Archive for the ‘research’ Category

Two More Studies Show Link Between mRNA Shots & Heart Issues

https://www.researchgate.net/publication/365782650_Autopsy-based_histopathological_characterization_of_myocarditis_after_anti-SARS-CoV-2-vaccination

Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination

November 2022

Clinical Research in Cardiology

DOI:10.1007/s00392-022-02129-5
Authors:
Constantin Schwab
Lisa Maria Domke
Laura Hartmann
Albrecht Stenzinger

Abstract and Figures

Cases of myocarditis, diagnosed clinically by laboratory tests and imaging have been described in the context of mRNA-based anti-SARS-CoV-2 vaccination. Autopsy-based description of detailed histological features of vaccine-induced myocarditis is lacking. We describe the autopsy findings and common characteristics of myocarditis in untreated persons who received anti-SARS-CoV-2 vaccination. Standardized autopsies were performed on 25 persons who had died unexpectedly and within 20 days after anti-SARS-CoV-2 vaccination.
  • In four patients who received a mRNA vaccination, we identified acute (epi-)myocarditis without detection of another significant disease or health constellation that may have caused an unexpected death. Histology showed patchy interstitial myocardial T-lymphocytic infiltration, predominantly of the CD4 positive subset, associated with mild myocyte damage.

Overall, autopsy findings indicated death due to acute arrhythmogenic cardiac failure. Thus, myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination. Our findings may aid in adequately diagnosing unclear cases after vaccination and in establishing a timely diagnosis in vivo, thus, providing the framework for adequate monitoring and early treatment of severe clinical cases.

http://

Dec. 21, 2022

Heidelberg University Hospital Autopsy Examination Reveals 5 of 25 Deceased Likely Linked to Vaxxed

German researchers from the esteemed Heidelberg University Hospital Institute of Pathology led by corresponding authors Thomas Longerich Deputy Director University Hospital Heidelberg and Peter Schirmacher, acting chairman of the German Society of Pathology, director of the Institute of Pathology also at Heidelberg University Hospital, and president of the German Association for the Study of the Liver, recently had their investigation published in the journal Clinical Research in Cardiology titled“Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination.” The real-world analysis examined 25 individuals who died unexpectedly AND within 20 days of the COVID-19 vaccination.

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https://www.sciencedirect.com/science/article/pii/S0264410X22014931

Surveillance of COVID-19 vaccine safety among elderly persons aged 65 years and older

https://doi.org/10.1016/j.vaccine.2022.11.069Get rights and content

Abstract

Background

Monitoring safety outcomes following COVID-19 vaccination is critical for understanding vaccine safety especially when used in key populations such as elderly persons age 65 years and older who can benefit greatly from vaccination. We present new findings from a nationally representative early warning system that may expand the safety knowledge base to further public trust and inform decision making on vaccine safety by government agencies, healthcare providers, interested stakeholders, and the public.

Methods

We evaluated 14 outcomes of interest following COVID-19 vaccination using the US Centers for Medicare & Medicaid Services (CMS) data covering 30,712,101 elderly persons. The CMS data from December 11, 2020 through Jan 15, 2022 included 17,411,342 COVID-19 vaccinees who received a total of 34,639,937 doses. We conducted weekly sequential testing and generated rate ratios (RR) of observed outcome rates compared to historical (or expected) rates prior to COVID-19 vaccination.

Findings

Four outcomes met the threshold for a statistical signal following BNT162b2 vaccination including pulmonary embolism (PE; RR = 1.54), acute myocardial infarction (AMI; RR = 1.42), disseminated intravascular coagulation (DIC; RR = 1.91), and immune thrombocytopenia (ITP; RR = 1.44). After further evaluation, only the RR for PE still met the statistical threshold for a signal; however, the RRs for AMI, DIC, and ITP no longer did. No statistical signals were identified following vaccination with either the mRNA-1273 or Ad26 COV2.S vaccines.

Interpretation

This early warning system is the first to identify temporal associations for PE, AMI, DIC, and ITP following BNT162b2 vaccination in the elderly. Because an early warning system does not prove that the vaccines cause these outcomes, more robust epidemiologic studies with adjustment for confounding, including age and nursing home residency, are underway to further evaluate these signals. FDA strongly believes the potential benefits of COVID-19 vaccination outweigh the potential risks of COVID-19 infection.

Important excerpt:

Per FDA communication of these findings, FDA is currently not taking any regulatory actions based on these signal detection activities because these signals are still under investigation and require more robust study.

Conflict of Interest Statement

Co-authors from U.S. Food and Drug Administration, Acumen LLC, and 4 Centers for Medicare & Medicaid Services declared no conflicts of interests.

