Archive for the ‘research’ Category

Will Hordes of Genetically Altered Mice Help Curb Lyme Disease?

https://www.bostonglobe.com/2022/04/21/science/an-effort-curb-lyme-disease-scientists-hope-release-thousands-genetically-altered-mice-nantucket/

Will hordes of genetically altered mice help curb Lyme disease?

By David Abel

Updated April 21, 2022

NANTUCKET — As spring emerged on this island of manicured estates and idyllic beaches, a group of scientists from the Boston area arrived on a recent afternoon with an extraordinary request for local officials: Let us release hordes of genetically altered mice into the wild. Hundreds of thousands of them, potentially.

The engineered rodents would look exactly like the native white-footed mice.  But each of their cells would carry genetic code, specially tailored in an MIT lab, for resistance to the bacteria that causes Lyme disease. White-footed mice are a key reservoir for the harmful bacteria.  (See link for article)

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SUMMARY:

  • Founder of the “Mice Against Ticks” project, Kevin Esvelt (Assoc. Prof. at MIT), admits technology can make the world worse.
  • The proposal supposedly will require significant vetting, and support for the project remains uncertain due to concerns about GMOs.
  • They plan on inserting specific Lyme-resistance genes within the mice that have developed immunity to the disease, rather than more risky specifically designed genetic code. The hope is that this immunity would be passed to descendants – eventually replacing all mice susceptible to the pathogen.
  • They plan to conduct field trials on several small largely uninhabited private islands in the region before releasing the mice into the wild.
  • They also plan to bring in independent ecologists to monitor the experiments.

Concerns of unintended consequences included:

  • Would this cause a surge in other invasive species?
  • Would the mice and rodent population grow significantly or exhibit new traits like becoming more aggressive?
  • Would there be harmful ramifications for species that consume the GMO mice?
  • Would this experiment be regulated effectively?
  • What could be done to halt negative consequences once the genie is out of the bottle?

I disagree with the following two beliefs presented as facts in the article:

  1. That the worst thing we can do is nothing.  In fact, a lot worse can happen as has been shown historically many times. After a few attempts to establish the Asian beetle as a biological control agent for aphids, we now have swarms of them AND the aphid problem and this is simple Simon met a pie man compared to the unknown results of genetically modifying mice and insects & releasing them into the wild.
  2. Climate change, is causing tick and disease proliferation. A recent report by the Global Warming Policy Foundation (GWPF) states that empirical evidence shows that there is “no evidence of a climate crisis.”  The climate issue has become a religion and a useful political tool for the current global power grab.  It has also been proven to be null and void regarding tick and Lyme disease proliferation.  The climate changes.  Always has and always will.  It does not; however, cause all the destruction many claim. There is clear evidence that man-made climate engineering to control the weather is destroying life and the planet.  They are spraying nanoparticles into the atmosphere and then using microwave transmissions such as 5G to weaponize the weather.  Many are oblivious to the fact that climate engineering is the crown jewel of the military industrial complex.

The article mentioned that the only other similar experiment was when GMO mosquitoes were released in the Florida Keys to reduce the spread of dengue, Zika, and chikungunya.  The FDA also approved a field trial in California.  What was omitted was the potential future devastation with the ongoing experiment. This article not only explains the issue, but shows residents explaining the troubling fact there is no independent oversight to this experiment.  Important quote:

Poorly done, secretive science and lack of transparency is once again being rewarded with a free pass by government officials who are ignoring the voices of concerned scientists and those most impacted.” said Dana Perls, Emerging Technology Program Manager at Friends of the Earth. “First in Brazil, and now in Florida, government agencies have missed the mark and promoted the interests of a private corporation over public health and ecosystem protection.”

