https://danielcameronmd.com/causes-treatment-delays-lyme-disease/

CAUSES OF TREATMENT DELAYS 16 LYME DISEASE PATIENTS

The longer time between onset of symptoms and treatment of Lyme disease has been associated with poor outcomes. [1] Unfortunately, delays in treatment are often reported. So, what are the causes for such delays?

I have identified several factors that might have contributed to treatment delays in 15 Lyme disease patients. All 15 subjects failed their initial antibiotic treatment. In many cases, their illness could have been mitigated had diagnosis and treatment occurred in the early stages of the disease.

These 15 patients were part of a case series which included 100 Lyme disease patients who were treated at a single private medical practice. The study was described in the Journal Evaluation Clinical Practice. [2] All patients in the series met the CDC’s two-tier criteria with at least 5 out of 10 IgG positive Western blot bands.

Treatment delays for Lyme disease

Case 1

35-year-old man presented with an erythema migrans rash. One week later, he had a blood test, which was negative. He was never re-tested. The man was not treated for Lyme disease for 8 years.
Failure to treat an erythema migrans rash despite a negative test

Case 2

16-year-old girl was diagnosed with Epstein Barr and a streptococcal infection. Her tonsils were subsequently removed. She was not treated for Lyme disease for 8 years.
Failure to consider Lyme disease

Case 3

57-year-old woman had a tick bite followed by a swollen right knee. She was diagnosed with a meniscus tear. She was not treated for Lyme disease for 6 years.
Failure to consider Lyme disease

Case 4

16-year-old girl was diagnosed with Bell’s palsy. She subsequently did poorly in school. She was not treated for Lyme disease for 6 years.
Failure to consider Lyme disease; failure to associate Lyme disease as a cause of poor school performance

Case 5

31-year-old man had a 6” x 6” rash. He was not treated for Lyme disease for 4 years.
Failure to recognize an erythema migrans rash

Case 6

35-year-old man with typical symptoms. He was told he did not have Lyme disease by two doctors. He was not treated for Lyme disease for 3 years.
Failure to seek a second opinion from a doctor experienced in treating chronic manifestations of Lyme disease

Case 7

42-year-old woman with Bell’s palsy. She was told she did not have Lyme disease based upon results from a spinal tap. She was not treated for Lyme disease for 3 years.
Relied on negative spinal tap results to dismiss Lyme disease; failure to consider Lyme disease even with Bell’s palsy manifestation

Case 8

22-year-old man with sinusitis followed by two sinus operations. He was not treated for Lyme disease for 17 months.
Failure to consider sinusitis as a symptom of Lyme disease

15 Lyme disease patients experience delays in diagnosis and treatment. Study reviews each case and possible causes behind the delays. CLICK TO TWEETCase 9

75-year-old man with aches and pains and walking difficulties. He was told the symptoms were related to a previous heart attack and stroke. He was not treated for Lyme disease for 15 months.
Failure to consider Lyme disease

Case 10

50-year-old man with a rotator cuff and meniscus tear. He was not treated for Lyme disease for 8 months.
Failure to consider Lyme disease

Case 11

36-year-old woman with an ill-defined rash with a positive Lyme disease test. She was told it was not Lyme disease by her doctor. She was not treated for Lyme disease for 6 months.
Failure to recognize an erythema migrans rash; failure to seek a second opinion from a doctor experienced in treating chronic manifestations of Lyme disease

Case 12

75-year-old man with edema. He was treated initially with diuretics followed by steroids for “water on knee.” He was not treated for Lyme disease for 4 months.
Failure to associate “water on knee” as a symptom of Lyme disease

Case 13

18-year-old woman with a 4” x 4” rash followed by pericarditis. She was treated with steroids instead of antibiotics. She was not treated for Lyme disease for 3 months.
Failure to recognize an erythema migrans rash

Case 14

37-year-old man with disseminated Lyme disease rashes and asthmatic bronchitis. He was treated with steroids instead of antibiotics. He was not treated for Lyme disease for 2 months.
Failure to recognize an erythema migrans rash

Case 15

20-year-old woman was treated three times for cellulitis. She was not treated for Lyme disease for 2 months.
Failure to recognize an erythema migrans rash

Editor’s Note: These 15 patients did well with retreatment or treatment of a co-infection. It would have been easier to treat in a timely manner. Timely treatment would also avoid needless suffering.

