How Lyme Evades the Immune System
Approx. 1 Min 30
Chronic Lyme disease complex is the culmination of Lyme disease and it’s co-infections. Treating chronic Lyme disease can be very difficult because of the many ways Borrelia evades the body’s immune system via constant surface antigen shifting (shifting its own genome), biofilm formation, and its ability to travel everywhere in the body, including particularly difficult places to treat. All of these factors often lead to antibiotic resistance and failed medical treatments. Finding the correct treatment protocol is crucial to having lasting relief from this debilitating disease.
Study found here: https://www.scirp.org/Journal/PaperInformation.aspx?PaperID=52890#.VK2lFivF8WI
Chronic Lyme Disease: Persistent Clinical Symptoms Related to Immune Evasion, Antibiotic Resistance and Various Defense Mechanisms of Borrelia burgdorferi
There are several factors involved in the ability of Borrelia burgdorferi to retain a persistent infection within a mammalian host. These factors of immune evasion include regulation of membrane proteins, variable epitopes of surface proteins, protection against the immune system through tick saliva, the ability to migrate to regions where it is not exposed to the immune system or antibiotics, invagination or invasion within various cells, pleomorphic forms, and the potential to produce biofilms. The window of conventional treatment for Lyme disease is short and has the potential to display different symptoms depending on the strain of Borrelia bugdorferi. These symptoms are dependent on the localization of Borrelia burgdorferi which correlates to the significance of diagnosing Lyme disease early to prevent such a spread throughout the body. Such complications of Borrelia burgdorferi may demand new clinical treatment discoveries for patient fighting the chronic form.
Published on Nov 11, 2015