Archive for the ‘research’ Category

Is MS an Infectious Disease?

The following link contains a collection of research on MS and infections including fungus, Lyme, parasites, and viruses.  Highly recommend.  The website is Pam Bartha’s who’s life was turned upside down at the age of 28 when she was diagnosed with MS.  She lost vision in one eye, was weak and had tingling in her legs, insomnia, and severe fatigue and headaches.  She was told by doctors there was nothing she could do but wait around and become disabled.  Her mother in law gave her a book that set her on a healing journey that continues today.  The book was “The Yeast Connection” by Dr. Crook.  In it he shared that he believed many diseases are actually caused by infections, especially the GI tract.  This doctor observed that when he treated the infections, his patients recovered. Go here to read Pam’s story as there are golden nuggets for all within and great recommendations.

Pam is a wellness researcher, educator and coach with a BS who is a certified teacher.  She offers a free consultation and personalized training on how to get your health back.  (I have no affiliation with this program and receive no monies)

https://livediseasefree.com/ms-infections/#multiple-sclerosis-and-lyme-disease

Multiple Sclerosis Infection – Is MS an Infectious Disease?

The following is an excerpt from Pam’s website.  Go to link for entire article

Multiple Sclerosis and Infection

Could Multiple Sclerosis be caused by infection? These studies and articles offer compelling evidence. Contact Us for more information.

Multiple Sclerosis and Infection
Multiple Sclerosis and Fungus
Multiple Sclerosis and Lyme Disease
Multiple Sclerosis and Parasites
Multiple Sclerosis and Viruses

1. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
Nature. 2011; 479(7374): 538-41. DOI: 10.1038/nature10554.

This study shows that microbes that live in the body (in particular the GI tract) are an essential factor in triggering the autoimmune response in MS and other diseases.

“Active multiple sclerosis lesions show inflammatory changes suggestive of a combined attack by autoreactive T and B lymphocytes against brain white matter. … The stimuli triggering this autoimmune conversion have been commonly attributed to environmental factors, in particular microbial infection. … We show that the commensal gut flora… is essential in triggering immune processes, leading to a relapsing-remitting autoimmune disease…“

2. Role of pathogens in multiple sclerosis.
International Reviews of Immunology. 2014; 33(4): 266-83. DOI: 10.3109/08830185.2013.823422.

This study states that “infectious pathogens (disease causing microbes) are the likely environmental factors involved in the development of MS.” It also identifies various microbes that are involved in the development of Multiple Sclerosis infection, which include various bacteria, parasites and viruses.

“Although the etiology of MS is unknown, genetic and environmental factors play a role. Infectious pathogens are the likely environmental factors involved in the development ofMultiple Sclerosis infection. Pathogens associated with the development or exacerbation of MS include bacteria, such as Mycoplasma pneumoniae and Chlamydia pneumoniae, the Staphylococcus aureus-produced enterotoxins that function as superantigens, viruses of the herpes virus (Epstein-Barr virus and human herpesvirus 6) and human endogenous retrovirus (HERV) families and the protozoa Acanthamoeba castellanii. Evidence, from studies with humans and animal models, supporting the association of these various pathogens with the development and/or exacerbation of MS will be discussed along with the potential mechanisms including molecular mimicry, epitope spreading and bystander activation. In contrast, infection with certain parasites such as helminthes (Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, Trichuris trichiura, Ascaris lumbricoides, Strongyloides stercolaris, Enterobius vermicularis) appears to protect against the development or exacerbation of MS… A complex interaction between the CNS (including the blood-brain barrier), multiple infections with various infectious agents (occurring in the periphery or within the CNS), and the immune response to those various infections may have to be deciphered before the etiology of MS can be fully understood.”

(See link for article)

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For more:

MS is another label that needs a better definition.  Since so many things can cause/exacerbate it, it’s a highly individual issue that needs to be approached as such.  There is no four-cornered box with this beast and you must be willing to go down many rabbit-holes to find answers.  This is a journey, not a destination.  There may be many issues that must be addressed in order to achieve health – just like with Lyme/MSIDS.

Category:

Activism, Candida, Lyme, Parasites, research, Viruses

Crypto-Infections Conference 2023: Lyme Disease & Other Hidden Infections

https://www.lymeresourcecentre.com/EUCIC2023

CRYPTO-INFECTIONS CONFERENCE 2023: LYME DISEASE & OTHER HIDDEN INFECTIONS

An invitation to the Third European

CRYPTO-INFECTIONS CONFERENCE: LYME DISEASE &
OTHER HIDDEN INFECTIONS BACTERIAL PERSISTENCE

Catherine Mc Auley Centre, 21 Nelson Street, Dublin 7, Ireland

SAVE THE DATE!

