Archive for the ‘Lyme’ Category

Kris Newby Interview – The Real News Network. Is the Rise in Lyme Disease Due to Weaponized Ticks?

https://therealnews.com/stories/is-the-rise-in-lyme-disease-due-to-weaponized-ticks

Is the Rise in Lyme Disease Due to Weaponized Ticks?

August 5, 2019

A Bold Plan Against Lyme And Other Tick-borne Diseases

https://www.lymedisease.org/keber-ahern/

A bold plan against Lyme and other tick-borne diseases

UK Lyme Disease Cases ‘Three Times Higher Than Estimated’

https://www.medscape.com/viewarticle/916256

UK Lyme Disease Cases ‘Three Times Higher Than Estimated’

Tim Locke

August 01, 2019

Current annual estimates of confirmed Lyme disease cases are between 2000 and 3000 in England and Wales, according to Public Health England.

However, research published in BMJ Open suggests the real figure for the tick-borne disease could be three times higher and may reach more than 8000 this year although an expert has urged caution, saying the findings could be an overestimation.

A second study published in the same journal supported targeted public health intervention at identified Lyme disease hotspots.

General Practice Data

The research team analysed anonymised data from Clinical Practice Research Datalink (CPRD) between 2001 and 2012. This covered around 8.4 million individuals from 658 general practices – around 8% of the UK population.

Lyme disease diagnoses were categorised as

  • Diagnosed clinically (1702, 42%)
  • Suspected and treated (1913, 47%)
  • Possible and treated (468, 11%)

Summers saw the highest number of Lyme disease cases and the largest amount were in Scotland. This was thought to be due to the popularity of hiking, and a rainier climate. The regions coming second and third for Lyme disease incidence were South Central England and South West England, but cases were seen in all areas.

CPRD recorded cases rose from 60 in 2001 to 595 in 2012, and a UK-wide estimate of 7738 for 2012.

Unsurprising Findings

“I wasn’t very surprised, because plenty of people have been suggesting that the incidence is higher than has been estimated,” one of the study authors, retired doctor Victoria Cairns from Oxford told Medscape News UK.

With some diseases, incidence can rise along with public and medical awareness of symptoms. However, “There’s more I think,” Dr Cairns said: “Every year there is more.”

The new research paper doesn’t speculate about the reasons for the growth in cases. “Other people have speculated that it’s climate change, Dr Cairns said. “There are all sorts of explanations. Partly, climate change is warmer. In some places, there are more deer so ticks are feeding off different animals, so that could be part of it.”

She has a personal interest in the subject: “I have had Lyme disease, quite a long time ago.”

She documented it – and post-Lyme disease symptoms – in the International Journal of Epidemiology in 2005.

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For more: https://madisonarealymesupportgroup.com/2018/08/13/study-shows-lyme-not-propelled-by-climate-change/  Warm winters are lethal to black legged ticks.

https://madisonarealymesupportgroup.com/2018/11/07/ticks-on-the-move-due-to-migrating-birds-and-photoperiod-not-climate-change/

EM: Course & Outcome in Patients Treated With Rituximab

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634433/

. 2019 Jul; 6(7): ofz292.
Published online 2019 Jun 19. doi: 10.1093/ofid/ofz292
PMCID: PMC6634433
PMID: 31334301

Erythema Migrans: Course and Outcome in Patients Treated With Rituximab

Abstract

Background

Information on Lyme borreliosis (LB) in patients treated with rituximab is limited to individual case reports.

Methods

We reviewed data on adult patients diagnosed with typical erythema migrans (EM) at the LB outpatient clinic of the University Medical Center Ljubljana, Slovenia, in the 10-year period 2008–2017. For all patients, clinical and laboratory information was acquired prospectively using a standardized questionnaire.

Results

Among 4230 adult patients with a diagnosis of EM, 7 patients (0.17%), 5 women and 2 men with a median age of 65 years (range, 55–66 years), were receiving rituximab for an underlying medical condition. In these 7 patients, signs of disseminated LB (43%) and the isolation rates of borreliae from blood before antibiotic treatment (40%) were unusually high compared with corresponding findings in immunocompetent patients who had EM diagnosed at the same institution (8% vs <2%, respectively). The rates of LB-associated constitutional symptoms and borrelial antibodies in serum were lower than expected (14% and 29%, respectively, in patients receiving rituximab vs 25% and 65% in immunocompetent patients). One of the 7 patients (14%) experienced treatment failure; nevertheless, the outcome of early LB 1 year after antibiotic treatment, as used for immunocompetent patients with EM, was excellent in all 7 patients.

