Archive for the ‘Transmission’ Category

Wisconsin – 117% Increase in Human Version of Mad Cow Disease

In a recent article by Dr. Mercola,  http://articles.mercola.com/sites/articles/archive/2017/07/25/chronic-wasting-disease.aspx?utm_source=dnl&utm_medium=email&utm_content=art3&utm_campaign=20170725Z1_UCM&et_cid=DM152228&et_rid=2092836335,  statistics reveal there is a a 117% increase in Wisconsin and an 85% increase in the U.S. of the human version of mad cow disease, Creutzfeldt-Jakob, which is a contagious neurological disease caused by eating beef contaminated with brain, spinal cord or other central nervous system tissue from infected cattle.

Now the Canadian Government is warning that chronic wasting disease (CWD), a similar disease found in the deer family may jump to humans as well.  Both mad cow disease and chronic wasting disease cause transmissible spongiform encephalopathies (TSE).

The deer family is also known to pick up hitchhiking ticks and carry them long distances.

This warning is due to a study which found CWD was transmitted to three out of five macaque monkeys infected with white tail deer meat.  There is also a systematic literature review showing CWD could also be transmitted to squirrel monkeys.

There is a potential for transmission to humans exposed to deer through diet, health products containing antler velvet, slaughter, velvet harvest, field dressing, preparing trophies and hunting lures.

The state of Wisconsin offers free CWD testing to hunters.

The Milwaukee Journal Sentinel states,

“Wisconsin Department of Natural Resources (DNR)] figures show that tens of thousands of hunters are killing deer in areas where CWD is prevalent and are not submitting them for testing. In 2016, in a CWD-prone area that the DNR describes as the southern farmland zone, 442 deer tested positive for disease out of 3,760 samples. More than 65,000 deer were killed in that zone and were not tested, according to DNR figures.”

Animals infected with CWD shed prions in saliva and urine and remain contagious for life and contaminate land and water.

Similar to Chronic Lyme Disease, CWD does not evoke a detectable immune response or inflammatory reaction. It is different; however, in that it is smaller than most viruses.  It also persists in the environment which is why animals raised in captivity are more likely to infect each other.  Avoid meat from those who force natural herbivores to eat animal parts (routine in concentrated feeding operations).

Researchers have also found an infectious protein (TDP-43) in Alzheimer’s patients is quite similar to prions in mad cow disease and CWD and was found in 200 of 340 autopsied brains of Alzheimer’s patients.  Patients with TDP-43 are 10 times more likely to have been cognitively impaired at death.

A 2005 study published in the journal Medical Hypotheses, stated:

“In the opinion of experts, ample justification exists for considering a similar pathogenesis for Alzheimer’s, Creutzfeldt-Jakob and the other spongiform encephalopathies such as Mad Cow disease. In fact, Creutzfeldt-Jakob and Alzheimer’s often coexist and at this point are thought to differ merely by time-dependent physical changes. A recent study links up to 13 percent of all ‘Alzheimer’s’ victims as really having Creutzfeldt-Jakob disease.”

**Please have your meat tested.  It’s free and it may save your life.**

How Long-Term IV Antibiotics Saved a Family

This is the story of three people who vastly improved with long-term IV antibiotics.  Although the CDC recently came out with a damning article for using IV treatment for Lyme/MSIDS,  https://www.cdc.gov/mmwr/volumes/66/wr/mm6623a3.htm?s_cid=mm6623a3_e, their anecdotal report of five patients who experienced complications due to the treatment brought on a fire-storm of rebuttals:  https://madisonarealymesupportgroup.com/2017/06/21/ilads-rebuttal-to-mmwr-article/

https://www.lymedisease.org/teenager-lyme-story/

A teenager’s story: Born with Lyme disease, finally on road to recovery

By Elizabeth Hancock

My Lyme disease story begins before I was even born. It starts with a nymphal tick, no bigger than the tip of a Sharpie, that infected my mother and changed the course of my family’s life.

A few years later my mom, still undiagnosed, had my brother, Tommy, and then two years later, she had me. From birth on, my brother and I were continually sick.

My mom persistently worked with the gastroenterologist, allergist, ENT, ophthalmologist, dermatologist, occupational therapist, physical therapist, speech therapist, and pediatrician to help us.