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**Comment**

This well written article asks WHY it has taken so long for the FDA to print their findings.  An in an October investigation for The BMJ, the FDA first disclosed findings in July 2021, noting the detection of four types of potential serious adverse events following receipt of Pfizer’s vaccine in the elderly (65s & over):

  1. acute myocardial infarction
  2. disseminated intravascular coagulation
  3. immune thrombocytopenia
  4. pulmonary embolism

But these findings were only posted on the agency’s website, with no corresponding press release, preprint, or journal publication.  The article also points out a concern that the FDA’s analysis is already out of date due to the cut-off date of Jan. 15, 2022 (four months after the study was submitted to Vaccine), which means there’s now a year’s worth of additional data that has not been reported on by the FDA.

The webpage stated that the FDA “will further investigate these findings” and “share further updates and information with the public as they become available.”

But over one year later, crickets…..

The FDA finally just came out with the information, which claims it shows the system is working.

“How can the FDA seriously assert it’s supporting decision-making when, in the 20 months that they have been aware of the signal, there has not been a single press release or Dear Health Care Provider letter about the FDA’s studies on safety signals, and the label has yet to be updated?” ~ Peter Doshi, associate professor at the University of Maryland School of Pharmacy and senior editor at The BMJ

These studies confirm what concerned doctors, researchers, and injured patients have been shouting about for two years.  The FDA finally came out of its coma to notice, but per usual is doing nothing about it.

Dr. Peter McCullough, chief medical adviser for the Truth for Health Foundation, told the Epoch Times via email that the new paper:

“corroborates the concerns of doctors that the large uptick in blood clots, progression of atherosclerotic heart disease, and blood disorders is independently associated with COVID-19 vaccination.”

What’s truly disheartening is that this information should available BEFORE the shots were rolled out to an unsuspecting and trusting public who now must simply deal with the hideous aftermath.  Please also note that the push for these shots initially was on the vulnerable, elderly population despite the fact it is common knowledge that “vaccines” are less effective in the elderly due to a declining immune system.

Some of the worst medical and civil rights tyranny is occurring in health care settings like senior residential facilities.  A common lunacy heard around the world is, “take the jab or lose your job.” Health care workers, the military, pilots, many schools, workers in companies with more than 100 employees, and many more were mandated to get the jab. This was also true for many senior homes and other institutions.  People felt they had no choice.  Many quit their jobs due to this. Further, Whistleblowers claim elderly patients were chemically constrained and physically forced to get the injections.  Allegedly, caretakers lied to residents about the shot, and forged signatures multiple times.  These claims have been corroborated by multiple care directors.

Now, the FDA finally admits that these very people who were often forced to get the jab have a statistical signal for blood clotting due to the very thing they were forced to get.

This does not bode well for public health.

http://  (Approx. 14 Min)

FDA Drops Bombshell over Pfizer Shot

Redacted with Natali and Clayton Morris

Dec. 19, 2022

Category:

Activism, Heart Issues, research, vaccines, Viruses

Long-Term Outcomes in Treated Lyme Carditis

https://www.sciencedirect.com/science/article/abs/pii/S0146280621001547?via%3Dihub

Long-term Outcomes in Treated Lyme Carditis

https://doi.org/10.1016/j.cpcardiol.2021.100939Get rights and content

Abstract

Lyme disease is the most reported tick-borne illness in North America. Lyme carditis (LC) is an early-disseminated manifestation of Lyme disease, most commonly presenting as symptomatic high-degree atrioventricular block (AVB) which resolves with appropriate antibiotic therapy. However, long-term outcomes of treated LC have not previously been described. We present a series of 7 patients (median 28 years, 6 male) with serologically confirmed LC treated with a standard protocol developed at our center including antibiotics and pre-discharge stress test to assess AV node stability. At a mean follow-up of 20.8 months, all patients were asymptomatic, had resumed normal activities, and were free of conduction abnormalities. None required permanent pacing. Our study supports avoidance of permanent pacing for LC if conduction is stable at discharge.

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**Comment**

These patients were followed for a minimum of 12 months after hospital discharge and had no heart symptoms.  The researchers state there is no protocol for ongoing monitoring of these discharged patients that that long-term follow-up should be further explored.  I couldn’t agree more.

For more:

Category:

Heart Issues, Lyme, research, Treatment

Lyme Disease & Herxheimer Reaction in Newborn

https://danielcameronmd.com/lyme-disease-herxheimer-reaction-newborn/

LYME DISEASE AND HERXHEIMER REACTION IN NEWBORN

Newborn with lyme disease and herxheimer reaction being examined by doctor.

The Herxheimer reaction, also referred to as a Jarisch-Herxheimer reaction, is “a transient clinical phenomenon that occurs in patients infected by spirochetes who undergo antibiotic treatment.”¹ It was first described in patients with syphilis but has also been associated with other spirochetal infections including leptospirosis, Lyme disease, and relapsing fever. The reaction is associated with the onset of new symptoms or a worsening of existing symptoms in patients receiving antibiotic treatment.