Conclusions

Findings in 7 patients with EM who were receiving rituximab for underlying disease suggest that although early LB in these patients is more often disseminated than in immunocompetent patients, the outcome 1 year after antibiotic treatment, as used for immunocompetent patients, is excellent.

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**Comment**

There should be followed up done on these patients. A one year outcome, if you understand Lyme disease at all, is a short period of time.

Rituximab, a cancer medicine that interferes with the growth and spread of cancer cells, is used alone or in combination with other medicines to treat the following conditions in adults:

Rituximab may cause a serious brain infection that can lead to disability or death, as well as severe skin problems. You are supposed to tell your doctor if you have any of the following before using the drug:

  • liver disease or hepatitis (or if you are a carrier of hepatitis B)
  • kidney disease
  • lung disease or a breathing disorder
  • a weak immune system (caused by disease or by using certain medicines)
  • an active infection, including herpes, shingles, cytomegalovirus, chickenpox, parvovirus, West Nile virus, or hepatitis B or C
  • heart disease, angina (chest pain), or heart rhythm disorder
  • if you have used rituximab in the past
  • pregnancy – it can harm the unborn baby

According to this, Rituximab suppresses the immune system:   https://medivizor.com/blog/SampleLibrary/rheumatoid-arthritis/the-effect-of-rituximab-treatment-on-the-immune-system/

Biological drugs are becoming more popular as a treatment for rheumatoid arthritis (RA). Rituximab is one such drug that works by blocking the activity of immune cells. This then reduces the high level of inflammation seen in the joints of RA patients. Longer courses of treatment are needed for rituximab to be completely effective.

This prolonged treatment can weaken a patient’s immune response and can lead to a condition called hypogammaglobulinemia. This is an immune disorder where the body’s antibody levels are severely reduced, which increases the risk of serious infections.

LLMD’s typically do not recommend immune suppressants for Lyme/MSIDS patients unless they are on antibiotics in tandem. This research study shows why – those in Rituximab had more disseminated Lyme and more borrelia isolated from the blood.  By suppressing the immune system the infection has a greater ability to take over. The fact they had fewer constitutional symptoms and borrelia antibodies in serum means little.  Given time, this could change in a heart-beat. I suspect there were more treatment failures if they followed up on these patients up over years of time.

Patients in the study with solitary EM were prescribed oral antibiotics:

  • doxycycline (100 mg twice daily for 14 days)
  • cefuroxime axetil (500 mg twice daily for 15 days)
  • azithromycin (500 mg twice daily on the first day followed by 500 mg once daily for 4 subsequent days)
  • patients with multiple EM were treated with ceftriaxone (2 g once daily intravenously for 14 days)

For this study, treatment failure was defined as

  1. the occurrence of objective extracutaneous manifestations of LB within 1 year after the start of antibiotic treatment
  2. the appearance/persistence of subjective symptoms or their increased intensity (at the 1-year follow-up visit) that could not be attributed to other causes
  3. persistence of a skin lesion (ie, still visible EM) at a follow-up visit 2–3 months after commencement of treatment
  4. demonstration of borreliae by skin culture at the site of previous EM 2–3 months after the start of treatment (only patients with isolation of borreliae from skin before antibiotic treatment underwent repeated biopsy)

Patients with treatment failure were treated again with an alternative antibiotic.

By looking at the drugs listed, we can see right away that doxy has been shown to throw the spirochete into the non-cell wall form to reemerge later:   https://madisonarealymesupportgroup.com/2019/04/30/the-functional-molecular-effects-of-doxycycline-treatment-on-borrelia-burgdorferi-phenotype/

The emphasis on external lesions is a mistake. Research has shown that antibiotics clear the EM but won’t clear a systemic infection:  https://madisonarealymesupportgroup.com/2017/03/24/one-pill-of-doxy-only-reduces-prevalence-of-rash-not-lyme-disease/

And something must be said about antibiotic levels as well.  In this timely video, Dr. Burrascano explains how some patients need higher drug levels to kill pathogens:  https://madisonarealymesupportgroup.com/2018/12/28/the-history-of-lyme-disease-dr-burrascano/

A one sized approach for Lyme/MSIDS is another mistake.