And if you want to be creeped out even more:

  • Financially backed by the Bill & Melinda Gates Foundation, Oxitec has been experimenting with GMO mosquitoes for years.
  • One of the biggest threats is that the GMO mosquitoes will breed and create hybrid wild mosquitoes that end up worsening the spread of mosquito-borne diseases. These GMO mosquitoes may also end up becoming more resistant to insecticides than wild mosquitoes.
  • There is further evidence to suggest that biting females will be released, despite objections from Oxitec that this will not happen. These biting females would put humans at risk of attack and infection, without their informed consent.
  • The timing of this could not be more questionable.  If adverse reactions occur, lines will be blurred on yet another confounding factor in relation to COVID-19 and disease. ‘Authorities’ will only be too happy to blame any and all negative outcomes on COVID and NOT on released GMO mosquitoes.  They already are denying any negative outcomes from the COVID shot which have caused more destruction than another other vaccine in the history of VAERS.
  • Another point to stress is that the CRISPR gene-editing technology (tinkering with genes) has been shown to create unintended mutations:  http://articles.mercola.com/sites/articles/archive/2017/06/13/crispr-gene-editing-dangers This article shows 100 deletions and insertions and more than 1,500 unintended single-nucleotide mutations occurred.  
  • The New York Times recently reported that a 57 year old man died after receiving a GMO pig heart and became infected with a pig virus that may have contributed to his death.
  • This article states CRISPR has the potential to cause cancer in a whole generation of humans.
  • Noam Prywes, PhD candidate in chemistry at Harvard, claims that CRISPR/Cas-9-based gene drives will:

    “add a twist – introducing one gene drive after another to correct unforeseen consequences as they are discovered,” and that “decisions by researchers would become permanently written into the genomes of entire wild populations.” He also adds that there are alternative ways to wipe out local populations of mosquitoes carrying disease that are much safer.

    In this same vein, David Burwitz of Tel Aviv University, feels that gene drive research should be classified to prevent weapon development, and he’s not alone. http://nextstageprep.com/gene-drivesthis-next-weapon-mass-destruction/ In theory, a terrorist could create a handful of insects with a gene for making a toxin, and power it with a gene drive. Pretty soon, all of these insects would make the toxin, and every insect bite would be lethal. However, according to Austin Burt, who proposed the theoretical method for making gene drives, the gene drives only work in sexually reproducing species, unlike the vast majority of genetically engineered microbes which produce asexually and they’ve only been shown to work for one generation – so far.

Let’s suffice it to say that nobody has a clue of the outcome of such an experiment.  And once the cat is out of the bag, it is unlikely it can be put back.

I remember hearing Esvelt years ago at a conference.  I thought he was a mad scientist then and I still think he’s a mad scientists.  No thank you.

For more:

Correlation Between Mask Compliance & COVID-19 Outcomes in Europe

https://www.cureus.com/articles/93826-correlation-between-mask-compliance-and-covid-19-outcomes-in-europe

Compliance and COVID-19 Outcomes in Europe



Abstract

Masking was the single most common non-pharmaceutical intervention in the course of the coronavirus disease 2019 (COVID-19) pandemic. Most countries have implemented recommendations or mandates regarding the use of masks in public spaces. The aim of this short study was to analyse the correlation between mask usage against morbidity and mortality rates in the 2020-2021 winter in Europe. Data from 35 European countries on morbidity, mortality, and mask usage during a six-month period were analysed and crossed. Mask usage was more homogeneous in Eastern Europe than in Western European countries. Spearman’s correlation coefficients between mask usage and COVID-19 outcomes were either null or positive, depending on the subgroup of countries and type of outcome (cases or deaths). Positive correlations were stronger in Western than in Eastern European countries. These findings indicate that countries with high levels of mask compliance did not perform better than those with low mask usage.

Excerpt:

“….the lack of negative correlations between mask usage and COVID-19 cases and deaths suggest that the widespread use of masks at a time when an effective intervention was most needed, i.e., during the strong 2020-2-21 autumn-winter peak, was NOT able to reduce COVID-19 transmission.

Moreover, the moderate positive correlation between mask usage and deaths in Western Europe also suggests that the universal use of masks may have had harmful unintended consequences.”

There was a statistically significant correlation between higher deaths in countries that locked down hard, with vast mask usage, and COVID deaths.

To hear the study explained:  https://rumble.com/v13607x-more-harm-than-good-a-new-study-shows-that-masks-not-only-didnt-work-but-th.html  (Approx. 3 Min)

For more:

Top Killer for Chronic Lyme is Suicide

https://themighty.com/2017/09/lyme-disease-suicide/

The Importance of Reaching Out If Lyme Disease Has Left You Feeling Suicidal

By Annie Perkins-Rosenberg

Editor’s note: If you experience suicidal thoughts, the following post could be potentially triggering. You can contact the Crisis Text Line by texting “START” to 741-741.