When I was a baby, my depleted immune system triggered several autoimmune disorders. I looked malnourished with a bloated stomach. By the time I was two, I was diagnosed with celiac disease.

A year later, still unaware of my Lyme disease, I was re-infected by a tick. Following the bite, my eyes crossed and I experienced headaches, back pain, night sweats, and even a small seizure. By the time I was four years old, we all had developed late-stage Lyme.

I used bifocals, my brother experienced multiple emergency visits for central nervous system issues, and my mom’s symptoms worsened considerably. She felt as though she was detached from the world physically and mentally. She experienced horrific tremors and pain from head to toe, and made many emergency room visits for shortness of breath. She couldn’t lift her head, get out of bed, or raise her children.

What pains me most is that this lifelong suffering could have been avoided had doctors listened to her and diagnosed us earlier. Even though we lived in a Lyme-endemic area on the east coast, finding a doctor that was knowledgeable and willing to treat us was like looking for a needle in a hay stack.

For years, although my mom consulted many orthopedic, rheumatology, infectious disease, and primary doctors with her classic Lyme symptoms, they always diagnosed her with something else.

Top specialists in New York City for neurology and rheumatology failed to recognize what was really wrong with her. My mom even specifically requested to be tested for Lyme multiple times, and the few doctors that agreed ran inappropriate tests that provided inaccurate results.

She had MRIs, CAT scans, spinal tap, bone density, nerve conduction tests, and many other labs and procedures, in an effort to determine what was the cause of all of her health problems. Unsure of the root cause, doctors began treating her as if she had ALS, MS, or fibromyalgia, with very strong narcotics.

My mom kept searching for answers and finally found a rheumatologist who was highly regarded in the Lyme community. Her appointment with this doctor lasted several hours and was a very in-depth exploration of her issues. They evaluated all of her records and completed the appropriate labs and brain scans for tick-borne diseases. She was positive for Lyme, Babesia, Bartonella and Ehrlichia.

Having been diagnosed so late, my mom was completely debilitated and had severe brain inflammation. Soon after her diagnosis, my brother and I were appropriately tested and found positive for Lyme, Babesia and Bartonella.

Finally, after a ten-year journey, we were all diagnosed and put on a rigorous treatment plan that included weekly visits and three years of PICC lines.

Fortunately, we had wonderful family support like our cousins, Brenda and Carol, who dropped everything to come live with us. My grandparents helped us with our homework, bathed us, and drove us to school and appointments. My dad supported the family, took care of my mom and did everything he could to ensure that my brother and I had a normal childhood despite the obvious tribulations.

I am lucky to have this kind of family support (especially my mom’s persistence), and I know without them I would not be on a positive road to recovery.

Elizabeth Hancock is entering her senior year in high school in Columbus, Ohio. She hopes to continue her education in college and work in Washington D.C. someday.

**Comment**

Here is a case of congenital Tick Borne Illness of two children and their infected mother who all benefitted from long-term IV antibiotics.  This story is hardly singular.  IDSA founder, Dr. Waisbren, also disagreed with the IDSA stance that Lyme can not persist.  His book, Treatment of Chronic Lyme Disease, highlights 51 cases, most of which used extended IV treatments successfully, often for years:  https://madisonarealymesupportgroup.com/2017/07/09/idsa-founder-used-potent-iv-antibiotics-for-chronic-lyme/

Please forward this story to those who believe that IV antibiotics are too dangerous and don’t work.

There are thousands of these cases out here in the real world, but not in Pubmed.

Busting Lyme Myths – NYC

Senator Sue Serino’s Lyme and Tick Borne Disease Forum 2017

NYC Senator, Sue Serino of the 41st District, is the Chair of the Senate’s Task Force on Lyme and TBIs.  Task Force members and state leaders in New York are holding awareness events across the state.  One event was a public forum, in the video above, busting prevalent myths surrounding all things TBI related.

Microbiologist Holly Ahern speaks first and educates the public on common Lyme and TBI myths.  Then Dr. Matt Frye, Integrative Pest Management IPM specialist, speaks on myths about ticks.

https://a.pgtb.me/tgZFPJ  Take a Bite Out of Lyme Disease website with more info.