There are multiple factors associated with treatment delays. These cases are reflective of only one practice and may not be generalizable to the broader population. Other factors may have contributed to these treatment delays.

Lyme disease patients should not have to suffer for months to years before being treated. More researcher on the causes behind treatment delays is required.

References:
  1. Hirsch AG, Poulsen MN, Nordberg C, et al. Risk Factors and Outcomes of Treatment Delays in Lyme Disease: A Population-Based Retrospective Cohort Study. Front Med (Lausanne). 2020;7:560018. doi:10.3389/fmed.2020.560018
  2. Cameron DJ. Consequences of treatment delay in Lyme disease. J Eval Clin Pract. Jun 2007;13(3):470-2. doi:10.1111/j.1365-2753.2006.00734.x

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/29172177?

HHS Request for Information

JUN 7, 2021 — 

Please see below my submission to HHS Request for Information: (Deadline June 11th)

How to submit a comment:  https://www.federalregister.gov/documents/2021/04/27/2021-08167/request-for-information-rfi-developing-the-national-public-health-strategy-for-the-prevention-and

June 6, 2021

Developing the National Public Health Strategy for the Prevention and Control of Vector-Borne Diseases in Humans

It was once believed that rifampin was curative in treating Brucellosis but when symptoms returned doxycycline was added to the mix and when that too failed a third antibiotic, streptomycin was added to the current treatment regimen. [1] [2]

In 1985 the worldwide incidence of leprosy was 6,000,000. In 2018, it was 208,619. The only thing that changed was the addition of rifampin to dapsone in the treatment of the disease. Rifampin was added to dapsone because the M leprae were becoming resistant and it was a new antibiotic at that time.

Treatments for multidrug-resistant tuberculosis have been introduced (bedaquiline and delamanid) with more in the pipeline. [3]

A new treatment for recurrent Clostridium difficile was recently studied (bezlotoxumab) for reducing the risk of a repeat infection. [4]

In contrast, oral amoxicillin or doxycycline remains the treatment of choice for treating Lyme disease for over thirty years regardless if debilitating symptoms return. Since 1977 Dr. Allen Steere knew that these antibiotics were not effective for all patients [5] but there has been no change in treatment or research to find more effective ways to eradicate the infection in all stages of disease.

To my knowledge, a “Federal Working Group” was never established for brucellosis, leprosy, tuberculosis or C. difficile but then again there was no rush to create a vaccine as there was with Lyme disease. It would appear that a chronic relapsing seronegative disease did not fit the vaccine model.

All patients in the 2018 Middelveen et al pilot study were culture positive for infection (genital secretions, skin and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics. [6]

Here’s what researchers at Johns Hopkins and Northeastern are saying: [7]

“Under experimental stress conditions such as starvation or antibiotic exposure, Borrelia burgdorferi can develop round body forms, which are a type of persister bacteria that appear resistant in vitro to customary first-line antibiotics for Lyme disease.”

Dr. Brian Fallon of Columbia University recently published his findings of autopsy specimens from a patient previously treated for Lyme disease. Persistent infection with the Lyme disease spirochete was identified in the brain of the Lyme patient who died with a diagnosis of Lewy body dementia. [8]

Any published evidence identifying persistent infection after extensive antibiotic treatment has been completely ignored. Please see my letter to the editor of the BMJ published June 2020 for examples. [9] The research to find a cure for this antibiotic resistant/tolerant superbug has been denied for decades as the co-chair of the Tick-Borne Disease Working Group, Dr David Walker calls persistent infection after extensive antibiotic treatment a “religious belief” [10] This partnership to deny chronic Lyme disease has left hundreds of thousands if not millions around the globe in a debilitated state.

For three decades now patient testimony all across America (and around the globe) has been describing a disease that is destroying lives, ending careers while leaving its victim in financial ruin.

