Archive for the ‘Inflammation’ Category

Injection of Diabetic Drug Into Joints of Bb-Infected Mice Decreased Ankle Swelling & Immune Cell Recruitment

https://www.ncbi.nlm.nih.gov/m/pubmed/30700583/

Treatment of Borrelia burgdorferi-Infected Mice with Apoptotic Cells Attenuates Lyme Arthritis via PPAR-γ.

Hilliard KA, et al. J Immunol. 2019.

Abstract

Infection of mice with Borrelia burgdorferi causes an inflammatory arthritis that peaks 3-4 wk postinfection and then spontaneously resolves. Although the recruitment of neutrophils is known to drive the development of arthritis, mechanisms of disease resolution remain unclear. Efficient clearance of apoptotic cells (AC) is likely an important component of arthritis resolution. In this article, we show the number of AC increases in the joints of B. burgdorferi-infected mice around day 21 postinfection and peaks around day 28. Injection of AC directly into the ankles of B. burgdorferi-infected mice limited ankle swelling but had no effect on spirochete clearance or arthritis severity scores. In vitro, addition of AC to bone marrow macrophage cultures decreased B. burgdorferi-induced TNF-α and KC and increased IL-10. In addition, phagocytosis of B. burgdorferi and neutrophil migration to LTB4 were inhibited by AC. Exogenous AC caused an increase in peroxisome proliferator-activated receptor-γ (PPAR-γ) expression both in vitro and in vivo during B. burgdorferi infection. The PPAR-γ agonist rosiglitazone elicited similar changes in macrophage cytokine production and neutrophil migration as exogenous AC. Addition of the PPAR-γ antagonist GW 9662 abrogated the effects of AC in vitro. Injection of rosiglitazone directly into the tibiotarsal joints of B. burgdorferi-infected mice decreased ankle swelling and immune cell recruitment, similar to the injection of AC.

These results suggest that clearance of AC plays a role in the resolution of inflammation during experimental Lyme arthritis through the activation of PPAR-γ. PPAR-γ agonists, such as rosiglitazone, may therefore be effective treatments for inducing arthritis resolution.

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**Comment**

Apoptosis is programmed cell death without causing damage to other cells.  https://science.howstuffworks.com/life/cellular-microscopic/apoptosis.htm

apoptosis-diagram

When cells recognize viruses and gene mutations, they may induce death to prevent the damage from spreading.  In apoptosis the cell shrinks and sends out distress signals, which are answered by vacuum cleaners known as macrophages. The macrophages clean away the shrunken cells, leaving no trace.

Scientists are trying to learn how to modulate apoptosis, so that they can control which cells live and which undergo programmed cell death.  Many diseases and disorders are linked with the life and death of cells such as AIDS & Parkinson’s.  Decreased apoptosis can be a signal for lupus or cancer.

In the study above, they state that injecting the diabetic drug rosiglitazone (reduces blood glucose) into Bb infected mouse joints reduced swelling & immune cell recruitment similarly to injecting of apoptic cells.

Most interesting; however, is the admission that the injection of AC had no effect on spirochete clearance or arthritis severity scores.  

So the question becomes once again, is getting rid of inflammation/swelling the sole issue for those of us “chronically/persistently” infected or is spirochete clearance important?

I predict that while rosigliazone might help with inflammation and pain (like so many other substances), spirochete clearance is still important.  

This study begs the answer to what is causing persistent symptoms.  I think it also important to suggest it may be a number of factors and it may vary from patient to patient.

If there’s one thing I’ve learned about Lyme/MSIDS, it’s that it is highly variable & complex.

https://madisonarealymesupportgroup.com/2018/06/27/autophagy-finally-considered-for-disease-treatment/

What are the Similarities Between Autophagy and Apoptosis?  https://www.differencebetween.com/difference-between-autophagy-and-vs-apoptosis/#Autophagy%20vs%20Apoptosis%20in%20Tabular%20Form

  • Both result in programmed cell death.
  • Both are natural phenomena.
  • Both processes do not cause damage to other cells or cellular components.
  • Both are important in development and normal physiology.
  • Both are important in understanding the cellular basis of different pathological conditions including cancer and immune system related disorders.

 

Category:

Inflammation, Lyme, Pain Management, research, Treatment

Which Herbs For Inflammation?

https://www.medicalnewstoday.com/articles/324368.php?

Which herbs help reduce inflammation?

By Aaron Kandola
Reviewed by
Many herbal remedies could have anti-inflammatory properties. However, the evidence to support the majority of these claims is lacking. Inflammation is the body’s primary defense mechanism against infections, wounds, and other forms of harm.

