Archive for the ‘research’ Category

Study: 92% of Pediatric Bipolar Disorder Had Evidence of Tick-Borne Exposure

https://www.frontiersin.org/journals/child-and-adolescent-psychiatry/articles/10.3389/frcha.2025.1685016/full

ORIGINAL RESEARCH article

Front. Child Adolesc. Psychiatry, 05 November 2025

Sec. Developmental Psychopathology and Mental Health

Volume 4 – 2025 | https://doi.org/10.3389/frcha.2025.1685016

This article is part of the Research TopicSevere Mental Illnesses in Children: Unravelling Developmental Trajectories, Neuropsychiatric Impairments, and Chronic PainView all 3 articles

Investigating the frequency of tick-borne infections in a case series of 37 youth diagnosed with pediatric bipolar disorder

Rosalie Greenberg1,2*
  • 1Medical Arts Psychotherapy Associates, P.A., Summit, NJ, United States
  • 2Overlook Medical Center, Summit, NJ, United States

Introduction: This retrospective chart review examined 37 youth with pediatric bipolar disorder from a private practice in the Lyme-endemic state of New Jersey, expanding on findings from 27 previously reported cases to explore the potential contribution of tick-borne infections to disease etiology.

Methods: Diagnoses were based on DSM-IV-TR and DSM-V criteria using parent and child interviews, questionnaires, and school reports. Initial screening evaluated for possible PANDAS/PANS, with testing for Group A beta-hemolytic streptococcus, Borrelia burgdorferi, Babesia, Bartonella, and Mycoplasma pneumoniae. Lyme disease testing included ELISA, Western Blot (IgM/IgG), and immunoblots, interpreted per CDC guidelines. Other pathogens were assessed via IgM/IgG titers, anti-streptolysin O, anti-DNAase B, fluorescent in situ hybridization, and blood cultures. A positive diagnosis required both laboratory evidence and clinician confirmation.

Results: Babesia was detected in 51% (19/37), Bartonella in 49% (18/37), Mycoplasma pneumoniae in 38% (14/37), Borrelia burgdorferi in 22% (8/37), and Group A Streptococcus in 19% (7/37).

Overall, 92% (34/37) had evidence of tick-borne exposure, with 81% (30/37) meeting both laboratory and clinical criteria.

Discussion: More than three-quarters of the cohort demonstrated confirmed tick-borne infections. Overlaps between bipolar disorder and tick-borne illness—such as immune dysregulation, chronic symptomatology, and responsiveness to treatments like minocycline and anti-inflammatory agents—support further exploration of infectious contributors to pediatric bipolar disorder. While limited by its single-practice retrospective design, these findings suggest that tick-borne pathogens may play a role in the pathogenesis of bipolar symptoms in youth, warranting larger, controlled studies.

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Category:

Babesia, Bartonella, Lyme, Mycoplasma, PANS, Psychological Aspects, research

Imaging Shows Early Vascular Interactions of Borrelia in Skin

https://www.nature.com/articles/s41467-025-64326-w

Open access

Published: 

Targeted volume imaging reveals early vascular interactions of Lyme disease pathogen in skin

Nature Communications volume 16, Article number: 9330 (2025) Cite this article

Abstract

Although the contours of the dissemination pathways of human pathogenic spirochetes in the vertebrate hosts are known, detailed high-resolution information on these processes remain lacking. In this study, we establish an efficient serial block-face scanning electron microscopy workflow incorporating semi-automatic AI-driven segmentation to investigate the architecture of early events following the deposition of Borrelia burgdorferi at the tick bite site in mice. We capture evidence of Borrelia penetrating the lymphatic endothelium via both transcellular and paracellular routes and observe its early presence within the lumen of the lymphatic vessel. The multistep process of transcellular migration is documented in detail, showing sequential invagination and encasement of shorter Borrelia segments by the lymphatic endothelial cells during intravasation. Our findings reveal that the first contact of B. burgdorferi and blood vessels is not random but involves close interactions with pericytes. We also capture the infiltration of immune cells in the skin and their interactions with invading bacteria. Altogether, these observations suggest that Borrelia strategically targets vascular regions with lower mechanical resistance to breach the endothelial barrier, thereby enhancing its dissemination.

