Archive for the ‘research’ Category

Lyme Disease Increases Risk for Multiple Gynecological Conditions

https://www.medrxiv.org/content/10.1101/2025.03.03.25323258v1

Lyme disease increases risk for multiple gynecological conditions

Paige S. Hansen Colburn, Grace Blacker, Sarah Galloway, Qingying Feng, Prasanna S. Padmanabham, Guido Pisani, Brandon T. Lee, Grace Loeser, Monika W Perez, Kunzan Liu, Jade Kuan, Emelia von Saltza, Satu Strausz, Lisa M. Mattei, Sophie VanderWeele, George R. Nahass, Amie Kitjasateanphun,  Rangarajan Bharadwaj, Hari-Hara SK Potula, Maia Atzmon Shoham, Finngen, Victoria L. Mascetti, Eric Gars, Hanna M Ollila, Kaylon L. Bruner-Tran, Irving Weissman,  Sixian You, Beth Pollack, Linda Griffith, Nasa Sinnott-Armstrong,  Michal Caspi Tal
doi: https://doi.org/10.1101/2025.03.03.25323258

This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

Abstract

Lyme disease (LD) is an illness caused by the spirochete Borrelia burgdorferi (B. burgdorferi). Borrelia is known to disseminate through organs, including the skin, joints, spinal cord, bladder, and heart, leading to Lyme arthritis, neuroborreliosis, and Lyme carditis. While previous studies have investigated the impact of LD on pregnancy in both mice and humans and have found the presence of B. burgdorferi in the uterus of mice, we studied the impact of LD on the non-pregnant female reproductive tract. We use a mouse model for LD and find an ongoing and severe infection of the reproductive tract of female mice, which persists up to 15-months post-inoculation. This infection results in uterine glandular cysts and endometrial hyperplasia as well as vaginal epithelial thickening, polymorphonuclear and mononuclear cell epithelial infiltration, and epithelial desquamation into the vaginal lumen. Strikingly, we find that age has an impact on the extent of gynecologic pathology such that aged female mice (1-year old) that are reproductively senescent have more gynecologic pathology with infection compared to young mice (15-weeks old) when infected for the same length of time. Using large-scale electronic healthcare record data, we report that LD additionally results in increased infection-associated risk of:

  1. menorrhagia (1.5-fold)
  2. miscarriage (1.62-fold)
  3. uterine fibroids (1.42-fold)
  4. endometriosis (1.93-fold)

Underreporting of gynecological outcomes is pervasive throughout many different infectious diseases, and LD-associated gynecological pathologies may have been similarly underappreciated in the field. This work suggests that further study of the female reproductive tract and the effects of B. burgdorferi infection therein will help clarify and expand the knowledge of myriad LD outcomes.

For more:

Category:

Lyme, research, Transmission

Study: Fatal Malignant Cardiac Tumors Following COVID-19 mRNA Injection

https://www.thefocalpoints.com/p/new-study-fatal-malignant-cardiac

NEW STUDY – Fatal Malignant Cardiac Tumors Following COVID-19 mRNA Injection

Growing body of evidence suggests COVID-19 mRNA injections are likely carcinogenic, contributing to the sharp rise in rapidly progressing, fatal cancers.

Mar 06, 2025

by Nicolas Hulscher, MPH

The study titled, Heart-breaking tumors: a case series of malignant pericardial effusion, was recently published in European Heart Journal – Case Reports:

Background

Malignant pericardial effusions are often linked to metastases from solid tumours, such as those in the lung or breast, or haematological diseases. Primary cardiac tumours are rare, occurring in only 0.02% of cases, with pericardial tumours comprising 6.7%–12.8% of all primary cardiac tumours.

Case summary

In Case 1, a 49-year-old Black African male presented with chest pain and breathlessness after a COVID-19 vaccine. Initially treated for pericarditis, he returned with worsening symptoms. Echocardiography revealed pericardial effusion and cardiac tamponade. Imaging confirmed a right atrial mass diagnosed as malignant biphasic mesothelioma. He died 4 months after diagnosis. In Case 2, a 43-year-old Caucasian male developed breathlessness and fever post-COVID-19 vaccine. Imaging identified a large posterior pericardial mass, later diagnosed as synovial sarcoma. Chemotherapy yielded minor tumour reduction, but he succumbed to his illness, spending his final days in a hospice.