Friday 19th of May to Saturday 20th May 2023

HYBRID ATTENDANCE IN PERSON OR ONLINE

Join Zoom Meeting links will be provided before the event.

TO BOOK please use the following link:
BOOKING FORM

Aims and eligibility- Presenters can present in person or online.

Abstracts should contain original material from recent work that is not yet in publication. The conference encourages research on crypto infections as well as best practice examples and lessons learned. The theme of this year’s conference is Persistance of Infection.

Abstract categories
Please see below list of topics/ tracks available for submitted abstracts for Crypto-Infections 2023:

  1. Human studies
  2. Animal studies
  3. Epidemiology
  4. Diagnostics and therapeutics

For abstracts submitted by students, the registration for the conference will be waived, but all costs related to the conference participation should be covered by you, including flight and accommodation if you decide to attend in person.

Please send your abstract in pdf format to gavramovic@mater.ie by the 2nd May 2023. Word count limit is 250 words excluding title and authors. The abstract should contain the following sections: Title and Authors, Introduction, Methods, Results and Discussion. Authors should indicate if they wish to apply for an oral presentation or poster only

Category:

Activism, Lyme, research

Two More Studies Show Link Between mRNA Shots & Heart Issues

https://www.researchgate.net/publication/365782650_Autopsy-based_histopathological_characterization_of_myocarditis_after_anti-SARS-CoV-2-vaccination

Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

November 2022

Clinical Research in Cardiology

DOI:10.1007/s00392-022-02129-5
Authors:
Constantin Schwab
Lisa Maria Domke
Laura Hartmann
Albrecht Stenzinger

Abstract and Figures

Cases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common characteristics of myocarditis in untreated persons who received anti-SARS-CoV-2 vaccination. Standardized autopsies were performed on 25 persons who had died unexpectedly and within 20 days after anti-SARS-CoV-2 vaccination.
  • In four patients who received a mRNA vaccination, we identified acute (epi-)myocarditis without detection of another significant disease or health constellation that may have caused an unexpected death. Histology showed patchy interstitial myocardial T-lymphocytic infiltration, predominantly of the CD4 positive subset, associated with mild myocyte damage.

Overall, autopsy findings indicated death due to acute arrhythmogenic cardiac failure. Thus, myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases.

http://

Dec. 21, 2022

Heidelberg University Hospital Autopsy Examination Reveals 5 of 25 Deceased Likely Linked to Vaxxed

German researchers from the esteemed Heidelberg University Hospital Institute of Pathology led by corresponding authors Thomas Longerich Deputy Director University Hospital Heidelberg and Peter Schirmacher, acting chairman of the German Society of Pathology, director of the Institute of Pathology also at Heidelberg University Hospital, and president of the German Association for the Study of the Liver, recently had their investigation published in the journal Clinical Research in Cardiology titled“Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination.” The real-world analysis examined 25 individuals who died unexpectedly AND within 20 days of the COVID-19 vaccination.

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https://www.sciencedirect.com/science/article/pii/S0264410X22014931

Surveillance of COVID-19 vaccine safety among elderly persons aged 65 years and older

https://doi.org/10.1016/j.vaccine.2022.11.069Get rights and content

Abstract

Background

Monitoring safety outcomes following COVID-19 vaccination is critical for understanding vaccine safety especially when used in key populations such as elderly persons age 65 years and older who can benefit greatly from vaccination. We present new findings from a nationally representative early warning system that may expand the safety knowledge base to further public trust and inform decision making on vaccine safety by government agencies, healthcare providers, interested stakeholders, and the public.

Methods

We evaluated 14 outcomes of interest following COVID-19 vaccination using the US Centers for Medicare & Medicaid Services (CMS) data covering 30,712,101 elderly persons. The CMS data from December 11, 2020 through Jan 15, 2022 included 17,411,342 COVID-19 vaccinees who received a total of 34,639,937 doses. We conducted weekly sequential testing and generated rate ratios (RR) of observed outcome rates compared to historical (or expected) rates prior to COVID-19 vaccination.

Findings

Four outcomes met the threshold for a statistical signal following BNT162b2 vaccination including pulmonary embolism (PE; RR = 1.54), acute myocardial infarction (AMI; RR = 1.42), disseminated intravascular coagulation (DIC; RR = 1.91), and immune thrombocytopenia (ITP; RR = 1.44). After further evaluation, only the RR for PE still met the statistical threshold for a signal; however, the RRs for AMI, DIC, and ITP no longer did. No statistical signals were identified following vaccination with either the mRNA-1273 or Ad26 COV2.S vaccines.

