Archive for the ‘research’ Category

Evidence for the Presence of Borrelia Burgdorferi in Invasive Breast Cancer Tissues

https://www.researchgate.net/publication/378802154_Evidence_for_the_presence_of_Borrelia_burgdorferi_in_invasive_breast_cancer_tissues

Evidence for the presence of Borrelia burgdorferi in invasive breast cancer tissues

March 2024

DOI:10.1556/1886.2024.00021
Authors:  Niraj Jatin Patel, Sahaja Thippani, Jasmine Jathan, Gauri Gauri
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Abstract

Borrelia burgdorferi , the causative agent of Lyme disease, has recently been demonstrated to infect and enhance the invasive properties of breast cancer cells, while also influencing the expression of inflammatory chemokines (CXCL8 and CXCL10). This study investigates the presence of B. burgdorferi in invasive breast cancer tissues using commercially available, FDA-approved breast cancer tissue microarrays consisting of 350 ductal, 32 lobular, and 22 intraductal invasive breast carcinomas, alongside 29 normal breast tissues. Employing fluorescent immunohistochemical staining and high-resolution imaging, the findings revealed that
  • approximately 20% of invasive lobular and ductal carcinomas, followed by
  • 14% of intraductal carcinomas, tested positive for B. burgdorferi,
  • while all normal breast tissues tested negative.
  • PCR analysis further confirmed the presence of B. burgdorferi DNA in breast cancer tissues.
  • Moreover, 25% of B. burgdorferi – positive tissues exhibited expression of both chemokines, CXCL8 and CXCL10, which was not observed in B. burgdorferi – negative tissues.
  • Analysis of available patient data, including age, indicated a correlation between older patients and B. burgdorferi – positive tissues.

This study validates the presence of B. burgdorferi in invasive breast cancer tissues and highlights the involvement of key CXCL family members associated with inflammatory processes.

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**Comment**

It all of a sudden becomes quite clear why ‘the powers that be’ simply had to bury ivermectin and HCQ.  These drugs are turning out to be highly anti-viral and anti-cancer.  More and more is coming out on these safe, cheap drugs that have been effectively repurposed for cancer.  Due to a court order, the FDA had to remove its controversial verbiage on ivermectin from its website.  Predictably, the FDA claims no wrongdoing despite an estimated 500,000 deaths due to its suppression of ivermectin, as well as the fact doctors lost their jobs for simply endorsing the drug.

The FDA has a lot to answer for.

I also highly recommend reading and listening to this:  https://robertyoho.substack.com/p/302-how-to-save-your-life-if-you

On a personal side note relating to the above link: my holistic doctor (RIP) once told me that he successfully treated female cancers with testosterone and male cancers with estrogen.  At the time there weren’t any studies on this hormone approach for cancer and all he had to support it was his 35 years of clinical experience.  Now, it finally appears there are some studies:  https://hormonebalance.org/publications/

Another doctor we used has completely restored women who have severe endometriosis by using a cocktail of synthetic testosterones (nandrolone and stanozolol) that doesn’t break down into estrogen as well as the anti-androgen spironolactone to counter any facial hair or lowering of the voice.  My daughter still uses this treatment and it has worked amazingly for over ten years.  To say it has changed her life would be an understatement.

This too is a big reason hormone therapy is nearly banned in mainstream medicine.  It just does too many things for health which interferes with Big Pharma profits.

If you haven’t figured it out yet, the FDA could care less about true health.