Discussion

Initial clinical signs are critical in determining the origin of pericardial effusion. Malignancy should be suspected in cases with cardiac tamponade, unexplained haemorrhagic pericardial fluid, or recurrent symptoms. Negative cytology warrants further investigation with advanced imaging or biopsy to improve diagnostic sensitivity. Diagnosing rare tumours involves multiple imaging modalities, fluid analysis, biopsies, and an interdisciplinary approach, with pathological analysis being the gold standard. Treatment remains challenging due to the rapid progression of these tumours, with surgery often not feasible. A multi-pronged diagnostic approach is crucial, and clinicians must maintain suspicion for malignancy in persistent pericardial effusion cases, even in the context of other potential confounding factors.

As this study indicates, rapidly progressing fatal cancers shortly following COVID-19 mRNA injection are real, not “disinformation” as the mass media suggests. A growing body of evidence suggests that COVID-19 mRNA injections are likely carcinogenic and have contributed to the alarming rise in cancer rates.  (See link for article)

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For more:

“We must stop messenger RNA [mRNA] at all costs… it’s not only mad, it’s EVIL.” – Dr. Angus Dalgleish, world-renowned ocologist

Category:

Cancer, research, vaccines, Viruses

Treating Bartonella: Medical Detective Pts 1-5

https://medicaldetective.substack.com/p/bartonella-the-second-great-imitator

Bartonella: The Second “Great Imitator” Underlying Many Chronic Illnesses – Part 1 of 5

Richard Horowitz
Feb 05, 2025

Bartonella is the third “B” of the triad found in the vast majority of my chronically ill patients who suffer from chronic Lyme disease/PTLDS, along with Borrelia and Babesia.A gram-negative intracellular bacteria, it’s controversial and misunderstood and has been throwing a monkey wrench into my treatments for decades. I barely remember learning about it in medical school, except when they were teaching me about cat scratch fever in children that would cause small, localized rashes (papules) at the site of the scratch with swollen lymph nodes and fevers. It would be treated with a short course of antibiotics like azithromycin. These images show classical cat scratch disease before and after treatment when the lesions are starting to crust up.  (See link for article)

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https://medicaldetective.substack.com/p/bartonella-establishing-the-diagnosis

Bartonella: Establishing the Diagnosis, and the Role of Multiple Bartonella Species and MSIDS Factors in Chronic Illness – Part 2 of 5

Richard Horowitz
Feb 12, 2025

As you learned last week in Bartonella Part 1, this is a very tricky bacteria, with symptoms overlapping many of those associated with chronic Lyme disease and other co-infections. Since there are so many species of Bartonella, the first step is to determine if Bartonella is actually in your body. As a Medical Detective, I know that there are certain clues to follow, but what exactly are they?

Clues to the Existence of Lyme and Bartonella in Chronic Illness

Let’s start at the beginning. You’ve been diagnosed with chronic Lyme disease–you had a prior EM rash and/or filled out the questionnaire and scored above 63, implying a high likelihood of exposure. See the prior Medical Detective Substacks on using this HMQ questionnaire:

https://cangetbetter.com/wp-content/uploads/2021/02/MSIDS-QUESTIONNAIRE-FINALR.pdf

(See link for article)

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https://medicaldetective.substack.com/p/effective-treatments-for-bartonella

Effective Treatments for Bartonella Infections – Part 3 of 5

Richard Horowitz
Feb 19, 2025

Bartonella is an intracellular biofilm/persister bacteria, like Borrelia burgdorferi, the bacterial agent of Lyme disease. For years, many doctors were using single drug therapies for Cat Scratch Disease (CSD), even in the chronic persistent phases of the infection (some may still). This was before we understood the complexity of how this bacteria persists.