Article excerpt:

The important message of this article is to help those out there who deal with the psychiatric manifestations, the judgments and the daily struggle of living life with a complex disease like Lyme. It can be heavy some days, and anyone can have dark questioning moments pass through their minds. When those moments do arise, it can be complicated to find someone to trust and to talk to. Quite often, Lyme patients are paying for treatments out of pocket and this does not leave much money left for proper psychiatric help. With the limited time in office visits with our doctors, there is not much time left to talk about how we are feeling emotionally, and our doctors are generally not trained psychiatrists, as much as we wish they were. With Lyme disease being largely unknown, others close to you may judge you and you may feel like there is no one left to talk to. Even if there is, the psychiatric disturbances the disease can cause can make you feel like there is no one out there who can understand you, no one who can listen to you and no one to reach out to, but there is. There always is.

One of the techniques the author used was Googling the suicide prevention hotline so she had a plan if things got dark.  She also removed anything bothersome and overwhelming to her, set boundaries, learned to speak up, and found a small group of people on the same journey as her for comfort.  She also reminded herself that each day she was getting better, that she was healthy and could beat this.  When the dark thoughts came, she sought out help.

All, great advice.

The following abstract by Dr. Bransfield is telling:

LAD contributed to suicidality, and sometimes homicidality, in individuals who were not suicidal before infection. A higher level of risk to self and others is associated with multiple symptoms developing after acquiring LAD, in particular, explosive anger, intrusive images, sudden mood swings, paranoia, dissociative episodes, hallucinations, disinhibition, panic disorder, rapid cycling bipolar, depersonalization, social anxiety disorder, substance abuse, hypervigilance, generalized anxiety disorder, genital–urinary symptoms, chronic pain, anhedonia, depression, low frustration tolerance, and posttraumatic stress disorder. Negative attitudes about LAD from family, friends, doctors, and the health care system may also contribute to suicide risk.

By indirect calculations, it is estimated there are possibly over 1,200 LAD suicides in the US per year.

http://  Approx 1 Min

Robert Bransfield, MD, DLFAPA, private practice, Psychiatry, in Red Bank, New Jersey, discusses direct methods that can be used to acquire statistics related to suicides that are a result of Lyme and associated diseases

For more:

One of the best pieces of advice I got on the journey from another patient was, “don’t get depressed about being depressed.”  In other words, accept the fact there will be dark days with dark thoughts.  Don’t beat up on yourself over this.  Accept it and look forward to tomorrow which will be better.

While the topics regarding Lyme/MSIDS are endless, dealing with pain and insomnia are two issues that can really help with mental health.

For more:

I would be amiss if I didn’t mention detoxing at this point as well as not detoxing properly can also lead to pain:

Lyme Disease Triggers Inflammation in “Hindbrain”

https://danielcameronmd.com/lyme-disease-inflammation-hindbrain/

Lyme disease triggers inflammation in “hindbrain”

lyme-disease-inflammation-brain

A 52-year-old woman was hospitalized with rhombencephalitis (inflammation of the rhombencephalon, also known as the hindbrain). The condition was found to be triggered by an infection with Borrelia burgdorferi, the causative agent of Lyme disease.

In their article, “Neuroborreliosis with involvement of rhombencephalon: A case report,” ¹ Svingen and colleagues describe a unique presentation in which Lyme disease triggered inflammation of the rhombencephalon, a region of the brain also referred to as the hindbrain.

Over an 8-month period, the patient experienced intermittent fevers, dry cough, fatigue, headaches, night sweats, unintentional weight loss of about 15 lbs., double vision, a tremor in the neck, paresthesia and tremor in the extremities, an unsteady gait, and memory loss.

Approximately 4 weeks prior to symptom onset, the woman had been vacationing in a Lyme-endemic region of Norway. However, she did not recall a tick bite or rash.