However, inflammation itself can be harmful in some cases. For example, many conditions can cause inflammation to remain elevated, resulting in tissue damage.

A range of anti-inflammatory drugs exist to help control inflammation in the body. However, they often have side effects and may not always be effective.

Natural compounds that are present in certain herbal remedies also have the potential to be anti-inflammatory. However, there is much less research in this area.

This article will list herbal remedies with the most evidence for their anti-inflammatory properties.

Turmeric

Anti inflammatory herbs

 

Turmeric typically comes in the form of a yellow powder from the root of the turmeric plant.

It contains a chemical called curcumin, which may have anti-inflammatory properties.

Several studies have shown that turmeric can help reduce inflammation and discomfort in people with arthritis.

It works by limiting the production of molecules called cytokines, which cause inflammation.

Researchers continue to investigate how curcumin affects inflammation in a range of other conditions, such as inflammatory bowel disease. Curcumin has the most substantial evidence base for its anti-inflammatory effects compared with other herbal remedies.

Turmeric is available in the form of capsules, tablets, teas, pastes, and extracts. Methods of taking turmeric will vary, depending on the intended use.

Ginger

Ginger, or Zingiber officinale, is a tropical plant that has long had a place in traditional medicines.

Ginger may have anti-inflammatory properties. There is evidence showing that many of ginger’s constituents can limit the production of cytokines and the activity of cyclooxygenase enzymes, which promote inflammation.

Research has found that the anti-inflammatory properties of ginger could be useful in treating several conditions, including arthritis and pain.

Ginger can be fresh or a dried root. It can also come in the form of tablets, capsules, and teas.

Green tea

Anti inflammatory herbs green tea

Green tea comes from Camellia sinensis leaves. Research has linked it to a variety of health benefits, such as aiding weight loss.

Green tea has anti-inflammatory properties that could underlie some of these specific health benefits.

For example, there is evidence to suggest that a component of green tea could disrupt processes that cause inflammation in the arthritis.

Other studies have found that green tea can have a positive effect on inflammation in people with metabolic disorders. Researchers suggest that it may drive these anti-inflammatory effects.

Green tea typically comes as a hot or cold drink. It is also possible to buy capsules, tablets, and creams that contain green tea.

Many other herbal remedies may also have anti-inflammatory properties. Examples include:

  • thyme
  • white willow bark
  • frankincense
  • resveratrol

However, there is not much research available on these remedies. Without this research, it is not possible to say with certainty whether these anti-inflammatory effects exist, or if they are effective treatment options for people with inflammatory conditions.

While a greater evidence base exists for the remedies in this article, the research in this area is still in the early stages.

For example, scientists have conducted many studies into the anti-inflammatory benefits of turmeric. However, the quality of these studies is not high enough to support the claim that turmeric can effectively reduce inflammation in humans.

It is also important to remember that studies in this area tend to use highly concentrated forms of these herbal remedies.

In some cases, certain compounds are isolated. One example of this is curcumin from turmeric. This means that the effects may differ when taking different forms of the remedy.

Risks

Anti inflammatory herbs doctor

  • gastrointestinal problems
  • liver problems
  • abdominal discomfort
  • heartburn
  • diarrhea
  • gas
  • sleep problems

It is also possible for these herbal remedies to interact with certain medications. For example, green tea can interact with certain beta-blockers such as nadolol.

It is important to discuss any herbal remedies with a doctor, who can advise further on drug interactions that may occur.

Summary

There is some evidence to support the claim that turmeric, green tea, and ginger have anti-inflammatory properties.

For people with inflammatory health conditions, consuming these herbal remedies could be useful for reducing inflammation.

However, more high-quality research will be necessary to confirm these effects. These herbal remedies are generally safe, but it is important to consult a doctor before taking them in conjunction with other types of medication.

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Both DMSO & MSM are anti-inflammatory.  This in depth article explains their many uses – with recipes as well.
Both LDN and CBD are anti-inflammatory.

Category:

Herbs, Inflammation, Pain Management, research, Supplements, Treatment

UH Study Shows Hawaii Kids More Vulnerable to Bartonella

http://www.hawaiinewsnow.com/2019/01/17/uh-study-cat-scratch-disease-three-times-more-prevalent-hawaii-keiki-than-mainland-kids/

Cat scratch disease: It’s rare, but a UH study says Hawaii kids are more vulnerable

Cat scratch disease: It’s rare, but a UH study says Hawaii kids are more vulnerable
UH and Kapiolani doctors are warning about cat scratch disease.
By Mahealani Richardson | January 16, 2019 
HONOLULU (HawaiiNewsNow) – A new University of Hawaii study shows Hawaii keiki are more than three times more likely to get severe forms of cat scratch disease than mainland kids.
“It’s caused by a bacteria that you primarily get from cats that you get through a scratch or a bite and it’s transmitted to cats by fleas,” said Dr. Scarlett Johnson, a UH pediatric resident.