Years ago, however, I did recognize that at least 2 intracellular antibiotics were more effective than one for difficult-to-treat intracellular infections. So for many years I treated Bartonella with doxycycline/rifampin or Zithromax/rifampin. Although they helped to knock down symptoms, Bartonella would invariably return after antibiotics were stopped. Persisters persist! (See link for article)

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https://medicaldetective.substack.com/p/treating-bartonella-double-dose-dapsone

Treating Bartonella: Double Dose Dapsone Combination Therapy (DDDCT) – Part 4 of 5

Richard Horowitz
Feb 26, 2025
 
In Bartonella Parts 1, 2, and 3, you learned the basics of Bartonella testing, symptoms, and treatment options, with a detailed discussion of laboratory work needed before starting the protocol, and how/why the medication and support supplements are being used to increase the tolerability and safety of DDDCT and HDDCT. Please review this information with your doctor before proceeding with the antibiotic protocol listed below.  (See link for article)
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https://medicaldetective.substack.com/p/treating-bartonella-2-week-pulses

Treating Bartonella: 2-Week Pulses of Antibiotics for Chronic Bartonellosis – Part 5 of 5

Richard Horowitz
Mar 05, 2025
 
Bravo! You’ve made it to Part 5, the final Medical Detective Substack on diagnosing and treating chronic Bartonella infections. As you read in the previous 4 Substacks, Bartonella is often found in my chronic Lyme patients, at least 80% of the time, right behind active Babesia infections–watch for unexplained fevers, day/night sweats, chills, flushing, “air hunger,” and an unexplained cough if you have ongoing Babesia. (See link for article)
 
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For more:
 

Category:

Bartonella, research, Treatment

New Paper Identifies Chronic Disease ‘Smoking Gun’

https://worldcouncilforhealth.substack.com/p/new-paper-identifies-smoking-gun?

NEW Paper Identifies ‘Smoking Gun’ of Chronic Disease

… and most of us are in the crosshairs. The US Navy knew about it way back in 1971, yet nothing was done to stop it.

World Council for Health
Mar 04, 2025

In 1971, the U.S. Naval Medical Research Institute published a groundbreaking review of 2,311 scientific studies on the biological and health effects of electromagnetic fields. The findings were stark: 132 distinct biological effects, symptoms, and diseases were linked to wireless radiation exposure. The Navy’s report was a warning—a prophetic one, as it turns out. But like so many warnings about environmental and public health risks, it was ignored.

Today, we’re living in the shadow of that neglect. A new paper reveals the devastating consequences of that inaction. Announced at the Annual Conference of the American Academy of Environmental Medicine, the paper connects the dots between unheeded warnings from 50 years ago and the current epidemic of chronic disease in the United States.

The implications are staggering.

Of the 36 fastest-growing chronic diseases in the U.S., 23 were predicted by the Navy’s 1971 study. By 2015, these diseases accounted for over 549 million cases and added as much as $2 trillion in annual healthcare costs to the U.S. economy. The paper argues that this explosion in chronic illness is not a coincidence—it’s a direct result of unchecked exposure to wireless radiation.  (See link for article)

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**Comment**

Ever notice how ‘technology’ gets rolled out without ethical considerations or proper safety testing?  There’s a reason….

For more:

It’s important to note that 5G and the digitization it provides is needed for The Great Reset, the ‘powers that be’ are thrusting upon us.  They know very well the technology has deleterious effects upon all biological life forms but it’s all for ‘the greater good,’ which simply means what’s best for “Stakeholder Capitalism,” which has been described as ‘tyranny for the good of its victims.’ Touted as being inclusive, there are three firms in particular: “BlackRock, State Street, and Vanguard—that together are the largest shareholder in about 80% of the companies in the S&P 500 and have accumulated unprecedented control (commonly known as a monopoly) over U.S. corporations forcing their own ‘environmental, social, and governance’ (ESG) agenda upon the American corporate sector and by extension, on all of us.  It’s only good for those in power – not the average Joe.

This very data collection will be used against us for vast surveillance, control, and tyranny.  COVID gave us a glimpse of this, but it will be far far worse and every ‘pandemic’ will be used for this ultimate outcome which will include centralized medicine.  See: “The Big Picture: Life Inside the Control Grid,” to understand more.