Priority # 1 for Lyme disease:

Establish a Manhattan Project to Find a Cure for this antibiotic resistant/tolerant superbug and elevate Lyme to Highest Alert at the CDC while recognizing the disabling stage of Lyme disease.

Respectfully submitted,

Carl Tuttle
Hudson, NH

Member of Governor Chris Sununu’s Lyme Disease Study Commission
http://www.gencourt.state.nh.us/statstudcomm/details.aspx?id=1515&rbl=1&txtbillnumber=hb490

Cc: All members of the New Hampshire Lyme Disease Study Commission

References: 

[1] Chronic Brucellosis and Persistence of Brucella melitensis DNA
https://www.ncbi.nlm.nih.gov/pubmed/?term=Chronic+Brucellosis+and+Persistence+of+Brucella+melitensis+DNA

[2] Administration of a triple versus a standard double antimicrobial regimen for human brucellosis more efficiently eliminates bacterial DNA load.
https://www.ncbi.nlm.nih.gov/pubmed/25246401

[3] Global Introduction of New Multidrug-Resistant Tuberculosis Drugs—Balancing Regulation with Urgent Patient Needs
https://wwwnc.cdc.gov/eid/article/22/3/15-1228_article

[4] New C.diff treatment reduces recurrent infections by 40%
https://www.sciencedaily.com/releases/2017/01/170126081724.htm

[5] Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. 1977
https://pubmed.ncbi.nlm.nih.gov/836338/

Excerpt:

“The best treatment for this illness is not clear. Some physicians have reported that penicillin or tetracycline results in disappearance of the skin lesion (41,42), but others find antibiotics ineffective. Four of the patients with expanding skin lesions received penicillin but still developed arthritis.” 

[6] Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease
http://www.mdpi.com/2227-9032/6/2/33

[7] A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library
https://pubmed.ncbi.nlm.nih.gov/27242757/

[8] Detecting Borrelia Spirochetes: A Case Study With Validation Among Autopsy Specimens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141553/

[9] Lyme borreliosis: diagnosis and management
https://www.bmj.com/content/369/bmj.m1041/rr-1

[10] Public comment: Does that sound like a religious belief, Dr. Walker?
https://www.lymedisease.org/tuttle-comment-tbdwg-nov17/

Request for Information (RFI): Developing the National Public Health Strategy for the Prevention and Control of Vector-Borne Diseases in Humans
The development of a national strategy on vector-borne diseases including tickborne diseases was…

US State Department Covered Up That China Was Responsible For COVID

https://www.foxnews.com/opinion/tucker-carlson-us-government-officials-helped-china-cover-up-covid-origins  News video  here (6/4/21).  Approx. 11 Min

 _______________________

**Comment**

I recommend watching the entire news segment as there is crucial information on numerous topics but specifically regarding the state of Lyme/MSIDS.

Important quotes:

So why did they lie to us about it for so long? A shocking new piece in, of all places, the celebrity suck-up magazine Vanity Fair, answers that question in great detail. You should read it. In short, many research scientists are addicted to tax dollars. If the public understood just how recklessly they’ve behaved — endangering the entire world with their weird little experiments in poorly relegated labs in China — the money might dry up. As a former NSC official called Jamie Metzl put it, ‘If the pandemic started as part of a lab leak, it had the potential to do to virology what Three Mile Island and Chernobyl did to nuclear science.’

Can’t have that. Got to keep the money flowing. So they lied about it. And then they intimidated anyone who told the truth.  Tucker Carlson

A perfect example of this intimidation is from the previous director of the CDC, Robert Redfield, who received death threats from scientists after he suggested the virus came from a lab.  Redfield states he expected the lashing out from politicians but not scientists.

This year has demonstrated the death-toll of science for anyone paying attention.  It has been replaced with propaganda by self-serving, grant seeking researchers who will do anything for a buck – even lie, cover up, and manipulate data.

