Archive for the ‘Ticks’ Category

CAPC Study: Lyme Disease Spreading to Regions Once Thought Low-risk

http://veterinarynews.dvm360.com/capc-study-lyme-disease-spreading-regions-once-thought-low-risk

CAPC study: Lyme disease spreading to regions once thought low-risk

Condition in dogs could signal increasing threat to people, researchers say.

Jan 19, 2019

By dvm360.com staff

DVM360 MAGAZINE

(andriano cz/stock.adobe.com)

The Companion Animal Parasite Council (CAPC) recently released a study that shows that Lyme disease is spreading to regions not previously thought to be at risk for tick-borne disease. States such as Illinois, Iowa, North Dakota, Ohio, Michigan, West Virginia and Tennessee have all seen an increase in the prevalence of Lyme disease, according to a media release discussing the study, which CAPC conducted from January 2012 to December 2016. Results from the study were recently published in Environmetrics.

“The results of this milestone study show increasing risk for Lyme disease in endemic areas and pinpoint regions in the U.S. where Lyme is spreading—areas not historically considered endemic,” says Michael Yabsley, PhD, a professor in the Department of Population Health, College of Veterinary Medicine and Warnell School of Forestry and Natural Resources at the University of Georgia. “This expanding risk of Lyme disease demands heightened vigilance in protecting both our pets and our families.”

New research from CAPC found that the prevalence of Lyme disease is trending up in areas previously thought to be at a lower risk for tick-borne diseases. (Image courtesy of CAPC)

The study was motivated by the increase in Lyme disease cases in the U.S. and, in particular, in states not traditionally considered Lyme-endemic, the release states. Results suggest that:

  • Canine prevalence rates for Lyme disease are rising.
  • Lyme prevalence rates are increasing most in areas where the pathogen has encroached recently.
  • Lyme prevalence in dogs is rising in states traditionally not considered to be of high Lyme risk, suggesting that human risk may also be increasing in these areas, including regions in Illinois, Iowa, North Dakota, Ohio, Michigan and Tennessee.
  • Significant increases in canine Lyme prevalence have been seen in some areas that are not yet reporting significant human incidence. Researchers speculate that canine prevalence is more sensitive to changes in Lyme risk and could serve as an early warning system for changes in human risk.

The study was created to investigate regional trends in the prevalence of antibodies to Borrelia burgdorferi, the disease-causing bacterium of Lyme disease, according to the release. To conduct the research, the CAPC team analyzed more than 16 million Lyme tests from domestic dogs in the U.S. over 60 months. The serologic data was provided by IDEXX Laboratories.

“CAPC research shows the risk for Lyme disease is not static. The way it’s changing varies spatially across the country,” says Christopher McMahan, associate professor in the department of mathematical sciences at Clemson University, in the release.

Crucial in the fight against Lyme, Yabsley says, is year-round tick protection. Different species of ticks are active all 12 months of the year, and ticks that transmit Lyme are active at different times in the year in different regions, the release states. For instance, as you move further south, adult ticks are more active in the winter.

“I’ve been practicing for over 34 years in Nashville where many people don’t think Lyme disease is a concern. But I’ve seen canine Lyme increasing in Tennessee for several years and regularly test and vaccinate for the disease,” says Craig Prior, BVSC, CVJ, a veterinarian and former owner of VCA Murphy Road Animal Hospital in Nashville, Tennessee. “Many people tend to believe that if they don’t go on hikes or spend time in wooded areas, they aren’t at risk for Lyme. Ticks are everywhere—including suburban and gated communities where deer, raccoons, opossum, birds and other hosts frequent back yards. That’s why CAPC recommends year-round tick prevention for dogs—and cats—and regular screening to protect dogs from this debilitating disease that can be extremely hard to treat.”