For more:

Category:

Cancer, Inflammation, Lyme, research

Bacterial Biofilm & Its Role in the Pathogenesis of Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167820/

 2020 Feb; 9(2): 59.
Published online 2020 Feb 3. doi: 10.3390/antibiotics9020059
PMCID: PMC7167820
PMID: 32028684

Bacterial Biofilm and its Role in the Pathogenesis of Disease

Lene K. Vestby,1 Torstein Grønseth,2 Roger Simm,3 and Live L. Nesse4,*
Author information Article notes Copyright and License information PMC Disclaimer

Abstract

Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm infections are typically chronic in nature, as biofilm-residing bacteria can be resilient to both the immune system, antibiotics, and other treatments. This is a comprehensive review describing biofilm diseases in the auditory, the cardiovascular, the digestive, the integumentary, the reproductive, the respiratory, and the urinary system. In most cases reviewed, the biofilms were identified through various imaging technics, in addition to other study approaches. The current knowledge on how biofilm may contribute to the pathogenesis of disease indicates a number of different mechanisms. This spans from biofilm being a mere reservoir of pathogenic bacteria, to playing a more active role, e.g., by contributing to inflammation. Observations also indicate that biofilm does not exclusively occur extracellularly, but may also be formed inside living cells. Furthermore, the presence of biofilm may contribute to development of cancer. In conclusion, this review shows that biofilm is part of many, probably most chronic infections. This is important knowledge for development of effective treatment strategies for such infections.

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Category:

Biofilm, Inflammation, Lyme, research, Uncategorized

Obstetrical and Neonatal Outcomes in Women With Gestational Lyme Disease

https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.15380

Obstetrical and neonatal outcomes in women with gestational Lyme disease

First published: 21 January 2024
https://doi.org/10.1002/ijgo.15380
Read the full text

Abstract

Objective

The incidence of Lyme disease (LD) infections has risen in recent decades. Gestational LD has been associated with adverse pregnancy outcomes; however, the results have been contradictory. The study objective was to examine the effects of gestational LD on obstetrical and neonatal outcomes.

Methods

Using the Healthcare Cost & Utilization Project National (Nationwide) Inpatient Sample from the United States, we conducted a retrospective cohort study of pregnant patients admitted to the hospital between 2016 and 2019. The exposed group consisted of pregnant patients with gestational LD infection (International Classification of Diseases, Tenth Revision [ICD-10] code A692x), while the comparison group consisted of pregnant patients without gestational LD. Descriptive statistics and multivariate logistic regression models, adjusted for baseline maternal characteristics, were used to determine the associations between gestational LD and obstetrical and neonatal outcomes.

Results

The cohort included 2 ,943, 575 women, 226 of whom were diagnosed with LD during pregnancy. The incidence of LD was 7.67 per 100, 000 pregnancy admissions. The incidence of gestational LD was stable over the study period. Pregnant patients with LD were more likely white, older, to have private health insurance, and to belong to a higher income quartile. Gestational LD was associated with an increased risk of placental abruption (adjusted odds ratio [aOR], 3.45 [95% confidence interval (CI), 1.53–7.80]) and preterm birth (aOR, 1.58 [95% CI, 1.03–2.42]).

Conclusion

Gestational LD is associated with a higher risk of placental abruption and preterm birth. Pregnancies complicated by LD, while associated with a higher risk of certain adverse outcomes, can be followed in most healthcare settings.

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Category:

Lyme, Pregnancy, research, Transmission

First Record of Ixodes Keiransi (Acari: Ixodidae) in NJ

https://academic.oup.com/jme/advance-article-abstract/doi/10.1093/jme

First record of Ixodes keiransi (Acari: Ixodidae) in New Jersey, USA

Zoe E Narvaez, Andrea M Egizi, Dana C Price
Journal of Medical Entomology, tjae037, https://doi.org/10.1093/jme/tjae037
Published:  16 March 2024

Abstract

The hard tick, Ixodes keiransi Beati, Nava, Venzal, & Guglielmone, formerly the North American lineage of Ixodes affinis Neumann, is expanding its range northward along the US East Coast. In July 2023, we collected I. keiransi adult female and nymph in a single sampling event, suggesting its range now includes southern New Jersey. In this area, I. keiransi is sympatric with northern populations of Ixodes scapularis Say (Acari: Ixodidae), the primary vector of Lyme disease. Given its status as an enzootic vector of spirochaetes in the Borrelia burgdorferi sensu lato complex, proper differentiation of these 2 species will be critical for accurate estimates of entomological risk. Targeted surveillance should be implemented to monitor further I. keiransi expansion and to elucidate the phenology and enzootic role of this and other understudied Ixodes spp. in the northeastern United States.

