Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

Alessandro SetteShane Crotty

T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses.

As data start to accumulate on the detection and characterization of SARS-CoV-2 T cell responses in humans, a surprising finding has been reported: lymphocytes from 20–50% of unexposed donors display significant reactivity to SARS-CoV-2 antigen peptide pools1,2,3,4.

In conclusion, it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. (See link for full article)


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Telling quote:

“The entire world simply claimed that there was no immunity…..that wasn’t science, but pure speculation based on a gut feeling that was then parroted by everyone.” Beda Stadler

Important Quote:

“The likelihood that these latest admissions by the WHO about asymptomatic transmission reach the mainstream airwaves is minimal, at best.”