On petdiseasealerts.org, CAPC now provides monthly forecasts for Lyme disease and other tick-borne diseases. It also provides access to monthly canine test results in prevalence maps, a CAPC resource available free online at petsandparasites.org. With more than 21 million canine B. burgdorferi antibody test results collected between 2012 and 2017 in dogs, these maps allow veterinarians, physicians, pet owners and travelers to assess the risk of exposure across the United States and Canada.

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**Comment**

Wisconsin prevalence rate for Lyme, Anaplasmosis, and Ehrlichiosis in pets:  https://capcvet.org/maps/#2012/all/lyme-disease/dog/united-states/wisconsin/  As you can see there are many counties where NO DATA has been collected.  Please remember maps are a very loose guide to what’s happening out there and have been used against patients for decades – denying them accurate diagnosis and treatment.  FYI:  Dane County is at HIGH risk for all 3.

According to independent Canadian tick researcher, John Scott, the reason for this tick proliferation is due to migrating birds and photoperiod, NOT climate change:  https://madisonarealymesupportgroup.com/2018/08/13/study-shows-lyme-not-propelled-by-climate-change/

https://madisonarealymesupportgroup.com/2018/11/07/ticks-on-the-move-due-to-migrating-birds-and-photoperiod-not-climate-change/

Also, infected dogs spread infections as well as ticks when they cross borders:  https://madisonarealymesupportgroup.com/2018/03/09/infected-dogs-with-tbis-spreading-infection-across-borders/  Think of pets as luggage that can and do carry pathogens right into your home.  Please do not allow your dog on your bed or furniture and make sure you use tick prevention on all pets.

 

 

 

 

 

Category:

Activism, Anaplasmosis, Ehrlichiosis, Lyme, research, Ticks, Transmission

2018 Review of Previous Pathogen Transmission Time Studies in Deer Ticks

https://www.ncbi.nlm.nih.gov/pubmed/29398603

2018 Mar;9(3):535-542. doi: 10.1016/j.ttbdis.2018.01.002. Epub 2018 Jan 31.

Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks.

Eisen L1.

Abstract

The blacklegged tick, Ixodes scapularis, is the primary vector to humans in the eastern United States of the deer tick virus lineage of Powassan virus (Powassan virus disease); the protozoan parasite Babesia microti (babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum (anaplasmosis), Borrelia burgdorferi and Borrelia mayonii (Lyme disease), Borrelia miyamotoi (relapsing fever-like illness, named Borrelia miyamotoi disease), and Ehrlichia muris eauclairensis (a minor causative agent of ehrlichiosis).

With the notable exception of Powassan virus, which can be transmitted within minutes after attachment by an infected tick, there is no doubt that the risk of transmission of other I. scapularis-borne pathogens, including Lyme disease spirochetes, increases with the length of time (number of days) infected ticks are allowed to remain attached. This review summarizes data from experimental transmission studies to reinforce the important disease-prevention message that regular (at least daily) tick checks and prompt tick removal has strong potential to reduce the risk of transmission of I. scapularis-borne bacterial and parasitic pathogens from infected attached ticks.

The most likely scenario for human exposure to an I. scapularis-borne pathogen is the bite by a single infected tick. However, recent reviews have failed to make a clear distinction between data based on transmission studies where experimental hosts were fed upon by a single versus multiple infected ticks. A summary of data from experimental studies on transmission of Lyme disease spirochetes (Bo. burgdorferi and Bo. mayonii) by I. scapularis nymphs indicates that the probability of transmission resulting in host infection, at time points from 24 to 72 h after nymphal attachment, is higher when multiple infected ticks feed together as compared to feeding by a single infected tick.

