The Chronic Lyme Debate and tag team of Sood and Dixon
Mar 1, 2022 —
The following correspondence was sent to the Tick-Borne Disease Working Group following today’s scheduled online meeting. The second meeting will be held tomorrow March 1st…
February 28 – March 1, 2022, TBDWG Meeting (online)
———- Original Message ———-
From: CARL TUTTLE <firstname.lastname@example.org>
To: “Dennis.Dixon1@nih.hhs.gov” <Dennis.Dixon1@nih.hhs.gov>, “SSood@nshs.edu” <SSood@nshs.edu>
Cc: “email@example.com” <firstname.lastname@example.org>
(All members of the TBDWG)
Date: 02/28/2022 5:40 PM
Subject: Re: Questioning the appointment of Dr. Sunil K. Sood to the Working Group
To: Drs Dixon and Sood,
I happened to log onto today’s session right when the topic was persistent infection. I just finished a round of doxycycline for a chronic epididymitis that I have been treating for the past five months! As soon as symptoms return, I have been prescribed yet another antibiotic and the urologists aren’t telling me it’s post treatment epididymitis.
In my early twenties it took eighteen months to clear a chronic prostatitis and the military clinicians at the time didn’t say, “You’ve had enough antibiotics because chronic prostatitis is a religious belief.”
In reference to Lyme, my daughter returned to baseline health after 3.5yrs on a combination of antibiotics and my wife returned to baseline health after 2.5 years; both were seriously ill. Thanks to Dr. Sam Donta they received a diagnosis because both had CDC negative Western blots.
I sent you and all members of the TBDWG a copy of Lyme patient Vicki Logan’s positive culture test performed at the CDC’s Fort Collins lab. Ms. Logan was treated with many months of oral and IV antibiotics so how does this one single patient culture immediately positive for the infection when hundreds of test subjects from the Klempner trials did not? You can understand why the Lyme patient community is suspect of NIH trials that may have design flaws leading to results that support the existing dogma.
In addition, what about this study of twelve Lyme patients from Canada?
Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
All of these patients were culture positive for infection (genital secretions, skin “Morgellons” and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics.
Dr. Dixon, one of those studies you mentioned today showed patients with Lyme had a quality of life equal or worse to those with congenital heart disease and yet Lyme patients are routinely denied Social Security Disability compensation. Why is that?
For the record, here are links to the seven-page autopsy results of patient Vicky Logan showing histopathologic findings consistent with neurologic manifestations of chronic Lyme disease. (personal Dropbox storage area)
(Vicky Logan’s Autopsy results Page #1, 2, 3, 4, 5, 6, 7)
The destructive nature of Borrelia is evident in Vicky Logan’s liver (nutmeg liver), kidneys, heart, lungs and brain. The patient died after the insurer refused additional IV antibiotic therapy. (Medical Execution)
And we’re still debating persistent infection? WHY???
See additional references below…
1. Seronegative Chronic Relapsing Neuroborreliosis.
Lawrence C.a · Lipton R.B.b · Lowy F.D.c · Coyle P.K.d
aDepartment of Medicine, bDepartment of Neurology, and cDivision of Infectious Diseases, Albert Einstein College of Medicine, and dDepartment of Neurology, State University of New York at Stony Brook, New York, NY., USA
Eur Neurol 1995; 35:113–117 (DOI:10.1159/000117104)
We report an unusual patient with evidence of Borrelia burgdorferi infection who experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids and free antigen.
Let’s review another early publication where persistent infection was recognized:
May 13, 1988
2. Fatal Adult Respiratory Distress Syndrome in a Patient With Lyme Disease
Michael Kirsch, MD; Frederick L. Ruben, MD; Allen C. Steere, MD; et al
JAMA. 1988;259(18):2737-2739. doi:10.1001/jama.1988.03720180063034
A dry cough, fever, generalized maculopapular rash, and myositis developed in a 67-year-old woman; she also had markedly abnormal liver function test results. Serologic tests proved that she had an infection of recent onset with Borrelia burgdorferi, the agent that causes Lyme disease. During a two-month course of illness, her condition remained refractory to treatment with antibiotics, salicylates, and steroids. Ultimately, fatal adult respiratory distress syndrome developed; this was believed to be secondary to Lyme disease.
3. Granulomatous hepatitis associated with chronic Borrelia burgdorferi infection: a case report
The patient had active, systemic Borrelia burgdorferi infection and consequent Lyme hepatitis, despite antibiotic therapy. Spirochetes were identified as Borrelia burgdorferi by molecular testing with specific DNA probes.
4. Culture evidence of Lyme disease in antibiotic treated patients living in the Southeast.
Rudenko and colleagues reported culture confirmation of chronic Lyme disease in 24 patients in North Carolina, Florida, and Georgia. All had undergone previous antibiotic treatment
5. DNA sequencing diagnosis of off-season spirochetemia with low bacterial density in Borrelia burgdorferi and Borrelia miyamotoi infections.
Faulty/misleading antibody tests landed a sixteen year old male in a psychiatric ward when his lab results did not meet the CDC’s strict criteria for positive results. His Western blot had only four of the required five IgG bands. Subsequent DNA sequencing identified a spirochetemia in this patient’s blood so his psychiatric issues were a result of neurologic Lyme disease misdiagnosed by antiquated/misleading serology. This patient was previously treated with antibiotics.
6. The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease
Autopsy tissue sections of the brain, heart, kidney, and liver were analyzed by histological and immunohistochemical methods (IHC), confocal microscopy, fluorescent in situ hybridization (FISH), polymerase chain reaction (PCR), and whole-genome sequencing (WGS)/metagenomics. We found significant pathological changes, including borrelial spirochetal clusters, in all of the organs using IHC combined with confocal microscopy.
7. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
“This pilot study recently identified chronic Lyme disease in twelve patients from Canada. All of these patients were culture positive for infection (genital secretions, skin and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics.”
Persistent infection after extensive antibiotic treatment has been identified through the use of direct detection methods in academic centers and autopsy findings yet the average patient cannot obtain these tests to justify how sick they are with their chronic active infection. Serology cannot be used to gauge treatment failure or success which makes it the ideal tool for concealing persistent infection.
Serology has allowed the 30-year dogma to persevere [iii] whereas direct detection methods are exposing the exact opposite.
We are dealing with a life-altering/life-threatening infection with faulty/misleading antibody tests, inadequate treatment, no medical training and absolutely no disease control whatsoever; a public health disaster. And what was the reason for the mishandling of this coexisting pandemic you might ask?
A chronic relapsing seronegative disease does not fit the vaccine model. The rush to create a vaccine here in the United States promoted the denial of persistent infection and focusing on the acute stage of disease hides the horribly disabled.
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