**This is a fantastic talk full of great and accurate information.

My only possible disagreement is that Frye states ticks can not fall & bite from trees.  I’ve heard many patients swear (including the recent video I posted of TV anchor Mike Schneider) they were bit as they sat under a tree on a patio.  https://madisonarealymesupportgroup.com/2017/07/13/tv-anchor-speaks-out-about-lyme-disease/

Besides loving Japanese Barberries (shrub), https://madisonarealymesupportgroup.com/2015/09/30/barberry-friend-or-foe/  ticks at least here in Wisconsin love certain pine trees and I personally know of a family that would hang their laundry on a line outside where the clothes would gather ticks quite possibly from the pine trees that hung over top the line.  They would find the ticks when they dumped the laundry onto the bed.  Both the husband and wife become infected this way.

https://madisonarealymesupportgroup.com/2017/03/13/ticks-found-on-rocks/  This link reveals that ticks can show up in unexpected places like on top of rocks, under picnic tables, and on picnic benches.

As to trees and using logic, if birds and small rodents travel up and down trees 24/7, it only makes sense some are going to drop off and find a blood meal.

 

Transmission time for Borrelia Mayonii by Nymphal Ticks – Mouse Model

https://academic.oup.com/jme/article-lookup/doi/10.1093/jme/tjx089

Transmission of the Lyme Disease Spirochete Borrelia mayonii in Relation to Duration of Attachment by Nymphal Ixodes scapularis (Acari: Ixodidae)
Marc C. Dolan Nicole E. Breuner Andrias Hojgaard Karen A. Boegler J. Charles Hoxmeier Adam J. Replogle Lars Eisen
J Med Entomol
Published: 05 July 2017

Abstract
The recently recognized Lyme disease spirochete, Borrelia mayonii, has been detected in host-seeking Ixodes scapularis Say ticks and is associated with human disease in the Upper Midwest. Although experimentally shown to be vector competent, studies have been lacking to determine the duration of time from attachment of a single B. mayonii-infected I. scapularis nymph to transmission of spirochetes to a host. If B. mayonii spirochetes were found to be transmitted within the first 24 h after tick attachment, in contrast to Borrelia burgdorferi spirochetes (>24 h), then current recommendations for tick checks and prompt tick removal as a way to prevent transmission of Lyme disease spirochetes would need to be amended. We therefore conducted a study to determine the probability of transmission of B. mayonii spirochetes from single infected nymphal I. scapularis ticks to susceptible experimental mouse hosts at three time points postattachment (24, 48, and 72 h) and for a complete feed (>72–96 h). No evidence of infection with or exposure to B. mayonii occurred in mice that were fed upon by a single infected nymph for 24 or 48 h. The probability of transmission by a single infected nymphal tick was 31% after 72 h of attachment and 57% for a complete feed. In addition, due to unintended simultaneous feeding upon some mice by two B. mayonii-infected nymphs, we recorded a single occasion in which feeding for 48 h by two infected nymphs resulted in transmission and viable infection in the mouse. We conclude that the duration of attachment of a single infected nymphal I. scapularis tick required for transmission of B. mayonii appears to be similar to that for B. burgdorferi: transmission is minimal for the first 24 h of attachment, rare up to 48 h, but then increases distinctly by 72 h postattachment.

Discussion

We report here that transmission of B. mayonii appears to be associated with presence of spirochetes in the saliva of the feeding tick (Table 4). Although this finding is not surprising, it provides evidence to support the salivary route of transmission for this Lyme disease spirochete, similar to transmission of B. burgdorferi (Ribeiro et al. 1987, Ewing et al. 1994). Additional studies are needed to explore the dynamics of how B. mayonii spirochetes, as well as B. burgdorferi and the relapsing fever group spirochete Borrelia miyamotoi, disseminate within I. scapularis ticks and multiply within the salivary glands during attachment, resulting in subsequent passage to mammalian hosts via the saliva of a feeding tick.