Epidemiologist Kurt Wittowski has stated that funding for research has relied more and more on government grants, and less and less upon independent sources.  He states:

“Well, I’m not paid by the government, so I’m entitled to actually do science.”  Source

This is true for every area, but specifically for all issues surrounding Lyme/MSIDS.  The only transparent, forward moving science has been done by independent researchers who don’t have to follow an accepted narrative to receive funding.

As Carlson mentions in the video, our government never admits fault.  

Do we really expect this same government, which is accused of funding and performing research where ticks were tweaked in a lab and then dropped from airplanes, to admit this damning backstory and the years of faulty research done by The Cabal, based on carefully selected parameters to disprove chronic/persistent infection, and then rigging treatment guidelines for their own patent purposes?  And talk about intimidation.  Countless doctors have been wrongly accused, sanctioned, and had their medical licenses suspended or revoked for simply treating Lyme/MSIDS patients.  They are bullied and maligned by their own colleagues and called “quacks.”

To date, the myths and lies about tick-borne illness continue unabated.  
 
  • Fauci speaks favorably of dual use research of concern, or DURC, stating, “the risk-benefit ratio of such research clearly tips towards benefiting society”
  • Due to its controversial nature and potential to fuel bioweapons, several moratoriums have been placed on GOF research, including one in October 2014, after a string of high-profile “incidents” at U.S. biocontainment laboratories
  • NIAID has funded GOF research on bat coronaviruses at the Wuhan Institute of Virology (WIV), but Fauci — amid growing calls that COVID-19 was the result of a laboratory accident — has denied that such funding occurred
Currently there are 15 potentially deadly DURC pathogens – Tularemia is one of them (a pathogen also transmitted by ticks).

Because GOF, or DURC, can be used to make pathogens more readily able to infect humans, it poses major biosecurity risks, which makes publication of such data almost as controversial as the research itself.

Two studies on highly pathogenic H5N1 avian influenza ignited the debate in 2012. One, led by Yoshihiro Kawaoka at the University of Madison‐Wisconsin, identified molecular changes in H5N1 that would allow it to transmit among mammals.7

According to Ronnie Cummins, co-founder of the Organic Consumers Association (OCA) and Alexis Baden-Mayer, OCA’s political director (as mentioned earlier in the Mercola link on GOF experiments), moratoriums were placed on GOF research:

“Exemptions to this ‘pause,’ eventually reviewed by a secret government panel, were nonetheless allowed to go forward. The ban was lifted in 2017. Yet between 2014 and 2016, the NIH and Fauci-led NIAID continued funding gain-of-function research overseas at the Wuhan lab, via [Peter] Daszak’s EcoHealth Alliance.

Not surprisingly both Fauci and Daszak have been staunch defenders of the official Chinese government story that the virus that causes COVID-19 (SARS-CoV-2) ‘naturally’ evolved from bats and/or other host species to infect humans.”

Clear Links Show NIAID Funded GOF Research

In a May 11, 2021, Senate hearing, Sen. Rand Paul questioned Fauci on the NIAID’s funding of GOF research on bat coronaviruses, some of which was conducted at the WIV. Fauci denied the charge, saying, “The NIH has not ever, and does not now, fund gain-of-function research in the Wuhan Institute.”18 However, NIH’s funding of such research can be easily double-checked.

In a Truth in Media report,19 investigative journalist Ben Swann reviews documents proving Fauci lied to Congress, including a paper titled “SARS-Like WIV1-CoV Poised for Human Emergence,20submitted to PNAS in 2015 and subsequently published in 2016. In this paper, the authors state:

“Overall, the results from these studies highlight the utility of a platform that leverages metagenomics findings and reverse genetics to identify prepandemic threats. For SARS-like WIV1-CoV, the data can inform surveillance programs, improve diagnostic reagents, and facilitate effective treatments to mitigate future emergence events.

However, building new and chimeric reagents must be carefully weighed against potential gain-of-function (GoF) concerns.”

At the end of that paper, the authors thank “Dr. Zhengli-Li Shi of the Wuhan Institute of Virology for access to bat CoV sequences and plasmid of WIV1-CoV spike protein.” They also specify that the research was supported by the NIAID under the grant awards U19AI109761 and U19AI107810, which together total $41.7 million.

