Systemic Enzymes

Systemic Enzymes – What are They?

When we hear the word enzymes we normally think of digestive enzymes, and while they are crucial for breaking down our food, they are not “systemic,” but are in fact utilized in the GI tract. For some people adding digestive enzymes makes all the difference in their health. If you suffer from GERD, for instance, adding digestive enzymes will revolutionize your health. Food enzymes are found in raw food. And by raw food, I mean uncooked. Systemic enzymes, on the other hand, are used all over the body and have been found to help many disease processes, and in fact, can be downright miraculous.  Enzymes are proteins used by every cell in the body that help chemical reactions within our body. We produce these enzymes but as we age, they decline like everything else.  If you think about it, this means every chemical reaction in our body is affected. These systemic enzymes help break down mucus, fibrin, toxins including viruses, allergens, and clotting factors. These are key areas to address for MSIDS (multi systemic infectious disease syndrome) patients. Unlike NSAIDS, enzymes do not hurt the liver and they also help white blood cell efficiency. And get this – they help manage yeast overgrowth. They also help you absorb vital nutrients and improve your performance.

**The following information is for educational purposes only. Please consult with your health care practitioner before starting any therapy. There can be interactions with other things you are taking.   According to Dr. Howenstine, enzymes cannot be patented, which means mainstream medicine doesn’t promote their usage. In Europe, large doses of enzymes are used in cancer therapy. They have an enteric coating so they are not dissolved in the stomach, making them able to get into the blood without being destroyed. Systemic enzymes are also able to remove the thick layer of fibrin around cancer cells. The thick fibrin cloaks malignant cells so they are able to get by the killer immune cells. Enzymes remove this coating as well as stimulate immune cells to increase more tumor necrosis factor to attack tumors and viruses. Dr. Wyba states that one-third of pancreatic cancer cases have been cured using Wobenzyme a specific patented systemic enzyme. The patient takes up to 30 pills three times a day for life or the cancer returns.

Many MSIDS patients suffer with hyper coagulation, or thick blood, often due to infection. There are numerous factors for this but one is high levels of parasites in the blood and biofilms. Systemic enzymes dissolve blood clots and therefore lessen coagulation. The only contraindication is for those with hemophilia and those on anticoagulant drugs as they may have thinner blood with enzyme therapy. Make sure to work with your health care professional if you have either of these issues as extra precautions will need to be taken.

Regarding viruses, enzymes eat the exterior coating, rendering the virus permanently incapacitated. You have to take enough to get ahead of rapid viral replication, requiring 5-10 capsules three times a day or more. It was also discovered that those with prosthetics often need these parts replaced as bacteria are able to prevent antibiotics from killing infection due to biofilm formation. MSIDS patients have the same problem. The enzyme serrapeptase enhanced Ofloxin in cultures by preventing biofilms. Systemic enzymes could be the magic bullet to help break down biofilms in MSIDS patients.  Regarding allergens, a low dose of 2-3 caps a day should prevent asthma attacks – if taken as maintenance. Enzymes thin and decrease secretions as well as alleviate symptoms of hay fever and other allergies.

Regarding pain, enzymes have helped headaches, arthritis, bursitis, and synovitis – all symptoms that are frequent with MSIDS. It is also a promising therapy for sarcoidosis. Safer than cortisone, regular enzymes will reduce fibrosis.

The truly miraculous effects of systemic enzymes is their ability to remove necrotic (dead cells) debris, reduce inflammation, balance the immune system, and remove viruses and toxins, all issues faced by the MSIDS patient.   He also states they can benefit fibromyalgia patients. Mycoplasma, anaerobic bacteria, fungi, and borrelia have all been found in FM patients with high-resolution microscopy. Several FM patients have recovered by taking nattokinase – another enzyme that lessens fibrin production, improving blood circulation. Kidney diseases can be helped by systemic enzymes by their ability to lower swelling, inflammation, scarring (fibrosis), and immune complexes. Other conditions such as fibrocystic breasts, uterine fibroids, endometriosis, PCOS, benign prostatis hypertrophy, breast, prostate, and uterine cancers, are all estrogen excess states, producing fibrosis – which for those having these conditions correctly equate with PAIN. Endometriosis may require five or more caps three times a day until pain disappears. Fibrocystic breast disease patients should stay on enough enzymes to prevent symptoms. Taking systemic enzymes after surgery or injuries prevents excessive scar formation. All of these conditions can be helped with systemic enzymes.

**Please read Dr. Howensteine’s article in the link above if you suffer with any of these estrogen dominant diseases as he discusses in far more detail the interaction of various hormones and why these disease states are becoming more prevalent. I feel there is a desperate need for this information as this issue is far more common than not. Also, for more information regarding the use of bioidentical hormones please listen to PhD Kathy Lynch from Women’s International Pharmacy:

**Do not take systemic enzymes 24-36 hours before elective surgery and do not resume until 24-36 hours after the operation as they could prevent normal clotting in small blood vessels.