Category:

Lyme, research

Case Report of Male With Anaplasmosis

https://www.cureus.com/articles/416304-relative-bradycardia-in-a-61-year-old-male-with-anaplasmosis-a-case-report#!/

Relative Bradycardia in a 61-Year-Old Male With Anaplasmosis: A Case Report

Jessica A. James • Melissa Brown • Samuel M. Segal • Maria Gutierrez-Castillo

Published: October 17, 2025

DOI: 10.7759/cureus.94785 

Open Access
Peer-Reviewed

Cite this article as: James J A, Brown M, Segal S M, et al. (October 17, 2025) Relative Bradycardia in a 61-Year-Old Male With Anaplasmosis: A Case Report. Cureus 17(10): e94785. doi:10.7759/cureus.94785

Abstract

Human granulocytic anaplasmosis (HGA), or anaplasmosis, is a tick-borne illness caused by Anaplasma phagocytophilum, a gram-negative intracellular bacterium. A. phagocytophilum is primarily transmitted by Ixodes scapularis in the northeast United States and by Ixodes pacificus in California. Presenting symptoms typically include fever, chills, malaise, headache, myalgia, and rarely a rash. This case describes a 61-year-old Black male with a complex medical history, including prior tick-borne and arboviral infections (Lyme disease, dengue fever, and chikungunya), hypertension, mixed hyperlipidemia, bilateral carotid artery dissection, gastroesophageal reflux disease, atrial fibrillation with rapid ventricular response, and current tobacco use. This patient presented to an emergency department in upstate New York with a fever, fatigue, constipation, myalgia, and night sweats. Throughout the patient’s hospital course, he maintained a state of relative bradycardia. The patient reported that he had returned from Haiti and the Dominican Republic two weeks prior to presentation in the emergency department and received several mosquito bites while abroad. Initial guideline-based empiric treatment was started with doxycycline due to suspicion of tick-borne illness, given his history of Lyme disease and his onset of symptoms while in upstate New York. Treatment was continued to complete a 14-day course after confirming the diagnosis of anaplasmosis by PCR testing of whole blood. After completing treatment with doxycycline, the patient’s symptoms resolved completely. This case illustrates a unique finding of relative bradycardia and fever of unknown origin in the context of recent international travel and history of tick-borne and arboviral infections.

 

Category:

Anaplasmosis, Heart Issues, Lyme, mosquitoes, research, Uncategorized

How the CDC Validates Chronic Lyme is All Smoke & Mirrors

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/34076105?

Progress Toward Understanding Infection-Associated Chronic Conditions and Illnesses

Carl TuttleHudson, NH, United States

Nov 19, 2025

This letter was written after seeing the following Facebook post from “Tick Boot Camp”

CDC Validates Chronic Lyme
https://www.facebook.com/photo/?fbid=1392710922860645&set=a.445348080930272

Carl Tuttle

———- Original Message ———-
From: CARL TUTTLE <runagain@comcast.net>
To: afiore@cdc.gov
Cc: dpd1@cdc.gov, Matthew_Kuehnert@mtf.org, ebelay@cdc.gov, richard.bradbury@jcu.edu.au
Date: 11/19/2025 9:06 AM EST
Subject: Progress Toward Understanding Infection-Associated Chronic Conditions and Illnesses

Emerging Infectious Diseases  Volume 31, Supplement—October 2025
 
Progress Toward Understanding Infection-Associated Chronic Conditions and Illnesses
Anthony E. Fiore
https://wwwnc.cdc.gov/eid/article/31/14/25-1187_article

Excerpt:

“Complicating the frustrated patient’s predicament, clinicians attempting unproven treatments (e.g., repeated antibiotic courses) might exacerbate illness by introducing additional risks or temporarily masking potentially treatable causes.”

To: Anthony Fiore, MD, MPH,

In 2016 Dr. Paul Auwaerter, past president of the Infectious Diseases Society of America coauthored a study revealing the persister form of Borrelia burgdorferi resistant to antibiotics.

Here is a timeline of events:

2015

Standard antibiotic treatment for Lyme disease does not kill persistent Borrelia bacteria.
http://droopyyoupi.blogspot.com/2015/08/standart-antibiotic-treatment-for-lyme.html

Excerpt:

-What has tuberculosis and Borrelia burgdorferi in common? In the late stage of the disease occurs persistent (tolerant) bacteria, which essentially means that the bacteria lasts and lasts and lasts. They protect themselves against antibiotics and are difficult to treat.

– Both Borrelia burgdorferi and tuberculosis is relatively easy to cure in the early stages, even with the use of one antibiotic. In the late stage it is impossible to cure the disease with the same type of treatment in the acute phase, said Dr. Ying Zhang when he visited the year NorVect conference.

-Dr. Ying Zhang is a professor at the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health

-Two days after NorVect conference, published Dr. Ying Zhang’s latest research Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection.