By 

In 2020, investigators published a case involving a 13-year-old boy with Lyme arthritis, a common manifestation of Lyme disease, who developed a Herxheimer reaction when treated with doxycycline. On the 7th day of treatment, the boy developed a low-grade fever and severe arthralgias with intense hip, ankle and cervical spine pain and myalgias.

You can read more about the 13-year-old boy’s case in an earlier blog “Herxheimer reaction in a 13-year-old boy with Lyme disease.” 

Newborn with herxheimer reaction

In their article “Lyme disease in a neonate complicated by the Jarisch–Herxheimer reaction,” Prodanuk and colleagues² describe the case of a 21-day-old infant who was admitted to the hospital with decreased activity, poor feeding and abdominal distension.

The parents removed an engorged tick from the infant’s forearm 5 days earlier. An EM rash was present at the site of the tick bite.

“Given the erythema migrans lesion at the site from which the engorged tick was removed, we made a presumptive diagnosis of Lyme disease and administered IV ceftriaxone,” the authors write.

Two hours after treatment began, the infant developed a fever, tachycardia and other symptoms consistent with the Jarisch–Herxheimer reaction.

Testing for Lyme disease was negative.

Clinicians should also “be aware of the possibility of the Jarisch–Herxheimer reaction during the initial phase of treatment.”²

Several studies, they warn, indicate “newborns with findings consistent with early localized disease may also be at higher risk for disseminated disease.”

“Given the limited data for neonates and the possible predisposition of this population to disseminated Lyme disease, clinicians should strongly consider administering IV antibiotics to target Lyme disease,” the authors suggest.

Patients can experience a broad range of symptoms resulting from a herxheimer reaction, explains Nykytyuk and colleagues, including fever, severe polyarthralgias, myalgias, chills, hypotension, nonpruritic, nonpalpable rash, tachycardia, nausea, headache, strengthening of existing or occurrence of new symptoms of the underlying disease.¹

The exact cause of Jarisch-Herxheimer reactions is still unknown. “At first, the role of an endotoxin in the development of JHR was suggested, but later experimental studies showed that spirochetes do not have biologically active endotoxins,” the authors explained.¹

Related Articles:

What does a Lyme disease flare-up feel like?
Herxheimer reaction in a 13-year-old boy with Lyme disease
Lyme disease causes a mix of symptoms including autonomic dysfunction

References:
  1. Dhakal A, Sbar E. Jarisch Herxheimer Reaction. [Updated 2022 Apr 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557820/
  2. Prodanuk M, Groves H, Arje D, Bitnun A. Lyme disease in a neonate complicated by the Jarisch-Herxheimer reaction. CMAJ. 2022 Jul 18;194(27):E939-E941. doi: 10.1503/cmaj.220112. PMID: 35851530; PMCID: PMC9299745.

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**Comment**

This infant won the lotto by having astute parents, a noticable tick bite, and EM rash.  Many are not so fortunate to have these clear signs.  Many also test negative.  Without the signs and positive test, many are misdiagnosed and miss this opportunity for early treatment which is imperative.

For more:

Category:

Inflammation, Lyme, research, Testing, Ticks, Treatment

Ischemic Stroke With Hemorrhagic Conversion in a Case of Lyme Neuroborreliosis

https://www.cureus.com/articles/97069-ischemic-stroke-with-hemorrhagic-conversion-in-a-case-of-lyme-neuroborreliosis

Ischemic Stroke With Hemorrhagic Conversion in a Case of Lyme Neuroborreliosis

Srinandan Sathi, Daniel Kim, Patrick Duplan, Paul Kim, Carl Shenkamn

Published: August 15, 2022 (see history)

DOI: 10.7759/cureus.28028

Cite this article as: Sathi S, Kim D, Duplan P, et al. (August 15, 2022) Ischemic Stroke With Hemorrhagic Conversion in a Case of Lyme Neuroborreliosis. Cureus 14(8): e28028. doi:10.7759/cureus.28028

Abstract

Lyme disease is an infectious tick-borne illness predominant in northeastern and midwestern United States. The clinical presentation varies significantly and only a few cases develop Lyme neuroborreliosis (LNB), which makes diagnosis difficult. A 59-year-old male visiting from Michigan presented to a hospital in Florida with an ischemic stroke with aphasia and acute confusion for two days. He had imaging that noted a subacute infarct in the left parietal lobe along with multiple areas of white matter signal abnormalities and CSF serology positive for Borrelia burgdorferi IgM and IgG antibodies. The patient was placed on ceftriaxone for 30 days and showed significant clinical improvement. We present a case of ischemic stroke with hemorrhagic conversion and an incidental finding of LNB.