Sadly, the authors conclude that after one year everyone’s dandy, when nothing could be further from the truth.

 

 

 

 

 

Kris Newby Responds to Telford’s Criticism of BITTEN

Kris Newby responds to Telford’s criticism of BITTEN

Dr. Sam Telford is an infectious diseases researcher at Tufts University. He recently published an article dismissing concerns about possible connections between Lyme disease and the US government’s past biowarfare research.

Author Kris Newby responds.

Open letter to Dr. Telford:

I’m the author of “BITTEN: The Secret History of Lyme Disease and Biological Weapons,” and I’d like to discuss some of the points you raised in your article in “The Conversation.”

First, I heartily agree that the Lyme bacterium, Borrelia burgdorferi, would be an “unlikely weapon.” This organism reproduces very slowly and it can’t be mass produced in large volumes like other tick-borne agents, such as tularemia.

The evidence laid out in BITTEN leads us to believe that a different organism, likely a rickettsia-viral hybrid, was made more virulent by military scientists and that Willy was asked to cover it up. As with this article, the Lyme bacterium, first described in a journal in 1982, appears to be a convenient misdirection to what the military doesn’t want us to see.

I strongly disagree your statement that “the most important characteristics of a biowarfare agent is its ability to quickly disable target soldiers.” In 1953 the U.S. biological weapons program started weaponizing fleas, ticks, and mosquitoes by infecting them with either lethal or slow-acting incapacitating microbes, depending on the military objective.

The Army explained: “In 1953, the Biological Warfare Laboratories at Fort Detrick established a program to study the use of arthropods for spreading anti-personnel BW agents. The advantages of arthropods as BW carriers are these: they inject the agent directly into the body, so that a mask is no protection to a soldier, and they will remain alive for some time, keeping an area constantly dangerous.” Source: U.S. Army Chemical Corps, “Summary of Major Events and Problems (Fiscal Year 1959),” Rocky Mountain Arsenal Archive.

Burgdorfer, the discoverer of the Lyme bacterium, was a key member of this project team. He worked on weaponizing ticks and teamed up with fellow tick expert James Oliver at the Ft. Detrick bioweapons headquarters to develop ways to mass produce infected ticks so that they could be dropped from airplanes on enemy territory. These claims are backed up by interviews with these scientists, as well as with extensive government documentation from multiple reliable sources, all listed in BITTEN.

You go on to say: “That Burgdorfer alluded to biowarfare or biodefense programs in interviews toward the end of his life should not be construed as an admission of participation in top-secret work.”

OK, but read BITTEN to evaluate the strength of the evidence. I filmed Burgdorfer detailing these bug bomb programs and it was no “prank.” He had also made these claim to others over the years. And after my interview, I verified his claims with recently released documents, including a 1962 Memorandum to the NIH Director that says that Dr. Burgdorfer, “was engaged for 3 years on classified projects (Army) from which findings could not be published because of their impact on national defense.”

I have publicly posted many of these supporting documents, and I look forward to carrying on this conversation, and possibly even adding a new discussion topic to your class on Biosecurity.

Click here to view the BITTEN files:  https://www.documentcloud.org/public/search/Project:%20%22BITTEN%20files%22

Respectfully, @krisnewby

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Telford’s article:  https://theconversation.com/no-lyme-disease-is-not-an-escaped-military-bioweapon-despite-what-conspiracy-theorists-say-120879

For more:  https://madisonarealymesupportgroup.com/2019/07/19/biological-warfare-experiment-on-american-citizens-results-in-spreading-pandemic/

https://madisonarealymesupportgroup.com/2019/07/27/lyme-biowarfare-4-video-series/

https://madisonarealymesupportgroup.com/2019/07/31/tick-expert-admits-to-working-on-ticks-dropping-them-out-of-airplanes/

https://madisonarealymesupportgroup.com/2019/07/21/got-15-minutes-the-officially-ignored-link-between-lyme-plum-island/