“An MRI scan demonstrated pathology in rhombencephalon with quite symmetric T2 hyperintensity involving capsula interna bilaterally, extending through mesencephalon to pons,” the authors wrote.

Borrelia burgdorferi-specific IgM and IgG antibodies were identified using Chemiluminescence Immunoassay (CLIA).

An MRI scan revealed inflammation in rhombencephalon (also referred to as the hindbrain) that are extremely rare in patients with Lyme disease, the authors wrote.

The patient was treated successfully for 4 weeks with intravenous ceftriaxone.

“The MRI findings in rhombencephalon had almost disappeared,” according to the authors. Seven months later, a follow-up MRI “was completely normal, and she had further improvement of her symptoms.”

The authors suggest, “Significant improvement of neurological symptoms and resolution of the MRI findings after proper treatment confirmed the diagnosis neuroborreliosis with rhombencephalitis.”

Furthermore, “we recommend that neuroborreliosis should be considered among the differential diagnoses in patients where neurological symptoms and findings suggesting inflammation in the CNS, despite unusual or normal neuroimaging findings.”

Rhombencephalitis can be caused by infections with Listeria monocytogenes as the most common agent followed by Enterovirus 71 and Herpes simplex virus, the authors wrote. However, it is “exceedingly rare” to find Borrelia burgdorferi as an infectious cause of rhombencephalitis.
References:
  1. Svingen H, Orrem J, Nørgaard Eskesen A. Neuroborreliosis with involvement of rhombencephalon: A case report. IDCases. 2022;28:e01472. Published 2022 Mar 8. doi:10.1016/j.idcr.2022.e01472

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**Comment**

Please remember everything is considered “rare” regarding Lyme, even though many may have the symptoms.  They are rarely recorded.  Big difference.

For more:

MS Drug Targeting EBV Shows Promise

https://www.medicalnewstoday.com/articles/multiple-sclerosis-ms-drug-targeting-epstein-barr-virus-shows-promise

Multiple sclerosis (MS): Drug targeting Epstein-Barr virus shows promise

  • Researchers are investigating the effects of a drug that targets the Epstein-Barr virus in people with multiple sclerosis (MS) in an ongoing phase 1 clinical trial.
  • The drug improves MS symptoms and may even reverse the condition.
  • The researchers are now recruiting for a Phase 2 clinical trial to further study the drug’s effects.

Multiple sclerosis (MS) is a chronic condition that affects the central nervous system (CNS). It is characterized by the immune system attacking myelin sheaths — fatty layers that surround nerve fibers and enable them to communicate.

A study published in early 2022 found that contracting the Epstein-Barr virus (EBV), a herpes virus, significantly increases a person’s risk of MS. Multiple studies have also found EBV-infected immune B cells in patients with MS.

Researchers still don’t know how EBV may increase MS risk. However, one study suggests that EBV proteins may mimic human myelin proteins and induce an immune reaction against myelin by CNS antigens.   (See link for article)

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SUMMARY:

  • Atara Biotherapeutics, Inc. is in the middle of a Phase 1 clinical trial utilizing ATA118 that targets EBV-infected cells in people with MS.
  • Of 24 volunteers receiving varying doses, 20 showed improvement or halt in progression after 1 year.
  • Of 18 volunteers who took the drug for up to 39 months, half achieved sustained disability improvement with 7 showing signs of remyelination
  • Results will be presented at a conference by Atara on October 13th, 2022.
  • A188 might:
    • Interrupt cell-mediated autoimmune cascade driven by EBV-infected B cells.
    • Reduce the production of myelin-targeted antibodies made by EBV-infected plasma cells.
  • No serious or fatal side-effects were experienced, although one volunteer suffered a relapse.
  • Higher doses led to greater clinical responses.
  • The small sample size requires further research.
  • Atara is actively recruiting for a randomized, Phase 2, double-blind, placebo-controlled trial.

Important quote:

“A majority of persons with MS appear to have been exposed to EBV. There is a protein on the EBV that is the same as a protein in myelin. When the body’s immune system attacks the virus, it also ends up attacking the myelin. Clearing the virus would decrease the stimulus for the immune cells to attack the myelin.” ~ Barbara Giesser, MD, neurologist and MS specialist