Included in this quagmire is AWZ Venture Capital, an investment fund that invests in transformational nanotechnology that is next generation AI powered, and whose board of Directors is the who’s who of Israeli, US and UK Intelligence.  This ‘transformational nanotechnology’ includes smart dust, self assembly nanotechnology, mesogen microchips, Quantum Dot biosensors – all of which are DUAL PURPOSE militarized applications for bioelectronic surveillance, remote control and torture and can be used not just for bidirectional telemetry but also remote extermination – all AI controlled.  

Sound crazy?  We’re about to find out.

Category:

Activism, research

The Lymeland Emperor Has No Clothes On

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/33299384?

The emperor has no clothes!

Carl Tuttle
Hudson, NH, United States
Mar 3, 2025

Please see the following inquiry that will most likely go unanswered. Note that Dr. John Aucott is a coauthor of this study who often says he believes in chronic Lyme disease but only at Lyme disease events held by advocacy groups. 

———- Original Message ———-
From: CARL TUTTLE <runagain@comcast.net>
To: “aghirsch@geisinger.edu” <aghirsch@geisinger.edu>
Cc: “aejustice1@geisinger.edu” <aejustice1@geisinger.edu>, “cmnordberg@geisinger.edu” <cmnordberg@geisinger.edu>, “nsjosyula@geisinger.edu” <nsjosyula@geisinger.edu>, “jaucott@jhmi.edu” <jaucott@jhmi.edu>, “alison.rebman@gmail.com” <alison.rebman@gmail.com>, “bschwar1@jhu.edu” <bschwar1@jhu.edu>, “bmcinfectiousdiseases@biomedcentral.com” <bmcinfectiousdiseases@biomedcentral.com>, “irina.masalagiu@springernature.com” <irina.masalagiu@springernature.com>, “rauf.bhat@springernature.com” <rauf.bhat@springernature.com>
Date: 03/01/2025 12:04 PM EST

Subject: A comparison of genome-wide association analyses of persistent symptoms after Lyme disease, fibromyalgia, and myalgic encephalomyelitis – chronic fatigue syndrome

A comparison of genome-wide association analyses of persistent symptoms after Lyme disease, fibromyalgia, and myalgic encephalomyelitis – chronic fatigue syndrome
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-10238-x

Annemarie G. Hirsch, Anne E. Justice, Amy Poissant, Cara M. Nordberg, Navya S. Josyula, John Aucott, Alison W. Rebman & Brian S. Schwartz

To: Annemarie G. Hirsch, Corresponding Author

I read your manuscript with great interest and wanted to share a comment on your article I received from a fellow researcher who has experienced first-hand the devastation of Lyme disease. I added HTML links (references) to his statement and included my own comment. Additionally, I have a question for you and your co-authors.

Comment received:

“With respect may I say as Lyme and PTLD victim, Borrelia has the following characteristics:

Or, maybe it’s as the authors claim that PTLD is associated with:

“Our top index single nucleotide polymorphism (SNP), rs77857587, is in high linkage disequilibrium with a long-range protein quantitative locus SNP, rs111774530, for the MARC2 (Mitochondrial Amidoxime Reducing Component 2) protein.”

Carl Tuttle’s comment:

If I’m interpreting his comment correctly, it would appear that we have been dealing with an antibiotic resistant/tolerant superbug and essentially, “the emperor has no clothes.”

Question:

What academic discipline would you encounter if your department acknowledged chronic Lyme disease and began focusing on finding effective antimicrobial treatments for all borrelia forms; round body, biofilm etc.?

A response to this inquiry is requested.

Carl Tuttle
Independent Researcher
Hudson, NH

Cc: Rauf Bhat, Senior Editor

Stefan Baral, Senior Editorial Board Member

Letter to the Editor of the BMJ published June 2020
https://www.bmj.com/content/369/bmj.m1041/rr-1

(It should be noted that the corresponding author refused to reply after repeated requests by BMJ Editor Fiona Godlee)

For more:

 

Category:

Activism, Lyme, research