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**Comment**

There is no way on earth that only a few cases develop Lyme neuroborrliosis.  This statement shows the researcher’s complete disconnect from reality.

Testing is so abysmal, thousands fall through the diagnostic crack.  Then, if they manage to win the lottery and test positive, they are told it’s a “false positive,” and to “go home and be well.”

This patient in fact did win the lottery and managed to get diagnosed in Florida, which like all Southern states has had to fight tooth and nail to get public health to even recognize it.  And that probably wouldn’t have happened if it weren’t for infected researcher, Kerry Clark, who is finding Southern borrelia strains that will never be picked up in a million years using current CDC two-tier testing.  He also showed DNA of Bbsl in Lone Star ticks which might be a bridge vector of transmission to humans, but is still considered by ‘the powers that be’ to not transmit Lyme disease.  Instead, infected Southerners have been told they have STARI, a disease that looks, acts, and smells just like Lyme.

This patient, despite showing significant improvement, requires follow-up which will never happen.  If and when symptoms reappear he will simply be told it’s all “in his head.”

Category:

Lyme, Psychological Aspects, research, Testing, Treatment

‘Near-Universal’ Negative Experiences With Healthcare Providers Reported by Lyme Disease Patients

https://danielcameronmd.com/near-universal-negative-experiences-with-healthcare-providers-reported-by-lyme-disease-patients/

‘NEAR-UNIVERSAL’ NEGATIVE EXPERIENCES WITH HEALTHCARE PROVIDERS REPORTED BY LYME DISEASE PATIENTS

Lyme patient expressing frustration with doctor.

Lyme disease can be a challenging illness for both physicians and their patients. In an article entitled “Knowing the entire story – a focus group study on patient experiences with chronic Lyme-associated symptoms (chronic Lyme disease),” Baarsma et al. share various perspectives of self-identified chronic Lyme disease patients from the Dutch Lyme community.

By Dr. Daniel Cameron

“Healthcare providers frequently struggle to provide effective care to patients with chronic Lyme-associated symptoms…potentially causing these patients to feel misunderstood or neglected by the healthcare system,” the authors wrote.

They listed 6 themes that emerged from the participants experiences: Late diagnosis, abandonment, loss, unpredictability, lack of understanding, and a need for a holistic experience.

The authors unfortunately found, “Negative experiences with healthcare providers were near-universal, also in patients with short-lived CLD-associated symptoms.”

Here are a few of the participants experiences with healthcare providers.

Lack of in-depth questioning

“If the GP had asked something, then I would have remembered. If he had asked: “Have you been in the woods, have you had a tick bite?”, then I would have [said]: “Yeah, I did have a tick bite.” And then maybe, well, then you hope that it [would have] been treated at that time. But that didn’t happen and he didn’t ask.”

Lack of seeing the ‘big picture’

“They only look at that one thing, […] but all that time no-one looked at the entire picture.”

Need to fit into clinician’s viewpoint

“You go to a doctor with the anticipation that they are going to make an effort for you, but along the way you notice that they have their own interests and ideas, and if you don’t fit into their frame of reference then you can go. Yeah, the doctor is only insulting.”

Patients feeling not heard

“What I think is a pity, is… you go through a lot in a short while, all sort of things happen, and, uhm, there’s a doctor in front of you who doesn’t want to hear it. Look, when you try to describe a symptom, you experience that for the first time, you also don’t know what the medical term is. You try to describe something, but you just notice that the other side of the table is completely disinterested.”

Symptoms dismissed as psychiatric

“Well, they can’t find anything, so it must be ‘between the ears.’”

“In summary, we find that CLD patients experience significant symptoms, for which they only rarely find adequate relief from regular medical practitioners.”

The authors concluded, “Verbalizing these themes, patients use various repertoires for their shared experiences, such as a feeling of abandonment or not being heard by the medical system, feelings of loss with respect to their previous health, and the idea that they might have been better off had they been diagnosed sooner.”

Furthermore, “We hypothesize that these findings are not unique to CLD, but may also be applicable to other conditions with an uncertain aetiology, such as Long COVID,” they wrote.

Related Articles:

Symptoms of Lyme disease are not excessive
Dismissing chronic Lyme disease for somatic symptom disorder diagnosis
My child has Lyme disease: parents describe fear and frustration

References:
  1. Baarsma ME, Claassen SA, van der Horst HE, Hovius JW, Sanders JM. Knowing the entire story – a focus group study on patient experiences with chronic Lyme-associated symptoms (chronic Lyme disease). BMC Prim Care. Jun 2 2022;23(1):139. doi:10.1186/s12875-022-01736-5

Category:

Activism, Lyme, research