In the specific context of risk for human infection, the most relevant experimental studies therefore are those where the probability of pathogen transmission at a given point in time after attachment was determined using a single infected tick. The minimum duration of attachment by single infected I. scapularis nymphs required for transmission to result in host infection is poorly defined for most pathogens, but experimental studies have shown that Powassan virus can be transmitted within 15 min of tick attachment and both A. phagocytophilum and Bo. miyamotoi within the first 24 h of attachment. There is no experimental evidence for transmission of Lyme disease spirochetes by single infected I. scapularis nymphs to result in host infection when ticks are attached for only 24 h (despite exposure of nearly 90 experimental rodent hosts across multiple studies) but the probability of transmission resulting in host infection appears to increase to approximately 10% by 48 h and reach 70% by 72 h for Bo. burgdorferi. Caveats to the results from experimental transmission studies, including specific circumstances (such as re-attachment of previously partially fed infected ticks) that may lead to more rapid transmission are discussed.

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**Comment**

There are a number of problematic issues with this study:

  1. This is a review of previous studies.  There is nothing NEW here.  
  2. It’s important to note that ticks typically carry more than just borrelia and transmission times have not taken this fact into account: https://madisonarealymesupportgroup.com/2017/05/01/co-infection-of-ticks-the-rule-rather-than-the-exception/ and https://www.lymedisease.org/lyme-basics/co-infections/about-co-infections/  Infection with more than one pathogen is associated with more severe illness.https://madisonarealymesupportgroup.com/2018/10/30/study-shows-lyme-msids-patients-infected-with-many-pathogens-and-explains-why-we-are-so-sick/  For the first time, Garg et al. show a 85% probability for multiple infections including not only tick-borne pathogens but also opportunistic microbes such as EBV and other viruses.  This is a BIG DEAL.  Finally, a study showing what we face as patients in the real world.  They also never take into account nematodes (worms), mycoplasma, tularemia, and/or Bartonella.  These are infections many if not most patients have to contend with.  Some have been bioweaponized.
  3. They assume that the most likely scenario is for a person to be bitten by one tick.  Assuming makes an ass out of u and me.  When you take into account the latest information on the Asian tick, you quickly realize the probability of coming into contact with hundreds if not thousands of ticks at one time:  https://madisonarealymesupportgroup.com/2018/09/12/three-surprising-things-i-learned-about-asian-longhorned-ticks-the-tick-guy-tom-mather/  While human infection has yet to be found in the U.S., this tick is responsible for plenty of misery in Asia:  https://madisonarealymesupportgroup.com/2018/06/12/first-longhorned-tick-confirmed-in-arkansas/  It spreads SFTS (sever fever with thrombocytopenia syndrome), “an emerging hemorrhagic fever,” but the potential impact of this tick on tickborne illness is not yet known. In other parts of the world, it has been associated with several tickborne diseases, such as spotted fever rickettsioses, Anaplasma, Ehrlichia, and Borrelia, the causative agent of Lyme Disease.
  4. While they discuss the probability of multiple tick attachment, they never discuss the issue of partially fed ticks, where spirochetes would be in the salivary glands – leading to quicker transmission: http://iai.asm.org/content/61/6/2396.full.pdf  Ticks can spontaneously detach – and the authors of this study found that they did so 15% of the time in mice.  They also state that about a tenth of questing nymphs appear distended with partially fed sub-adult ticks being common.
  5. While the current review states, “There is no experimental evidence for transmission of Lyme disease spirochetes by single infected I. scapularis nymphs to result in host infection when ticks are attached for only 24 h (despite exposure of nearly 90 experimental rodent hosts across multiple studies), this study shows transmission can occur in under 16 hours:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278789/
  6. https://madisonarealymesupportgroup.com/2017/04/14/transmission-time-for-lymemsids-infection/  Within this video, microbiologist Holly Ahern discusses the numerous problems with animal Bb transmission studies.  Transmission Time:  Only one study done on Mice. At 24 hours every tick had transmitted borrelia to the mice; however, animal studies have proven that transmission can occur in under 16 hours and it occurs frequently in under 24 hours.  No human studies have been done and https://www.dovepress.com/lyme-borreliosis-a-review-of-data-on-transmission-time-after-tick-atta-peer-reviewed-article-IJGM  no studies have determined the minimum time it takes for transmission.  And, never forget the case of the little girl who couldn’t walk or talk after a tick bite attachment of 4-6 hours:  https://madisonarealymesupportgroup.com/2016/12/07/igenex-presentation/
  7. They continue to blame Lyme/MSIDS on the black legged tick as the sole perp when experience and studies show there’s more potential transmitters at play:  https://madisonarealymesupportgroup.com/2018/11/07/are-mosquitoes-transmitting-lyme-disease/, https://madisonarealymesupportgroup.com/2016/07/23/german-study-finds-borrelia-in-mosquitos/, https://madisonarealymesupportgroup.com/2019/01/17/remember-deer-keds-study-shows-bartonella-causing-deer-ked-dermatitis-in-humans/
Please, quit doing reviews of previous data and do something new using better laboratory techniques!  We don’t need MORE of the same thing.

