https://news.yale.edu/2020/06/30/fat-check-researchers-find-explanation-stress-damage-brown-fat
In their search for what triggers the damaging side-effects caused by acute psychological stress, Yale researchers found an answer by doing a fat check.
In the face of psychological stress, an immune system response that can significantly worsen inflammatory responses originates in brown fat cells, the Yale team reports June 30 in the journal Cell.
Since the hormones associated with stress, cortisol and adrenaline, generally decrease inflammation, it has long puzzled researchers how stress can worsen health problems such as diabetes and autoimmune disease as well as depression and anxiety.
“In the clinic, we have all seen super-stressful events that make inflammatory disease worse, and that never made sense to us,” said Dr. Andrew Wang, assistant professor of internal medicine and immunobiology, and corresponding author of the study.
Cortisol and adrenaline, hormones released in the classic “flight or fight” stress response, generally suppress the immune system, not activate it. These hormones also initiate a massive metabolic mobilization that provides fuel to the body as it addresses threats.
The scientists found that it was an immune system cell — the cytokine interleukin-6 (IL-6) — that triggers inflammation in times of stress. IL-6 has also been shown to play a role in autoimmune diseases, cancer, obesity, diabetes, depression and anxiety.
Wang and colleagues began to study the role of IL-6 in stress after a simple observation: When the researchers drew blood from mice, a very stressful procedure, the blood showed elevated levels of the cytokine.
In a series of experiments in mice, designed by Hua Qing and Reina Desrouleaux in Wang’s lab, the researchers found that IL-6, which is usually secreted in response to infections, was induced by stress alone and worsened inflammatory responses in the stressed animals.
And to their surprise, they found that in times of stress IL-6 was secreted in brown fat cells, which are most known for their roles in regulating metabolism and body temperature. When signals from the brain to brown fat cells are blocked, stressful events no longer worsened inflammatory responses.
“This was a completely unexpected finding,” said Qing, a postdoctoral associate at Yale School of Medicine.
The researchers reasoned that IL-6 must play another role in the “fight or flight” response besides triggering inflammation. They learned it also helps prepare the body to increase production of glucose in anticipation of threats. The brown fat cell response causes IL-6 levels to peak well after the metabolic production of glucose and the release of cortisol and adrenaline. This may explain why stress can trigger inflammation even while immune-suppressing hormones are being released, the researchers said.
Wang and his team also suspect IL-6 may play a role in mental health disorders such as depression and anxiety. Wang observes that many of symptoms of depression, such as loss of appetite and sex drive, mimic those caused by infectious diseases such as the flu — so-called “sickness behaviors” — that can be triggered by IL-6.
Existing drugs designed to treat autoimmune diseases such as rheumatoid arthritis block the activity of IL-6. Preliminary findings suggest these drugs may help alleviate symptoms of depression, the authors note. There is also preliminary evidence that IL-6 may also play a role in diabetes and obesity as well.
“There is an ever-growing literature on the role of IL-6 outside of immunity. Our work is exciting because it contributes to shortening that gap of knowledge,” said Desrouleaux, a graduate student in biology and biomedical science.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404712/
We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses. (See link for article)
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**Comment**
Important quote:
In the prepandemic period of our study, we did not observe a statistically significant reduction in confirmed seasonal influenza virus infections in the TIV (inactivated influenza vaccine) recipients (Table 3), although serological evidence (Supplementary Appendix) and point estimates of vaccine efficacy based on confirmed infections were consistent with protection of TIV recipients against the seasonal influenza viruses that circulated from January through March 2009 [16]. We identified a statistically significant increased risk of noninfluenza respiratory virus infection among TIV recipients (Table 3), including significant increases in the risk of rhinovirus and coxsackie/echovirus infection, which were most frequently detected in March 2009, immediately after the peak in seasonal influenza activity in February 2009 (Figure 1).
You read that correctly. Not only did the TIV NOT reduce the flu, those that received it simnifically increased their risk of other respiratory virus infections.
The article goes onto discuss “viral interference.” This article explains that the flu vaccine can cause this: https://www.ageofautism.com/2020/01/coronavirus-can-be-caused-by-viral-interference-a-known-result-of-flu-vaccines.html
Excerpt:
..after saying that indeed those who are vaccinated DO get more acute pathogen-creating illness, like CORONAVIRUS, that should make us all wonder if there are any connections here. The acknowledging that patients DO get ill after flu shots from these other viruses (VIRAL INTERFERENCE) is priceless yet disturbing. Basically patients have been made to feel like they were wrong for decades. I am sure deaths too, have been involved but to correctly blame it on the vaccine has been taboo. Mutating bacteria and viruses are possible for sure and vaccines can also be responsible for that.
