoi. CLICK TO TWEET

They recommend further testing if the Western blot is negative.

“We propose that a positive C6 EIA with negative immunoblot, especially in patients with fever several weeks after a tick bite, warrants further testing for B. miyamotoi.”

Testing for the glycerophosphodiester phosphodiesterase (GlpQ) gene may be helpful in detecting B. miyamotoi infection.

“Our results demonstrate that cross-reactive antibodies against the C6 peptide regularly occur in patients with [Borrelia miyamotoi disease],” writes Koetsveld.

He adds, “with as much as 90% (95% CI 68.3–98.8) of patients being C6-reactive in samples taken 10 to 19 days after onset of disease.”

Editor’s note: It is also possible that the patients could have seronegative Lyme disease concurrent with B. miyamotoi.  In fact, 10 of their 39 patients were reactive by Western blot for Lyme disease.
Related Articles:

The best antibiotics to treat Borrelia miyamotoi?

Blood smear not reliable in diagnosing Borrelia miyamotoi

Doctors face challenges in diagnosing Borrelia miyamotoi

References:
  1. Koetsveld J, Platonov AE, Kuleshov K, et al. Borrelia miyamotoi infection leads to cross-reactive antibodies to the C6 peptide in mice and men. Clin Microbiol Infect. 2019.
  2. Molloy, P.J., Weeks, K.E., Todd, B., and Wormser, G.P. Seroreactivity to the C6 peptide in Borrelia miyamotoi infections occurring in the northeastern United States. Clin Infect Dis. 2018; 66: 1407–1410

Category:

Borrelia Miyamotoi (Relapsing Fever Group), Lyme, research, Testing