Interpretation

This early warning system is the first to identify temporal associations for PE, AMI, DIC, and ITP following BNT162b2 vaccination in the elderly. Because an early warning system does not prove that the vaccines cause these outcomes, more robust epidemiologic studies with adjustment for confounding, including age and nursing home residency, are underway to further evaluate these signals. FDA strongly believes the potential benefits of COVID-19 vaccination outweigh the potential risks of COVID-19 infection.

Important excerpt:

Per FDA communication of these findings, FDA is currently not taking any regulatory actions based on these signal detection activities because these signals are still under investigation and require more robust study.

Conflict of Interest Statement

Co-authors from U.S. Food and Drug Administration, Acumen LLC, and 4 Centers for Medicare & Medicaid Services declared no conflicts of interests.

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**Comment**

This well written article asks WHY it has taken so long for the FDA to print their findings.  An in an October investigation for The BMJ, the FDA first disclosed findings in July 2021, noting the detection of four types of potential serious adverse events following receipt of Pfizer’s vaccine in the elderly (65s & over):

  1. acute myocardial infarction
  2. disseminated intravascular coagulation
  3. immune thrombocytopenia
  4. pulmonary embolism

But these findings were only posted on the agency’s website, with no corresponding press release, preprint, or journal publication.  The article also points out a concern that the FDA’s analysis is already out of date due to the cut-off date of Jan. 15, 2022 (four months after the study was submitted to Vaccine), which means there’s now a year’s worth of additional data that has not been reported on by the FDA.

The webpage stated that the FDA “will further investigate these findings” and “share further updates and information with the public as they become available.”

But over one year later, crickets…..

The FDA finally just came out with the information, which claims it shows the system is working.

“How can the FDA seriously assert it’s supporting decision-making when, in the 20 months that they have been aware of the signal, there has not been a single press release or Dear Health Care Provider letter about the FDA’s studies on safety signals, and the label has yet to be updated?” ~ Peter Doshi, associate professor at the University of Maryland School of Pharmacy and senior editor at The BMJ

These studies confirm what concerned doctors, researchers, and injured patients have been shouting about for two years.  The FDA finally came out of its coma to notice, but per usual is doing nothing about it.

Dr. Peter McCullough, chief medical adviser for the Truth for Health Foundation, told the Epoch Times via email that the new paper:

“corroborates the concerns of doctors that the large uptick in blood clots, progression of atherosclerotic heart disease, and blood disorders is independently associated with COVID-19 vaccination.”

What’s truly disheartening is that this information should available BEFORE the shots were rolled out to an unsuspecting and trusting public who now must simply deal with the hideous aftermath.  Please also note that the push for these shots initially was on the vulnerable, elderly population despite the fact it is common knowledge that “vaccines” are less effective in the elderly due to a declining immune system.

Some of the worst medical and civil rights tyranny is occurring in health care settings like senior residential facilities.  A common lunacy heard around the world is, “take the jab or lose your job.” Health care workers, the military, pilots, many schools, workers in companies with more than 100 employees, and many more were mandated to get the jab. This was also true for many senior homes and other institutions.  People felt they had no choice.  Many quit their jobs due to this. Further, Whistleblowers claim elderly patients were chemically constrained and physically forced to get the injections.  Allegedly, caretakers lied to residents about the shot, and forged signatures multiple times.  These claims have been corroborated by multiple care directors.

Now, the FDA finally admits that these very people who were often forced to get the jab have a statistical signal for blood clotting due to the very thing they were forced to get.

This does not bode well for public health.

http://  (Approx. 14 Min)

FDA Drops Bombshell over Pfizer Shot

Redacted with Natali and Clayton Morris

Dec. 19, 2022

Category:

Activism, Heart Issues, research, vaccines, Viruses

Long-Term Outcomes in Treated Lyme Carditis

https://www.sciencedirect.com/science/article/abs/pii/S0146280621001547?via%3Dihub

Long-term Outcomes in Treated Lyme Carditis

https://doi.org/10.1016/j.cpcardiol.2021.100939Get rights and content

Abstract

Lyme disease is the most reported tick-borne illness in North America. Lyme carditis (LC) is an early-disseminated manifestation of Lyme disease, most commonly presenting as symptomatic high-degree atrioventricular block (AVB) which resolves with appropriate antibiotic therapy. However, long-term outcomes of treated LC have not previously been described. We present a series of 7 patients (median 28 years, 6 male) with serologically confirmed LC treated with a standard protocol developed at our center including antibiotics and pre-discharge stress test to assess AV node stability. At a mean follow-up of 20.8 months, all patients were asymptomatic, had resumed normal activities, and were free of conduction abnormalities. None required permanent pacing. Our study supports avoidance of permanent pacing for LC if conduction is stable at discharge.