Symptoms include fever and swollen lymph nodes. UH and Kapiolani Medical Center doctors studied 18 children who got severe reactions.

“These were children who had infections of their spleen, liver, meningitis, encephalitis. involvement of their eye. Some even developed bone lesions so it was a significant illness in these children,” said Dr. Jessica Kosut, a pediatric hospitalist.

Sarah Pacheco got a mild form of the illness years ago when her new kitten, Kipling, scratched her arm.

“I had just gotten a kitten and they play and you are bound to get scratched, but I noticed I lost my voice completely,” she said.

Cat scratch disease is still rare. Doctors think Hawaii’s humid climate, outdoor lifestyle and higher feral cat population could be partly to blame.

“I don’t think it’s cats that are in people’s homes, but it can be, but a couple of the children that we took care of described playing with cats that were out in the neighborhood and one child was hiding cats in his closet to keep them a secret from his mother,” said Dr. Kosut.

Doctors say cat scratch disease is treatable. Just make sure your cat doesn’t have fleas and doesn’t play with feral cats, and you don’t have to kick out your kitty.

“I’m definitely a fan of cats and I wouldn’t say that this should discourage anyone from getting cats or adopting cats. I just want providers to be aware of it,” said Dr. Johnson.

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**Comment**
Cat Scratch Disease (CSD) or Bartonella IS NOT RARE!  And while some develop fever and swollen lymph nodes, it presents in a million different ways – some purely psychological.
And cats aren’t the only things transmitting it.

http://townsendletter.com/July2015/bartonellosis0715_3.html
Mode of Transmission: Arthropod vectors including fleas and flea feces, biting flies such as sand flies and horn flies, the human body louse, mosquitoes, and ticks; through bites and scratches of reservoir hosts; and potentially from needles and syringes in the drug addicted. Needle stick transmission to veterinarians has been reported. There is documentation that cats have received it through blood transfusion. 3.2% of blood donors in Brazil were found to carry Bartonella in their blood. Bartonella DNA has been found in dust mites. Those with arthropod exposure have an increased risk, as well as those working and living with pets that have arthropod exposure. 28% of veterinarians tested positively for Bartonella compared with 0% of controls. About half of all cats may be infected with Bartonella – as high as 80% in feral cats and near 40% of domestic cats. In various studies dogs have close to a 50% rate as well. Evidence now suggests it may be transmitted congenitally from mother to child – potentially leading to birth defects.

I’m glad they mentioned:
  • infections of their spleen & liver
  • meningitis
  • encephalitis
  • involvement of the eye
  • bone lesions
Because, these are the things crossing my desk on a daily basis.
Bartonella is prolific, tenacious, and can cause severe illness, and many LLMD’s consider it a major coinfection of Lyme.
To read more about the organism and successful treatments:  https://madisonarealymesupportgroup.com/2016/01/03/bartonella-treatment/
For more:  
  • Heart involvement –
  • Eye involvement –
  • Neurological involvement –
https://madisonarealymesupportgroup.com/2019/02/04/from-cat-scratch-disease-to-bartonellosis/  A table within this article states Bart can cause hallucinations.
  • Skull & bone infections –
https://www.ncbi.nlm.nih.gov/pubmed/19303175  Besides the case report of a woman with osteomyelitis, the study states a literature review identified 51 other cases of osteomyelitis associated with cat scratch disease, 14 of those confirmed by PCR.
  • Thoracic involvement –
  • Cancer

https://madisonarealymesupportgroup.com/2019/01/02/bartonella-langerhans-cell-histiocytosis-cancer/

  • Chronic abdominal pain, esophageal heartburn, purpuric skin rash, mesenteric adenitis (swollen lymph nodes inside the abdomen)   

https://www.lymediseaseassociation.org/images/NewDirectory/Studies-Papers/Fried_Bartonella-2002.pdf

  • Granulomas & bony lesions

https://madisonarealymesupportgroup.com/2018/07/05/cat-scratch-disease-in-a-1-5-year-old-girl-case-report/

  • Rheumatological involvement –

https://madisonarealymesupportgroup.com/2018/05/09/rheumatological-presentation-of-bartonella-koehlerae-henselae-a-case-report-chiropractors-please-read/   Please note the joint popping with each articulation and continual joint subluxation issue.