As noted by Swann, this paper clearly spells out that the NIAID spent $41.7 million on GOF research, with the aim of determining how bat coronaviruses can be made more pathogenic to humans, and that this research continued after the 2014 moratorium on such funding was implemented.  Source

According to Dr. Martin, the actual number is $191 BILLION dollars of audited funds for the bioweaponization of viruses against humanity.

https://jameslyonsweiler.com/2021/05/17/study-finds-patterns-in-vaers-data-that-provide-evidence-of-causality/

STUDY FINDS PATTERNS IN VAERS DATA THAT PROVIDE EVIDENCE OF CAUSALITY

If vaccine adverse events and deaths following COVID19 vaccination were truly not causally related, there would be an equal number of reports in the days following the vaccine administration. That’s a valid null hypothesis.

Do the data support non-causality? No. A new peer-reviewed study has found deaths clustered near the day of vaccine exposure, which is inconsistent with non-causality, and a dramatic increase in the autoimmune reports associated with COVID19 vaccination, consistent with predictions made by earlier studies predicting specific autoimmmune-related reactions based on the SARS-CoV-2 virus proteins.

The study, by Dr. Jessica Rose, is a report on carefully analyzed data from the Vaccine Adverse Events Reporting System, is attached, along with the Editorial introducing it.  Both are also available and shareable from the journal website.

The results are numerous and compelling. Since anaphylaxis is known to be caused by COVID19 vaccines, Dr. Rose used anaphylaxis as a positive control, finding the same pattern of clustering of events in time in deaths and in many serious adverse events.

Dr. Rose also reported an expected increase increase in autoimmune-related reports in VAERS over time, which she attributed to the same mechanism I proposed and predicted in April 2020: Pathogenic Priming.

This study will be hotly debated because it drives to the core presumption that the VAERS data resource cannot be used to assess causality. Temporal association is a critical piece of evidence in causality; the test for clustering of the events so near the vaccination event provides a critical test of the hypothesis of causality.

Study here:  Rose, J. 2021. A Report on the U.S. Vaccine Adverse Events Reporting System (VAERS) of the COVID-19 Messenger Ribonucleic Acid (mRNA) Biologicals. Sci Publ Health Pol & Law 2:59-80. [LINK]  

(See link for graphs and tables)

_________________________

For more:

Vaccine specialist Dr. Geert Vanden Bossche states: 

Virologist, Dr. Montagnier states: 

Montagnier states:

  • SARS-CoV-2 appears to be a benign bat coronavirus modified to integrate spike proteins that allows the virus to enter human cells by attaching to ACE-2 receptors
  • The virus also appears to have been modified to integrate an envelope protein from HIV called GP141, which tends to impair the immune system. A third modification appears to involve nanotechnology, which allows the virus to remain airborne longer

https://danielcameronmd.com/long-take-infected-tick-transmit-lyme-disease/

HOW LONG DOES IT TAKE TO GET LYME DISEASE?

how-long-does-it-take-to-get-lyme-disease

The risk that a deer tick may transmit Lyme disease rises the longer the tick is attached, according to a review by Eisen from the Centers for Disease Control and Prevention (CDC) published in the January 2018 journal Ticks and Tick-borne Diseases. [1]

By Dr. Daniel Cameron

A study by Eisen and colleagues addressed a frequently asked question: “How long does it take to get Lyme disease?” According to their findings,  the probability of an individual becoming infected with Borrelia burgdorferi (Bb), the pathogen which causes Lyme disease, increases the longer the tick is attached. [1]

Researchers found the risk increases:

  • Approximately 10% after a tick has been attached for 48 hours;
  • 50% after 63 – 67 hours;
  • 70% by 72 hours;
  • 90% for a complete feed.

The time it takes to become infected with the Lyme disease bacteria has “generated lively debate in the United States,” writes Eisen.

Several mouse studies indicate that a single tick bite from a nymph tick cannot transmit Lyme disease in less than 24 hours. But others disagree.

“The possibility that transmission of Lyme disease spirochetes could occur within 24 hours of nymphal attachment under unusual circumstances should not be discounted,” writes Eisen.