Category:

Anaplasmosis, Babesia, Borrelia Miyamotoi (Relapsing Fever Group), Ehrlichiosis, Lyme, research, Ticks, Transmission, Viruses

Remember Deer Keds? Study Shows Bartonella Causing Deer Ked Dermatitis in Humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC525279/

. 2004 Nov; 42(11): 5320–5323.
PMCID: PMC525279
PMID: 15528732

Isolation of Bartonella schoenbuchensis from Lipoptena cervi, a Blood-Sucking Arthropod Causing Deer Ked Dermatitis

Christoph Dehio,1,* Ursula Sauder,2 and Rosemarie Hiestand1
Author information Article notes Copyright and License information Disclaimer

ABSTRACT

Bartonella schoenbuchensis, which commonly causes bacteremia in ruminants, was isolated from the deer ked Lipoptena cervi and was shown to localize to the midgut of this blood-sucking arthropod, causing deer ked dermatitis in humans. The role of B. schoenbuchensis in the etiology of deer ked dermatitis should be further investigated.

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**Important Take-aways**

  • Deer Ked incidental infestation in humans is well documented
  • Skin tests with deer red whole-body extracts were positive in ALL patients
  • Testing showed both immediate & delayed reactions
  • 57% of patients had elevated serum immunoglobulin E (IgE) levels
  • Deer keds appear to be an ideal vector for efficient transmission
  • The risk for transmission to humans is apparent
  • B. schoenbuchensis is most closely related to B bacilliformis, an important human pathogen also transmitted by a fly (Lutzomyia verrucarum)
  • Five variants were found – some of which may pose a larger risk than others
  • Clinical scenario of deer led dermatitis resembles a primary manifestation of Cat Scratch disease caused by B. henselae.
  • A positive delayed-type hypersensitivity skin test, like that characteristically observed for B. henselae antigens in cat scratch disease (), was also reported for all cases of deer ked dermatitis when whole deer ked extracts were used for the skin test (). Also, C3 deposits in dermal vessels like those described for deer ked dermatitis () are consistent with infection by vasculotropic bartonellae (). Taken together, certain clinical and histological characteristics of deer ked dermatitis are reminiscent of human infection by bartonellae, indicating that these pathogens should be considered possible etiological agents of deer ked dermatitis.

In summary, our study has provided evidence that deer keds collected from roe deer and red deer in Germany are commonly infected by B. schoenbuchensis. Furthermore, we have shown that B. schoenbuchensis colonizes the midgut of these arthropods and that this pathogen can be cultured at high titers from surface-sterilized arthropods. Our data suggest an important risk for the transmission of B. schoenbuchensis or related bartonellae to humans by the bite of an infected deer ked and suggest that a potential role of bartonellae in the etiology of deer ked dermatitis should be investigated further.