**Comment**

Transmission Time research, similarly to geographical maps of tick populations, has been used against patients for decades.  Please read all transmission time studies with healthy skepticism, realizing many patients have become infected in under the oft quoted 24-72 hours.  Thankfully, the CDC is now telling doctors to treat patients empirically, without waiting for test results, if they suspect tick borne illness.  https://madisonarealymesupportgroup.com/2017/07/12/start-treatment-if-tbis-are-suspected/

https://madisonarealymesupportgroup.com/2017/04/14/transmission-time-for-lymemsids-infection/   Bob Giguere of IGeneX states a case of a little girl who went outside to play about 8:30a.m. and came inside at 10:30 with an attached tick above her right eye. By 2 o’clock, she had developed the facial palsy. At the hospital she was told it couldn’t be Lyme as the tick hadn’t been attached long enough. They offered a neuro-consult…..(not treatment)

This story plays out again and again with doctors not believing patients, often times even refusing to test them, and send theming packing when they have a serious infection(s) that will fester for years until a correct diagnosis is made. 

By then there can be irreversible damage.

https://madisonarealymesupportgroup.com/2017/06/08/review-of-tick-attachment-time-for-different-pathogens/

 

 

 

Start Treatment if TBI’s are Suspected

http://www.mdedge.com/ccjm/article/141387/dermatology/tickborne-diseases-other-lyme-united-states  Cleveland Clinic Journal of Medicine. 2017 July;84(7):555-567

KEY POINTS

  • Tickborne illnesses should be considered in patients with known or potential tick exposure presenting with fever or vague constitutional symptoms in tick-endemic regions.
  • Given that tick-bite history is commonly unknown, absence of a known tick bite does not exclude the diagnosis of a tick-borne illness.
  • Starting empiric treatment is usually warranted before the diagnosis of tickborne illness is confirmed.
  • Tick avoidance is the most effective measure for preventing tickborne infections.

____________________________________________________________________________

The article delineates symptoms, transmission, reservoirs, testing, and treatment of the following TBI’s:  Rocky Mountain Spotted Fever, Rickettsiosis, Ehrlichioses, Babesiosis, Tickborne relapsing fever, Borrelia miyamotoi, Southern Tick-associated Rash illness, Tularemia, and Tickborne viral infections.

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I need to address the following statements at the end of the article:

“Knowledge of the geographic locations of potential exposure is paramount to determining which tickborne infections to consider, and the absence of a tick bite history should not exclude the diagnosis in the correct clinical presentation.

Clinicians need to tread carefully here.  Many patients have been denied testing and treatment due to a map.  These maps should be viewed with the same suspicion as the testing.  

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Until you tell the fox, squirrel, bird, deer, lizards, and hundreds of other reservoirs to stay put, ticks will be traveling everywhere along with the pathogens they carry.  Since Lyme Disease (borrelia) has been found in every continent except for Antarctia (it will be found there too), you can assume that means ticks are there too.  

I’m glad the authors stated this:

In addition, it is important to recognize the limitations of diagnostic testing for many tickborne infections; empiric treatment is most often warranted before confirming the diagnosis.”132_fail316x316

For those of us in this war, this “empiric treatment” by mainstream medicine is new.  Patient after patient has had to wait for test results before doctors will treat them.  Often, since the testing is so poor, it comes back negative and the patient is sent packing, even if the patient has every symptom in the book.  The next step is for authorities to admit and acknowledge that diagnosis of Tick borne infections is a clinical one.  This means doctors need to learn a whole lot more.  For docs willing to learn, please see:  https://www.lymecme.info

Even the CDC admits the tests suck: https://madisonarealymesupportgroup.com/2017/07/01/good-morning-america-cdc-advises-multiple-lyme-tests-due-to-false-negative-results/ CDC spokesperson at end of video.

Another very important point needs to be made.  The CDC has pushed this one pathogen for one tick mantra for too long.  Many patients are co-infected making cases infinitely more complex and challenging to treat.  Lyme literate doctors trained by ILADS understand this and treat accordingly.  Until mainstream medicine realizes and admits people can have numerous pathogens, and treat for them, people will not get better.  This is why all the doxycycline in the world will not help some patients.

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One last point is that mycoplasma, Bartonella, and other pathogens are not included here but are quite common in patients.  Many of these pathogens are persistent and are adept at surviving.  More research needs to be done on these co-infections.

Please see:

https://madisonarealymesupportgroup.com/2017/05/01/co-infection-of-ticks-the-rule-rather-than-the-exception/  If ticks are co-infected, so are patients.

https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/

https://madisonarealymesupportgroup.com/2016/03/20/why-we-cant-get-better/