55_chronic316x316 Lymestats.org


Is There Really Chronic Lyme Disease?

There is an abundant, growing body of research evidencing persistent infection after standard courses of antibiotic treatment for Lyme Disease, often leading to chronic, debilitating illness. Lyme patients desperately need research to develop more effective treatments.


Health Care Costs, Utilization and Patterns of Care following Lyme Disease http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116767

Severity of Chronic Lyme Disease compared to other chronic conditions:  A Quality of Life Survey  PeerJ Quality of Life Survey

An Optimized SYBR Green I/PI Assay for Rapid Viability Assessment and Antibiotic Susceptibility Testing for Borrelia burgdorferi  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111809

Drug Combinations against Borrelia burgdorferi Persisters In Vitro: Eradication Achieved by Using Daptomycin, Cefoperazone and Doxycycline   http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117207

Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library http://www.nature.com/emi/journal/v3/n7/full/emi201453a.html

Counterpoint: Long-Term Antibiotic Therapy Improves Persistent Symptoms Associated with Lyme Disease  https://academic.oup.com/cid/article/45/2/149/420106/Counterpoint-Long-Term-Antibiotic-Therapy-Improves

Resurgence of Persisting Non-Cultivable Borrelia burgdorferi following Antibiotic Treatment in Mice  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086907

Persistence of Borrelia burgdorferi in Rhesus Macaques following Antibiotic Treatment of Disseminated Infection  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029914


Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048277


Researchers at Brown University poke holes in the Klempner study, which the IDSA uses to justify denying long-term treatment to Lyme patients  http://www.lymedisease.org/retreatment-study-flawed/


Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection  http://www.nature.com/emi/journal/v4/n6/full/emi201531a.html

Eradication of Biofilm-Like Microcolony – Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime  http://journal.frontiersin.org/article/10.3389/fmicb.2016.00062/full

List of 700 articles citing chronic infection associated with tick-borne disease compiled by Dr. Robert Bransfield  http://www.ilads.org/ilads_news/2017/list-of-700-articles-citing-chronic-infection-associated-with-tick-borne-disease-compiled-by-dr-robert-bransfield/


A Drug Combination Screen Identifies Drugs Active against Amoxicillin-induced Round Bodies of Borrelia burgdorferi Persisters from an FDA Drug Library  http://journal.frontiersin.org/article/10.3389/fmicb.2016.00743/full

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Lastly, microbiologist Holly Ahern points out that stating that only 10-20% go on to develop symptoms is inaccurate:  https://madisonarealymesupportgroup.com/2019/02/25/medical-stalemate-what-causes-continuing-symptoms-after-lyme-treatment/

In short, the 10-20% is a group that was diagnosed and treated early.  There’s another larger group, approximately 30-40%, that was diagnosed and treated late that develops chronic symptoms.  When you add the two groups:

60% of all patients could go onto develop life-long symptoms







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