Here’s what’s in systemic enzymes and what each ingredient does:

Rutin: a bioflavinoid that strengthens and controls the permeability of blood vessels and capillary walls, lowering blood pressure and slowing aging.
Serrapeptase: anti-inflammatory, anti-edema, and fibrinolytic properties. Less swelling after surgery, less breast pain for fibrocystic patients, electrophysiologic proof of recovery in carpal tunnel syndrome patients.
Protease: breaks down proteins and are important to digestion as they liberate needed amino acids. Helps with inflammation, immune regulation, breaking down cellular debris including toxins in the blood, freeing up the immune system to concentrate on bacterial, parasitical, and viral infections. Those with a protease deficiency have excess alkalinity which can cause anxiety and insomnia, arthritis, osteoporosis and other calcium-deficient diseases. Inadequate protein digestion results in hypoglycemia, which means moodiness.“>

How Proteases Support Immune Health from Transformation Enzymes on Vimeo

Amylase: breaks down sugar and starch, and also digests dead white blood cells. Involved in anti-inflammatory reactions such as those caused by the release of histamine. The amylase deficient may have issues with psoriasis, eczema, hives, insect bites, allergies, atopic dermatitis, all types of herpes, and lung problems such as asthma and emphysema.
Papain: found naturally in unripe papayas, it has been used as a meat tenderizer as it breaks down the fibers in muscle tissue, as well as in preparation of cell cultures due to its ability to dissolve bonds between cells. It helps break down foods for digestion.
Trypsin: also breaks down protein into amino acids for absorption in the blood stream, as well as breaking down casein in milk, dissolving blood cloths in its microbial form, and treating inflammation in its pancreatic form. Atlantic cod trypsin in an oral spray was found to protect those inoculated with rhinovirus.
Lipase: breaks down fats into fatty acids and glycerol. Helps control appetite and healthy cholesterol and triglyceride levels. Those deficient in lipase have decreased cell permeability which means nutrients cannot get in and waste cannot get out, as well as muscle spasms, and spastic colon.
Chymotrypsin: Also breaks down proteins to produce enzymes for digestion and absorption of food. Also is anti-inflammatory. The presence and amount in stool is measured as a test of pancreatic function. Used for those with pancreatic insufficiency (impaired digestion, malabsorption and passing of undigested food in stool, gas, abdominal bloating, and nutrient deficiencies. Incomplete digestion of proteins may result in allergies and the formation of toxic substances. Helps keep the small intestine free from parasites such as bacteria, yeast, protozoa, and worms. Used to treat shingles, acne, age spots, sun damage, ulcerations and abscesses, arthritis and other autoimmune diseases, infections, injuries, and possibly cancer.
Bromelain: found in pineapples, it too digests protein. Used for indigestion and inflammation. When used on the skin it may be useful for removing dead tissue from third-degree burns. May reduce cough and nasal mucus as well as pain. It can kill some viruses and bacteria, and has anti-tumor properties and may help the effectiveness of certain chemotherapy drugs.
Quercetin Dihydrate: a bioflavonoid (plant pigment) found in fruits, vegetables, grains, and leaves. It is an anti-oxidant, anti-carcinogenic, neuroactive, anti-artherogenic, supports cardiovascular health, balanced blood pressure, protects against stress, and has an antihistamine effect.
Questions about Systemic Enzymes

“When is the best time to take a protease supplement?
For maximum systemic benefit, it is best to take proteases between meals as this allows for faster absorption into circulation. However, if this is not realistic for your patient, then it is ok to take proteases with meals knowing that some of the protease enzymes may be used to digest food proteins. Also, it is better to take small doses several times throughout the day rather than one or two large doses in a day. Common dosing times are first thing in the morning, mid-morning, mid-afternoon, and bedtime.
Can protease enzymes be taken with NSAIDS and/or prescription medications?
Digestive enzymes function by breaking down specific chemical bonds in foods. In most cases digestive enzymes can therefore safely be taken with medications. However, it is of course always recommended to let your health care provider know what you are taking.
Can protease enzymes be taken with prescription blood thinners?
One area of caution is with prescription blood thinning agents. These types of prescription drugs interfere with the natural blood clotting mechanisms, while proteases break down fibrin allowing for better blood flow. They can be taken in conjunction, but it is recommended to dose them about four hours apart and monitor lab work closely. We recommend notifying and working with the doctor prescribing the medications.
Can you take protease enzymes when taking prescription “protease inhibitors”?
More often than not, the term “protease” that describes proteolytic enzymes is used in very general terms. There are many metabolic proteases in our body, each with many different functions. The medications that are designed as protease inhibitors are targeting a very specific viral protease. The supplemental digestive proteases are very different and will not interfere with the medication. In fact, oral supplemental digestive enzymes can be very supportive to those patients with auto-immune disorders.”

How to choose the best systemic enzymes:

Some examples of Systemic Enzymes:





I’m sure there are many more types out there.  Do a google search and more will crop up.  I personally have used WobenzymN as well as Vascuzyme with great success.  The WobenzymN was expired by two years and still worked.  I switched to Vascuzyme by Ortho Molecular as it was stronger and my LLMD sells it in his office.  Make sure to read about the different types as they have different ingredients, dosages, and strengths.

**As you read above, please consult with your health care professional – particularly if you are taking blood thinners or have a blood disorder.  One site also stated that you SHOULD NOT take systemic enzymes if you are also taking antibiotics.  Discuss all of this with your practitioner.

My husband and I both tried WobenzymN while in antibiotic treatment and felt nothing.  After we quit antibiotics due to not herxing any longer and being fairly symptom-free for 3-4 months (except the excruciating pain in my head/neck/spine and his itching and fatigue) we started an herbal program for maintenance.  After 4 months of this with the pain still there, I retried the WobenzymN and within the first dose it took 70% of my pain away.  Since then, a month later, the pain is 99% gone.  All I take is 3 capsules each morning on an empty stomach.  For some of you, this may be the thing that will help you turn the corner and is certainly worth considering.

*Although you can buy these over the counter, make sure to run this and all supplements by your health practitioner as there are cross reactions with certain medications.

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