  • Can turn off antibodies to Lyme, Babesia, Ehrlichia, Anaplasma, and even itself –

http://www.townsendletter.com/July2009/ed_lyme0709.html  Dr. Shaller feels that due to this, Bartonella should be considered in ALL initial consults.

I’m going to stop at this point as I’m growing weary.  The question begs to be asked:
Does this look rare to you?

 

 

Category:

Activism, Bartonella, Eye Issues, Heart Issues, Inflammation, Psychological Aspects, research, Testing, Transmission

Webinar – How to Reduce Exposure to Harmful Cellphone & WiFi Radiation

https://www.activistpost.com/2019/01/united-educators-of-san-francisco-webinar-on-how-to-reduce-kids-exposure-to-harmful-cell-phone-and-wifi-radiation-in-schools.html

By B.N. Frank

JANUARY 28, 2019

Earlier this month, Theodora Scarato, Executive Director of Environmental Health Trust and Dr. Cindy Russell of Physicians For Safe Technology presented a webinar for UESF on safe technology use in schools.

It included:

  • A review of the United Educators of San Francisco Resolution on Technology Safety that addresses wireless radiation
  • A review of the scientific evidence on health effects of wireless radiation.
  • Recommendations for schools on how they can reduce radiofrequency radiation exposures.
  • Examples of actions and reports by teacher unions in North America to protect students and staff.
  • International and and US policy that addresses radiofrequency radiation and works to reduce exposures.
  • Examples of schools banning cell phones in classrooms.
  • Examples of schools and governments banning Wi-Fi in classrooms.
  • Published resources and recommended videos to learn more.

 Approx. 1 hr 10 Min

Doctors recommend reducing EMF in the classroom and to children in general as much as possible.

As dozens of scientists state in their letters (compiled by Environmental Health Trust here) wired networks and corded phones are an important part of a safe and healthy school. For example, read letters to Petaluma Public Schools: Dr. Carpenter, Dr. Anthony Miller, Dr. Martha Herbert, Dr. Lennart Hardell.

  • Over 250 medical doctors are calling on the United Nations for urgent action on this issue. Please read their published appeal at the European Journal of Oncology (read the list of doctors signing.)
  • The American Academy of Pediatrics has repeatedly written the US government calling for cell phone/wireless radiofrequency radiation exposure limits to be updated to protect children who are more vulnerable. Read the American Academy of Pediatrics Letter to US Representative Dennis Kucinich in Support of the Cell Phone Right to Know Act  and the Time Magazine News Article –  “Pediatricians Say Cell Phone Radiation Standards Need Another Look”
  • The EPA recognized educational campaign The BabySafe Project has a statement now signed by over 250 doctors and educators urging pregnant women to reduce wireless exposure to minimize risks to their babies’ brain development. A medical research team at Yale, led by Dr. Hugh Taylor, Chief of Obstetrics at Yale Medicine, found radiofrequency radiation exposure led to higher hyperactivity, poorer memory, and altered brain function—corroborating prior published research findings of altered brain development after exposure.

Environmental Health Trust offers many printable resources regarding this topic as well:

Additional videos on this topic recommended by Environmental Health Trust include:

Children are the future.  Thanks to EHTrust for continuing to share this information with the world.

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For more:  https://madisonarealymesupportgroup.com/2019/01/16/award-winning-journalist-exposes-wifi-disaster-in-canadian-public-school-that-injured-dozens-of-children-health-alert-on-cell-phones/

https://madisonarealymesupportgroup.com/2019/01/08/5g-will-blanket-earth-with-ultra-high-microwave-frequencies/

https://madisonarealymesupportgroup.com/2019/01/14/un-secretary-general-confesses-ignorance-on-known-5g-dangers/

https://madisonarealymesupportgroup.com/2019/01/30/petition-26000-scientists-oppose-5g-roll-out/

https://madisonarealymesupportgroup.com/2018/05/22/latest-on-electromagnetic-radiation/

https://madisonarealymesupportgroup.com/2018/08/24/take-back-your-power-smart-meter-documentary/

Category:

Activism, Inflammation

PANS PANDAS & Autoimmune Encephalitis – Rickert Hong

https://www.corebrainjournal.com/2019/01/292-pans-pandas-autimmune-encephalitis-rickert-hong/

292 PANS PANDAS & Autoimmune Encephalitis – Rickert-Hong

By Dr Charles Parker | 01/22/2019 
PANS, PANDASPhoto by Mohamed Abdelgaffar from Pexels
https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/tracks/307277478&color=%23ff5500&auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false&show_teaser=true&visual=true“>

Urgent Childhood and Adult Psychiatric Details So Often Overlooked

So many kids these days have rages, OCD, tics, aggressive behavior, prolonged tantrums and anxietyall living downstream from PANS, PANDAS and Autoimmune Encephalitis.