While the tick is attached, the Bb spirochete have time to multiply in the gut, escape into the hemocoel and invade and multiply in the salivary glands before transmitting the Lyme bacteria.

In a review article, Cook writes, “It is frequently stated that the risk of infection is very low if the tick is removed within 24–48 hours, with some claims that there is no risk if an attached tick is removed within 24 hours or 48 hours.” [2]

In animal models, transmission can occur in less than 16 hours, and “the minimum attachment time for transmission of infection has never been established.”

Spirochetes in tick salivary glands 

Additionally, studies have found the presence of spirochetes in the tick salivary glands prior to the tick feeding, which could result in a rapid transmission of Borrelia burgdorferi bacteria.

Studies suggest, “in cases where the spirochetes are present in the tick salivary glands, they can be injected into the host during the preparatory transfers of antihistamines and anticoagulants prior to the commencement of feeding, ie, immediately after attachment of the tick to the host,” Cook writes.

There is also evidence that the transmission times and virulence varies depending upon the tick and Borrelia species, he adds.

Are you the tick’s 2nd meal?

A tick that is partially fed may be able to transmit diseases faster, Eisen explains.

“Partially fed ticks able to re-attach could result from detachment from dead animals or possibly by host grooming.”

Researchers have shown that infected I. scapularis nymph ticks which had been previously attached to a host for 24 – 48 hours, then removed and placed onto a new host, can effectively transmit B. burgdorferi spirochete within 24 hours of their re-attachment, Eisen writes.

Ticks harbor multiple diseases 

Blacklegged ticks may be harbor multiple pathogens, leading to Lyme disease and/or other tick-borne infections.

In fact, studies have found that ticks can harbor up to a dozen different types of bacteria. And, some of these pathogens can be transmitted in less than 24 hours.

Several studies have shown that the Powassan virus can be transmitted within 15 minutes of tick attachment, while Anaplasmosis and Borrelia miyamotoi can be transmitted within the first 24 hours of attachment, explains Eisen.

Meanwhile, partially fed Amblyomma aureolatum ticks have been shown to transmit Rickettsia rickettsii in as little as 10 minutes after attachment.

Underestimating tick attachment time

There is, however, pitfalls in relying on tick attachment time to determine your risk of infection.

“Bites by I. scapularis nymphs often go entirely undetected and tick-bite victims typically underestimate how long a nymph was attached before it was detected and removed,” writes Eisen.

One study found that people “consistently underestimate the actual time the tick was attached prior to being discovered.”

Lastly, an individual would not know if they had been bitten by a partially fed tick, which would increase their chances of becoming infected and infected faster.

UPDATED: June 7, 2021

References:
  1. Eisen L. Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks. Ticks Tick Borne Dis. 2018.
  2. Cook MJ. Lyme borreliosis: a review of data on transmission time after tick attachment. Int J Gen Med. 2014;8:1-8. Published 2014 Dec 19. doi:10.2147/IJGM.S73791

_________________________

For more:

  1. Clinical evidence for rapid transmission of Lyme disease following a tick bite: https://www.sciencedirect.com/science/article/abs/pii/S0732889311004159?via%3Dihub
  2. B. Patmas, MA, Remora, C. Disseminated Lyme Disease After Short-Duration Tick Bite. JSTD 1994; 1:77-78: https://www.lymedisease.org/hard-science-on-lyme-ticks-can-transmit-infection-the-first-day/
  3. Lyme borreliosis: a review of data on transmission time after tick attachment: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278789/  The claims that removal of ticks within 24 hours or 48 hours of attachment will effectively prevent LB are not supported by the published data, and the minimum tick attachment time for transmission of LB in humans has never been established.
  4. Regarding Tick Attachment Times –  https://history.nih.gov/display/history/Burgdorfer%2C+Willy+1986

There are about 5 to 10 percent of infected ticks that have a generalized infection, including salivary glands and saliva at the time of attachment. In such cases, transmission of spirochetes would and does occur immediately at time of attachment.” —Willy Burgdorfer