Archive for the ‘Treatment’ Category

Twenty-Three Years of Unnecessary Suffering: How the Medical Establishment Got Away With Maligning Hormones

https://popularrationalism.substack.com/p/twenty-three-years-of-unnecessary?

Twenty-Three Years of Unnecessary Suffering: What the Women’s Health Initiative Actually Showed — and What the Medical Establishment Did With It

If you are a woman 40 to 50, your choice to pay attention to or ignore this information will – not may, WILL dramatically impact your quality of life.
James Lyons-Weiler, PhD
Apr 12, 2026

On November 10, 2025, the United States Food and Drug Administration quietly did something it almost never does: it reversed itself.

The FDA announced the removal of what it described as “misleading warnings” on hormone replacement therapy, stating in language that should be read carefully by every woman over forty in this country that “estrogen is a key hormone for women’s health where every single part of a woman’s body depends on estrogen to operate at its best — including the brain, bones, heart, and muscles.”

That sentence took twenty-three years to come out of a federal regulatory agency. Those twenty-three years have a body count — not of deaths from hormone therapy, but of preventable fractures, preventable cardiovascular events, preventable cognitive decline, and an incalculable accumulation of unnecessary suffering by women who were told, on the authority of science, to stop their treatment. Or to never start it.

The story of how this happened is the kind of story this publication exists to tell. It involves a landmark study whose design was unsuited to the question it was used to answer, relative risk inflation dressed up as settled science, a medical establishment that moved faster to alarm than to correct, and a generation of women who paid the cost.  (See link for article)

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**Comment**

Hormones are huge.  Huge.

Besides helping virtually everything physiologically, they are also drivers of behavior (or lack thereof). However, due to all the xenoestrogens in plastics, pesticides, and personal care products, our society is typically estrogen high – and the wrong, synthetic form at that, disrupting hormonal balance and affecting health negatively.  Just watch a film made in the 70’s or 80’s and then compare the bodies in it to the average population now.

BTW: I’m not a fan at all of equine estrogen due to the horrible way it is made, and I’m not a big fan of synthetic hormones created in a lab often from animal sources (unless for rare special circumstances).  In my opinion, bioidentical hormones that are chemically identical to the hormones naturally produced in the human body are more bioavailable as well as safer.

The sad truth is that the Women’s Health Initiative (WHI) was stopped early due to a small but statistically significant increase in breast cancer, cardiovascular events, and stroke in the hormone group compared to the placebo group.  From that point on, hormones were branded as killers and avoided like the plague by mainstream doctors.

Weiler points out the following problems with the study:

  • the average age of participants in the trial was 63
  • many had pre-existing cardiovascular risk
  • many were put on hormone therapy for the first time years AFTER their estrogen collapsed

Further, there’s the sticky problem of absolute risk – a problem  discussed regarding the COVID jabs as well, and a widely used technique to get a study to say what you want it to say.

The absolute risk increase for breast cancer in the combined hormone group — the number that actually describes what happened to real women in real terms — was approximately eight additional cases per ten thousand women per year, compared to placebo. That is a relative risk increase that translates, in absolute terms, to a risk that is smaller than the baseline absolute risk increase associated with drinking one alcoholic beverage per day, or with being sedentary, or with being obese.

Weiler further adds that while breast cancer is devastating and must be included in the conversation:

relative risk, stripped of its denominator, is a rhetorical instrument. When the baseline rate is small, a relative risk of 1.26 can be presented as a twenty-six percent increase in breast cancer — which is how it was widely framed — or as eight additional cases per ten thousand women per year in a specific, older population — which is what it actually meant. These are not equivalent framings. The first drives panic. The second permits informed decision-making.

The risks became headlines but the significant benefits in reduced hip fractures, colorectal cancer, and relief from vasomotor symptoms became the footnote.  This is how you rig a study.

Researchers now understand that  there is a critical window regarding HRT and the benefit-risk profile is different depending on when it is initiated.

I short, women who begin HRT within a ten year window of the onset of menopause (or before age 60) have cardiovascular outcomes that are neutral to favorable.  Women who start HRT a decade or more after menopause show a less favorable profile because the vascular and neural adaptation to estrogen withdrawal have already occurred.