2016

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library
Jie Feng 1, Wanliang Shi 1, Shuo Zhang 1, David Sullivan 1, Paul G Auwaerter 2, Ying Zhang 1
https://pubmed.ncbi.nlm.nih.gov/27242757/

Abstract

Under experimental stress conditions such as starvation or antibiotic exposure, Borrelia burgdorferi can develop round body forms, which are a type of persister bacteria that appear resistant in vitro to customary first-line antibiotics for Lyme disease. To identify more effective drugs with activity against the round body form of B. burgdorferi, we established a round body persister model induced by exposure to amoxicillin (50 μg/ml) and then screened the Food and Drug Administration drug library consisting of 1581 drug compounds and also 22 drug combinations using the SYBR Green I/propidium iodide viability assay. We identified 23 drug candidates that have higher activity against the round bodies of B. burgdorferi than either amoxicillin or doxycycline.

2022

Nitroxoline Drug Combinations Are More Active Than Lyme Antibiotic Combination and Can Eradicate Stationary-Phase Borrelia burgdorferi
Alvarez-Manzo, Hector S.1; Zhang, Yumin1; Zhang, Ying2,✉
https://journals.lww.com/imd/fulltext/2022/09000/nitroxoline_drug_combinations_are_more_active_than.7.aspx

Abstract

Lyme disease (LD), caused by Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. Despite the standard 2–4 weeks’ antibiotic treatment, approximately 10%–20% of patients will develop posttreatment LD syndrome, a condition that is poorly understood. One of the probable causes is thought to be the presence of B. burgdorferi persister forms that are not effectively killed by the current LD antibiotics. In this study, we evaluated nitroxoline, an antibiotic used to treat urinary tract infections, for its activity against a stationary-phase culture enriched with persister forms of B. burgdorferi. Nitroxoline was found to be more active than doxycycline and equally active as cefuroxime (standard LD antibiotics) against B. burgdorferi. Importantly, the nitroxoline two-drug combinations nitroxoline + cefuroxime and nitroxoline + clarithromycin, as well as the nitroxoline three-drug combination nitroxoline + cefuroxime + clarithromycin, were as effective as the persister drug daptomycin-based positive control three-drug combination cefuroxime + doxycycline + daptomycin, completely eradicating stationary-phase B. burgdorferi in the drug-exposure experiments and preventing regrowth in the subculture study. Future studies should evaluate these promising drug combinations in a persistent LD mouse model.

Dr. Fiore… This is the missing research that should have been conducted early in the discovery phase of the disease but as we now know, all the eggs were put into the vaccine basket while a campaign was orchestrated to discredit the sick and disabled patient population along with the courageous clinicians attempting to help these patients. https://pubmed.ncbi.nlm.nih.gov/21867956/

What has been deceitfully established here in the US is wreaking havoc globally. Example:
Lyme disease: Australians ‘being treated worse than a dog riddled with mange’, Senator John Madigan says
https://www.abc.net.au/news/2016-01-11/lyme-disease-treatment-in-australia-criticised-by-john-madigan/7080708

This research is being suppressed as the disabled Lyme patient population around the globe remain sick indefinitely. (Three decades and counting)

Carl Tuttle
Independent Researcher
Hudson, NH

Cc: D. Peter Drotman, MD, MPH Editor-in-Chief

Category:

Activism, Lyme, research, vaccines

Anomalous Amyloid Microclots Found in 100% of COVID Vaxxed

https://www.thefocalpoints.com/p/breaking-study-anomalous-amyloid?

BREAKING STUDY: Anomalous Amyloid Microclots Found in 100% of the COVID-19 Vaccinated

In a cohort that was 94% vaccinated, every participant had amyloid microclots —the same pathology behind the large white fibrous clots now being pulled from corpses worldwide.

Nov 17, 2025

by Nicolas Hulscher, MPH

A new peer-reviewed study has quietly revealed one of the most consequential biological findings of the pandemic era — and the authors never acknowledge it: Every single vaccinated participant in the study had fibrinolysis-resistant, ThT-positive amyloid microclots circulating in their blood.

Hidden in the supplementary tables is a demographic and biochemical pattern that completely reframes the paper:

  • 94% of all participants were vaccinated
  • 100% of these vaccinated individuals had amyloid microclots — including every “healthy control”

The condition labeled “Long COVID” occurred almost entirely in a heavily vaccinated population, without any laboratory confirmation of prior SARS-CoV-2 infection. In reality, the study is observing Long VACCINE pathology, not Long COVID.

And because the authors’ own mechanistic experiments show that purified spike protein alone produces these amyloid, fibrinolysis-resistant clots, the implications are profound. (See link for article and graphs)

_______________

**Comment**

Not quite sure how much more damning evidence is needed, but these things needed to be thrown in the dust bin years ago....

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Category:

Activism, research, vaccines