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**Comment**

These patients were followed for a minimum of 12 months after hospital discharge and had no heart symptoms.  The researchers state there is no protocol for ongoing monitoring of these discharged patients that that long-term follow-up should be further explored.  I couldn’t agree more.

For more:

Category:

Heart Issues, Lyme, research, Treatment

Lyme Disease & Herxheimer Reaction in Newborn

https://danielcameronmd.com/lyme-disease-herxheimer-reaction-newborn/

LYME DISEASE AND HERXHEIMER REACTION IN NEWBORN

Newborn with lyme disease and herxheimer reaction being examined by doctor.

The Herxheimer reaction, also referred to as a Jarisch-Herxheimer reaction, is “a transient clinical phenomenon that occurs in patients infected by spirochetes who undergo antibiotic treatment.”¹ It was first described in patients with syphilis but has also been associated with other spirochetal infections including leptospirosis, Lyme disease, and relapsing fever. The reaction is associated with the onset of new symptoms or a worsening of existing symptoms in patients receiving antibiotic treatment.

By 

In 2020, investigators published a case involving a 13-year-old boy with Lyme arthritis, a common manifestation of Lyme disease, who developed a Herxheimer reaction when treated with doxycycline. On the 7th day of treatment, the boy developed a low-grade fever and severe arthralgias with intense hip, ankle and cervical spine pain and myalgias.

You can read more about the 13-year-old boy’s case in an earlier blog “Herxheimer reaction in a 13-year-old boy with Lyme disease.” 

Newborn with herxheimer reaction

In their article “Lyme disease in a neonate complicated by the Jarisch–Herxheimer reaction,” Prodanuk and colleagues² describe the case of a 21-day-old infant who was admitted to the hospital with decreased activity, poor feeding and abdominal distension.

The parents removed an engorged tick from the infant’s forearm 5 days earlier. An EM rash was present at the site of the tick bite.

“Given the erythema migrans lesion at the site from which the engorged tick was removed, we made a presumptive diagnosis of Lyme disease and administered IV ceftriaxone,” the authors write.

Two hours after treatment began, the infant developed a fever, tachycardia and other symptoms consistent with the Jarisch–Herxheimer reaction.

Testing for Lyme disease was negative.

Clinicians should also “be aware of the possibility of the Jarisch–Herxheimer reaction during the initial phase of treatment.”²

Several studies, they warn, indicate “newborns with findings consistent with early localized disease may also be at higher risk for disseminated disease.”

“Given the limited data for neonates and the possible predisposition of this population to disseminated Lyme disease, clinicians should strongly consider administering IV antibiotics to target Lyme disease,” the authors suggest.

Patients can experience a broad range of symptoms resulting from a herxheimer reaction, explains Nykytyuk and colleagues, including fever, severe polyarthralgias, myalgias, chills, hypotension, nonpruritic, nonpalpable rash, tachycardia, nausea, headache, strengthening of existing or occurrence of new symptoms of the underlying disease.¹

The exact cause of Jarisch-Herxheimer reactions is still unknown. “At first, the role of an endotoxin in the development of JHR was suggested, but later experimental studies showed that spirochetes do not have biologically active endotoxins,” the authors explained.¹

Related Articles:

What does a Lyme disease flare-up feel like?
Herxheimer reaction in a 13-year-old boy with Lyme disease
Lyme disease causes a mix of symptoms including autonomic dysfunction

References:
  1. Dhakal A, Sbar E. Jarisch Herxheimer Reaction. [Updated 2022 Apr 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557820/
  2. Prodanuk M, Groves H, Arje D, Bitnun A. Lyme disease in a neonate complicated by the Jarisch-Herxheimer reaction. CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112. PMID: 35851530; PMCID: PMC9299745.

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**Comment**

This infant won the lotto by having astute parents, a noticable tick bite, and EM rash.  Many are not so fortunate to have these clear signs.  Many also test negative.  Without the signs and positive test, many are misdiagnosed and miss this opportunity for early treatment which is imperative.

For more:

Category:

Inflammation, Lyme, research, Testing, Ticks, Treatment