Who benefits from this travesty?
Big Pharma of course

Women who stopped taking HRT switched over to individual pharmacological agents targeting individual symptoms – and there’s a bevy of them!  Since the systemic solution of hormone therapy that would have solved all the symptoms was maligned, Big Pharma now had a collection of targeted interventions bringing in separate revenue streams!

Weiler then drives the message home by showing the HRT saga is not an isolated event but a documented pattern of what happens when:

a large, expensive, federally funded study  conducted on a population that does not match the clinical target using a formulation or intervention that does not match the clinical practice being evaluated, producing findings that are communicated in relative rather than absolute terms, and whose findings are translated into guidelines and clinical practice with a speed and thoroughness that is never matched by the subsequent corrections.

And this, right here, is why I’m against ANY large, expensive, federally funded study for Lyme disease – and for the same reasons.

The WHI results changed clinical practice within months but took a decade and a half to change – yet, are still not uniformly reflected in practice.  

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Category:

Activism, Hormones, research, Treatment

FREE Homeopathy Film April 10-16, 2026
Introducing Homeopathy - The Film
To celebrate World Homeopathy Awareness Week (April 10–16), Children’s Health Defense invites you to a special streaming event on CHD TV featuring the groundbreaking film Introducing Homeopathy. Because you previously signed up for updates, we wanted to make sure you had direct access.
WATCH HERE
Watch the film that aims to bring the transformative healing modality of homeopathy into every household and healthcare system globally. Through interviews with medical doctors, professional homeopaths, scientific researchers, and Nobel laureates, this film provides a comprehensive look at the principles, science, and clinical applications of homeopathy while exploring its transformative impact on the lives of real individuals.
​​“I have some familiarity with homeopathy, but I learned so much from the film! It’s a wonderful achievement that I’m sure will open many people’s eyes to this amazing modality.Mary Holland, CEO, Children’s Health Defense
Homeopathy has the potential to revolutionize how we approach health, from addressing chronic conditions like autism, infertility, AIDS, and more, to offering solutions for agricultural and veterinary challenges. Despite its proven effectiveness, homeopathy has long been marginalized and silenced within mainstream medicine.This documentary is a must-watch for anyone seeking alternatives to conventional medicine, curious about the healing potential of homeopathy, or interested in understanding how this modality can benefit both individuals and communities worldwide.

Whether you’re a healthcare professional, a patient seeking alternatives, or simply curious about the future of medicine, “Introducing Homeopathy” offers valuable insights into a healing modality that has the potential to change lives and transform healthcare systems worldwide.
WATCH HERE
To natural healing,The Children’s Health Defense Team

Visit the Homeopathy Resources page on the Introducing Homeopathy website to find homeopathy classes, books, providers, research, and more!

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Category:

Activism, Treatment

1 in 3 Cancer-Free: Ivermectin Trial Stuns, but RESET-5 Aims Even Higher

https://zenodo.org/records/19455636

Real-World Clinical Outcomes of Ivermectin and Mebendazole in Cancer Patients: Results from a Prospective Observational Cohort

Authors/Creators

Nicolas Hulscher, MPH1, 2, Kelly Victory, MD2, James A. Thorp, MD2, Drew Pinsky, MD2, Alejandro Diaz-Villalobos, MD2, Peter Gillooly, MSc2, Foster Coulson2, Melissa Annazone2, Chloe Radesi2, Jessica Brooks2, Peter A. McCullough, MD, MPH1, 2, Harvey Risch, MD, PhD3, 2

April 7, 2026

Description

Abstract

Background: Drug repurposing offers a pathway to identify accessible, low-toxicity cancer therapies. Ivermectin and mebendazole have demonstrated multi-target anti-cancer activity in preclinical models, including the inhibition of cancer cell proliferation and the targeting of cancer stem cells. This paper evaluates real-world patient-reported outcomes, safety, and adherence in a cohort of cancer patients utilizing this combination protocol.

Methods: We analyzed a prospective observational cohort of 197 cancer patients who were prescribed ivermectin and mebendazole off-label through a telemedicine platform by licensed U.S. healthcare providers. Participants received compounded oral capsules containing 25 mg ivermectin and 250 mg mebendazole. As part of a clinical program evaluation, data were collected via voluntary, standardized digital surveys at baseline and at approximately 6-month follow-up. Of the initial cohort (N = 197), baseline characteristics, including cancer type and disease status, were assessed. A total of 122 participants completed the follow-up survey (61.9% response rate) to evaluate self-reported cancer outcomes, medication adherence, and adverse events. 95% confidence intervals (CI) were calculated for primary outcome measures using the Wilson score method. Dose-stratified analyses for outcomes and safety were conducted using Chi-square statistics.