Here’s a current research article showing the exact same thing:
Vaccine. 2020 Jan 10;38(2):350-354. doi: 10.1016/j.vaccine.2019.10.005. Epub 2019 Oct 10. Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017-2018 influenza season.
Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. … Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus…..
We will read that this Coronavirus is from “bats, pigs and small mammals”, Biowarfare labs , yet you can bet vaccines will be dismissed in a heartbeat.
I posted on that study here: https://madisonarealymesupportgroup.com/2020/03/23/flu-vaccine-increases-coronavirus-infection-risk-36/
The good news is that according to this immunologist, our body already has some immunity to COVID-19 due to the fact it is not completely novel as we’ve been told: https://madisonarealymesupportgroup.com/2020/07/10/coronavirus-why-everyone-was-wrong/ The very name of it: SARS-COV-2, shows it is closely related to SARS, a virus that has already circulated. This also reveals, clearly, that COVID-19 has yet to be singularly purified, which is why testing is so poor and a vaccine can never be properly made. They don’t even have the singular organism isolated and purified. Big problem and another elephant in the room everyone is side-stepping.
https://www.nature.com/articles/s41577-020-0389-z
Alessandro Sette & Shane Crotty
Nature Reviews Immunology (2020)
T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses.
As data start to accumulate on the detection and characterization of SARS-CoV-2 T cell responses in humans, a surprising finding has been reported: lymphocytes from 20–50% of unexposed donors display significant reactivity to SARS-CoV-2 antigen peptide pools1,2,3,4.
In conclusion, it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. (See link for full article)
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For more: https://madisonarealymesupportgroup.com/2020/07/10/coronavirus-why-everyone-was-wrong/
Telling quote:
“The entire world simply claimed that there was no immunity…..that wasn’t science, but pure speculation based on a gut feeling that was then parroted by everyone.” Beda Stadler
Important Quote:
“The likelihood that these latest admissions by the WHO about asymptomatic transmission reach the mainstream airwaves is minimal, at best.”
JUL 12, 2020 —
———- Original Message ———-
From: CARL TUTTLE <runagain@comcast.net>
To: tickbornedisease@hhs.gov
Cc: (99 Undisclosed recipients)
Date: 07/12/2020 9:45 AM
Subject: “Shapiro and Walker operated as a tag team throughout the meeting”
TOUCHED BY LYME: TBD Working Group and FACA’s open meeting rules
https://www.lymedisease.org/tbdwg-faca-open-meeting-rules/
Donta to Walker:
“I’m dumbfounded why you would not want to try to understand the mechanisms of persistent Lyme. We know this happens with other infections”
To the Tick-Borne Disease Working Group,
One of the strategies of the racketeering scheme (Lisa Torrey vs IDSA) was to suppress evidence of persistent infection after extensive antibiotic treatment and then claim there is no evidence. The deliberate and well-orchestrated denial has left hundreds of thousands if not millions worldwide in a debilitated state.
Let me remind everyone on this panel that the maximum penalty authorized for a RICO violation is 20 years in jail but being investigated for a serious crime did not disqualify Eugene Shapiro from appointment to the group.
-Would we have appointed film producer Harvey Weinstein to the TBDWG while he was under investigation?
-How about Jeffrey Epstein or Bill Cosby while they were being investigated for a serious crime?