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**Comment**

Some of you will remember this: http://danielcameronmd.com/swarming-deer-flies-quickly-expose-people-lyme-disease-anaplasmosis/  Entomologists corrected Dr. Cameron and he published, “RETRACTION: STILL NO EVIDENCE THAT DEER FLIES OR DEER KEDS TRANSMIT B. BURGDORFERI OR A. PHAGOCYTOPHILUM.”

Yet, this 2018 study shows the deer ked does carry Bb and Anaplasma:  https://madisonarealymesupportgroup.com/2018/10/04/deer-fly-lyme-carrying-ectoparasite-on-the-move/  Although rarely reported in the United States, this vector (Lipoptena cervi, i.e. deer ked), recently has been shown to carry Borrelia burgdorferi and Anaplasma phagocytophylum from specimens collected domestically.

In 2016, Bb and Anaplasma was found via PCR in a Pennsylvanian deer led:  https://www.ncbi.nlm.nih.gov/pubmed/27860010

In 2017, Bartonella spp. was found in Polish deer ked:  https://www.ncbi.nlm.nih.gov/pubmed/29037227

Besides, Bb and Anaplasma, Bartonella has also been found in Norwegian Deer Flies: https://madisonarealymesupportgroup.com/2018/10/02/bartonella-found-in-deer-flies-deer-moose/  Bartonella, a huge player in Lyme/MSIDS, was found in 85% pools of adult wingless deer ked (n = 59). Two Bartonella lineages were identified based on phylogenetic analysis of the gltA gene and ITS region sequences.

Research is now desperately needed to connect these potential dots of how Lyme/MSIDS patients are acquiring Bartonella and other TBI’s.  We need transmission studies done on many, many vectors.  The one used by entomologists to downplay other vectors is 30 years old:  https://www.ncbi.nlm.nih.gov/pubmed/?term=3170711

And even it shows Bb infection or antibodies in various horse flies & mosquitoes.

https://madisonarealymesupportgroup.com/2017/04/18/bartonella-vectors/

https://madisonarealymesupportgroup.com/2018/11/07/are-mosquitoes-transmitting-lyme-disease/

https://madisonarealymesupportgroup.com/2016/07/23/german-study-finds-borrelia-in-mosquitos/

 

 

 

 

 

 

 

 

 

 

 

Category:

Bartonella, research, Testing, Ticks, Transmission

Study Shows Diminished Pathogen-specific Antibody Production in Coinfected Mice Contributing to Persistent Infection

https://www.ncbi.nlm.nih.gov/pubmed/30619263

Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity.

Djokic V1, Primus S1, Akoolo L1, Chakraborti M1, Parveen N1.

Abstract

Lyme disease is the most prominent tick-borne disease with 300,000 cases estimated by CDC every year while ~2,000 cases of babesiosis occur per year in the United States. Simultaneous infection with Babesia microti and Borrelia burgdorferi are now the most common tick-transmitted coinfections in the U.S.A., and they are a serious health problem because coinfected patients show more intense and persisting disease symptoms. B. burgdorferi is an extracellular spirochete responsible for systemic Lyme disease while B. microti is a protozoan that infects erythrocytes and causes babesiosis. Immune status and spleen health are important for resolution of babesiosis, which is more severe and even fatal in the elderly and splenectomized patients.

Therefore, we investigated the effect of each pathogen on host immune response and consequently on severity of disease manifestations in both young, and 30 weeks old C3H mice.

At the acute stage of infection, Th1 polarization in young mice spleen was associated with increased IFN-γ and TNF-α producing T cells and a high Tregs/Th17 ratio. Together, these changes could help in the resolution of both infections in young mice and also prevent fatality by B. microti infection as observed with WA-1 strain of Babesia. In older mature mice, Th2 polarization at acute phase of B. burgdorferi infection could play a more effective role in preventing Lyme disease symptoms. As a result, enhanced B. burgdorferi survival and increased tissue colonization results in severe Lyme arthritis only in young coinfected mice. At 3 weeks post-infection, diminished pathogen-specific antibody production in coinfected young, but not older mice, as compared to mice infected with each pathogen individually may also contribute to increased inflammation observed due to B. burgdorferi infection, thus causing persistent Lyme disease observed in coinfected mice and reported in patients.