Results: The cohort represented a diverse clinical profile of cancer patients, with mean age of 67 years and nearly balanced sex distribution (52.3% male, 47.7% female). Cancer types included prostate (27.9%), breast (18.3%), lung (8.6%), colon (5.1%), urologic (4.6%), pancreatic (3.0%), liver (2.5%), gynecologic (2.5%), and hematologic (2.5%) malignancies. At enrollment, participants had a median duration since initial diagnosis of 1.2 years, with 37.1% experiencing active disease progression. At 6-month follow-up, medication adherence was high with 86.9% of participants completing the full initial 90-capsule ivermectin-mebendazole prescription and 66.4% remaining on the protocol at 6 months. The Clinical Benefit Ratio (CBR) was 84.4% (95% CI: 77.0–89.8%). Notably, 48.4% (95% CI: 39.7–57.1%) of the cohort reported the strongest positive outcomes, consisting of regression (15.6%; 95% CI: 10.2–23.0%) or no current evidence of disease (NED, 32.8%; 95% CI: 25.1–41.5%). Disease stability was reported to be maintained in 36.1% (95% CI: 28.1–44.9%) of participants, while 15.6% (95% CI: 10.2–23.0%) reported disease progression. While 25.4% reported mild side effects (primarily gastrointestinal), 93.6% of those affected continued treatment through minor dose adjustments. Some participants reported concurrent conventional therapies, including chemotherapy (27.9%), radiation therapy (21.3%), and surgery (19.7%), as well as adjunctive interventions such as supplement use (49.2%), dietary modification (37.7%), and other integrative approaches.

Conclusions: In this prospective real-world cohort, the combination of ivermectin and mebendazole was associated with high rates of self-reported clinical benefit, with nearly half of participants reporting tumor regression or no current evidence of disease across a heterogeneous population of cancer patients. These findings provide a compelling clinical signal that these well-tolerated, repurposed agents may offer therapeutic benefit. However, given the observational design, reliance on self-reported outcomes, and potential for selection bias and uncontrolled confounding, these findings should be interpreted as hypothesis-generating. Urgent prospective, randomized, placebo-controlled clinical trials are warranted to validate these observations and further define optimal dosing strategies. (Go to link for full-length study)

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**Comment**

http://

Could These Overlooked Drugs Be a Cancer Game-Changer?

Dr. Ken Stoller, April 12, 2026

For a wonderful breakdown of the study:  https://justusrhope.substack.com/p/1-in-3-cancer-free-ivermectin-trial?  Excerpt:

Dosages and Concurrent Therapies

Patients were prescribed the medications off-label through a telemedicine platform. They received compounded oral capsules containing:

  • 25 mg of Ivermectin
  • 250 mg of Mebendazole

The study noted that these were not strictly monotherapies. Many patients were undergoing concurrent conventional treatments, including chemotherapy (27.9%), radiation therapy (21.3%), and surgery (19.7%). Additionally, many used adjunctive interventions such as supplements (49.2%) and dietary modifications (37.7%).

Study Completion and Attrition

Of the initial 197 patients, 75 patients failed to complete the study (meaning they did not complete the 6-month follow-up survey).

  • A total of 122 participants completed the 6-month follow-up survey, resulting in a 61.9% response rate.
  • Among the 122 who responded, adherence was high: 86.9% completed the full initial 90-capsule prescription, and 66.4% chose to remain on the protocol at the 6-month mark.

Clinical Outcomes and Tolerability

The authors reported an overall Clinical Benefit Ratio (CBR) of 84.4% among the 122 patients who completed the survey. The self-reported outcomes broke down as follows:

  • No Evidence of Disease (NED): 32.8%
  • Disease Stabilization: 36.1%
  • Tumor Regression: 15.6%
  • Disease Progression: 15.6%

Within the article, Justuserhope asked AI to evaluate the benefit of adding one agent at a time from the RESET-5 Protocol (Mebendazole, ivermectin, sulforaphane, metformin, and aged garlic extract) to the Hulscher et. al study.  The full RESET-5 reduces the likelihood of resistance development, enhances immune function, and depletes tumors of a critical survival tool – compensatory glutathione production.

