Research on Morgellons

Morgellons Disease – Video abstract 116608  Uploaded on Sep 28, 2016
Video abstract of review paper “Morgellons disease: a filamentous borrelial dermatitis” to be published in the International Journal of General Medicine by Middelveen and Stricker.

https://www.dovepress.com/articles.php?article_id=29451
Marianne J Middelveen, Raphael B Stricker

International Lyme and Associated Diseases Society, Bethesda, MD, USA

Morgellons disease: a filamentous borrelial dermatitis

Abstract: Morgellons disease (MD) is a dermopathy characterized by multicolored filaments that lie under, are embedded in, or project from skin. Although MD was initially considered to be a delusional disorder, recent studies have demonstrated that the dermopathy is associated with tickborne infection, that the filaments are composed of keratin and collagen, and that they result from proliferation of keratinocytes and fibroblasts in epithelial tissue. Culture, histopathological and molecular evidence of spirochetal infection associated with MD has been presented in several published studies using a variety of techniques. Spirochetes genetically identified as Borrelia burgdorferi sensu stricto predominate as the infective agent in most of the Morgellons skin specimens studied so far. Other species of Borrelia including Borrelia garinii, Borrelia miyamotoi, and Borrelia hermsii have also been detected in skin specimens taken from MD patients. The optimal treatment for MD remains to be determined.

Morgellons disease – Video abstract: 39017  Published on Jan 8, 2013
Video abstract of original research paper “Characterization and evolution of dermal filaments from patients with Morgellons disease” by Middelveen MJ, Mayne PJ, Kahn DG, et al.

https://www.dovepress.com/characterization-and-evolution-of-dermal-filaments-from-patients-with–peer-reviewed-article-CCID
Marianne J Middelveen,1 Peter J Mayne,1 Douglas G Kahn,2 Raphael B Stricker1

1International Lyme and Associated Diseases Society, Bethesda, MD, USA; 2Department of Pathology, Olive View–UCLA Medical Center, Sylmar, CA, USA

Characterization and evolution of dermal filaments from patients with Morgellons disease

Abstract: Morgellons disease is an emerging skin disease characterized by formation of dermal filaments associated with multisystemic symptoms and tick-borne illness. Some clinicians hypothesize that these often colorful dermal filaments are textile fibers, either self-implanted by patients or accidentally adhering to lesions, and conclude that patients with this disease have delusions of infestation. We present histological observations and electron microscopic imaging from representative Morgellons disease samples revealing that dermal filaments in these cases are keratin and collagen in composition and result from proliferation and activation of keratinocytes and fibroblasts in the epidermis. Spirochetes were detected in the dermatological specimens from our study patients, providing evidence that Morgellons disease is associated with an infectious process.

https://www.dovepress.com/filament-formation-associated-with-spirochetal-infection-a-comparative-peer-reviewed-article-CCID
Marianne J Middelveen, Raphael B Stricker
International Lyme and Associated Diseases Society, Bethesda, MD, USA

Filament formation associated with spirochetal infection: a comparative approach to Morgellons disease

Abstract: Bovine digital dermatitis is an emerging infectious disease that causes lameness, decreased milk production, and weight loss in livestock. Proliferative stages of bovine digital dermatitis demonstrate keratin filament formation in skin above the hooves in affected animals. The multifactorial etiology of digital dermatitis is not well understood, but spirochetes and other coinfecting microorganisms have been implicated in the pathogenesis of this veterinary illness. Morgellons disease is an emerging human dermopathy characterized by the presence of filamentous fibers of undetermined composition, both in lesions and subdermally. While the etiology of Morgellons disease is unknown, there is serological and clinical evidence linking this phenomenon to Lyme borreliosis and coinfecting tick-borne agents. Although the microscopy of Morgellons filaments has been described in the medical literature, the structure and pathogenesis of these fibers is poorly understood. In contrast, most microscopy of digital dermatitis has focused on associated pathogens and histology rather than the morphology of late-stage filamentous fibers. Clinical, laboratory, and microscopic characteristics of these two diseases are compared.