Thus, higher combined proinflammatory response to B. burgdorferi due to Th1 and Th17 cells likely reduced B. microti parasitemia significantly only in young mice later in infection, while the presence of B. microti reduced humoral immunity later in infection and enhanced tissue colonization by Lyme spirochetes in these mice even at the acute stage, thereby increasing inflammatory arthritis.

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**Comment**
Glad to see more work done on the polymicrobial nature of Lyme/MSIDS as most of us out here in Lyme-land struggle with numerous pathogens, not just Lyme (borrelia).

Key Quote:  “Our findings recognize that microbial infections in patients suffering from TBDs do not follow the one microbe, one disease Germ Theory as 65% of the TBD patients produce immune responses to various microbes.”

Another problem:  

83% of all commercial tests focus only on Lyme (borrelia), despite the fact we are infected with more than one microbe.

https://madisonarealymesupportgroup.com/2018/11/17/investigating-disease-severity-in-an-animal-model-of-concurrent-babesiosis-lyme-disease/  These findings suggest that B. Burgdorferi coinfection attenuates parasite growth while B. Microti presence exacerbates Lyme Disease-like symptoms in mice.

https://madisonarealymesupportgroup.com/2018/10/02/1st-documented-case-of-girl-with-blood-stream-infection-with-bartonella-with-coinfection-of-another-bartonella-strain/

https://madisonarealymesupportgroup.com/2017/05/01/co-infection-of-ticks-the-rule-rather-than-the-exception/  Our study reveals high pathogen co-infection rates in ticks, raising questions about possible co-transmission of these agents to humans or animals, and their consequences to human and animal health. We also demonstrated high prevalence rates of symbionts co-existing with pathogens, opening new avenues of enquiry regarding their effects on pathogen transmission and vector competence.

https://madisonarealymesupportgroup.com/2018/10/11/babesia-found-in-patient-with-persistent-symptoms-following-lyme-treatment/  Because the Ixodes scapularis tick can harbour and transmit multiple parasites simultaneously, the possibility of coinfection should be considered in any patient not responding to appropriate initial medical therapy.

To date, ticks can transmit 18 and counting pathogens – ALL as devastating as Lyme: https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/

https://madisonarealymesupportgroup.com/2017/10/28/lyme-wars-part-5-coinfections/  (Click on NBC link for new story.  Approx 5 Min.)  All tests came back negative.  Don’t be fooled.  This stuff ISN’T RARE!  Dr. Phillips discusses how Bartonella isn’t even on the radar and is often confused with Lyme as symptoms overlap greatly.

 

Category:

Babesia, Lyme, research, Testing, Ticks, Transmission

Lyme Disease Story – BBC Evening News

 Approx. 2.3 Min.

BBC South East Evening News – Lyme Disease

Outdoor Survival Expert tells of the dangers of Lyme Disease.

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Great video reminding us of how our those working in the outdoors including search and rescue folks, police, fire, EMS, and forest workers are in harms way.  These folks are in the elements, including grassy ditches and other tick friendly habitats.

https://madisonarealymesupportgroup.com/2018/09/07/lyme-taking-toll-on-lunenburg-county-search-and-rescue-team/

Tick prevention is crucial:  https://madisonarealymesupportgroup.com/2017/05/11/tick-prevention-and-removal-2017/

https://madisonarealymesupportgroup.com/2018/05/27/study-conforms-permethrin-causes-ticks-to-drop-off-clothing/

To purchase permethrin-sprayed socks and support Wisconsin Lyme Network (WLN):  https://wisconsinlymenetwork.z2systems.com/np/clients/wisconsinlymenetwork/giftstore.jsp

Category:

Activism, Lyme, Prevention, Ticks, Treatment