The full RESET-5 Protocol boosts improvement even further by 30-40%.

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**Comment**

For those of you studying this, 25 mg of ivermectin and 250mg of Mebendazole are considered pretty low dosages.  Many patients are taking much more than that, so the fact they are getting such great improvement with such low dosages is fairly amazing.  Lower dosages typically mean lower side-effects so this should be safe for nearly all to take.  Share with your doctor and work together to get the best fit.

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Category:

Cancer, research, Treatment

A New Ivermectin/Mebendazole Cocktail for Cancer Treatment

https://justusrhope.substack.com/p/a-new-ivermectinmebendazole-cocktail?

A New Ivermectin/Mebendazole Cocktail for Cancer Treatment

Announcing the RESET-5™ Protocol
Justus R. Hope
Apr 05, 2026

Article Excerpts:

Resistance to chemotherapy and radiation is a well-documented challenge in oncology. Clinicians have increasingly reported that resistance can also emerge even when core repurposed drug metabolic cocktails are added to standard treatment regimens.

The Care Oncology Clinic’s 4-Drug COC Protocol — comprising Doxycycline, Atorvastatin, Mebendazole, and Metformin — represents a strong foundational approach to metabolic cancer therapy. In the METRICS trial, adding this protocol to standard of care in Glioblastoma was associated with nearly a one-year increase in survival.

The Problem of Resistance in Metabolic Protocols

Despite these promising results, resistance to the COC Protocol has been reported as well. The core problem lies in the nature of Cancer Stem Cells (CSCs): these cells are remarkably adaptable. When placed under primarily metabolic pressure, CSCs exploit alternative fuel sources and, given enough time, appear to reliably escape any single-axis metabolic attack.

Building a more powerful, resistance-prevention protocol requires a broader strategy — one that targets far more than cancer’s metabolism alone.

The RESET-5™ Protocol (Redox, Epigenetic, and Stem-cell Eradication Therapy)

Why it works:

The word “reset” profoundly captures what this protocol does compared to COC. While COC essentially attempts to starve the tumor, this protocol chemically resets the cancer’s mutated epigenome (via SFN), resets the gut microbiome (via AGE), and eradicates the root stem cells.

  • The RESET-5 Protocol (Mebendazole, Ivermectin, Sulforaphane, Metformin, Aged Garlic Extract) represents a significant improvement over the traditional 4-drug Care Oncology Clinic (COC) protocol (Doxycycline, Atorvastatin, Metformin, Mebendazole).
  • While the COC protocol relies on broad metabolic starvation and mitochondrial toxicity, the RESET-5 protocol systematically targets cancer stem cell (CSC) networks, reverses epigenetic mutations, and modulates the redox environment without destroying the host’s immune system or microbiome.

(See link for article and charts)

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Category:

Cancer, Treatment

Review of Parasites and Their Treatments: Parasite Detox & Parasite Cleanse Guide

https://theplqn.substack.com/p/review-of-parasites-and-their-treatments?

Review of Parasites and their Treatments: Parasite Detox and Parasite Cleanse Guide

How to safely and effectively get rid of parasites
DR. ASCENSION’S HEALTH HUB
Dec 14, 2023

Disclaimer: I am a physician for 25+ years, and I’ve worked on establishing clinical practice guidelines for numerous healthcare entities (insurers and hospitals) as part of my career. Having said that, I’m not your personal physician. I believe that each person deserves personalized care based on their symptoms, test results, presence or absence of risk factors associated with parasites, diet and lifestyle, personal & family history, etc. This post is to provide you with the necessary information about 2 types of parasites: protozoa and helminths (worms). Compared to many countries who have many risk factors, including their environment and contaminated food/water supplies, the US nearly does not have the number of parasitic infections than they do. However, recent surge of illnesses, rise in inflammatory bowel disease and auto-immune disorders, association of parasites with cancers, and the fact that COVID was treatable by anti-parasitic drugs, people are reevaluating whether ‘parasites’ are a real problem in the US as well. For this reason, the information provided below, should help one evaluate their own risk so that they can determine the need for treatment and/or a cleanse, with their physician’s guidance. Please keep in mind the following:

  1. While i’ve tried to make it a thorough review, there are numerous parasites. There maybe some missing, either because they don’t infect humans, or there were no recommended treatments found for them. Feel free to add comments if I missed any that you want more information on.
  2. This review does not cover fungal infections or viral infections. Many viruses are known to cause cancers as well, such as, EBV, HPV, HCV, etc. They have their own treatment protocols.
  3. I’ve included recommended treatments based on review of multiple sources. If there is new evidence that supports the use of a drug for a parasite that I have not listed, feel free to add in comments, so I can review the study and add to the recommendations.

What are Parasites?

Parasites require a host to survive and spread. The adult forms of parasites live and feed from within the host (animals, humans). The eggs and larvae are what ‘spread’ through various means (food, water, flies, bugs and mosquitos). Most parasites, go undetected, and people are ‘asymptomatic’ because the parasite does not disturb the environment. Sometimes, there are slight symptomatic changes, but the person doesn’t think of them as worm related. For example, feeling more hungry, desiring more sweet foods, bloating or indigestion, abdominal discomfort or pain if you don’t eat, and general fatigue and malaise. These maybe signals sent by the parasite, so you take the actions that benefit them, i.e. survive, and have a constant source of food.

General To-Do’s and Not-To-Do’s about Parasites

Here are some To-Do’s:

  • Vitamin rich foods or supplements:
    • Carrots, sweet potatoes, and squash are high in beta-carotene, which turns into Vitamin A, which helps to resist parasitic worms and larvae.
    • Eat foods rich in Vitamins C & B
      • B12 is depleted by many worms
      • Folic acid (Vitamin B9) also depletes from malabsorption due to worms
  • Minerals such Selenium and Zinc: Selenium and Zinc are required for immune function and resistance to infection
  • Include more garlic in your meals: raw garlic has sulfur containing amino acids that are anti-parasitic
  • Ensure you have “good” bacteria in your gut by taking probiotics or eating probiotic rich foods like yogurt. (see below regarding probiotics used for natural treatment and prevention of parasites)
  • Perform ‘gut cleansing’, such as with psyllium, beetroot, flaxseeds or supplements containing Senna
  • Wash all foods well, including vegetables and fruits, prior to use

Here are some Not-To-Do’s:

  • Don’t eat raw or undercooked meats, fish, crustaceans, and snails
  • Avoid coming in contact with any animal feces or saliva, including from pets
  • Avoid coffee, sugar, alcohol, and refined grains

More information on natural prevention and treatments is provided later.

Anti-Parasitic Treatments

Parasites can be treated both naturally and with anti-parasitic medications. Natural herbs and supplements can help maintain an internal environment that prevents parasitic infections in the first place. Some herbs and supplements however, do directly reduce adult worms and egg count. But the effectiveness rate is not as high as anti-parasitic medications that have very targeted mechanism of action. More on natural treatments later.

You are likely to come across Ivermectin, Fenbendazole, Doxycycline and others drugs as treatments. Febendazole is a benzimidazole, and is just one of many other benzimidazoles available, such as albendazole, parbendazole, mebendazole, flubendazole, etc. It is a common practice for drug manufacturers to make different compounds under the same class of drugs, and those products are used in different markets and for different purposes such as animal vs. human use. Fenbendazole is used with animals and majority of data and studies on this drug are from animal studies. So while fenbendazole and albendazole are the same class of drugs, albendazole is a product recommended for use in humans but requires prescription, whereas fenbendazole is over the counter for animal use. What matters most is whether fenbendazole and albendazole have the same level of efficacy. Based on a review of many comparative studies, the efficacies vary based on parasite type. One was superior than the other in each study, but all were animal models. Efficacy studies on humans are available for albendazole, mebendazole, flubendazole, triclabendazole etc. Below, when discussing each parasite and treatment, you will notice that albendazole was recommended as ‘drug of choice’ for many parasites due to higher efficacy, compared to mebendazole, flubendazole and other benzimidazoles. Therefore, these drugs do not all work equally in terms of efficacy.

My review below is based on studied, recommended and approved drugs for the treatment of each parasite in humans. (See link for article)

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**Comment**

A wonderfully thorough article.

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Category:

Parasites, Treatment