Let’s all review what is known about Dr. Eugene Shapiro……………
Memorable and Not So Memorable Quotes by Lyme Disease Denialists
Quotes from Shapiro:
“Lyme disease prevention requires only minimal precautions; even for people living in areas with the highest concentration of positively identified cases”:
-Eugene D. Shapiro, MD, Yale Children’s Health Letter, April 1995
“Over time, the [Lyme] disease tends to burn itself out, even without treatment, in many people”:
-Eugene Shapiro, MD, quoted by Karen Freeman in The New York Times, October 24, 1996
“Children with only non-specific symptoms, such as headache, fatigue, or arthralgia, are very unlikely to have Lyme disease. Serologic tests for Lyme disease should not be ordered for such patients because a positive test result is very likely to be a false-positive”:
-Eugene D. Shapiro, MD, in ACP’s Lyme Disease, page 131
“Nearly 90% of children who develop Lyme disease have either single or multiple sites of erythema migrans”:
-Eugene D. Shapiro, MD, ibid., page 132
“As many as 40% of the patients with well-documented late stage Lyme disease will not have had a preceding lesion of erythema migrans . . . as the only clinical manifestation of early Lyme disease. . . . The existence of a flu-like illness without erythema migrans of early Lyme disease has been clearly established”:
-Eugene D. Shapiro, MD, et al., “Early Lyme Disease: A Flu- like Illness Without Erythema Migrans,” Pediatrics 91, (1993): 456-59
“There is no evidence that congenital Lyme disease is a problem”:
-Eugene D. Shapiro, MD, in ACP’s Lyme Disease, page 132
“The prognosis of children with Lyme disease, both early and late, is excellent, with no evidence of chronic symptoms or long- term sequelae”:
-Eugene D. Shapiro, MD, ibid., page 132
“Because of the low risk of Lyme disease and the excellent prognosis of children who do develop Lyme disease, prophylactic antimicrobial treatment is not recommended for children who are bitten by a deer tick”:
-Eugene D.Shapiro, MD, ibid., page
“In patients presenting with nonspecific symptoms, the positive predictive value of serologic testing for Lyme disease is low”:
-Eugene D. Shapiro, MD, ACP’s Lyme Disease, page 224
“There are a ton of people with non-specific symptoms and most of their positives are false positives [for the ELISA and Western Blot], so they think they have this diagnosis of Lyme”:
-Eugene Shapiro, MD, quoted by Stefanie Ramp in the Fairfield County Weekly, May 20, 1999
“If all you know is that you found a deer tick on your child, the risk is 1 to 2 percent at most of having Lyme disease. And then greater than 90 percent of those will show a rash at the site of the bite.”:
-Eugene Shapiro, MD, in the April 1995 issue of Yale Children’s Health Letter
“Most ticks are not infected and even if a child has been bitten by an infected tick, 36 to 48 hours are needed before transmission of the bacteria takes place.”:
-Eugene Shapiro, MD, ibid.
“There are probably better ways to spend health-care dollars” than on a vaccine for Lyme disease:
-Eugene Shapiro, MD in the April 1995 issue of Yale Children’s Health Letter
“It [LYMErix vaccine] is fairly expensive, and I think that the biggest problem is not Lyme disease but anxiety about Lyme disease, and I’m not sure how effective the vaccine is against anxiety about Lyme disease….I don’t think most people are at really high risk for Lyme disease, so the benefits don’t necessarily qualify the costs.”:
-Eugene Shapiro, MD, a professor of pediatrics at Yale, quoted by Stefanie Ramp in the Fairfield Co. Weekly on May 20, 1999
“It’s usually not Lyme disease unless it looks, smells, and tastes like Lyme disease”:
-Eugene Shapiro, MD, in the April 1995 issue of Yale Children’s Health Letter
“If you only go to a Lyme literate doctor, you are likely to be diagnosed with Lyme disease, because that’s what they do. If you go to Midas, you’re going to get a muffler.” (Chronic Lyme sufferers believe that the medical world would benefit immensely from Shapiro having a Midas muffler installed on his person).
“So, you know, in an anecdotal sense, taking antibiotics and feeling better doesn’t mean that the antibiotics are the reason that you felt better. It may have something to do with the belief that this doctor cares for me, I’m doing something to help myself, it’s very complicated and we don’t know all the answers…”(Shapiro’s rambling and inane commentary was rightfully terminated by the host of the program).
-Maryland Public Television – Direct Connection – Lyme Disease – Under Our Skin Review – June 27, 2011
WHY IS SHAPIRO ON THE TBDWG????
Please call for his immediate removal.
Respectfully Submitted,
Carl Tuttle
Hudson, NH USA
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**Comment**
Perhaps Shapiro is somehow related to Bill Gates? They both seem to have extraordinary power over thousands if not millions of people’s health.
BTW: Shapiro urges the medical community to develop ways to prevent “healthcare-seeking behaviors” by parents who believed their children may have Lyme disease:
https://madisonarealymesupportgroup.com/2019/06/11/dr-eugene-shapiro-medically-unexplained-symptoms/
“…it’s very clear that simply telling parents that Lyme disease is not the cause of these nonspecific symptoms such as fatigue, various pain syndromes that is not sufficient and that we need a new paradigm to how to best manage such patients. Often it’s not the pediatric infectious disease specialists who doesn’t have an ongoing relationship with his patients who is likely the best but someone who can develop a trusting relationship with them. Very frequently these parents are seeking affirmation that these symptoms are real and in fact they are real it’s just that they’re not caused by Lyme disease…..” Eugene Shapiro