If these profound and puzzling symptoms prevail you must look into PANS (Pediatric Acute-onset Neuropsychiatric Syndrome), PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Strep) and Autoimmune Encephalitis – especially if your child exhibited sudden behavioral changes or a markedly unpredictable developmental regression.

Listen up; Maria spells out your options.

Autism, ADHD, Executive Function, and Sensory Processing Disorder

Even kids with autism, ADHD and Sensory Processing Disorder should be evaluated for this condition as some practitioners believe that nearly 2/3 of kids with neurodevelopmental disorders also suffer from PANS. As you listeners know, and those of you who have followed our updates over the years, immunity is a relentless and ubiquitous focus in my offices for treatment failure for many years.

The good news: if you identify it correctly and take the necessary steps treatment failure will often, quite surprisingly, turn around.

Note Well

  • PANS is an umbrella term that includes diagnoses such as Lyme disease, PANDAS, PITANDS (Pediatric Infection-Triggered Autoimmune Neuropsychiatric Disorders), and Autoimmune Encephalitis — all of which describe a condition marked by concerning psychiatric and physical symptoms that often, but now always, appear suddenly.
  • Children in the U.S. now suffer from PANS at a very concerning rate – it’s far more prevalent than many assume.

In this CBJ/292 Episode, We Discuss

  • What PANS, PANDAS and Autoimmune Encephalitis are and why so many children are being diagnosed with these conditions.
  • What causes PANS.
  • Why PANS is so commonly seen in children with autism.
  • How PANS is treated.
  • How to get to the root cause(s) of PANS.
  • What parents of children with PANS have done to bring their children back to good health.
  • What leading PANS experts have to say about the cause and treatment of PANS.

Maria co-wrote this book with remarkable colleagues at Epidemic Answers: Beth Lambert, Roseann Capanna-Hodge, Lauren Stone and Jennifer Giustra-Kozek. We’re excited to present this resource to you in your quest for improving your child’s health!

Connections

CBJ Experts On Similar Insights

 

About our mission, Dr. Charles Parker

Our CBJ hosting objective is critical: upgrade mind and brain data through informed dialogue with neuroscience experts to build more predictable, more comprehensive, more understandable solutions for you and your family. Today’s technology drives significantly improved mind-prognosis – beyond traditional psychiatric measures. Inaccurate labels, speculation, and guesswork are out – critical thinking, data, and measurement are in. Let’s work together to connect advanced biomedical wisdom with everyday street reality. 

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More on PANS/PANDAS/Autoimmune encephalitis:

https://madisonarealymesupportgroup.com/2017/12/01/guidelines-for-treating-pans-its-real/

https://madisonarealymesupportgroup.com/2018/12/17/my-kid-is-not-crazy-study-shows-1-3-kids-with-pans-have-hallucinations/

https://madisonarealymesupportgroup.com/2017/06/30/child-with-lymemsidspans-told-by-doctors-she-made-it-all-up/

https://madisonarealymesupportgroup.com/2018/07/28/stories-of-pandas/

https://madisonarealymesupportgroup.com/2018/01/05/scary-side-of-childhood-strep/

https://madisonarealymesupportgroup.com/2018/11/06/diagnosing-treating-autoimmune-encephalitis-in-patients-with-persistent-lyme-symptoms/

https://madisonarealymesupportgroup.com/2017/10/01/panspandas-steroids-autoimmune-disease-lymemsids-the-need-for-medical-collaboration/  Boy’s Lyme Disease Morphs into Autoimmune encephalopathy.  It took 10 years and 20 doctors to find out 12-year-old Patrik had Lyme disease. Just 4 months later the doctors discovered he also has a condition where his immune system attacks his brain.

https://madisonarealymesupportgroup.com/2019/01/24/toddler-suffering-from-hallucinations-seizures-diagnosed-with-rare-brain-disease/

Spread the word!  Many doctors are still in denial about these conditions.

 

 

 

Category:

Activism, Inflammation, Lyme, PANS, Psychological Aspects