Category:

research, Ticks

Fewer Ticks = Less Lyme? Nope

https://highlandscurrent.org/2024/03/15/fewer-ticks-less-lyme-maybe-not/

Fewer Ticks = Less Lyme? Maybe Not.

by Brian PJ Cronin

Tick Project releases results of five-year study

Article Excerpts:

First, the good news: Over five years, 46 Millbrook-based researchers found that bait boxes reduced the tick population in the yards of Dutchess County residents by half.

The bad news: It didn’t matter. Although there were fewer ticks, it had little effect on reducing illness or people’s encounters with them, findings in line with a preliminary study completed in 2016.

For the study, researchers selected 24 neighborhoods in Dutchess County, including some in Beacon. They applied fungal spray and bait boxes, both of which are commercially available and safe for people, pets and the environment.

The spray, which is sold as Met52, is made from Metarhizium anisopliae, which is found in forest soil in the eastern U.S. “It makes its living by attacking and killing arthropods on the forest floor, digesting them and using them as a food source,” said Ostfeld.

The bait boxes attract rodents that, once inside, rub against a wick that applies a non-toxic insecticide with the same active ingredient as Frontline, a tick treatment for pets. “It’s safe for vertebrates but lethal for ticks,” Ostfeld said.  (See link for article)

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**Comment**

There are no easy answers here.  Sorry.

This is why our family has been without pets for years now.  Living in the Wisconsin woods is bad enough without inviting ticks into the house via pets.

While the article states Frontline is “safe,” I’ve actually known dogs to get sick and/or die after using it.  Also, a flea and tick collar caused our dog to lose his hair.  Our healthy, albeit older, dog suddenly developed a poor immune system and eventually died.  I don’t believe this a coincidence and the suspicious timing of the collar is too great to ignore.

Besides the most common reactions Frontline causes like hair loss, itching, and redness, and neurological issues like uncoordinated movement and lethargy, research by the EPA in 2009 examined incident data for spot-on pesticides used on dogs, including fipronil products for dogs and cats. The report on Frontline Plus for Dogs shows that of a total of 2469 incidents, they classified:

  • 1,872 (76%) as minor
  • 51 (21%) as moderate
  • 47 (2%) as major
  • 39 (<2%)  were deaths
These side effects are not addressed anywhere on Frontline’s website.

The EPA’s study also covered many other spot-on pesticides for dogs, and while some incidents were classified as minor, it’s important to note there were major incidents and deaths associated with every product.

Dr Jennifer Ramelmeier, a veterinarian who advises her patients to avoid using it states:

“The first response of the body when the patient develops a toxic load is to discharge from the body via the eyes, the ears, the skin and through loose stool … these discharges make a great medium for bacterial and yeast growth (which live naturally on your dog’s body).”

Frontline Plus is produced and owned by Merial, the animal subsidiary of Sanofi, a multinational pharmaceutical company

Ramelmeier and some other veterinarians started noticing that after the initial dose and bodily discharges, repeated doses are linked to conditions that don’t improve, cancer, and then death.

Others disagree and simply state it’s safe.

Here is some of the best advice from holistic vets:

  • Maintain the health of your pet. This means a healthy diet and physical activity. Also minimize the use of unnecessary pharmaceuticals. Healthy animals have lower body temperatures and cooler animals attract fewer fleas.
  • To actively repel fleas, she recommends products like neem oil.
  • Use Shoo tags
  • Feed garlic
  • Apply geranium oil to the collar of your dog to prevent fleas and ticks

Want to know how you can keep the fleas and ticks away naturally? Check out this article for more information on safe flea and tick protection.

Regarding Neem oil – I’ve used it for years as a pesticide on plants with very good effect.  I have not used it on pets.

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Category:

research, Ticks